公开(公告)号：US20140038166A1

公开(公告)日：2014-02-06

申请号：US14044247

申请日：2013-10-02

Applicant: OPKO Diagnostics, LLC

Inventor： Vincent Linder ,  David Steinmiller

IPC: B01L3/00 ,  G01N21/59

CPC classification number: B01L3/502746 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L7/52 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/0673 ,  B01L2200/0684 ,  B01L2200/143 ,  B01L2200/146 ,  B01L2200/147 ,  B01L2300/021 ,  B01L2300/023 ,  B01L2300/027 ,  B01L2300/04 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/12 ,  B01L2300/14 ,  B01L2300/16 ,  B01L2300/168 ,  B01L2300/1827 ,  B01L2300/1894 ,  B01L2400/0475 ,  B01L2400/049 ,  B01L2400/0666 ,  B01L2400/082 ,  G01N21/05 ,  G01N21/59 ,  G01N21/64 ,  G01N21/76 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/57434 ,  G01N2201/02 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/0621 ,  G01N2201/0697 ,  G01N2333/96433 ,  Y10T137/0324 ,  Y10T436/12

Abstract: Systems and methods for controlling fluids in microfluidic systems are generally described. In some embodiments, control of fluids involves the use of feedback from one or more processes or events taking place in the microfluidic system. For instance, a detector may detect one or more fluids at a measurement zone of a microfluidic system and one or more signals, or a pattern of signals, may be generated corresponding to the fluid(s). In some cases, the signal or pattern of signals may correspond to an intensity, a duration, a position in time relative to a second position in time or relative to another process, and/or an average time period between events. Using this data, a control system may determine whether to modulate subsequent fluid flow in the microfluidic system. In some embodiments, these and other methods can be used to conduct quality control to determine abnormalities in operation of the microfluidic system.

Abstract translation: 通常描述用于控制微流体系统中的流体的系统和方法。 在一些实施例中，流体的控制涉及使用来自在微流体系统中发生的一个或多个过程或事件的反馈。 例如，检测器可以在微流体系统的测量区域处检测一种或多种流体，并且可以对应于流体产生一个或多个信号或信号模式。 在某些情况下，信号的信号或图案可以对应于强度，持续时间，在时间上或相对于另一进程相对于第二位置的时间位置和/或事件之间的平均时间段。 使用该数据，控制系统可以确定是否调制微流体系统中随后的流体流动。 在一些实施方案中，这些和其它方法可用于进行质量控制以确定微流体系统的操作异常。

公开(公告)号：US20120212738A1

公开(公告)日：2012-08-23

申请号：US13364226

申请日：2012-02-01

Applicant: Dar Bahatt ,  Chirag Patel ,  Roy H. Tan ,  Derek Prothro

Inventor： Dar Bahatt ,  Chirag Patel ,  Roy H. Tan ,  Derek Prothro

IPC: G01J3/28

CPC classification number: G01N21/31 ,  G01J3/10 ,  G01J3/12 ,  G01J3/18 ,  G01J3/189 ,  G01J3/2803 ,  G01J3/2823 ,  G01J3/4406 ,  G01J2003/1204 ,  G01J2003/1208 ,  G01J2003/1213 ,  G01J2003/1226 ,  G01N21/0332 ,  G01N21/253 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6456 ,  G01N21/76 ,  G01N2021/6421 ,  G01N2021/6432 ,  G01N2201/06113 ,  G01N2201/0621 ,  G01N2201/0697

Abstract: Systems, including methods, apparatus, and algorithms, for spectrally imaging a two-dimensional array of samples.

Abstract translation: 用于对二维样本阵列进行光谱成像的系统，包括方法，装置和算法。

公开(公告)号：US20110139690A1

公开(公告)日：2011-06-16

申请号：US12967562

申请日：2010-12-14

Applicant: Kunihiko Akita ,  Tomoya Murakami ,  Takayuki Hirano ,  Yasushi Takakuwa

Inventor： Kunihiko Akita ,  Tomoya Murakami ,  Takayuki Hirano ,  Yasushi Takakuwa

IPC: A61M1/36

CPC classification number: A61M1/367 ,  A61M1/1692 ,  A61M2205/3306 ,  G01N21/05 ,  G01N21/274 ,  G01N21/59 ,  G01N2201/062 ,  G01N2201/0621

Abstract: A blood purification instrument for extracorporeally circulating a patient's blood and a concentration detector detects a concentration of liquid during blood purification wherein the concentration detector has a light emitter irradiating light onto the liquid, a light receiver receives the light as transmitted through the liquid, a reference light receiver receives reference light branched from the light emitter without transmission through the liquid, and a detector detecting the light intensity respectively of the transmitted light and the reference light received by the light receiver and the reference light receiver, respectively. The blood purification apparatus further includes an error corrector detecting the concentration of the liquid based on the received light intensity of the light received by the light receiver and detected by the detector and for correcting a detected error of the concentration detector based on the received light intensity of the reference light received by the reference light receiver.

Abstract translation: 用于体外循环患者血液的血液净化装置和浓度检测器检测血液净化期间的液体浓度，其中浓度检测器具有将发光体照射到液体上的发光体，光接收器接收透过液体的光，参考 光接收器接收从光发射器分支的参考光，而不透射通过液体;检测器分别检测由光接收器和参考光接收器接收的透射光和参考光的光强度。 血液净化装置还包括误差校正器，其基于由光接收器接收并由检测器检测到的光的接收光强度来检测液体的浓度，并且用于基于接收的光强度校正浓度检测器的检测误差 由参考光接收器接收的参考光。

公开(公告)号：US07906766B2

公开(公告)日：2011-03-15

申请号：US12139831

申请日：2008-06-16

Applicant: Philip Randall Cox

Inventor： Philip Randall Cox

IPC: G01J1/42

CPC classification number: G01J1/429 ,  G01J1/02 ,  G01J1/0219 ,  G01J1/0228 ,  G01J1/0271 ,  G01J1/08 ,  G01N21/274 ,  G01N21/33 ,  G01N2201/0621 ,  G01N2201/0694

Abstract: A light emission system that comprises a light source that comprises at least one light emitting diode (LED) that provides ultraviolet light. The system also comprises a controller that controls the intensity of the ultraviolet light provided by the light source such that the ultraviolet light provided by the light source simulates a vehicle exhaust plume.

Abstract translation: 一种发光系统，包括包含提供紫外光的至少一个发光二极管（LED）的光源。 该系统还包括控制器，其控制由光源提供的紫外线的强度，使得由光源提供的紫外线模拟车辆排气羽流。

公开(公告)号：US5717210A

公开(公告)日：1998-02-10

申请号：US646327

申请日：1996-06-04

Applicant: Per Bexelius ,  Andreas Todor

Inventor： Per Bexelius ,  Andreas Todor

IPC: G01N21/31 ,  G01N21/53 ,  G01N21/85 ,  G01N21/01 ,  G01N21/49

CPC classification number: G01N21/8507 ,  G01N21/53 ,  G01N21/314 ,  G01N21/532 ,  G01N2201/0621 ,  G01N2201/0696 ,  G01N2201/08

Abstract: A device for measuring the mass of solids contained in a fluid with light. The device includes at least two pairs of light transmitters arranged crosswise. The light transmitters in each pair are able to, at the same time, transmit pulses of light with a certain wavelength, where the wavelengths of the pairs of transmitters are different from each other. The device further includes at least one detector that is able to detect light pulses reflected from the solids as a result of the transmitted light pulses. The detected light pulses are processed to obtain a measurement of the mass of the solids contained in the fluid.

Abstract translation: PCT No.PCT / SE94 / 01073 Sec。 371日期1996年6月4日 102（e）日期1996年6月4日PCT 1994年11月15日PCT PCT。 WO95 / 15488 PCT公开号 日期1995年6月8日用于测量包含在具有光的流体中的固体质量的装置。 该装置包括至少两对交叉布置的光发射器。 每对中的光发射器能够同时传输具有一定波长的光的脉冲，其中发射器对的波长彼此不同。 该装置还包括至少一个检测器，其能够检测作为透射光脉冲的结果从固体反射的光脉冲。 对检测到的光脉冲进行处理，以获得流体中所含固体质量的测量值。

公开(公告)号：US5397538A

公开(公告)日：1995-03-14

申请号：US194262

申请日：1994-02-10

Applicant: Hartmut Stark ,  Peter Dreyer

Inventor： Hartmut Stark ,  Peter Dreyer

IPC: G01N21/78 ,  G01N21/86 ,  G01N35/00 ,  G01J1/50

CPC classification number: G01N21/8483 ,  G01N2021/8627 ,  G01N2021/8645 ,  G01N2035/00108 ,  G01N21/783 ,  G01N2201/0621 ,  Y10T436/11 ,  Y10T436/110833 ,  Y10T436/112499

Abstract: The invention is directed to an apparatus for optically evaluating colorimetric coloration zones automatically wherein not only a single testing tube but also a plurality of reaction zones applied one behind the other to a common carrier can be evaluated. The least quantity of indicator substances for the coloration zones is used and an adequate signal intensity with the least possible consumption of power for the optical signal evaluation is attained. At the same time, the sensitivity to faults is reduced. Such an apparatus includes transmission as well as receiving units on a common mounting carrier. The light of the transmitting unit is conducted via a light conductor through the region of the reagent carrier which is transmittent and the coloration of the channel-shaped reaction zones of the carrier is detected in transmission and reflectance.

Abstract translation: 本发明涉及一种用于自动光学评估比色着色区的装置，其中不仅可以评估单个测试管，而且将多个反应区域一个接一个地应用于公共载体。 使用最少量的着色区域的指示剂物质，并且获得具有对于光学信号评估的功率的最小消耗的足够的信号强度。 同时，降低对故障的敏感度。 这种装置包括传输以及在公共安装载体上的接收单元。 发射单元的光通过光导体穿过穿透的试剂载体的区域，并且在透射和反射率中检测载流子的通道形状的反应区的着色。

公开(公告)号：US5218207A

公开(公告)日：1993-06-08

申请号：US795997

申请日：1991-11-22

Applicant: Robert D. Rosenthal

Inventor： Robert D. Rosenthal

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/024 ,  A61B5/107 ,  A61B5/1455 ,  G01N21/31 ,  G01N21/35 ,  G01N33/487

CPC classification number: G01N21/359 ,  A61B5/02433 ,  A61B5/107 ,  A61B5/14532 ,  A61B5/1455 ,  G01N21/314 ,  A61B5/6826 ,  G01N2201/0621

Abstract: A near-infrared quantitative analysis instrument for measuring a constituent of a sample material is disclosed which effectively utilizes energy in the 1200 to 1800 nanometer wavelengths regions by isolating and employing harmonic wavelengths emitted by typical, low cost commercially available light emitting diodes (LEDs) or infrared emitting diodes (IREDs). The analysis instrument utilizes these very desirable wavelength regions for quantitative analysis measurements by interposing suitable narrow bandpass filters which permit passage of only the selected harmonic wavelengths.

Abstract translation: 公开了一种用于测量样品材料的组成的近红外定量分析仪器，其通过隔离并采用由典型的低成本市售发光二极管（LED）发射的谐波波长，有效地利用1200至1800纳米波长区域中的能量 红外发射二极管（IRED）。 分析仪器利用这些非常理想的波长区域进行定量分析测量，通过插入允许仅通过所选择的谐波波长的合适的窄带通滤波器。

公开(公告)号：US5210595A

公开(公告)日：1993-05-11

申请号：US790835

申请日：1991-11-12

Applicant: James A. Devore ,  Gary F. Meenan ,  Hayward B. Oblad

Inventor： James A. Devore ,  Gary F. Meenan ,  Hayward B. Oblad

IPC: G01N21/53

CPC classification number: G01N21/53 ,  G01N2201/0621

Abstract: An optoelectric detector having transparent tubes separated by a thin opaque barrier with LEDs in one tube adjacent one side of the barrier and a photoconductor in the other tube adjacent to the opposite side of the barrier. The LEDs and photoconductor being in close proximity with the photoconductor with the photoconductor only receiving light emitted by the LEDs which is reflected from the solids in medium in which the detector is used.

Abstract translation: 一个光电检测器，其具有由薄不透光屏障隔开的透明管，其中一个管中的LED邻近阻挡层的一侧，另一个管中的光电导体与屏障的相对侧相邻。 光电导体与感光体非常接近，光电导体仅接收由发射的LED发出的光，该光从被使用检测器的介质中的固体反射。

公开(公告)号：US5148217A

公开(公告)日：1992-09-15

申请号：US719452

申请日：1991-06-24

Applicant: David D. Almeter ,  William A. Resch, III

Inventor： David D. Almeter ,  William A. Resch, III

IPC: G01J1/16 ,  G01J1/18 ,  G01N21/47 ,  G03G15/00

CPC classification number: G01J1/18 ,  G01N21/4738 ,  G03G15/5041 ,  G01J2001/161 ,  G01N2021/4769 ,  G01N2201/0621 ,  G03G2215/00042

Abstract: A densitometer includes a light source positioned to project light rays to a test surface. A photodetector is positioned to receive light rays from the surface, and has an output which is characteristic of the amount of light received. The densitometer includes a voltage source and a photodetector which generates an output signal which is a function of a measured density and of the voltage of the source. A log amp produces a signal which is substantially proportional to the ratio of the output of the photodetector and a second output signal which is also a function of the voltage of the source.

Abstract translation: 密度计包括定位成将光线投射到测试表面的光源。 光电检测器被定位成从表面接收光线，并且具有作为所接收的光量的特征的输出。 密度计包括电压源和光电检测器，其产生作为测量的密度和源的电压的函数的输出信号。 对数放大器产生与光电检测器的输出和第二输出信号的比率基本成比例的信号，该信号也是源的电压的函数。

公开(公告)号：US5134302A

公开(公告)日：1992-07-28

申请号：US588628

申请日：1990-09-26

Applicant: Robert D. Rosenthal

Inventor： Robert D. Rosenthal

IPC: G01J3/427 ,  A61B5/00 ,  G01J3/10 ,  G01N21/25 ,  G01N21/35

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  G01J3/108 ,  G01N21/255 ,  G01N21/359 ,  G01N2201/0621

Abstract: A method and means for generating synthetic spectra allowing quantitative measurement utilizes dual chip alternatively energized IREDs with optical bandpass filter(s) passing two optical bands which could be combined with curvilinear interpolation to be utilized in a low cost small size quantitative measuring instrument.

Abstract translation: 用于产生允许定量测量的合成光谱的方法和装置利用具有通过两个光谱带的光学带通滤光器的双芯片交替供电的IRED，其可以与曲线插值组合以用于低成本小尺寸定量测量仪器中。