公开(公告)号：US11965869B2

公开(公告)日：2024-04-23

申请号：US17944569

申请日：2022-09-14

Applicant: RENSSELAER POLYTECHNIC INSTITUTE

Inventor： Matthew R. Urschel ,  Andrew Turk ,  Tessa Hilary Pocock

IPC: G01N33/00 ,  G01N21/64

CPC classification number: G01N33/0098 ,  G01N21/64 ,  G01N2201/062 ,  G01N2201/0696

Abstract: An apparatus for remote detection of plant growth dynamics is described. The apparatus includes an excitation LED (light emitting diode) module, a detection module and a controller module coupled to the excitation LED module and the detection module. The excitation LED module includes at least one LED. Each LED is configured to emit an excitation light in response to an excitation control signal. The excitation light has an emitted light spectrum.
The detection module includes a photodetector configured to detect an initial chlorophyll a fluorescence (“ChlF”) light and an excited ChlF light from a plant species. The photodetector is further configured to convert the detected initial ChlF light into an initial detection electrical signal and the detected excited ChlF light into an excited detection electrical signal. The excited ChlF light is emitted from the plant species in response to receiving the excitation light.
The controller module is configured to provide the excitation control signal to the excitation module, to capture the initial and excited detection electrical signals from the detection module and to determine chlorophyll fluorescence data based, at least in part, on the initial and excited detection electrical signals. The excitation LED module and the detection module are configured to be positioned remotely from the plant species. The chlorophyll fluorescence data represents a growth characteristic of the plant species.

公开(公告)号：US20240044797A1

公开(公告)日：2024-02-08

申请号：US18228989

申请日：2023-08-01

Applicant: Thorlabs, Inc.

Inventor： Sterling Backus ,  Scott Domingue ,  Matthew Kirchner

IPC: G01N21/64 ,  H01S3/00

CPC classification number: G01N21/6458 ,  H01S3/0057 ,  G01N2201/06113 ,  G01N2201/0696

Abstract: A system and method of producing energetic laser pulses suitable for multi-photon microscopy, in which laser pulses from an ultrafast pump source operating at greater than 40 MHz repetition rate are directed onto an optical cavity, where the pulses build-up to a higher energy inside of that cavity over the period of many pulses. After the intra-cavity pulses achieve sufficient energy, an active element inside of the cavity switches out the enhanced light pulse with a reduced a repetition rate relative to the pump source. The increased pulse energy and reduced repetition rate will enable the pump source, originally designed for two-photon microscopy, to perform new imaging modalities, such as deep, in-vivo, three-photon microscopy.

公开(公告)号：US11726036B2

公开(公告)日：2023-08-15

申请号：US17346390

申请日：2021-06-14

Applicant: Apple Inc.

Inventor： Mark Alan Arbore ,  Matthew A. Terrel

IPC: G01N21/59 ,  G01N21/49 ,  G01N21/17 ,  G01N21/47

CPC classification number: G01N21/59 ,  G01N21/49 ,  G01N2021/1782 ,  G01N2021/4709 ,  G01N2021/4711 ,  G01N2201/066 ,  G01N2201/0691 ,  G01N2201/0696 ,  G01N2201/12

Abstract: An illuminator/collector assembly can deliver incident light to a sample and collect return light returning from the sample. A sensor can measure ray intensities as a function of ray position and ray angle for the collected return light. A ray selector can select a first subset of rays from the collected return light at the sensor that meet a first selection criterion. In some examples, the ray selector can aggregate ray intensities into bins, each bin corresponding to rays in the collected return light that traverse within the sample an estimated optical path length within a respective range of optical path lengths. A characterizer can determine a physical property of the sample, such as absorptivity, based on the ray intensities, ray positions, and ray angles for the first subset of rays. Accounting for variations in optical path length traversed within the sample can improve accuracy.

公开(公告)号：US20180231684A1

公开(公告)日：2018-08-16

申请号：US15511336

申请日：2015-09-09

Applicant: SCHLUMBERGER TECHNOLOGY CORPORATION

Inventor： Timothy Jones ,  Nathan Lawrence ,  Go Fujisawa ,  Sheng Chao ,  Li Jiang

IPC: G01V8/14 ,  G01N21/3577 ,  G01N21/552 ,  G01N21/15 ,  G01N21/3504 ,  G01N33/00 ,  E21B49/08

CPC classification number: G01V8/14 ,  E21B49/08 ,  E21B2049/085 ,  G01N21/15 ,  G01N21/3504 ,  G01N21/3577 ,  G01N21/552 ,  G01N33/004 ,  G01N2021/154 ,  G01N2201/0696 ,  G01N2201/12 ,  Y02A50/244

Abstract: A sensor is provided for monitoring a mineral acid dissolved in a liquid. The sensor includes an internal reflection window which, in use, is in direct contact with the liquid. The sensor further includes a mid-infrared light source which directs a beam of mid-infrared radiation into said window for attenuated internal reflection at an interface between the window and the liquid. The sensor further includes a first narrow bandpass filter which preferentially transmits mid-infrared radiation over a band of wavelengths corresponding to an absorbance peak of the dissolved mineral acid to filter internally reflected mid-infrared radiation received from the window. The sensor further includes an infrared detector which detects filtered mid-infrared radiation transmitted through the first filter. The sensor further includes a processor arrangement, operably coupled to the infrared detector, which measures the intensity of the detected mid-infrared radiation transmitted through the first filter, and determines therefrom an amount of the mineral acid dissolved in the liquid.

公开(公告)号：US09885657B2

公开(公告)日：2018-02-06

申请号：US14821688

申请日：2015-08-07

Applicant: Quantum-Si Incorporated

Inventor： Jonathan M. Rothberg ,  Ali Kabiri ,  Jason W. Sickler ,  Brett J. Gyarfas ,  Jeremy Lackey ,  Gerard Schmid ,  Lawrence C. West ,  Keith G. Fife ,  Benjamin Cipriany ,  Farshid Ghasemi

IPC: G01N21/01 ,  G01N21/64 ,  C12Q1/68

CPC classification number: G01N21/6408 ,  C12Q1/6869 ,  C12Q1/6874 ,  G01N21/6428 ,  G01N21/6454 ,  G01N21/648 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6439 ,  G01N2021/6463 ,  G01N2201/0696 ,  G01N2201/08 ,  G01N2201/12

Abstract: System and methods for analyzing single molecules and performing nucleic acid sequencing. An integrated device includes multiple pixels with sample wells configured to receive a sample, which when excited, emits radiation. The integrated device includes at least one waveguide configured to propagate excitation energy to the sample wells from a region of the integrated device configured to couple with an excitation energy source. A pixel may also include at least one element for directing the emission energy towards a sensor within the pixel. The system also includes an instrument that interfaces with the integrated device. The instrument may include an excitation energy source for providing excitation energy to the integrated device by coupling to an excitation energy coupling region of the integrated device. One of multiple markers distinguishable by temporal parameters of the emission energy may label the sample and configuration of the sensor within a pixel may allow for detection of a temporal parameter associated with the marker labeling the sample.

公开(公告)号：US20180017491A1

公开(公告)日：2018-01-18

申请号：US15717651

申请日：2017-09-27

Applicant: Apple Inc.

Inventor： Mark Alan ARBORE ,  Matthew A. TERREL

IPC: G01N21/59 ,  G01N21/49 ,  G01N21/17 ,  G01N21/47

CPC classification number: G01N21/59 ,  G01N21/49 ,  G01N2021/1782 ,  G01N2021/4709 ,  G01N2021/4711 ,  G01N2201/066 ,  G01N2201/0691 ,  G01N2201/0696 ,  G01N2201/12

Abstract: An illuminator/collector assembly can deliver incident light to a sample and collect return light returning from the sample. A sensor can measure ray intensities as a function of ray position and ray angle for the collected return light. A ray selector can select a first subset of rays from the collected return light at the sensor that meet a first selection criterion. In some examples, the ray selector can aggregate ray intensities into bins, each bin corresponding to rays in the collected return light that traverse within the sample an estimated optical path length within a respective range of optical path lengths. A characterizer can determine a physical property of the sample, such as absorptivity, based on the ray intensities, ray positions, and ray angles for the first subset of rays. Accounting for variations in optical path length traversed within the sample can improve accuracy.

公开(公告)号：US09726601B1

公开(公告)日：2017-08-08

申请号：US15594418

申请日：2017-05-12

Applicant: Airware, Inc.

Inventor： Jacob Y Wong ,  Thomas Campbell

IPC: G01N21/3504

CPC classification number: G01N21/3504 ,  G01J3/10 ,  G01J3/42 ,  G01J3/427 ,  G01N21/3151 ,  G01N21/3577 ,  G01N21/61 ,  G01N33/49 ,  G01N2021/3159 ,  G01N2201/0696

Abstract: NDIR is used to determine a concentration of a chosen molecule M in a liquid sample which contains one or more interfering molecules MJ which absorb radiation at the signal wavelength used in the NDIR process by addition of an interference source. M is calculated by electronics which use Rave(t) from a pulsed signal and reference channel output and a calibration curve which is validated by use of RJave(t2) from a pulsed interference and reference channel output. Signal, interference and reference sources are pulsed at a frequency which is sufficiently fast so that a given molecule of M or MJ will not pass in and out of the liquid sampling matrix within the pulsing frequency.

公开(公告)号：US09664670B2

公开(公告)日：2017-05-30

申请号：US14088588

申请日：2013-11-25

Applicant: Siemens Healthcare Diagnostics Products GmbH

Inventor： Wolfgang Steinebach

IPC: G01N21/59 ,  G01R23/167 ,  G01N33/50

CPC classification number: G01N33/5002 ,  G01N21/59 ,  G01N2201/0696

Abstract: The invention is in the field of in vitro diagnostics and relates to a method for ascertaining a transmission value for a light signal that is pulsed at a frequency through a specimen in an automatic analysis appliance. It also relates to a transmission measurement apparatus for an automatic analysis appliance, comprising a light source that is pulsed at a frequency and a photodetector having a downstream A/D converter.

公开(公告)号：US09625386B2

公开(公告)日：2017-04-18

申请号：US14482614

申请日：2014-09-10

Applicant: IWASAKI ELECTRIC CO., LTD. ,  KOCHI UNIVERSITY

Inventor： Mitsuyuki Hatanaka ,  Takashi Sato ,  Nozomu Kajiwara ,  Takaaki Komiya ,  Takayuki Sato

IPC: G01N21/359 ,  G01N21/64 ,  A61B5/00

CPC classification number: G01N21/6456 ,  A61B5/0071 ,  A61B5/0077 ,  G01N21/359 ,  G01N21/6408 ,  G01N21/6486 ,  G01N2021/646 ,  G01N2201/061 ,  G01N2201/0621 ,  G01N2201/0696

Abstract: An imaging system includes: a first lighting device for irradiating an imaging target object with visible light; a second lighting device for irradiating the imaging target object with near-infrared light; and an image sensor for photodetecting visible light caused by the visible light and coming from the imaging target object and fluorescence caused by the near-infrared light and coming from the imaging target object during a predetermined shutter open period every frame of a predetermined period. The image sensor outputs photodetection signals corresponding to photodetection amounts of the visible light and the fluorescence. The imaging system also includes a controller that generates a composite image of a visible image and a fluorescence image based on the photodetection signals, and has a lighting controller that turns on the second lighting device with optical power corresponding to the shutter open period in synchronism with the shutter open period.

公开(公告)号：US09606053B1

公开(公告)日：2017-03-28

申请号：US15358873

申请日：2016-11-22

Applicant: Airware, Inc.

Inventor： Jacob Y Wong ,  Thomas Campbell

IPC: G01N21/3504

CPC classification number: G01N21/3151 ,  G01J3/28 ,  G01J3/2803 ,  G01J3/42 ,  G01J2003/2869 ,  G01N21/3577 ,  G01N2021/3159 ,  G01N2201/0696

Abstract: A concentration of a chosen molecule in a liquid phase in a sample space is determined through use of a signal channel output/reference channel ratio obtained by use of an NDIR absorption technique in which scattering noise attributable to the liquid phase is reduced by alternately and successively pulsing infrared radiation from signal and reference sources which are multiplexed and collimated into a pulsed beam directed through the sample space containing the liquid phase and the pulse frequency is sufficiently fast so that a given molecule of the chosen molecule will not pass in and out of the sample space within the pulse frequency.