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公开(公告)号：US20220125389A1
公开(公告)日：2022-04-28
申请号：US17568771
申请日：2022-01-05
Applicant: NORTHWESTERN UNIVERSITY
Inventor： John A. Rogers , Siddharth Krishnan , Tyler R. Ray , Amit B. Ayer , Philipp Gutruf , Jonathan T. Reeder , Kun Hyuck Lee , Chun-Ju Su
Abstract: Provided are conformable devices to measure subdermal fluid flow and related methods. A soft, stretchable and flexible substrate supports a thermal actuator and various specially positioned temperature sensors. A microprocessor in electronic communication with sensors calculates subdermal fluid flow from the measured upstream and downstream temperatures, as well as various application-dependent parameters. Devices and methods provided herein are particularly useful for measuring cerebral spinal fluid in a ventricular shunt placed for treatment of hydrocephalus.
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Patent Agency Ranking
公开(公告)号：US20240260910A1
公开(公告)日：2024-08-08
申请号：US18633768
申请日：2024-04-12
Applicant: NORTHWESTERN UNIVERSITY
Inventor： John A. Rogers , Siddharth Krishnan , Tyler R. Ray , Amit B. Ayer , Philipp Gutruf , Jonathan T. Reeder , Kun Hyuck Lee , Chun-Ju Su
CPC classification number: A61B5/7278 , A61B5/01 , A61B2562/0271 , A61B2562/164 , A61B2562/18
Abstract: Hydrocephalus and shunt-related expenditures cost the US system over $2 billion dollars in annual expenses, with 125,000 shunt surgeries per year and an untreated mortality rate estimated at 50-60%. Existing diagnostics are expensive, inaccurate, and often harmful or invasive, and can lead to unnecessary admissions, further testing, or needless surgery. Collaborative efforts between Northwestern materials engineers headed by Dr. John Rogers alongside the leadership of neurological surgeons at Northwestern Memorial Hospital and Lurie Children's Hospital have produced and validated a noninvasive, thermal biosensor capable of diagnosing ventricular shunt malfunction.
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公开(公告)号：US11439356B2
公开(公告)日：2022-09-13
申请号：US17568771
申请日：2022-01-05
Applicant: NORTHWESTERN UNIVERSITY
Inventor： John A. Rogers , Siddharth Krishnan , Tyler R. Ray , Amit B. Ayer , Philipp Gutruf , Jonathan T. Reeder , Kun Hyuck Lee , Chun-Ju Su
Abstract: Provided are conformable devices to measure subdermal fluid flow and related methods. A soft, stretchable and flexible substrate supports a thermal actuator and various specially positioned temperature sensors. A microprocessor in electronic communication with sensors calculates subdermal fluid flow from the measured upstream and downstream temperatures, as well as various application-dependent parameters. Devices and methods provided herein are particularly useful for measuring cerebral spinal fluid in a ventricular shunt placed for treatment of hydrocephalus.
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公开(公告)号：US20250032311A1
公开(公告)日：2025-01-30
申请号：US18716989
申请日：2022-12-09
Applicant: NORTHWESTERN UNIVERSITY , WASHINGTON UNIVERSITY
Inventor： John A. Rogers , Jonathan T. Reeder , Matthew MacEwan , Wilson Z. Ray
Abstract: A device for reversibly blocking activities of a target region of a subject includes a microfluidic system configured to route a fluid around the target region to change a local temperature of the target region; and an electronic system coupled with the microfluidic system for providing a real-time feedback.
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公开(公告)号：US20220125390A1
公开(公告)日：2022-04-28
申请号：US17568791
申请日：2022-01-05
Applicant: NORTHWESTERN UNIVERSITY
Inventor： John A. Rogers , Siddharth Krishnan , Tyler R. Ray , Amit B. Ayer , Philipp Gutruf , Jonathan T. Reeder , Kun Hyuck Lee , Chun-Ju Su
Abstract: Provided are conformable devices to measure subdermal fluid flow and related methods. A soft, stretchable and flexible substrate supports a thermal actuator and various specially positioned temperature sensors. A microprocessor in electronic communication with sensors calculates subdermal fluid flow from the measured upstream and downstream temperatures, as well as various application-dependent parameters. Devices and methods provided herein are particularly useful for measuring cerebral spinal fluid in a ventricular shunt placed for treatment of hydrocephalus.
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公开(公告)号：US11259754B2
公开(公告)日：2022-03-01
申请号：US17043111
申请日：2019-03-29
Applicant: NORTHWESTERN UNIVERSITY
Inventor： John A. Rogers , Siddharth Krishnan , Tyler R. Ray , Amit B. Ayer , Philipp Gutruf , Jonathan T. Reeder , Kun Hyuck Lee , Chun-Ju Su
Abstract: Provided are conformable devices to measure subdermal fluid flow and related methods. A soft, stretchable and flexible substrate supports a thermal actuator and various specially positioned temperature sensors. A microprocessor in electronic communication with sensors calculates subdermal fluid flow from the measured upstream and downstream temperatures, as well as various application-dependent parameters. Devices and methods provided herein are particularly useful for measuring cerebral spinal fluid in a ventricular shunt placed for treatment of hydrocephalus.
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