公开(公告)号：US20180259453A1

公开(公告)日：2018-09-13

申请号：US15975686

申请日：2018-05-09

Applicant: Quidel Corporation

Inventor： David Dickson Booker ,  Jhobe Steadman

IPC: G01N21/64 ,  G01N21/27 ,  G01N33/543

CPC classification number: G01N21/645 ,  G01N21/274 ,  G01N21/278 ,  G01N33/54386 ,  G01N2201/062 ,  G01N2201/068 ,  G01N2201/10 ,  G01N2201/12746 ,  G01N2201/12753 ,  G01N2201/12761

Abstract: Disclosed herein is a method for improving the precision of a test result from an instrument with an optical system that detects a signal. The method comprises including in the instrument a normalization target disposed directly or indirectly in the optical path of the optical system. Also disclosed are instruments comprising a normalization target, and systems comprising such an instrument and a test device that receives a sample suspected of containing an analyte.

公开(公告)号：US20180231458A1

公开(公告)日：2018-08-16

申请号：US15889765

申请日：2018-02-06

Applicant: ORTHO-CLINICAL DIAGNOSTICS, INC.

Inventor： David A. Heavner

IPC: G01N21/27

CPC classification number: G01N21/274 ,  G01J3/4406 ,  G01N21/6428 ,  G01N21/645 ,  G01N35/00693 ,  G01N2021/6439 ,  G01N2201/12746

Abstract: A method to normalize at least one of a population of subordinate clinical diagnostic analyzer to a master clinical diagnostic analyzer such that an assay result from a subordinate clinical diagnostic analyzer can be converted to the equivalent result of the master clinical diagnostic analyzer by using a simple multiplicative factor when the assay executed on each analyzer uses a common fluorescently labeled dye. Also a method to re-normalize a subordinate clinical diagnostic analyzer assay result to a master clinical diagnostic analyzer assay result by using a simple multiplicative factor when the assay executed on the subordinate clinical diagnostic analyzer uses a different fluorescently labeled dye than the assay executed on the master clinical diagnostic analyzer.

公开(公告)号：US20180230511A1

公开(公告)日：2018-08-16

申请号：US15715063

申请日：2017-09-25

Applicant: Life Technologies Corporation

Inventor： Jeffrey Marks

IPC: C12Q1/686 ,  G01N21/64 ,  G01N21/27

CPC classification number: C12Q1/686 ,  G01N21/274 ,  G01N21/6428 ,  G01N21/6452 ,  G01N2021/6421 ,  G01N2201/04 ,  G01N2201/068 ,  G01N2201/12746

Abstract: The present teachings relate to a method and system for normalizing spectra across multiple instruments. In an embodiment of the present invention, the method comprises at least one reference instrument and a test instrument. Each instrument comprises at least one excitation filter and at least one emission filter arranged in pairs. Each instrument further comprises a pure dye plate comprising a plurality of wells. Each well contains a plurality of dyes where each dye comprises a fluorescent component. Fluorescent spectra are obtained from each instrument for each dye across multiple filter combinations to contribute to a pure dye matrix Mref for the reference instrument and pure dye matrix M for the test instrument. The pure dye spectra can then be multiplied by correction factors for each filter pair to result in corrected pure dye spectra, then normalized and the multicomponenting data can be extracted.

公开(公告)号：US20180059011A1

公开(公告)日：2018-03-01

申请号：US15495173

申请日：2017-04-24

Applicant: Optionline LLC ,  Optionline Editora Eireli

Inventor： Luiz Grossmann ,  Marco Antonio Borges

IPC: G01N21/31 ,  G01N21/359

CPC classification number: G01N21/314 ,  G01N21/278 ,  G01N21/359 ,  G01N2021/3196 ,  G01N2201/0221 ,  G01N2201/12746

Abstract: Provided is method of comparison of spectra from the spectrum of a sample and at least one spectrum of a reference library, the method comprising the steps of: obtaining at least one relevant spectral peak from the sample spectrum and comparing each of the relevant spectral peaks obtained with the spectra in the reference library. Also provided is a method of comparison of spectra from the second derivative of the sample spectrum and the second derivative of the reference library spectra. Still further provided is a method of comparison of spectra with the previous identification of the major component of a sample, the method comprising the step of correlating triangularly the spectra of the sample, the reference and the major component. Lastly described are devices to ensure the uniformity of readings from various devices and compatibility with spectral libraries, the fastening and uniform positioning of the samples and standardization with the aid of calibrators.

公开(公告)号：US20160290920A1

公开(公告)日：2016-10-06

申请号：US15035395

申请日：2014-10-23

Applicant: COLGATE-PALMOLIVE COMPANY

Inventor： Deborah Ann Peru ,  Jason Nesta

IPC: G01N21/3577 ,  G01N21/359

CPC classification number: G01N21/3577 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/359 ,  G01N2201/12746 ,  G01N2201/129

Abstract: This application is directed to a fast method of quantitatively and qualitatively validating the amount of silicone adhesive in a composition comprising silicone adhesive and silicone polymer which comprises of testing a sample of the composition with near IR or mid IR spectroscopy. The method can be extended to analyzing the amount of silicone adhesive in an oral care composition.

Abstract translation: 本申请涉及一种定量和定性验证包含硅氧烷粘合剂和硅氧烷聚合物的组合物中硅氧烷粘合剂的量的快速方法，该组合物包括用近IR或中红外光谱测试组合物的样品。 该方法可以扩展到分析口腔护理组合物中的硅氧烷粘合剂的量。

公开(公告)号：US09423346B2

公开(公告)日：2016-08-23

申请号：US14213064

申请日：2014-03-14

Applicant: DATACOLOR HOLDING AG

Inventor： Zhiling Xu

IPC: G01J1/42 ,  G01N21/59 ,  G01N21/94 ,  G01N21/47

CPC classification number: G01N21/59 ,  G01N21/4738 ,  G01N21/94 ,  G01N2021/4707 ,  G01N2021/4735 ,  G01N2021/4773 ,  G01N2201/0633 ,  G01N2201/0634 ,  G01N2201/065 ,  G01N2201/12746

Abstract: The present invention is directed to an apparatus and method for measuring the haze value of transmissive samples. The apparatus comprises a first light source selectively configurable to emit a first light beam, a second light source selectively configurable to emit a second light beam, an integrating sphere having an outer surface and an inner surface, the inner surface configured to reflect light incident upon the inner surface, the inner surface further enclosing an interior volume. The integrating sphere is further equipped with an exit port configured to emit light from the interior volume of the integrating sphere. The exit port is positioned such that light from the first light source exits the integrating sphere without obstruction, and light from the second light source is diffused on the interior surface of the integrating sphere prior to exiting the exit port. A light detector is also included and is configured to generate a light-intensity signal when light exiting the integrating sphere has passed through a sample and is incident on the light detector. The apparatus further includes a processor configured to receive the light-intensity signal and generate an output signal to a user indicating the haze value. The present invention is also directed to a method of calculating the haze value of a sample using a stored calibration value, a diffuse transmission value (sample-absent diffuse light-intensity value), a direct transmission value (sample-absent direct light-intensity value), a measured diffuse transmission value (sample-present diffuse light-intensity value) and a measured direct transmission value (sample-present direct light-intensity value).

Abstract translation: 本发明涉及一种用于测量透射样品的雾度值的装置和方法。 该装置包括可选择性地配置为发射第一光束的第一光源，可选择地配置为发射第二光束的第二光源，具有外表面和内表面的积分球，所述内表面被配置为反射入射到其上的光 内表面，内表面还包围内部体积。 积分球还配备有出口端口，其被配置为从积分球的内部空间发射光。 出口端口被定位成使得来自第一光源的光不会阻塞地离开积分球，并且来自第二光源的光在离开出口之前扩散到积分球的内表面上。 还包括光检测器，并且被配置为当离开积分球的光已经通过样品并入射到光检测器上时产生光强度信号。 该装置还包括处理器，其被配置为接收光强度信号并且向用户生成指示雾度值的输出信号。 本发明还涉及一种使用存储的校准值，漫射透射值（无采样扩散光强度值），直接透射值（无采样直接光强度）的样品的雾度值来计算雾度值的方法 值），测量的漫射透射值（样品存在的漫射光强度值）和测量的直接透射值（样品存在的直接光强度值）。

公开(公告)号：US20160123872A1

公开(公告)日：2016-05-05

申请号：US14526903

申请日：2014-10-29

Applicant: Toni Zhang Miao ,  Ajit Ramachandra Pradhan ,  Michael Edward Moir ,  Eddy Lee ,  Ian Phillip Benson

Inventor： Toni Zhang Miao ,  Ajit Ramachandra Pradhan ,  Michael Edward Moir ,  Eddy Lee ,  Ian Phillip Benson

IPC: G01N21/3577 ,  G01N21/359

CPC classification number: G01N21/3577 ,  G01N21/359 ,  G01N2201/12746

Abstract: A method of estimating the relative concentration of at least two components contained in a mixture of the components is disclosed. At least two mixtures are produced by combining the at least two components, each of the at least two mixtures having different concentrations of the at least two components. NIR mixture spectra are acquired from each of the at least two mixtures. The NIR component spectra and the NIR mixture spectra are input into a computer utilizing chemometrics software and the spectra are analyzed to produce a calibration model for each component and each of the mixture NIR spectra. NIR monitored spectra for a monitored mixture of the components having an unknown concentration of the components is acquired. The calibration models are applied to the NIR monitored spectra to thereby estimate the concentration of at least one of the components in the monitored mixture. The method can be applied to monitor fluid mixtures produced from one or multiple hydrocarbon reservoirs and surface facilities including pipelines and tanks.

Abstract translation: 公开了一种估计包含在组分的混合物中的至少两种组分的相对浓度的方法。 通过组合至少两种组分来生产至少两种混合物，所述至少两种混合物中的每一种具有不同浓度的至少两种组分。 从所述至少两种混合物中的每一种获得NIR混合谱。 将NIR分量光谱和NIR混合谱输入到使用化学计量学软件的计算机中，并分析光谱以为每个组分和每个混合NIR光谱产生校准模型。 获得具有未知浓度组分的组分的监测混合物的近红外监测光谱。 将校准模型应用于NIR监测光谱，从而估计所监测混合物中至少一种组分的浓度。 该方法可用于监测从一个或多个烃储层和包括管道和罐的表面设施产生的流体混合物。

公开(公告)号：US20160097712A1

公开(公告)日：2016-04-07

申请号：US14873513

申请日：2015-10-02

Applicant: Seiko Epson Corporation

Inventor： Sakiko SHIMIZU ,  Kazuhiro NISHIDA

IPC: G01N21/27 ,  G01N33/49 ,  G01N21/31

CPC classification number: G01N21/274 ,  A61B5/0075 ,  A61B5/14532 ,  A61B5/7235 ,  G01N21/31 ,  G01N33/49 ,  G01N2201/12746

Abstract: A signal detection method includes acquiring a measurement signal including a first signal, which is a signal of a target component, and a second signal, which is a signal of an interference component; and performing an orthogonal operation for adjusting the measurement signal such that the measurement signal is orthogonal to the second signal.

Abstract translation: 信号检测方法包括获取包括作为目标分量的信号的第一信号和作为干扰分量的信号的第二信号的测量信号; 以及执行用于调整所述测量信号的正交操作，使得所述测量信号与所述第二信号正交。

公开(公告)号：US20130330764A1

公开(公告)日：2013-12-12

申请号：US14001405

申请日：2012-02-24

Applicant: Guillaume Chesneau ,  Pierre Weill

Inventor： Guillaume Chesneau ,  Pierre Weill

IPC: G01N21/35

CPC classification number: G01N21/3563 ,  G01N21/35 ,  G01N21/65 ,  G01N33/12 ,  G01N2201/12746 ,  G01N2201/1293

Abstract: The present invention relates to a method for determining, from a database, the amount of at least some fatty acids contained in various biological materials from a single animal raised for meat production. Said method can be used for determining the amount of both major and minor fatty acids, as well as the fatty acid content of another biological material from said single animal.

Abstract translation: 本发明涉及一种从数据库中确定从用于肉类生产的单一动物的各种生物材料中所含的至少一些脂肪酸的量的方法。 所述方法可用于测定主要和次要脂肪酸的量以及来自所述单一动物的另一生物材料的脂肪酸含量。

公开(公告)号：US20120291515A1

公开(公告)日：2012-11-22

申请号：US13471917

申请日：2012-05-15

Applicant: Achim Stangelmayer ,  Damian Andrzejewski

Inventor： Achim Stangelmayer ,  Damian Andrzejewski

IPC: G01N33/00 ,  G01D18/00

CPC classification number: G06T7/40 ,  G01N21/274 ,  G01N21/78 ,  G01N2021/7786 ,  G01N2201/1211 ,  G01N2201/1218 ,  G01N2201/12746

Abstract: A sensor unit is disclosed which includes a sensor and an information module. The sensor exhibits an optical behavior dependent on at least one variable of a sample. Sensor related information can be emitted by the information module as optical radiation. In embodiments the sensor related information includes calibration data for the sensor. The sensor related information may additionally include identification data for the sensor. In embodiments the information module measures at least one ambient parameter, and emits the measurement value in an optical signal. The measurement value is taken into account when determining at least one variable of a sample by means of the sensor unit. In embodiments the information module may also transmit status information of the sensor unit. Furthermore a method for determining a variable of a sample with a sensor unit and a measurement system is disclosed.

Abstract translation: 公开了一种传感器单元，其包括传感器和信息模块。 传感器表现出取决于样品的至少一个变量的光学行为。 传感器相关信息可由信息模块作为光辐射发射。 在实施例中，传感器相关信息包括传感器的校准数据。 传感器相关信息可另外包括传感器的识别数据。 在实施例中，信息模块测量至少一个环境参数，并且在光信号中发射测量值。 当通过传感器单元确定样品的至少一个变量时，考虑测量值。 在实施例中，信息模块还可以发送传感器单元的状态信息。 此外，公开了一种用传感器单元和测量系统确定样品的变量的方法。