公开(公告)号：US11676276B2

公开(公告)日：2023-06-13

申请号：US16593174

申请日：2019-10-04

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Ralph Dacosta

IPC: G06T7/00 ,  A61B5/00 ,  G01N21/64

CPC classification number: G06T7/0016 ,  A61B5/0071 ,  A61B5/0077 ,  A61B5/445 ,  G01N21/6486 ,  G06T2207/10016 ,  G06T2207/10024 ,  G06T2207/10048 ,  G06T2207/10064 ,  G06T2207/30088 ,  G06T2207/30096

Abstract: Systems and methods for obtaining diagnostic data of a target are disclosed. The systems include an imaging device and a drape. The imaging device includes at least one excitation light source for fluorescent imaging, and an optical sensor configured to detect signals responsive to illumination of the target with the excitation light. The drape is configured to reduce ambient light surrounding the target during imaging.

公开(公告)号：US20230121154A1

公开(公告)日：2023-04-20

申请号：US17903910

申请日：2022-09-06

Applicant: University Health Network ,  Notogen, Inc.

Inventor： William Mark ERWIN ,  Bjorn C. J. EEK

IPC: A61K31/737 ,  A61K31/7008 ,  A61K9/00 ,  A61K47/38 ,  A61K9/08 ,  C07K14/495 ,  C07H5/06 ,  A61K47/26 ,  C08L5/08 ,  A61K47/20 ,  A61K47/36 ,  C07K14/475 ,  C07H3/02 ,  A61K38/18 ,  A61K31/726 ,  A61P19/02

Abstract: There is disclosed herein compositions, methods, uses and systems for reducing pain in a patient that emanates from a body area, preferably spine or joint. Methods of treatment or prevention are described for a disease or condition selected from degenerative disc disease, disc injury, pain, arthritis, or suspected arthritis.

公开(公告)号：US11629185B2

公开(公告)日：2023-04-18

申请号：US17127719

申请日：2020-12-18

Applicant: NOVO NORDISK A/S ,  UNIVERSITY HEALTH NETWORK

Inventor： Tarlochan S. Nijjar ,  Avijit Chakrabartty ,  Jeffrey N. Higaki

IPC: A01K67/027 ,  C12P21/08 ,  A61K39/00 ,  C07K16/00 ,  C07K16/18 ,  G01N33/68

Abstract: The invention provides antibodies that specifically bind to transthyretin (TTR). The antibodies can be used for treating or effecting prophylaxis of diseases or disorders associated with TTR accumulation or accumulation of TTR deposits (e.g., TTR amyloidosis). The antibodies can also be used for diagnosing TTR amyloidosis and inhibiting or reducing aggregation of TTR, among other applications.

公开(公告)号：US11597917B2

公开(公告)日：2023-03-07

申请号：US16619883

申请日：2018-06-06

Applicant: THE MEDICAL COLLEGE OF WISCONSIN, INC. ,  UNIVERSITY HEALTH NETWORK ,  WASHINGTON UNIVERSITY IN ST. LOUIS

Inventor： Jeffrey A. Medin ,  John F. Dipersio ,  Murtaza S. Nagree

IPC: C12N9/04 ,  A61P43/00 ,  A61K9/00 ,  A61K35/28 ,  C12N5/0789 ,  C12N7/00 ,  C12N9/40 ,  C12N9/24 ,  C12N9/80 ,  C12N15/86

Abstract: The present invention is related to a dual promoter lentiviral vector and methods of use for the treatment of diseases and disorders, specifically lysosomal storage disorders.

公开(公告)号：US11572354B2

公开(公告)日：2023-02-07

申请号：US16961112

申请日：2019-01-09

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Donald Weaver ,  Michael G. Brant ,  Stephanie Wohnig ,  Fan Wu ,  Jake Goodwin-Tindall ,  Autumn Meek ,  Paolo Schiavini

IPC: C07D403/14 ,  C07D403/04 ,  C07D401/14

Abstract: Inhibition of indoleamine 2,3-dioxygenase (IDO1) is an attractive immunotherapeutic approach for the treatment of a variety of cancers. Dysregulation of this enzyme has also been implicated in other severe diseases such as Alzheimer's disease and arthritis. Small molecule inhibitors of Formula (Ia) and (Ib) of IDO, their synthesis, and uses thereof are provided.

公开(公告)号：US11560558B2

公开(公告)日：2023-01-24

申请号：US17519350

申请日：2021-11-04

Applicant: University Health Network ,  Sinai Health System

Inventor： Daniel Diniz De Carvalho ,  Shu Yi Shen ,  Rajat Singhania

IPC: C12N15/10 ,  C12Q1/6806 ,  C12Q1/6804 ,  G01N33/53 ,  C12Q1/6886 ,  C40B30/04

Abstract: There is described herein, a method of capturing cell-free methylated DNA from a sample having less than 100 mg of cell-free DNA, comprising the steps of: subjecting the sample to library preparation to permit subsequent sequencing of the cell-free methylated DNA; adding a first amount of filler DNA to the sample, wherein at least a portion of the filler DNA is methylated; denaturing the sample; and capturing cell-free methylated DNA using a binder selective for methylated polynucleotides.

公开(公告)号：US11547725B2

公开(公告)日：2023-01-10

申请号：US16478969

申请日：2017-12-21

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Pamela S. Ohashi ,  Michael St. Paul ,  Sam Saibil

IPC: A61K35/17 ,  C12N5/0783 ,  C07K16/22 ,  C07K16/24 ,  C07K16/28

Abstract: There is described herein, a method for inducing Tc22 lineage T cells from a population of CD8+ T cells, the method comprising: a) providing a population of CD8+ T cells; b) activating the population; and c) culturing or contacting the population of CD8+ T cells with Coenzyme A.

公开(公告)号：US20220361943A1

公开(公告)日：2022-11-17

申请号：US17744483

申请日：2022-05-13

Applicant: University Health Network

Inventor： Kumaraswamy Nanthakumar

IPC: A61B18/14 ,  A61B5/283 ,  A61B5/367 ,  A61B5/00

Abstract: Various embodiments are described herein for a bipolar catheter that generally comprises: a catheter body having a distal end portion and a proximal end portion; a first electrode at the distal end portion, the first electrode being on a spiral structure for rotational insertion into a physiological target region; a second electrode at the proximal end portion and spaced apart from the first electrode; and first and second electrode terminals spaced apart from one another at the proximal end portion and electrically coupled to the first and second electrodes respectively. The first and second electrodes are configured to function as active and dispersive electrodes respectively, or vice-versa. Also described are various embodiments of methods which generally include coupling the bipolar catheter to a signal generator; inserting the bipolar catheter at a physiological target region; and performing the procedure.

公开(公告)号：US11499195B2

公开(公告)日：2022-11-15

申请号：US16306724

申请日：2017-06-02

Applicant: ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) ,  UNIVERSITY HEALTH NETWORK

Inventor： Julia A. Hopkins ,  Paul Boutros ,  Robert G. Bristow

IPC: C12Q1/6886 ,  G01N33/574 ,  G16H50/30 ,  G16H50/20 ,  C12Q1/6881

Abstract: There is described herein a method of prognosing and/or predicting disease progression and/or in subject with prostate cancer, the method comprising: a) providing a sample containing mitochondrial genetic material from prostate cancer cells; b) sequencing the mitochondrial genetic material with respect to at least 1 patient biomarker selected from CSB1, OHR, ATP8 and HV1 (hypervariable region 1); c) comparing the sequence of the patient biomarkers to control or reference biomarkers to determine mitochondrial single nucleotide variations (mtSNVs); and d) determining the a prostate cancer prognosis; wherein a relatively worse outcome is associated with the presence of mtSNVs in CSB1, OHR, ATP8 and a relatively better outcome is associated with the presence of mtSNVs in HV1.

公开(公告)号：US11439615B2

公开(公告)日：2022-09-13

申请号：US16492494

申请日：2018-03-09

Applicant: University Health Network ,  The Regents of the University of California

Inventor： Jeremy M. Sivak ,  Izhar Livne-Bar ,  John G. Flanagan ,  Karsten Gronert ,  Jessica Wei

IPC: A61K31/202 ,  A61P25/28 ,  A61K31/557

Abstract: Methods and compositions for inhibiting or preventing neurodegeneration, specifically hippocampal, cortical, and/or retinal ganglion cell neurons (RGC), and degeneration and/or cell loss or treating related disorders and diseases comprising administering to a subject an effective amount of one or more lipoxin compounds and/or lipoxin analogues such that degeneration and/or cell loss of neurons is inhibited or prevented.