公开(公告)号：US20110273707A1

公开(公告)日：2011-11-10

申请号：US13100495

申请日：2011-05-04

Applicant: David Roger LABRECQUE

Inventor： David Roger LABRECQUE

IPC: G01J3/40 ,  B23P11/00 ,  G01J3/28

CPC classification number: G01J3/18 ,  G01J3/02 ,  G01J3/0229 ,  G01J3/0243 ,  G01J3/20 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/2846 ,  G01J3/4406 ,  Y10T29/49826

Abstract: The present invention provides apparatuses including a point light source, a diffraction grating oriented in a light path generated from the point light source wherein the diffraction grating diffracts and concentrates light from the point light source into one or more rings of light, a detector positioned to detect one or more of the rings of light or light transmitted from a sample exposed to said rings of light, and a computer operably connected to the detector to analyze the intensity of one or more of the rings of light or said light transmitted from said sample. Variations including samples and additional components and methods of making the apparatuses of the present invention are also disclosed.

Abstract translation: 本发明提供了一种装置，包括点光源，衍射光栅，其定向在从点光源产生的光路中，其中衍射光栅将来自点光源的光衍射并集中到一个或多个光环中，检测器定位成 检测从暴露于所述光环的样品透射的光或光的一个或多个环，以及可操作地连接到所述检测器的计算机，以分析从所述样品透射的一个或多个所述光或所述光的强度 。 还公开了包括样品和附加组分的变化以及制备本发明的装置的方法。

公开(公告)号：US20110213302A1

公开(公告)日：2011-09-01

申请号：US13102876

申请日：2011-05-06

Applicant: Steve A. Herweck ,  Paul Martakos ,  Geoffrey Moodie ,  Roger Labrecque ,  Theodore Karwoski ,  Trevor Carlton ,  Lisa Rogers ,  Joseph Ferraro

Inventor： Steve A. Herweck ,  Paul Martakos ,  Geoffrey Moodie ,  Roger Labrecque ,  Theodore Karwoski ,  Trevor Carlton ,  Lisa Rogers ,  Joseph Ferraro

IPC: A61L29/16 ,  B05D5/10

CPC classification number: B05D1/00 ,  A61F2/82 ,  A61F2/958 ,  A61F2250/0067 ,  A61L29/08 ,  A61L29/16 ,  A61L2300/606 ,  A61M25/1027 ,  A61M25/1038 ,  A61M2025/1031 ,  B05D2259/00 ,  Y10T29/49

Abstract: A non-polymeric or biological coating applied to a radially expandable interventional medical device in a collapsed, wrapped, or folded configuration, the coating applied within at least one fold. Properties of the coating material applied to the medical device are adjusted or varied to result in a desired combination of coverage of the surface of the medical device, drug loading, and coating thickness. The coating is sterile, and is capable of being carried by a sterile medical device to a targeted tissue location within the body following radial expansion. The therapeutic coating transfers off the medical device due in part to a biological attraction with the tissue and in part to a physical transference from the medical device to the targeted tissue location in contact with the medical device.

Abstract translation: 以折叠的，包裹的或折叠的形式施加到可径向展开的介入医疗装置的非聚合物或生物涂层，所述涂层施用在至少一个折叠内。 调整或改变施加到医疗装置上的涂层材料的性质，以产生医疗装置的表面，药物负载和涂层厚度的覆盖范围的期望组合。 涂层是无菌的，并且能够在径向膨胀后由无菌医疗装置携带到身体内的目标组织位置。 治疗涂层部分地由于与组织的生物吸引而部分地转移离开医疗装置，并且部分地从医疗装置到与医疗装置接触的目标组织位置的物理转移。

公开(公告)号：US07947015B2

公开(公告)日：2011-05-24

申请号：US11804478

申请日：2007-05-18

Applicant: Steve A. Herweck ,  Paul Martakos ,  Geoffrey Moodie ,  Roger Labrecque ,  Theodore Karwoski ,  Trevor Carlton

Inventor： Steve A. Herweck ,  Paul Martakos ,  Geoffrey Moodie ,  Roger Labrecque ,  Theodore Karwoski ,  Trevor Carlton

IPC: A61M37/00

CPC classification number: A61M25/1027 ,  A61L29/085 ,  A61L29/146 ,  A61L29/16 ,  A61L2300/22 ,  A61L2300/606 ,  A61M2025/1075 ,  A61M2025/1088 ,  C08L27/18

Abstract: A non-polymeric or biological coating applied to radially expandable medical delivery device provides uniform drug distribution and permeation of the coating and any therapeutic agents mixed therewith into a targeted treatment area within the body. The delivery device is expanded using the pressure of an inflation fluid. After expanding the delivery device to a pre-determined size and shape, the inflation fluid weeps through the porous surface of the delivery device. The coating releases the delivery device and floats on the inflation fluid until bonding to the tissue due to its affinity for the tissue. Once the coating bonds or affixes to the tissue, through an absorption mechanism by the tissue cells of the coating material, the coating and any therapeutics contained therein are delivered to the tissue. The fluid can contain a therapeutic agent, or can be otherwise biocompatible and/or inert.

Abstract translation: 应用于可径向扩张的医疗输送装置的非聚合物或生物涂层提供了涂层和与其混合的任何治疗剂的均匀的药物分布和渗透到体内的目标治疗区域。 输送装置使用充气流体的压力膨胀。 在将输送装置膨胀至预定尺寸和形状之后，充气流体通过输送装置的多孔表面而流失。 涂层释放输送装置并漂浮在充气流体上，直到由于其对组织的亲和力而结合到组织。 一旦涂层通过涂层材料的组织细胞通过吸收机制结合或固定到组织，涂层和其中包含的任何治疗剂被递送到组织。 流体可以含有治疗剂，或者可以以其他方式生物相容和/或惰性。

公开(公告)号：US20080015500A1

公开(公告)日：2008-01-17

申请号：US11804478

申请日：2007-05-18

Applicant: Steve Herweck ,  Paul Martakos ,  Geoffrey Moodie ,  Roger Labrecque ,  Theodore Karwoski ,  Trevor Carlton

Inventor： Steve Herweck ,  Paul Martakos ,  Geoffrey Moodie ,  Roger Labrecque ,  Theodore Karwoski ,  Trevor Carlton

IPC: A61M29/02

CPC classification number: A61M25/1027 ,  A61L29/085 ,  A61L29/146 ,  A61L29/16 ,  A61L2300/22 ,  A61L2300/606 ,  A61M2025/1075 ,  A61M2025/1088 ,  C08L27/18

Abstract: A non-polymeric or biological coating applied to radially expandable medical delivery device provides uniform drug distribution and permeation of the coating and any therapeutic agents mixed therewith into a targeted treatment area within the body. The delivery device is expanded using the pressure of an inflation fluid. After expanding the delivery device to a pre-determined size and shape, the inflation fluid weeps through the porous surface of the delivery device. The coating releases the delivery device and floats on the inflation fluid until bonding to the tissue due to its affinity for the tissue. Once the coating bonds or affixes to the tissue, through an absorption mechanism by the tissue cells of the coating material, the coating and any therapeutics contained therein are delivered to the tissue. The fluid can contain a therapeutic agent, or can be otherwise biocompatible and/or inert.

Abstract translation: 应用于可径向扩张的医疗输送装置的非聚合物或生物涂层提供了涂层和与其混合的任何治疗剂的均匀的药物分布和渗透到体内的目标治疗区域。 输送装置使用充气流体的压力膨胀。 在将输送装置膨胀至预定尺寸和形状之后，充气流体通过输送装置的多孔表面而流失。 涂层释放输送装置并漂浮在充气流体上，直到由于其对组织的亲和力而结合到组织。 一旦涂层通过涂层材料的组织细胞通过吸收机制结合或固定到组织，涂层和其中包含的任何治疗剂被递送到组织。 流体可以含有治疗剂，或者可以以其他方式生物相容和/或惰性。

公开(公告)号：US20060121081A1

公开(公告)日：2006-06-08

申请号：US11238554

申请日：2005-09-28

Applicant: Roger Labrecque ,  Geoffrey Moodie ,  Joseph Ferraro ,  Lisa Rogers ,  Paul Martakos ,  Theodore Karwoski ,  Steve Herweck ,  Suzanne Conroy ,  Brian Sunter ,  Georgette Henrich

Inventor： Roger Labrecque ,  Geoffrey Moodie ,  Joseph Ferraro ,  Lisa Rogers ,  Paul Martakos ,  Theodore Karwoski ,  Steve Herweck ,  Suzanne Conroy ,  Brian Sunter ,  Georgette Henrich

IPC: A61F2/06 ,  A61M35/00 ,  B05D3/02

CPC classification number: A61L31/08 ,  A61F2/82 ,  A61F2/86 ,  A61F2250/0067 ,  A61K47/10 ,  A61K47/22 ,  A61K47/44 ,  A61L31/10 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/22 ,  A61L2300/416 ,  A61L2300/428 ,  A61L2300/45 ,  A61L2300/606 ,  A61L2300/802 ,  A61L2420/02 ,  A61M25/0009 ,  A61M25/0045

Abstract: Methods and devices for the provision of a coating on an implantable medical device. The coating includes a bio-absorbable carrier component. In addition to the bio-absorbable carrier component, a therapeutic agent component can also be provided. The methods and devices provide a coating having improved uniformity and coverage which in turn allow for greater control of the amount and dosage of the coating.

Abstract translation: 用于在可植入医疗装置上提供涂层的方法和装置。 涂层包括生物吸收载体组分。 除了生物可吸收载体组分之外，还可以提供治疗剂成分。 所述方法和装置提供了具有改进的均匀性和覆盖度的涂层，其又允许更大程度地控制涂层的量和剂量。

公开(公告)号：US20060112536A1

公开(公告)日：2006-06-01

申请号：US11250768

申请日：2005-10-14

Applicant: Steve Herweck ,  Paul Martakos ,  Geoffrey Moodie ,  Roger Labrecque ,  Theodore Karwoski ,  Trevor Carlton ,  Lisa Rogers ,  Joseph Ferraro

Inventor： Steve Herweck ,  Paul Martakos ,  Geoffrey Moodie ,  Roger Labrecque ,  Theodore Karwoski ,  Trevor Carlton ,  Lisa Rogers ,  Joseph Ferraro

IPC: B23P17/04

CPC classification number: B05D1/00 ,  A61F2/82 ,  A61F2/958 ,  A61F2250/0067 ,  A61L29/08 ,  A61L29/16 ,  A61L2300/606 ,  A61M25/1027 ,  A61M25/1038 ,  A61M2025/1031 ,  B05D2259/00 ,  Y10T29/49

Abstract: A non-polymeric or biological coating applied to a radially expandable interventional medical device in a collapsed, wrapped, or folded configuration. Properties of the coating material applied to the medical device are adjusted or varied to result in a desired combination of coverage of the surface of the medical device, drug loading, and coating thickness. The coating is sterile, and is capable of being carried by a sterile medical device to a targeted tissue location within the body following radial expansion. The therapeutic coating transfers off the medical device due in part to a biological attraction with the tissue and in part to a physical transference from the medical device to the targeted tissue location in contact with the medical device.

Abstract translation: 以折叠的，包裹的或折叠的构造施加到可径向展开的介入医疗装置的非聚合或生物涂层。 调整或改变施加到医疗装置上的涂层材料的性质，以产生医疗装置的表面，药物负载和涂层厚度的覆盖范围的期望组合。 涂层是无菌的，并且能够在径向膨胀后由无菌医疗装置携带到身体内的目标组织位置。 治疗涂层部分地由于与组织的生物吸引而部分地转移离开医疗装置，并且部分地从医疗装置到与医疗装置接触的目标组织位置的物理转移。

公开(公告)号：US20060110457A1

公开(公告)日：2006-05-25

申请号：US11237263

申请日：2005-09-28

Applicant: Roger Labrecque ,  Philip McNamara ,  Joseph Ferraro ,  Lisa Rogers ,  Paul Martakos ,  Theodore Karwoski ,  Steve Herweck ,  Keith Faucher ,  Thomas Swanick

Inventor： Roger Labrecque ,  Philip McNamara ,  Joseph Ferraro ,  Lisa Rogers ,  Paul Martakos ,  Theodore Karwoski ,  Steve Herweck ,  Keith Faucher ,  Thomas Swanick

IPC: A61K9/14 ,  A61K31/225

CPC classification number: A61K35/60 ,  A61F2/06 ,  A61F13/02 ,  A61F13/023 ,  A61F2250/0067 ,  A61K9/0024 ,  A61K9/06 ,  A61K31/225 ,  A61K31/355 ,  A61K38/13 ,  A61K47/12 ,  A61K47/14 ,  A61L2/07 ,  A61L2/081 ,  A61L2/087 ,  A61L2/206 ,  A61L2/208 ,  A61L27/36 ,  A61L27/3604 ,  A61L27/52 ,  A61L27/54 ,  A61L31/005 ,  A61L31/10 ,  A61L31/145 ,  A61L2202/24 ,  A61L2300/22 ,  A61L2300/252 ,  A61L2300/404 ,  A61L2300/41 ,  A61L2300/414 ,  A61L2300/42 ,  A61L2300/602 ,  B05D3/067

Abstract: A method of curing and corresponding resulting non-polymeric cross-linked gel are provided. The cross-linked gel can be combined with a medical device structure. The cross-linked gel can provide anti-adhesion characteristics, in addition to improved healing and anti-inflammatory response. The cross-linked gel is generally formed of a naturally occurring oil, or an oil composition formed in part of a naturally occurring oil, that is at least partially cured forming a cross-linked gel derived from at least one fatty acid compound. In addition, the oil composition can include a therapeutic agent component, such as a drug or other bioactive agent. The curing method can vary the application of heat in both temperature and duration to achieve a desired amount of cross-linking forming the gel.

Abstract translation: 提供固化方法和相应的所得非聚合交联凝胶。 交联凝胶可以与医疗装置结构组合。 除了改善愈合和抗炎反应之外，交联凝胶还可提供抗粘附特性。 交联凝胶通常由天然存在的油或部分天然存在的油形成的油组合物形成，其至少部分固化形成由至少一种脂肪酸化合物衍生的交联凝胶。 此外，油组合物可以包括治疗剂组分，例如药物或其它生物活性剂。 固化方法可以在温度和持续时间内改变热量的应用以实现形成凝胶的所需量的交联。

公开(公告)号：US20060067974A1

公开(公告)日：2006-03-30

申请号：US11236908

申请日：2005-09-28

Applicant: Roger Labrecque ,  Geoffrey Moodie ,  Joseph Ferraro ,  Lisa Rogers ,  Paul Martakos ,  Theodore Karwoski ,  Steve Herweck

Inventor： Roger Labrecque ,  Geoffrey Moodie ,  Joseph Ferraro ,  Lisa Rogers ,  Paul Martakos ,  Theodore Karwoski ,  Steve Herweck

IPC: A61K35/60 ,  A61F2/00

CPC classification number: A61L31/08 ,  A61F2/82 ,  A61F2/86 ,  A61F2250/0067 ,  A61K47/10 ,  A61K47/22 ,  A61K47/44 ,  A61L31/10 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/22 ,  A61L2300/416 ,  A61L2300/428 ,  A61L2300/45 ,  A61L2300/606 ,  A61L2300/802 ,  A61L2420/02 ,  A61M25/0009 ,  A61M25/0045

Abstract: A coated medical device an a method of providing a coating on an implantable medical device result in a medical device having a bio-absorbable coating. The coating includes a bio-absorbable carrier component. In addition to the bio-absorbable carrier component, a therapeutic agent component can also be provided. The coated medical device is implantable in a patient to effect controlled delivery of the coating, including the therapeutic agent, to the patient.

Abstract translation: 涂覆的医疗装置是在可植入医疗装置上提供涂层的方法，导致具有生物吸收性涂层的医疗装置。 涂层包括生物吸收载体组分。 除了生物可吸收载体组分之外，还可以提供治疗剂成分。 涂覆的医疗装置可植入患者体内以实现对包括治疗剂在内的涂层的可控输送。

公开(公告)号：US06616876B1

公开(公告)日：2003-09-09

申请号：US09678765

申请日：2000-10-03

Applicant: Roger Labrecque ,  Joseph Ferraro ,  Tom Swanick ,  Paul Martakos

Inventor： Roger Labrecque ,  Joseph Ferraro ,  Tom Swanick ,  Paul Martakos

IPC: B29B1110

CPC classification number: A61F2/06

Abstract: The invention is directed to methods involving rewetting of expandable polymers with a wettable liquid to allow for enhanced expansion at or below room temperature without breakage, and in some cases, allows one to achieve a greater expansion ratio than that allowed at elevated temperatures using known methods. The present invention also allows one to achieve material with unique properties and handling characteristics. These properties included decreased material thickness, increased density, an altered node/fibril morphology, and a more consistent web in the case of flat material. This method is not limited to room temperature conditions and can be applied whenever the expandable polymer material is wet with a wettable liquid, and the expansion is performed at a temperature preferably below the vaporization or boiling points of that liquid.

Abstract translation: 本发明涉及包括用可湿性液体再湿润可膨胀聚合物以允许在室温或低于室温下增强膨胀而不破裂的方法，并且在某些情况下允许使用已知方法获得比在升高的温度下更大的膨胀比 。 本发明还可以实现具有独特性质和处理特性的材料。 这些性质包括材料厚度减小，密度增加，节点/原纤维形态改变，以及在平坦材料情况下更一致的网。 该方法不限于室温条件，只要可膨胀聚合物材料用可湿性液体润湿，并且膨胀在优选低于该液体的蒸发或沸点的温度下进行。