公开(公告)号：US08482730B2

公开(公告)日：2013-07-09

申请号：US13593945

申请日：2012-08-24

Applicant: Austin Tomaney ,  Mark Oldham

Inventor： Austin Tomaney ,  Mark Oldham

IPC: G01J1/42

CPC classification number: G01N21/6486 ,  G01N21/6428 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/08 ,  G01N2201/121 ,  H04N5/225 ,  H04N5/357 ,  H04N5/361 ,  H04N5/367

Abstract: A system and method for characterizing contributions to signal noise associated with charge-coupled devices adapted for use in biological analysis. Dark current contribution, readout offset contribution, photo response non-uniformity, and spurious charge contribution can be determined by the methods of the present teachings and used for signal correction by systems of the present teachings.

Abstract translation: 用于表征与适用于生物分析的电荷耦合器件相关的信号噪声的贡献的系统和方法。 暗电流贡献，读出偏移贡献，光响应不均匀性和杂散电荷贡献可以由本教导的方法确定并用于本教导的系统的信号校正。

公开(公告)号：US08390814B2

公开(公告)日：2013-03-05

申请号：US13199835

申请日：2011-09-09

Applicant: Mark Salerno ,  I-Tsung Shih ,  Craig Harrison

Inventor： Mark Salerno ,  I-Tsung Shih ,  Craig Harrison

IPC: G01N21/00

CPC classification number: G01N21/31 ,  G01N21/00 ,  G01N21/0303 ,  G01N21/05 ,  G01N21/255 ,  G01N21/59 ,  G01N2021/0346 ,  G01N2201/0612 ,  G01N2201/0853 ,  G01N2201/121

Abstract: This disclosure relates generally to a sampling device, and more particularly, a sampling device that facilitates spectroscopic measurements with a variable path length and the necessary software controlled algorithms and methods for such a device.

公开(公告)号：US20120319008A1

公开(公告)日：2012-12-20

申请号：US13593945

申请日：2012-08-24

Applicant: Austin B. Tomaney ,  Mark F. Oldham

Inventor： Austin B. Tomaney ,  Mark F. Oldham

IPC: G01N21/64

CPC classification number: G01N21/6486 ,  G01N21/6428 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/08 ,  G01N2201/121 ,  H04N5/225 ,  H04N5/357 ,  H04N5/361 ,  H04N5/367

Abstract: A system and method for characterizing contributions to signal noise associated with charge-coupled devices adapted for use in biological analysis. Dark current contribution, readout offset contribution, photo response non-uniformity, and spurious charge contribution can be determined by the methods of the present teachings and used for signal correction by systems of the present teachings.

Abstract translation: 用于表征与适用于生物分析的电荷耦合器件相关的信号噪声的贡献的系统和方法。 暗电流贡献，读出偏移贡献，光响应不均匀性和杂散电荷贡献可以由本教导的方法确定并用于本教导的系统的信号校正。

公开(公告)号：US08108173B2

公开(公告)日：2012-01-31

申请号：US12194112

申请日：2008-08-19

Applicant: Jesus D. Martin ,  John R. DelFavero

Inventor： Jesus D. Martin ,  John R. DelFavero

IPC: G06F19/00

CPC classification number: G01N21/6428 ,  A61B5/083 ,  G01N21/6408 ,  G01N2021/6432 ,  G01N2021/7786 ,  G01N2201/062 ,  G01N2201/121

Abstract: A sensor that determines information related to a gaseous analyte in a body of fluid. The sensor comprises an emitter, a luminescable medium, a radiation sensor, and a processor. The emitter emits electromagnetic radiation having an oscillating intensity. The luminescable medium communicates with the body of fluid and emits luminescent radiation in response to the received electromagnetic radiation. The radiation sensor receives the luminescent radiation, and generates an output signal based on the intensity of the received luminescent radiation. The processor samples the output signal generated by the radiation sensor at two or more predetermined periodic points over the oscillation of the intensity of the electromagnetic radiation to determine information from the samples related to a phase difference between the oscillation of the intensity of the electromagnetic radiation emitted by the emitter and oscillation of the intensity of the luminescent radiation received by the radiation sensor.

Abstract translation: 确定与流体体内的气态分析物相关的信息的传感器。 传感器包括发射器，可发光介质，辐射传感器和处理器。 发射器发射具有振荡强度的电磁辐射。 可发光介质与流体本体连通并响应于接收的电磁辐射发射发光辐射。 辐射传感器接收发光辐射，并且基于所接收的发光辐射的强度产生输出信号。 处理器在电磁辐射强度的振荡的两个或更多个预定周期点上对由辐射传感器产生的输出信号进行采样，以确定来自与所发射的电磁辐射的强度的振荡之间的相位差有关的信息的信息 通过发射器和由辐射传感器接收的发光辐射的强度的振荡。

公开(公告)号：US20090093968A1

公开(公告)日：2009-04-09

申请号：US11995632

申请日：2006-07-13

Applicant: Ryoko Kawamata ,  Mie Takahashi

Inventor： Ryoko Kawamata ,  Mie Takahashi

IPC: G01N33/52 ,  G01N1/10

CPC classification number: G01N21/78 ,  G01N21/8483 ,  G01N33/543 ,  G01N33/54366 ,  G01N2201/121

Abstract: In an analysis device for measuring a target substance in a liquid sample, highly precise measurement cannot be realized because reliability of measurement is degraded due to influences of properties of the liquid sample and an analysis element.There is provided an analysis device comprising a signal measurement unit for measuring a signal based on a reaction of the target substance in the liquid sample, a parameter collection unit for collecting a parameter that indicates a degree of influence on a measurement error from the liquid sample developed on a channel on the analysis element, an algorithm holding unit for previously holding an algorithm comprising a relationship among the parameter, the signal, and a true value of the target substance, and an arithmetic processing unit for arithmetically processing an analysis value of the target substance from the signal on the basis of the parameter, and the arithmetic processing unit reads out the algorithm, and obtains an analysis value of the target substance with the measurement error of the target substance being corrected, on the basis of the parameter obtained in the parameter collection unit by using the read algorithm.

Abstract translation: 在用于测量液体样品中的目标物质的分析装置中，由于液体样品和分析元件的性质的影响，测量的可靠性降低，不能实现高精度的测量。 提供了一种分析装置，包括：信号测量单元，用于基于液体样品中的目标物质的反应测量信号;参数收集单元，用于收集指示来自液体样品的测量误差的影响程度的参数 在分析元件上的通道上开发的算法保持单元，用于预先保持包括目标物质的参数，信号和真实值之间的关系的算法的算法保持单元，以及用于对所述目标物质的真实值进行算术处理的算术处理单元 根据参数从信号中获取目标物质，算术处理单元读出该算法，并根据获得的参数获得目标物质的测量误差被校正的目标物质的分析值 参数采集单元通过使用读取算法。

公开(公告)号：US12111270B2

公开(公告)日：2024-10-08

申请号：US17725917

申请日：2022-04-21

Applicant: Samsung Electronics Co., Ltd.

Inventor： Juntaek Oh ,  Jinwoo Ahn ,  Kijoo Hong ,  Youngkyu Park ,  Eunsoo Hwang

IPC: G01N21/95 ,  G01N21/21 ,  G01N21/55

CPC classification number: G01N21/9501 ,  G01N21/21 ,  G01N21/55 ,  G01N2201/121

Abstract: A method of inspecting a wafer comprising measuring an intensity of an incident light and storing the measurement as stored incident light intensity, irradiating the incident light to the wafer, measuring an intensity of a reflected light from the wafer and storing the measurement as stored reflected light intensity, and correcting the stored reflected light intensity based on a difference between the stored incident light intensity and a reference intensity of a reference incident light.

公开(公告)号：US12066433B2

公开(公告)日：2024-08-20

申请号：US17686802

申请日：2022-03-04

Applicant: SYSMEX CORPORATION ,  OSAKA UNIVERSITY ,  NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY

Inventor： Masaya Okada ,  Yuki Shimaoka ,  Shigeki Iwanaga ,  Kazuki Bando ,  Katsumasa Fujita ,  Yasunori Nawa ,  Satoshi Fujita

IPC: G01N21/65 ,  G01N21/25 ,  G01N21/31 ,  G01N33/543 ,  G01N33/58 ,  G01N33/68 ,  G06N3/08 ,  G16C20/20 ,  G16C20/70

CPC classification number: G01N33/54353 ,  G01N21/255 ,  G01N21/314 ,  G01N21/658 ,  G01N33/54346 ,  G01N33/588 ,  G01N33/6812 ,  G06N3/08 ,  G16C20/20 ,  G01N2201/121 ,  G01N2201/1296 ,  G16C20/70

Abstract: Disclosed is an analytical method for analyzing a test substance contained in a measurement sample, the method comprising: generating a data set based on a plurality of optical spectra acquired from a plurality of locations in the measurement sample; inputting the data set into a deep learning algorithm having a neural network structure; and outputting information on the test substance, on the basis of an analytical result from the deep learning algorithm.

公开(公告)号：US20240219296A1

公开(公告)日：2024-07-04

申请号：US18605163

申请日：2024-03-14

Applicant: MEGA CRYSTAL BIOTECHNOLOGY SINGAPORE PTE. LTD

Inventor： YI-SHENG TING ,  YU-TSUNG CHEN

IPC: G01N21/25 ,  G01N21/359 ,  G01N21/39 ,  H05B45/18

CPC classification number: G01N21/255 ,  G01N21/359 ,  G01N21/39 ,  H05B45/18 ,  G01N2201/0694 ,  G01N2201/121 ,  G01N2201/125

Abstract: A light emitting apparatus has light emitting units. The light emitting units can be respectively provided with current densities, so that the light emitted by each of the light emitting unit has a light intensity, wherein the current densities are different from each other, or partial of the current densities are different from each other. A number of the light emitting units can be larger than or equal to four, all of the four lighting frequencies of the four light emitting units are different from each other, or partial of the four lighting frequencies of the four light emitting units are identical to each other, and the light emitting apparatus and the object under test rotate relative to each other. A light emitting method, a spectrum detection method and a lighting correction method are also illustrated for increasing SNR, correcting the light intensity or the spectrum signal.

公开(公告)号：US20240094122A1

公开(公告)日：2024-03-21

申请号：US18370034

申请日：2023-09-19

Applicant: SICK AG

Inventor： Thomas BEYER ,  Julian EDLER

IPC: G01N21/39 ,  G01J3/433

CPC classification number: G01N21/39 ,  G01J3/4338 ,  G01N2201/121 ,  G01N2201/1273

Abstract: The invention relates to a method for measuring a concentration of a gas in a gas mixture, said method comprising that: a light beam modulated in a ramp shape and/or in a step shape in its wavelength and additionally periodically modulated, in particular in its wavelength, is transmitted from a light source, in particular a laser, into a measurement zone; the modulated light beam passes through a gas mixture in the measurement zone and is detected as reception light by a detector, wherein the reception light is converted by the detector into a detector signal; a derivative signal is determined based on the detector signal by performing a transformation of the detector signal into the frequency range, in particular by a Fourier transform of the detector signal, wherein an evaluation of the detector signal transformed into the frequency range is performed, in particular only, for an n-fold of the frequency of the modulated light beam in order to obtain the derivative signal; and at least two measurement values of a phase of the derivative signal are determined and a correction function is calculated based on the determined measurement values of the phase of the derivative signal in order to correct the derivative signal with the correction function.

公开(公告)号：US20230280338A1

公开(公告)日：2023-09-07

申请号：US18015463

申请日：2021-07-09

Applicant: VIDYA HOLDINGS LTD

Inventor： Marko Dorrestijn ,  David R. Klug ,  Vladimir Turek ,  Stefan Leo Van Workum

IPC: G01N33/543 ,  G01N21/63

CPC classification number: G01N33/54373 ,  G01N21/63 ,  G01N2201/121

Abstract: An apparatus for creating and correcting a two dimensional intensity map of one or more assay spots in a detection zone is provided. The apparatus comprising, a locator for affirming the location of the detection zone; a total internal reflection excitation device comprising a light source for illuminating the one or more assay spots in the detection zone; a detector configured to receive light that is emitted, reflected or scattered from the one or more assay spots and to create a two dimensional intensity map of the one or more assay spots comprising a two dimensional array of quantitative pixel values; and a processor configured to correct the intensity map to remove noise through analysis of corresponding pixel values from an earlier intensity map; wherein the analysis includes curve fitting.