公开(公告)号：US20170113949A1

公开(公告)日：2017-04-27

申请号：US15317233

申请日：2015-06-12

Applicant: Imperial Innovations Limited

Inventor： Christopher MOFFAT ,  Ramon Vilar COMPTE ,  Dominik WEISS

IPC: C02F1/28 ,  B01J20/22 ,  C02F1/72

CPC classification number: C02F1/285 ,  B01J20/223 ,  B01J20/321 ,  B01J20/3219 ,  B01J20/3265 ,  B01J20/3425 ,  C02F1/281 ,  C02F1/288 ,  C02F1/683 ,  C02F1/72 ,  C02F2101/103 ,  C02F2101/105 ,  C02F2103/06 ,  C02F2209/06 ,  C02F2303/16

Abstract: Method of reducing the arsenic concentration in an aqueous solution comprising undesired arsenic, which method comprises contacting the aqueous solution with a complex of Formula (I), (Formula (I)) wherein M1 and M2 are the same or different and are independently selected from V, Mn, Ga, Cu, Ni, Co, Fe or Zn; wherein a is 0, or 1, and b is 0, or 1, provided that a+b together must be at least 1; Q is a negatively charged counter ion; n is from 1 to 5; X1 is OH, O, SH or S; L1 is a group selected from —La1-C(O)NR—, —La2-C(O)OR—, —La3-NRC(O)—, La4-OC(O)—, La5-O— or La6-NRO—, wherein La1, La2, La3, La4, La5 and La6 are each C1-6 alkyl, optionally substituted, R is H or C1-6 alkyl optionally substituted; Linker is a polyethylene glycol (PEG) chain with from 1 to 10 repeating units, a C1-16 polyamine chain or a C1-16 alkyl chain; Z is a solid support; L2 to L7 are independently C1-3 alkyl, optionally substituted; and Het1 to Het4 are independently 5 to 14 membered heteroaryl group having at least one N atom and optionally substituted.

公开(公告)号：US20170065962A1

公开(公告)日：2017-03-09

申请号：US15357124

申请日：2016-11-21

Applicant: ASAHI KASEI CHEMICALS CORPORATION

Inventor： Naoyuki SHINOHARA ,  Yuta SATO

IPC: B01J20/26 ,  B01J20/288 ,  B01J20/32 ,  B01J41/20 ,  B01J41/04 ,  C07K1/22 ,  B01J47/12 ,  B01J39/04 ,  B01J39/20 ,  B01J39/26 ,  C08J5/22 ,  B01J20/28 ,  B01J41/14

CPC classification number: B01J20/265 ,  B01J20/28023 ,  B01J20/288 ,  B01J20/3078 ,  B01J20/321 ,  B01J20/3217 ,  B01J20/327 ,  B01J20/3278 ,  B01J20/3293 ,  B01J39/07 ,  B01J39/20 ,  B01J39/26 ,  B01J41/07 ,  B01J41/13 ,  B01J41/14 ,  B01J41/20 ,  B01J47/12 ,  B01J47/127 ,  B01J47/133 ,  B01J2220/52 ,  C07K1/22 ,  C08J5/2243 ,  C08J2351/06 ,  C08J2351/08

Abstract: A method for producing a protein adsorbent comprising a substrate and a molecular chain fixed on the surface of the substrate is disclosed. The method comprises, in this order: a dry-heat treatment step of heating a pretreatment adsorbent comprising the substrate and the molecular chain fixed on the surface of the substrate, in which the molecular chain contains a weak electrolytic ion-exchange group; and a wet-heat treatment step of heating the pretreatment adsorbent in a moistened state with a liquid or steam to obtain the protein adsorbent.

Abstract translation: 公开了一种生产蛋白质吸附剂的方法，该方法包括固定在基底表面上的基底和分子链。 该方法按照以下顺序进行：将包含基板的预处理吸附剂和固定在基板表面上的分子链进行加热的干热处理工序，其中分子链含有弱电解离子交换基团; 以及湿润处理步骤，用液体或蒸汽将预处理吸附剂加湿，得到蛋白质吸附剂。

公开(公告)号：US20170057840A1

公开(公告)日：2017-03-02

申请号：US15248236

申请日：2016-08-26

Applicant: Kevin L. Bicker ,  Robert William Tilford

Inventor： Kevin L. Bicker ,  Robert William Tilford

IPC: C02F1/28 ,  C02F1/66

CPC classification number: C02F1/288 ,  B01J20/14 ,  B01J20/267 ,  B01J20/3204 ,  B01J20/321 ,  B01J20/3219 ,  B01J20/3253 ,  B01J20/3261 ,  B01J20/3433 ,  C02F1/281 ,  C02F1/285 ,  C02F1/444 ,  C02F1/66 ,  C02F2101/301 ,  C02F2103/10 ,  C02F2103/365 ,  C02F2209/06 ,  C02F2303/16 ,  C02F2305/00

Abstract: A process for extracting a surfactant from a mixture using a boronic acid modified material.

Abstract translation: 使用硼酸改性材料从混合物中提取表面活性剂的方法。

公开(公告)号：US20170029304A1

公开(公告)日：2017-02-02

申请号：US15233165

申请日：2016-08-10

Applicant: Mia LEVITE ,  Yaar TEICHBERG ,  Nof Lyle TEICHBERG

Inventor： Vivian I. Teichberg

IPC: C02F3/34 ,  C02F1/72 ,  B01J20/28 ,  C12N9/86 ,  C12N9/80

CPC classification number: C02F3/342 ,  A61K38/00 ,  B01J20/28016 ,  B01J20/2805 ,  B01J20/3204 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/3274 ,  C02F1/725 ,  C02F2101/34 ,  C02F2101/38 ,  C02F2103/42 ,  C02F2301/046 ,  C02F2303/18 ,  C12N9/80 ,  C12N9/86 ,  C12N11/00 ,  C12Y305/01005 ,  C12Y305/01084 ,  C12Y305/02015

Abstract: A composition-of-matter for use in water treatment, composed of a water-insoluble matrix and one or more amidohydrolase, such as cyanuric acid amidohydrolase, incorporated in or on the matrix, is disclosed. Also disclosed are devices containing same and methods utilizing same for water treatment. The water treatment is effected by an enzymatically-catalyzed reduction of the concentration of an amide-containing compound, such as cyanuric acid, found in chlorinated water of swimming polls, spas and other similar structures.

Abstract translation: 公开了一种用于水处理的物质组合物，其由水不溶性基质和一种或多种酰胺水解酶组成，所述酰胺水解酶如并入基质中或基质上的氰尿酸酰胺水解酶。 还公开了含有其的装置和利用其进行水处理的方法。 水处理通过酶催化降低在游泳调查物质，水疗中心和其他类似结构的氯化水中发现的含酰胺化合物如氰尿酸的浓度来实现。

公开(公告)号：US20170021332A1

公开(公告)日：2017-01-26

申请号：US15285465

申请日：2016-10-04

Applicant: NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY ,  JNC CORPORATION

Inventor： MASAYO SAKATA ,  MASAMI TODOKORO

IPC: B01J20/26 ,  C08B37/16 ,  B01J20/32 ,  B01J20/286 ,  B01J20/30

CPC classification number: B01J20/267 ,  B01J20/286 ,  B01J20/30 ,  B01J20/3042 ,  B01J20/3085 ,  B01J20/3204 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3274 ,  B01J20/3282 ,  B01J2220/52 ,  C07H1/06 ,  C07H21/02 ,  C07H21/04 ,  C08B37/0012 ,  C08B37/0015 ,  C08G18/6484 ,  C08L5/16

Abstract: A means for selectively removing ET under coexistence of a substance showing a negative charge, such as nucleic acid is described. Endotoxin is selectively removed by bringing a polymer obtained by crosslinking cyclodextrin with an isocyanate-based crosslinking agent in contact with a solution containing endotoxin and the substance showing the negative charge such as nucleic acid.

Abstract translation: 描述了在显示负电荷的物质如核酸共存下选择性除去ET的方法。 通过将通过环糊精交联而得到的聚合物与异氰酸酯基交联剂与含有内毒素的溶液和显示负电荷的物质如核酸接触来选择性地除去内毒素。

公开(公告)号：US20160298065A1

公开(公告)日：2016-10-13

申请号：US15037539

申请日：2014-11-26

Applicant: GE Healthcare BioProcess R&D AB

Inventor： Jean-Luc Maloisel ,  Tobias Soderman ,  Ola Lind

IPC: C12H1/056 ,  B01J20/32 ,  B01J20/28 ,  C08F251/00

CPC classification number: C12H1/0424 ,  B01D15/00 ,  B01J20/28004 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/327 ,  B01J20/3278 ,  B01J20/3293 ,  B01J2220/58 ,  C08F251/00

Abstract: The invention discloses a separation matrix with a porous solid support and a plurality of polyvinylpyrrolidone (PVP) polymer chains covalently attached to the solid support. The polyvinylpyrrolidone polymer chains are either vinylpyrrolidone homopolymer chains or copolymer chains which comprise at least 70 mol % vinylpyrrolidone monomer residues and less than 2 mol % negatively charged monomer residues.

Abstract translation: 本发明公开了具有多孔固体支持物和共价连接到固体支持物上的多个聚乙烯吡咯烷酮（PVP）聚合物链的分离基质。 聚乙烯吡咯烷酮聚合物链是乙烯基吡咯烷酮均聚物链或包含至少70mol％乙烯基吡咯烷酮单体残基和小于2mol％带负电荷的单体残基的共聚物链。

公开(公告)号：US20160272676A1

公开(公告)日：2016-09-22

申请号：US15033940

申请日：2014-11-06

Applicant: EMD MILLIPORE CORPORATION

Inventor： Mikhail Kozlov ,  William Cataldo ,  Jeffrey Caron

IPC: C07K1/34 ,  C07K16/00 ,  C08F220/56 ,  C08F220/54 ,  C08F220/18 ,  B01J20/289 ,  C08J5/22 ,  C08F259/08 ,  B01D15/10 ,  B01D37/00 ,  B01J20/26 ,  B01J20/288 ,  C07K1/18 ,  C08F220/58

CPC classification number: C07K1/34 ,  B01D15/10 ,  B01D37/00 ,  B01J20/267 ,  B01J20/288 ,  B01J20/289 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/327 ,  B01J20/3276 ,  B01J20/3291 ,  B01J39/26 ,  B01J2220/80 ,  C07K1/18 ,  C07K16/00 ,  C08F220/18 ,  C08F220/54 ,  C08F220/56 ,  C08F220/58 ,  C08F259/08 ,  C08F2220/1825 ,  C08F2220/1858 ,  C08J5/2243 ,  C08J2351/00

Abstract: Novel compositions for re-moving impurities such as, protein aggregates, from a sample containing a protein of interest, e.g., an antibody. Such compositions can be used prior to the virus filtration step during protein purification, to remove aggregates and protect the virus filter from fouling, therefore improving virus filter capacity. A porous solid support including a co-polymer having at least two monomers, wherein at least one of the monomers comprises acrylamide and at least a second monomer comprises a hydrophobic binding group, where the solid support selectively binds protein aggregates, thereby to separate the monomeric protein of interest from the protein aggregates. The method can be performed under neutral to high pH and high conductivity conditions.

Abstract translation: 用于从含有目的蛋白质的样品例如抗体重新杂交诸如蛋白质聚集体的新型组合物。 这样的组合物可以在蛋白质纯化期间的病毒过滤步骤之前使用，以除去聚集体并保护病毒过滤器免于结垢，从而提高病毒过滤能力。 一种多孔固体支持物，包括具有至少两种单体的共聚物，其中所述单体中的至少一种包含丙烯酰胺，并且至少第二单体包含疏水性结合基团，其中所述固体支持物选择性地结合蛋白质聚集体，由此分离单体 来自蛋白质聚集体的目标蛋白质。 该方法可在中性至高pH和高电导条件下进行。

公开(公告)号：US20160266134A1

公开(公告)日：2016-09-15

申请号：US15067339

申请日：2016-03-11

Applicant: CLEMSON UNIVERSITY

Inventor： R. Kenneth Marcus ,  Liuwei Jiang

IPC: G01N33/68 ,  G01N33/72 ,  C12Q1/34

CPC classification number: B01J20/3282 ,  B01J20/28023 ,  B01J20/286 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3272 ,  B01J2220/84 ,  B01J2220/86 ,  G01N2030/524

Abstract: Separation technologies and a support/separation phases for use therein. A surface of a support phase can be modified to include a crosslinked polymer network as stationary phase to perform separation of one or more species from a liquid in highly efficient separations based on chemical interactions, i.e., chromatography. Optionally, the support phase can employ polymer fibers having channels extending axially along their surfaces. The use of the support phase to support the crosslinked stationary phase can be used in one embodiment in the process of performing micro-scale separations.

Abstract translation: 分离技术和用于其中的支持/分离阶段。 支撑相的表面可以被修饰为包括作为固定相的交联聚合物网络，以基于化学相互作用（即色谱）在高效分离中进行一种或多种物质与液体的分离。 任选地，支持相可以使用具有沿其表面轴向延伸的通道的聚合物纤维。 在执行微尺度分离的过程中，在一个实施方案中可以使用支持相来支持交联的固定相。

公开(公告)号：US09404166B2

公开(公告)日：2016-08-02

申请号：US13454932

申请日：2012-04-24

Applicant: Alfredo M. Angeles-Boza ,  Charles R. Landis ,  William W. Shumway

Inventor： Alfredo M. Angeles-Boza ,  Charles R. Landis ,  William W. Shumway

IPC: C02F1/00 ,  C02F1/42 ,  C02F1/62 ,  C22B3/24 ,  B01J20/22 ,  B01J20/32 ,  C02F1/68 ,  C22B3/20 ,  B01J20/12 ,  B01J20/18 ,  B01J20/26 ,  B01J20/30 ,  B01J20/34 ,  B01J20/16 ,  C02F1/28 ,  C02F101/10 ,  C02F101/20 ,  C02F101/22

CPC classification number: C22B3/24 ,  B01J20/12 ,  B01J20/165 ,  B01J20/18 ,  B01J20/22 ,  B01J20/261 ,  B01J20/265 ,  B01J20/267 ,  B01J20/3021 ,  B01J20/3204 ,  B01J20/3208 ,  B01J20/321 ,  B01J20/3248 ,  B01J20/3251 ,  B01J20/3425 ,  B01J20/3433 ,  B01J20/3475 ,  B01J2220/46 ,  C02F1/281 ,  C02F1/285 ,  C02F1/288 ,  C02F1/683 ,  C02F2101/103 ,  C02F2101/203 ,  C02F2101/206 ,  C02F2101/22 ,  C22B3/205 ,  Y02P10/234

Abstract: A composition comprising a substrate, an organic ion, and a metal binding agent, wherein the substrate comprises a natural clay, a synthetic clay, a natural zeolite, a synthetic zeolite, a polymer resin, lignite, kaolinite, serpentine, illite, chlorite, smectite, montmorillonite, saponite, sepiolite, nontronite, beidellite, hectorite, fuller's earth, attapulgite, bentonite, analcime, chabazite, heulandite, natrolite, phillipsite, stilbite, diethyl aminoethyl, quaternary aminoethyl, or combinations thereof, wherein the organic ion comprises quaternary amines, imidazolium salts, phosphonium salts, tetra alkyl ammonium, bis-(hydrogenated tallow)-dimethyl-ammonium chloride, bis-(hydrogenated tallow)-benzyl-methyl-ammonium chloride, 4,5-dihydro-1-methyl-2-nortallow-alkyl-1-(2-tallow-amidoethyl)-imidazolium methyl sulfate, 1-ethyl-4,5-dihydro-3-(2-hydroxyethyl)-2-(8-heptadecenyl)-imidazolium ethyl sulfate, or combinations thereof, and wherein the metal-binding agent comprises mercaptan, carboxylic acid, chelating agents, amines, esters, carboxylic acids, alcohols, ethers, aldehydes, ketones, alkenes, alkynes, mercaptans, thiols, tert-dodecanethiol, nonanethiol, octanethiol, n-stearic acid, iso-stearic acid, palmitic acid, or combinations thereof.

Abstract translation: 包含基材，有机离子和金属粘合剂的组合物，其中所述基材包括天然粘土，合成粘土，天然沸石，合成沸石，聚合物树脂，褐煤，高岭石，蛇纹石，伊利石，亚氯酸盐， 绿泥石，蒙脱石，皂石，海泡石，白云母，贝得石，锂蒙脱石，富勒土，绿坡缕石，膨润土，顺铂，菱沸石，胡萝卜素，钠钙石，氯化石，二氧化硅，二乙基氨基乙基，季氨基乙基或其组合，其中有机离子包括季胺 ，咪唑鎓盐，鏻盐，四烷基铵，双（氢化牛油） - 二甲基氯化铵，双（氢化牛油） - 苄基 - 甲基 - 氯化铵，4,5-二氢-1-甲基-2- - 烷基-1-（2-牛油酰胺基乙基） - 咪唑鎓甲基硫酸盐，1-乙基-4,5-二氢-3-（2-羟乙基）-2-（8-十七烯基） - 咪唑鎓乙基硫酸盐或其组合 ，并且其中所述金属结合剂包括硫醇，碳酸氢盐 羟基酸，螯合剂，胺，酯，羧酸，醇，醚，醛，酮，烯烃，炔烃，硫醇，硫醇，叔十二烷硫醇，壬硫醇，辛硫醇，正硬脂酸，异硬脂酸，棕榈酸， 或其组合。

公开(公告)号：US09308519B2

公开(公告)日：2016-04-12

申请号：US14646511

申请日：2013-11-19

Applicant: DAIKIN INDUSTRIES, LTD. ,  OSAKA UNIVERSITY

Inventor： Kenji Adachi ,  Masaki Kuramitsu ,  Mitsuru Akashi ,  Toshiyuki Kida

IPC: B01D15/38 ,  B01J20/26 ,  B01D15/08 ,  B01D15/26 ,  B01J20/28 ,  C07C51/50 ,  B01J20/34 ,  B01J20/32 ,  C02F1/28 ,  C08B37/16 ,  C08L5/16 ,  C02F101/36

CPC classification number: B01J20/265 ,  B01D15/08 ,  B01D15/265 ,  B01J20/261 ,  B01J20/28016 ,  B01J20/321 ,  B01J20/3219 ,  B01J20/3274 ,  B01J20/3425 ,  B01J20/3475 ,  C02F1/285 ,  C02F1/288 ,  C02F2101/36 ,  C02F2303/16 ,  C07C51/50 ,  C08B37/0012 ,  C08B37/0015 ,  C08L5/16

Abstract: The present invention is to provide a material that is capable of selectively adsorbing organic fluoro-compounds such as perfluorooctane sulfonic acid, allows the adsorbed organic fluoro-compounds to be recovered, and is reusable as an adsorbent, specifically to provide a polymer in which cyclodextrin is supported on the surface of a water-insoluble polymer, and an adsorbent containing the same, and a method of use of the same as a selective adsorbent of, in particular, an organic fluoro-compound.

Abstract translation: 本发明提供能够选择性吸附全氟辛烷磺酸等有机氟化合物的材料，能够吸收吸附的有机氟化合物，并且作为吸附剂可以重复使用，特别是提供其中环糊精 负载在水不溶性聚合物的表面上，和含有它的吸附剂，以及使用它们作为特别是有机氟化合物的选择性吸附剂的方法。