公开(公告)号：US07701632B2

公开(公告)日：2010-04-20

申请号：US11833761

申请日：2007-08-03

Applicant: Ralf Wolleschensky

Inventor： Ralf Wolleschensky

IPC: G02B21/06

CPC classification number: G01N15/1434 ,  G01J3/02 ,  G01J3/0224 ,  G01J3/0229 ,  G01J3/10 ,  G01J3/4406 ,  G01J3/447 ,  G01J2003/1282 ,  G01J2003/1286 ,  G01N21/6445 ,  G01N21/6458 ,  G01N2015/0065 ,  G01N2015/149 ,  G01N2015/1493 ,  G02B21/002

Abstract: Method and arrangement for changing the spectral composition and/or intensity of illumination light and/or specimen light in an adjustable manner, wherein a spatial separation into radiation components of different polarization is carried out with a first polarizing device, a spectral, spatial splitting of at least one radiation component is carried out with first dispersion device, the polarization state of at least one part of the spectrally spatially split radiation component is changed, and a spatial separation and/or combination of radiation components of different polarization are/is carried out by a second polarizing device, wherein a spatial combination of radiation components which are changed and not changed with respect to their polarization state is advantageously carried out by a second dispersion device.

Abstract translation: 用于以可调节的方式改变照明光和/或标本光的光谱组成和/或强度的方法和装置，其中利用第一偏振装置，光谱，空间分裂进行不同偏振的辐射分量的空间分离 使用第一分散装置执行至少一个辐射分量，改变光谱空间分裂的辐射分量的至少一部分的偏振状态，并且执行不同极化的辐射分量的空间分离和/或组合 通过第二偏振装置，其中通过第二分散装置有利地进行相对于它们的偏振状态改变而不改变的辐射分量的空间组合。

公开(公告)号：US07700929B2

公开(公告)日：2010-04-20

申请号：US12407429

申请日：2009-03-19

Applicant: Antonio Ting ,  Ilya Alexeev ,  Phillip Sprangle ,  Richard Hubbard ,  Glenn Rubel ,  Eldridge Briscoe ,  Christopher Moore

Inventor： Antonio Ting ,  Ilya Alexeev ,  Phillip Sprangle ,  Richard Hubbard ,  Glenn Rubel ,  Eldridge Briscoe ,  Christopher Moore

IPC: G01N21/64

CPC classification number: G01N21/6408 ,  G01J3/10 ,  G01J3/4406 ,  G01N21/1717 ,  G01N21/6404 ,  G01N21/6486 ,  G01N2021/6423

Abstract: A system for detecting atmospheric contamination, the system comprising a laser operable to generate an infrared light beam comprising a longitudinal component and a transverse component, the laser remote from the atmospheric contamination, and a processor operable to process a flouresence resulting from contact between the atmospheric contamination and an ultraviolet light being generated from the longitudinal and transverse components of the infrared light of the laser, wherein the processor determines the identity of the fluorescence by comparing the fluorescence to known fluorescence.

Abstract translation: 一种用于检测大气污染的系统，所述系统包括可操作以产生包括纵向分量和横向分量的红外光束的激光器，远离大气污染物的激光器和可操作以处理由大气中的接触产生的荧光的处理器 污染物和由激光的红外光的纵向和横向分量产生的紫外线，其中处理器通过将荧光与已知荧光进行比较来确定荧光的身份。

公开(公告)号：US20100093015A1

公开(公告)日：2010-04-15

申请号：US12462350

申请日：2009-08-03

Applicant: Janice L. Panza ,  John Maier ,  Jason Neiss

Inventor： Janice L. Panza ,  John Maier ,  Jason Neiss

IPC: C12Q1/02 ,  C12M1/34

CPC classification number: G01J3/44 ,  G01J3/10 ,  G01J3/36 ,  G01N15/1475 ,  G01N21/6458 ,  G01N21/65 ,  G01N2015/1006 ,  G01N2015/1488 ,  G02B21/0096

Abstract: A system and method to distinguish normal cells from cells having undergone a biochemical change. A pre-determined vector space is selected where the vector space mathematically describes a first plurality of reference spectral data sets for normal cells and a second plurality of reference spectral data sets for cells having undergone a biochemical change. A sample is irradiated to generate a target spectral data set based on photons absorbed, reflected, emitted, or scattered by the sample. The target spectral data set is transformed into a pre-determined vector space. A distribution of transformed data is analyzed in the pre-determined vector space. Based on the analysis, the sample is classified as containing normal cells, cells having undergone a biochemical change, and combinations thereof. The method includes treating the sample with a pharmaceutical agent prior to irradiating the sample and using the classification to assess the efficiency of the pharmaceutical agent.

Abstract translation: 将正常细胞与经历生物化学变化的细胞区分开的系统和方法。 选择预定向量空间，其中矢量空间数学地描述正常小区的第一多个参考频谱数据集，以及已经历生化变化的小区的第二多个参考频谱数据集。 照射样品以基于样品吸收，反射，发射或散射的光子产生目标光谱数据集。 将目标光谱数据集转换为预定向量空间。 在预定向量空间中分析变换数据的分布。 基于该分析，将样品分类为含有正常细胞，经历生物化学变化的细胞及其组合。 该方法包括在照射样品之前用药剂处理样品并使用分类来评估药剂的效率。

公开(公告)号：US07683346B2

公开(公告)日：2010-03-23

申请号：US11467580

申请日：2006-08-28

Applicant: Antonio C Ting ,  Ilya Alexeev ,  Phillip A Sprangle ,  Richard F Hubbard ,  Glenn Rubel ,  Eldridge C Briscoe ,  Christopher I Moore

Inventor： Antonio C Ting ,  Ilya Alexeev ,  Phillip A Sprangle ,  Richard F Hubbard ,  Glenn Rubel ,  Eldridge C Briscoe ,  Christopher I Moore

IPC: G01N21/64

CPC classification number: G01N21/6408 ,  G01J3/10 ,  G01J3/4406 ,  G01N21/1717 ,  G01N21/6404 ,  G01N21/6486 ,  G01N2021/6423

Abstract: A method used to detect and identify biological substances suspended in air in the form of aerosols or clouds including generating a remote infrared light beam directed toward the atmospheric contamination, producing an ultraviolet light beam from the infrared light beam by compression via the air through which the IR beam travels, and producing fluorescence of the atmospheric contamination, when the generated ultraviolet light contacts the atmospheric contamination. The fluorescent signals are then processed in order to identify the nature of the atmospheric contamination.

Abstract translation: 一种用于检测和识别以气溶胶或云形式悬浮在空气中的生物物质的方法，包括产生朝向大气污染物的远程红外光束，通过经由空气的空气从红外光束产生紫外光束， 当所产生的紫外线接触大气污染物时，红外光束传播并产生大气污染的荧光。 然后处理荧光信号以识别大气污染的性质。

公开(公告)号：US20100067004A1

公开(公告)日：2010-03-18

申请号：US12584207

申请日：2009-09-01

Applicant: Yoshiyuki Nagashima ,  Yasushi Gotto ,  Kazuya Kiyoi

Inventor： Yoshiyuki Nagashima ,  Yasushi Gotto ,  Kazuya Kiyoi

IPC: G01J3/28

CPC classification number: G01J3/28 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/027 ,  G01J3/10

Abstract: A spectral characteristic measuring apparatus includes: an illuminating section for irradiating illumination light onto a sample; a spectral section for separating light from the sample irradiated with the illumination light into light rays in accordance with wavelengths; a light receiving section including a plurality of light receiving elements for receiving the light rays separated by the spectral section in accordance with wavelengths, and converting the received light rays into electrical output signals; and a storing section for storing a combined central wavelength of each of the light receiving elements calculated in advance based a spectral intensity distribution of the illumination light.

Abstract translation: 光谱特性测量装置包括：用于将照明光照射到样品上的照明部分; 用于将照射光的样品的光根据波长分离成光线的光谱部分; 光接收部分，包括多个光接收元件，用于接收根据波长由光谱部分分离的光线，并将接收的光线转换成电输出信号; 以及存储部，其基于照明光的光谱强度分布，预先计算出的各光接收元件的组合中心波长。

公开(公告)号：US07679745B2

公开(公告)日：2010-03-16

申请号：US11603939

申请日：2006-11-21

Applicant: Ricardo Claps ,  Bradley A. Smith

Inventor： Ricardo Claps ,  Bradley A. Smith

IPC: G01J3/30

CPC classification number: G01N21/6408 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/10 ,  G01J3/2889 ,  G01J3/4406

Abstract: A time-resolved, fluorescence spectrometer makes use of a RadiaLight® optical switch and no dispersive optical elements (DOE) like gratings. The structure is unique in its compactness and simplicity of operation. In one embodiment, the spectrometer makes use of only one photo-detector and an efficient linear regression algorithm. The structure offers a time resolution, for multiple species measurements, of less than 1 s. The structure can also be used to perform fluorescence correlation spectroscopy and fluorescence cross-correlation spectroscopy.

Abstract translation: 时间分辨的荧光光谱仪利用RadiaLight®光开关，不使用像光栅这样的色散光学元件（DOE）。 该结构在其紧凑性和操作简单性方面是独一无二的。 在一个实施例中，光谱仪仅使用一个光电检测器和有效的线性回归算法。 该结构提供时间分辨率，用于多种物种测量，小于1秒。 该结构也可用于进行荧光相关光谱和荧光互相关光谱。

公开(公告)号：US20100053599A1

公开(公告)日：2010-03-04

申请号：US12614281

申请日：2009-11-06

Applicant: Thomas D. Milster ,  Pramod Kumar Khulbe ,  Barry Gelernt

Inventor： Thomas D. Milster ,  Pramod Kumar Khulbe ,  Barry Gelernt

IPC: G01J3/12 ,  G01J3/00 ,  G01J3/44

CPC classification number: G01J3/10 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/024 ,  G01J3/2823 ,  G01J3/44 ,  G02B21/16

Abstract: Apparatuses and methods for performing spectroscopy and optical microscopy are disclosed. In at least one embodiment, a Raman spectrometer includes a vacuum ultraviolet light source configured to generate light having a wavelength within a window in the vacuum ultraviolet region of the electromagnetic spectrum within which a local minimum in the absorption coefficient of Oxygen occurs. The spectrometer also includes a lens device that receives a first portion of the generated light, directs at least some of the first portion of the generated light toward a target location, receives reflected light from the target location, and directs the reflected light toward a further location. The spectrometer further includes a dispersive device that receives at least some of the reflected light and outputs dispersed light produced based thereupon, and a camera module that is positioned at additional location, where the camera module receives at least some of the dispersed light.

Abstract translation: 公开了用于执行光谱和光学显微镜的装置和方法。 在至少一个实施例中，拉曼光谱仪包括真空紫外光源，其被配置为产生在电磁光谱的真空紫外区域内具有波长的光的光，其中发生氧吸收系数的局部最小值。 光谱仪还包括接收所产生的光的第一部分的透镜装置，将所产生的光的第一部分中的至少一部分导向目标位置，接收来自目标位置的反射光，并将反射光引向另一个 位置。 光谱仪还包括分散装置，其接收至少一些反射光并输出基于其产生的分散光;以及相机模块，其位于附加位置处，其中相机模块接收至少一些分散的光。

公开(公告)号：US07671988B2

公开(公告)日：2010-03-02

申请号：US11539878

申请日：2006-10-10

Applicant: Robert Dal Sasso ,  David Logan ,  William Phelan

Inventor： Robert Dal Sasso ,  David Logan ,  William Phelan

IPC: G01N21/00

CPC classification number: G01N21/53 ,  G01J3/10 ,  G01N2201/06153

Abstract: A device (10) is provided for measuring at least one characteristic (12) related to presence of particles. The device (10) includes a light source unit (16) for emitting light into a region (18) containing particles (20), with the light source being configured to emit light from a plurality of locations in a manner so that the emitted light follows a desired intensity distribution (22), the desired intensity distribution (22) being desired for the measurement of the at least one characteristic (12). In preferred embodiments the intensity distribution is Lambertian.

Abstract translation: 提供了一种用于测量与颗粒存在有关的至少一个特征（12）的装置（10）。 装置（10）包括用于将光发射到包含颗粒（20）的区域（18）中的光源单元（16），其中光源被配置为以多个位置发射光，使得发射的光 遵循期望的强度分布（22），期望强度分布（22）用于测量至少一个特征（12）。 在优选实施例中，强度分布是朗伯式。

公开(公告)号：US07671981B1

公开(公告)日：2010-03-02

申请号：US11769488

申请日：2007-06-27

Applicant: Walid A. Atia ,  Dale C. Flanders ,  Robert K. Jenner ,  Lawrence P. McDermott ,  Bartley C. Johnson

Inventor： Walid A. Atia ,  Dale C. Flanders ,  Robert K. Jenner ,  Lawrence P. McDermott ,  Bartley C. Johnson

IPC: G01N21/00

CPC classification number: G01N21/39 ,  G01J3/10 ,  G01J3/26 ,  G01J3/4338 ,  G01J9/00 ,  G01N21/3554 ,  G01N21/3559

Abstract: A tunable laser spectroscopic carpet identification system comprises a tunable laser spectroscopy system for generating a tunable signal that is transmitted to a carpet sample. The system detects the tunable signal after interaction with the carpet sample so that an analyzer is able to relate a spectral response of the carpet sample to a chemical composition of the carpet sample. In one example, the spectroscopy system comprises a laser cavity in which the tunable signal is generated, a semiconductor gain medium in the laser cavity, and a tunable element for controlling a wavelength of tunable signal generated in the laser cavity. To deal with variations in water content, the analyzer estimates a water content of the carpet sample using the spectral response of the carpet sample and then determines the chemical composition of the carpet sample in part based on the estimate of the water content.

Abstract translation: 可调激光光谱地毯识别系统包括可调谐激光光谱系统，用于产生传输到地毯样品的可调信号。 该系统在与地毯样品相互作用后检测可调信号，使得分析仪能够将地毯样品的光谱响应与地毯样品的化学成分相关联。 在一个示例中，光谱系统包括其中产生可调信号的激光腔，激光腔中的半导体增益介质和用于控制在激光腔中产生的可调信号的波长的可调元件。 为了处理含水量的变化，分析器使用地毯样品的光谱响应估计地毯样品的含水量，然后基于含水量的估计部分地确定地毯样品的化学成分。

公开(公告)号：US20100014157A1

公开(公告)日：2010-01-21

申请号：US12445132

申请日：2007-10-06

Applicant: Andress Nolte ,  Matthias Kramer ,  Michael Brehm ,  Christian Boeker

Inventor： Andress Nolte ,  Matthias Kramer ,  Michael Brehm ,  Christian Boeker

IPC: G02B21/06

CPC classification number: G02B27/1006 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/10 ,  G01N21/6458 ,  G02B21/16 ,  G02B27/145

Abstract: The invention is directed to a multispectral illumination device for a microscope or for a reader. According to the invention, the illumination device comprises at least three receptacle positions for lighting modules and at least one receptacle position for coupling modules, the mechanical devices for connecting the lighting modules or coupling modules at the receptacle positions to the illumination device being designed in such a way that the lighting modules or coupling modules can be easily changed. Further, the receptacle positions are arranged in such a way that, with suitable selection of the lighting modules and coupling modules, all individual spectra of the lighting modules in a total spectrum are available simultaneously at the output of the illumination device.

Abstract translation: 本发明涉及用于显微镜或读取器的多光谱照明装置。 根据本发明，照明装置包括用于照明模块的至少三个插座位置和用于耦合模块的至少一个插座位置，用于将插座位置处的照明模块或耦合模块连接到照明装置的机械装置被设计为 照明模块或耦合模块可以方便地更换的方式。 此外，插座位置被布置成使得通过适当地选择照明模块和耦合模块，总体光谱中的照明模块的所有单独光谱可在照明装置的输出处同时获得。