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公开(公告)号：US12004996B2
公开(公告)日：2024-06-11
申请号：US17984046
申请日：2022-11-09
Inventor： Yu-Chong Tai , Aubrey M. Shapero , Nicholas E. Scianmarello , Mark S. Humayun
CPC classification number: A61F9/0017 , A61K9/0051 , A61M31/002 , A61F2250/0068 , B01L2400/082 , G02C7/049
Abstract: A microfluidic flow restrictor that uses micron-sized beads to impede flow is described. The flow rate can be adjusted by adding or removing the beads using injection needles through self-sealing ports, one injection needle injecting or aspirating beads and another injection needle pushing or pulling fluid from outside of a bead trap within the flow restrictor. In alternative embodiments, the beads or other filler material can be trapped in a manifold bead trap such that they block a subset of fluid channels of the flow restrictor, allowing fluid to flow freely through the rest of the fluid channels. The flow restrictor can be integrated with a contact lens or implantable medical device for use in dispensing liquid therapeutic agents at flow rates of microliters per minute or moving body fluids at a controlled rate from one part of the body to another.
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公开(公告)号：US20230166004A1
公开(公告)日：2023-06-01
申请号：US18070334
申请日：2022-11-28
Applicant: California Institute of Technology , City of Hope
Inventor： Yu-Chong Tai , Kuang-Ming Shang , Hirotake Komatsu
CPC classification number: A61L27/3804 , C12N5/0068 , A61L27/56 , A61L27/54 , C12N2533/30 , C12N2535/10
Abstract: A two-dimensional lattice or mesh scaffold for therapeutic cell implants is disclosed as well as methods for manufacture and use. The lattice is constructed of crisscrossing capillaries of hydrophobic parylene, such as parylene AF4, that may be coated with a hydrophilic polymer, such as parylene C, for cell adhesion. At each intersection of the crisscross, the intersecting capillaries are internally connected so as to allow oxygen to flow freely within. The walls of the capillaries are thin enough to be permeable to oxygen, on the scale of a micron thick, so that oxygen can flow through the lattice and permeate through the capillary walls. For some implants, cells are sandwiched between two or more lattices, the cells being slightly held apart from aggregation with each other by the lattice holes. The implants may then be surgically implanted within a subject.
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公开(公告)号：US20220389361A1
公开(公告)日：2022-12-08
申请号：US17776183
申请日：2020-11-13
Applicant: City of Hope , California Institute of Technology
Inventor： Colin Andrew Cook , Yuman Fong , Yu-Chong Tai , Saswati Chatterjee
Abstract: A cell cultivation apparatus for cultivating microorganisms and growing cells at high density is provided. The apparatus includes a membrane comprising multiple surface features on a first side of the membrane for cell placement. The surface features comprising one or more compartments within which a cell can be located. The membrane includes a material that is at least partially permeable to gas. A second side of the membrane defines a gas region. The second side of the membrane is separated from the first side of the membrane by the membrane. The apparatus further includes a media region for receiving media. The compartments are configured to at least partially reduce media flow shear forces on one or more cells in the compartments. The surface features may be ridges, protrusions, fins, wells, and/or posts.
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公开(公告)号：US11154639B2
公开(公告)日：2021-10-26
申请号：US16222918
申请日：2018-12-17
Applicant: University of Southern California , California Institute of Technology , The Regents of the University of California
Inventor： Mark S. Humayun , Ashish Ahuja , Yu-Chong Tai , David R. Hinton , Robert H. Grubbs , Dennis O. Clegg , Lincoln Vallance Johnson , Sherry T. Hikita
IPC: A61K47/34 , A61L27/18 , A61K35/30 , A61L27/38 , A61K35/545 , A61P27/00 , C12N5/079 , A61L27/34 , A61K9/00 , A61L27/56
Abstract: Disclosed herein are substrates for cell delivery to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide seeded cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.
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公开(公告)号：US10371640B2
公开(公告)日：2019-08-06
申请号：US15647039
申请日：2017-07-11
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Yu-Chong Tai , Wendian Shi , Harvey Kasdan
Abstract: The present invention provide compositions and methods for classifying leukocytes in a leukocyte population using fluorescence detection. The methods include contacting a leukocyte population in a sample having one or more leukocyte types with a diagnostic composition, exciting the leukocyte population with a light source; and measuring emitted light from each of the one or more leukocyte types to classify the leukocyte population.
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Patent Agency Ranking
公开(公告)号：US10188769B2
公开(公告)日：2019-01-29
申请号：US14314994
申请日：2014-06-25
Applicant: University of Southern California , California Institute of Technology , The Regents of the University of California
Inventor： Mark S. Humayun , Ashish Ahuja , Yu-Chong Tai , David R. Hinton , Robert H. Grubbs , Dennis O. Clegg , Lincoln Vallance Johnson , Sherry T. Hikita
Abstract: Disclosed herein are substrates for cell delivery to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide seeded cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.
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公开(公告)号：US20180229037A1
公开(公告)日：2018-08-16
申请号：US15878325
申请日：2018-01-23
Applicant: The Regents of the University of California , California Institute of Technology , University of Louisville Research Foundation, Inc.
Inventor： Victor Reggie Edgerton , Roland R. Roy , Yury Gerasimenko , Joel W. Burdick , Susan J. Harkema , Jonathan Hodes , Yu-Chong Tai , Mandheerej S. Nandra , Claudia A. Angeli , Thomas Anthony Desautels
CPC classification number: A61N1/36103 , A61H1/0237 , A61H1/0274 , A61N1/0551 , A61N1/0553 , A61N1/0556 , A61N1/36003 , A61N1/36153 , A63B21/00181 , A63B22/0235 , A63B69/0064 , A63B2213/004 , A63B2220/805 , A63B2230/60 , F04C2270/0421
Abstract: Methods comprising applying electrical stimulation to patients in conjunction with physical training are described.
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公开(公告)号：US10031348B2
公开(公告)日：2018-07-24
申请号：US14881935
申请日：2015-10-13
Inventor： Yu-Chong Tai , Nicholas E. Scianmarello , Charles M. T. DeBoer , Mark S. Humayun
Abstract: A contact lens fluid delivery device having a liquid reservoir connected to a channel with a flow regulator is described. Other eye hydration and variable dioptric power contact lenses are described herein. Also described are implantable liquid delivery apparatuses having a liquid storage reservoir connected to a channel with a flow regulator. These devices and apparatuses are useful for specific, targeted delivery of therapeutic liquids within a subject. In some embodiments, the devices incorporate actuation chambers which provide a driving force releasing the fluid into the targeted area e.g., the eye. The actuation chambers described herein can contain phase change materials or osmotic chambers or a combination thereof to drive the release of fluid.
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公开(公告)号：US09980388B2
公开(公告)日：2018-05-22
申请号：US14974242
申请日：2015-12-18
Applicant: California Institute of Technology
Inventor： Yu-Chong Tai , Han-Chieh Chang
CPC classification number: H05K1/189 , A61N1/0543 , A61N1/36046 , H05K3/064 , H05K2201/0154 , H05K2201/052 , H05K2201/1003 , H05K2201/10151
Abstract: A biocompatible, micro-fabricated ribbon cable is described in which at least one set of conductors diverges laterally into a bypass wing that forms an aperture through the ribbon cable. The bypass wing is folded in a line through the aperture and over a central portion of the ribbon cable, resulting in a ribbon cable with a narrow, stacked region. The narrow region can fit through small incisions in membranes, such as through an incision in a sclera of an eyeball. The ribbon cable can have an integrally-formed electrode array for attaching to a retina of an eyeball and other electronics for sending signals to the electrode array.
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公开(公告)号：US20180016533A1
公开(公告)日：2018-01-18
申请号：US15647156
申请日：2017-07-11
Applicant: California Institute of Technology , City of Hope
Inventor： Yu-Chong Tai , Yang Liu , Colin A. Cook , Yuman Fong , Nanhai G. Chen
Abstract: A polymer or other substrate optimized for growing cells is described, which takes the form of a micro-thin bag with gas permeable sides. Sides of the bag can be held at a fixed distance from one another with a multitude of tiny micropillars or other spacers extending between them, keeping the bag at a predetermined thickness and preventing the bag from collapsing and the sides from sticking together. In other embodiments, the sides may be held apart by gas pressure alone. A 0.01 μm to 1000 μm parylene or other biocompatible coating over the bag outsides controls the permeability of the bag material and provides a bio-safe area for cell growth. An alternate configuration uses open-cell foam with skins coated with a biocompatible coating. Tubes going into multiple bags can be connected to a manifold that delivers gaseous oxygen or removes carbon dioxide and other waste gases. Multiple bags can be stacked together tightly, with o-ring spacers in between, and housed within a vessel to form a high-surface area, ultra-compact cell growing system. For cells growing on the bags, liquid nutrients can be fed by way of the tube spacers, and oxygen and waste gases permeated through the bag sides and transported within the bags.
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