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公开(公告)号：US11786168B2
公开(公告)日：2023-10-17
申请号：US16616898
申请日：2018-06-01
Inventor： John A. Rogers , Johnathan T. Reeder , Amay J. Bandodkar , Sungbong Kim , Yurina Sekine , Jungil Choi , Tyler R. Ray , Aurelie Hourlier-Fargette , Philipp Gutruf , Kun Hyuck Lee , Milan Raj
IPC: A61B5/00 , A61B5/1455 , A61B5/1486 , A61B5/145 , A61B5/1477 , A61B5/01 , A61B5/103
CPC classification number: A61B5/4266 , A61B5/0022 , A61B5/01 , A61B5/1032 , A61B5/1455 , A61B5/1477 , A61B5/1486 , A61B5/14517 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B2562/0242 , A61B2562/0276 , A61B2562/164
Abstract: The invention provides a versatile sensing platform for sensing and analysis of biofluids, particularly well-suited for sensing and analysis of sweat. Systems of the invention allows for sensitive and selective detection of a range of analytes in sweat including metabolites, electrolytes and biomarkers. Systems of the invention provide a noninvasive and accurate means for quantitative characterization of important sweat characteristics including sweat volume, sweat loss and sweat rate. Systems of the invention are compatible with materials and device geometries for important class of conformal tissue mounted electronic devices, including epidermal electronic devices.
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公开(公告)号：US20220125389A1
公开(公告)日：2022-04-28
申请号：US17568771
申请日：2022-01-05
Applicant: NORTHWESTERN UNIVERSITY
Inventor： John A. Rogers , Siddharth Krishnan , Tyler R. Ray , Amit B. Ayer , Philipp Gutruf , Jonathan T. Reeder , Kun Hyuck Lee , Chun-Ju Su
Abstract: Provided are conformable devices to measure subdermal fluid flow and related methods. A soft, stretchable and flexible substrate supports a thermal actuator and various specially positioned temperature sensors. A microprocessor in electronic communication with sensors calculates subdermal fluid flow from the measured upstream and downstream temperatures, as well as various application-dependent parameters. Devices and methods provided herein are particularly useful for measuring cerebral spinal fluid in a ventricular shunt placed for treatment of hydrocephalus.
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公开(公告)号：US20240260910A1
公开(公告)日：2024-08-08
申请号：US18633768
申请日：2024-04-12
Applicant: NORTHWESTERN UNIVERSITY
Inventor： John A. Rogers , Siddharth Krishnan , Tyler R. Ray , Amit B. Ayer , Philipp Gutruf , Jonathan T. Reeder , Kun Hyuck Lee , Chun-Ju Su
CPC classification number: A61B5/7278 , A61B5/01 , A61B2562/0271 , A61B2562/164 , A61B2562/18
Abstract: Hydrocephalus and shunt-related expenditures cost the US system over $2 billion dollars in annual expenses, with 125,000 shunt surgeries per year and an untreated mortality rate estimated at 50-60%. Existing diagnostics are expensive, inaccurate, and often harmful or invasive, and can lead to unnecessary admissions, further testing, or needless surgery. Collaborative efforts between Northwestern materials engineers headed by Dr. John Rogers alongside the leadership of neurological surgeons at Northwestern Memorial Hospital and Lurie Children's Hospital have produced and validated a noninvasive, thermal biosensor capable of diagnosing ventricular shunt malfunction.
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Patent Agency Ranking
公开(公告)号：US11439356B2
公开(公告)日：2022-09-13
申请号：US17568771
申请日：2022-01-05
Applicant: NORTHWESTERN UNIVERSITY
Inventor： John A. Rogers , Siddharth Krishnan , Tyler R. Ray , Amit B. Ayer , Philipp Gutruf , Jonathan T. Reeder , Kun Hyuck Lee , Chun-Ju Su
Abstract: Provided are conformable devices to measure subdermal fluid flow and related methods. A soft, stretchable and flexible substrate supports a thermal actuator and various specially positioned temperature sensors. A microprocessor in electronic communication with sensors calculates subdermal fluid flow from the measured upstream and downstream temperatures, as well as various application-dependent parameters. Devices and methods provided herein are particularly useful for measuring cerebral spinal fluid in a ventricular shunt placed for treatment of hydrocephalus.
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公开(公告)号：US20220125390A1
公开(公告)日：2022-04-28
申请号：US17568791
申请日：2022-01-05
Applicant: NORTHWESTERN UNIVERSITY
Inventor： John A. Rogers , Siddharth Krishnan , Tyler R. Ray , Amit B. Ayer , Philipp Gutruf , Jonathan T. Reeder , Kun Hyuck Lee , Chun-Ju Su
Abstract: Provided are conformable devices to measure subdermal fluid flow and related methods. A soft, stretchable and flexible substrate supports a thermal actuator and various specially positioned temperature sensors. A microprocessor in electronic communication with sensors calculates subdermal fluid flow from the measured upstream and downstream temperatures, as well as various application-dependent parameters. Devices and methods provided herein are particularly useful for measuring cerebral spinal fluid in a ventricular shunt placed for treatment of hydrocephalus.
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公开(公告)号：US10925523B2
公开(公告)日：2021-02-23
申请号：US16616770
申请日：2018-06-01
Inventor： John A. Rogers , Jungil Choi , Tyler R. Ray , Johnathan T. Reeder , Yurina Sekine , Amay J. Bandodkar , Yi Zhang , Hexia Guo , Sungbong Kim , Diana Ostojich
Abstract: Provided are microfluidic systems for monitoring a biofluid property and related methods. Specially configured microfluidic networks and associated structural support and functional elements, including flexible substrates, capping layers, and fluidic conduits and controllers, provide reliable biofluid collection. Optical components and indicators provide a reliable and readily observable readout, including of any of a number of biofluid properties, including directly from biofluid collected in the microfluidic network.
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公开(公告)号：US11883165B2
公开(公告)日：2024-01-30
申请号：US17027887
申请日：2020-09-22
Inventor： John A. Rogers , Jungil Choi , Tyler R. Ray , Johnathan T. Reeder , Yurina Sekine , Amay J. Bandodkar , Yi Zhang , Hexia Guo , Sungbong Kim , Diana Ostojich
CPC classification number: A61B5/14539 , A61B5/0002 , A61B5/053 , A61B5/1032 , A61B5/1455 , A61B5/14517 , A61B5/14546 , A61B5/4842 , A61B5/6806 , B01L3/502715 , A61B5/6833 , A61B2562/028 , A61B2562/164 , B01L2300/025 , B01L2300/0663 , B01L2300/0803 , B01L2300/0864 , B01L2300/123 , B01L2400/0406 , B01L2400/0688
Abstract: A microfluidic system includes a flexible substrate having a skin-facing surface and a back-facing surface; a microfluidic network at least partially embedded in or supported by the flexible substrate; a sensor fluidically connected to the microfluidic network, wherein the microfluidic network is configured to transport a biofluid from a skin surface to the sensor; and a capping layer, having a capping layer skin-facing surface and a back-facing surface, wherein the back-facing surface of the capping layer is attached to the skin-facing surface of the substrate. The flexible substrate is at least partially formed of a thermoplastic elastomer or a polymer configured to provide a high barrier to vapor or liquid water transmission.
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公开(公告)号：US11259754B2
公开(公告)日：2022-03-01
申请号：US17043111
申请日：2019-03-29
Applicant: NORTHWESTERN UNIVERSITY
Inventor： John A. Rogers , Siddharth Krishnan , Tyler R. Ray , Amit B. Ayer , Philipp Gutruf , Jonathan T. Reeder , Kun Hyuck Lee , Chun-Ju Su
Abstract: Provided are conformable devices to measure subdermal fluid flow and related methods. A soft, stretchable and flexible substrate supports a thermal actuator and various specially positioned temperature sensors. A microprocessor in electronic communication with sensors calculates subdermal fluid flow from the measured upstream and downstream temperatures, as well as various application-dependent parameters. Devices and methods provided herein are particularly useful for measuring cerebral spinal fluid in a ventricular shunt placed for treatment of hydrocephalus.
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