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    Collection, genome editing, and washing of T-cell lymphocytes
    32.
    发明授权
    Collection, genome editing, and washing of T-cell lymphocytes 有权

    公开(公告)号：US12168087B2

    公开(公告)日：2024-12-17

    申请号：US16807254

    申请日：2020-03-03

    Applicant: Fenwal, Inc.

    Inventor： Kyungyoon Min ,  Benjamin E. Kusters

    IPC: C12N5/078 ,  A61K35/17 ,  A61M1/02 ,  A61M1/34 ,  A61M1/36 ,  A61M1/38 ,  C12M1/00 ,  C12M1/42 ,  C12N5/00 ,  C12N5/0783 ,  C12N5/10 ,  C12N13/00 ,  C12N15/85

    Abstract: Blood from a blood source is drawn into a fluid flow circuit. A mononuclear cell product is separated from the blood, followed by at least a portion of the mononuclear cell product being conveyed into an electroporation device without disconnecting the blood source from the fluid flow circuit. The electroporation device opens pores in a membrane of at least one of the cells of the mononuclear cell product to allow DNA material (which is added to the mononuclear cell product prior to electroporation) to enter and modify the genome of the cell. At least a portion of the modified mononuclear cell product is returned to the blood source. The mononuclear cell product may be washed prior to being conveyed into the electroporation device. The modified mononuclear cell product may be washed after exiting the electroporation device.

    Packaging Tray for a Blood Processing Kit
    33.
    发明公开
    Packaging Tray for a Blood Processing Kit 审中-公开

    公开(公告)号：US20240245840A1

    公开(公告)日：2024-07-25

    申请号：US18420050

    申请日：2024-01-23

    Applicant: Fenwal, Inc.

    Inventor： Benjamin E. Kusters ,  James Gregory Madsen ,  Kyungyoon Min

    IPC: A61M1/02 ,  B04B5/04 ,  B04B11/02

    CPC classification number: A61M1/0277 ,  B04B5/0442 ,  B04B11/02 ,  A61M2205/3393 ,  A61M2209/06

    Abstract: A packaging tray for use in a blood processing system including a blood processing device having device components arranged on a component surface and a removable fluid flow circuit having circuit components configured to interact with corresponding device components, wherein the packaging tray configured to be selectively arranged on and removable from the component surface. The packaging tray includes a first surface and a second surface opposite to the first surface and spaced apart by a thickness, component sections arranged at positions corresponding to positions of respective device components, the component sections respectively formed, at least partially, as openings extending through the thickness, and a plurality of recessed pathways formed on the first surface, the recessed pathways extending between the component sections. A blood processing device may include the packaging tray, and a blood processing system may include a blood processing device and the packaging tray.

    Maximization Of Plasma Collection And Collection Of Buffy Coat Or White Blood Cell Layer Using Collected Plasma
    35.
    发明公开
    Maximization Of Plasma Collection And Collection Of Buffy Coat Or White Blood Cell Layer Using Collected Plasma 审中-公开

    公开(公告)号：US20240157038A1

    公开(公告)日：2024-05-16

    申请号：US18388871

    申请日：2023-11-13

    Applicant: Fenwal, Inc.

    Inventor： Benjamin E. Kusters ,  Richard I. Brown ,  Kyungyoon Min

    IPC: A61M1/36

    CPC classification number: A61M1/3693

    Abstract: A blood processing device includes a pump system, a valve system, a centrifuge, and a controller configured and/or programmed to control the operation of the pump system, the valve system, and the centrifuge to execute a blood separation procedure. The blood separation procedure executed by the controller includes pumping blood into the centrifuge, separating the blood in the centrifuge into red blood cells and plasma, and collecting portions of the separated red blood cells and plasma. Subsequently, a portion of the collected red blood cells is pumped back into the centrifuge to collect an additional amount of the separated plasma. A buffy coat or white blood cell layer may be formed between the separated red blood cells and plasma in the centrifuge. If so, a portion of the collected plasma may be pumped back into the centrifuge to harvest the buffy coat or white blood cell layer.

    Systems And Methods For Setting A Continuous-Flow Centrifuge Rotation Rate
    38.
    发明公开
    Systems And Methods For Setting A Continuous-Flow Centrifuge Rotation Rate 审中-公开

    公开(公告)号：US20230181808A1

    公开(公告)日：2023-06-15

    申请号：US18076504

    申请日：2022-12-07

    Applicant: Fenwal, Inc.

    Inventor： Benjamin E. Kusters ,  Richard I. Brown

    IPC: A61M1/36 ,  B04B13/00

    CPC classification number: A61M1/3696 ,  B04B13/00

    Abstract: A fluid processing device includes a controller, a centrifuge, and a pump system. The controller controls the pump system to convey a fluid into a centrifuge chamber received by the centrifuge at first and second rates, with the controller also controlling the centrifuge to rotate the chamber at a first rotation rate when the fluid is being conveyed into the chamber at the first rate and controlling the centrifuge to rotate the chamber at a second rotation rate when the fluid is being conveyed into the chamber at the second rate. The first and second rotation rates are different, with each being based at least in part on a concentration of a fluid component within the fluid, the rate at which the pump system is conveying the fluid into the centrifuge chamber, and a target concentration of the fluid component in one of the first and second constituents.

    SYSTEMS AND METHODS FOR PROCESSING WHOLE BLOOD INTO RED BLOOD CELL, PLASMA, AND PLATELET PRODUCTS
    39.
    发明申请
    SYSTEMS AND METHODS FOR PROCESSING WHOLE BLOOD INTO RED BLOOD CELL, PLASMA, AND PLATELET PRODUCTS 有权

    公开(公告)号：US20220409799A1

    公开(公告)日：2022-12-29

    申请号：US17848821

    申请日：2022-06-24

    Applicant: Fenwal, Inc.

    Inventor： Benjamin E. Kusters ,  Richard I. Brown ,  Kyungyoon Min

    IPC: A61M1/36 ,  A61M1/38 ,  B04B11/02 ,  B04B5/04 ,  B01D36/04

    Abstract: A processing device includes a pump system, a valve system, a centrifuge, and a controller. A fluid flow circuit is mounted to the device to execute a procedure in which whole blood is processed into a red blood cell product, a plasma product, and a platelet concentrate product. The blood is first separated into red blood cells, buffy coat, and plasma using the centrifuge, with the red blood cells and plasma being removed from the centrifuge, while the buffy coat remains in the centrifuge. The fluid remaining in the centrifuge is circulated through the centrifuge to form a homogenous mixture. Once the mixture is formed, it is separated in the centrifuge into platelet concentrate and red blood cells. A platelet product is then collected by using whole blood or previously collected red blood cells to push the platelet concentrate from the centrifuge to a collection container.

    Systems and methods for harvesting MNCs as part of a plasma collection procedure
    40.
    发明授权
    Systems and methods for harvesting MNCs as part of a plasma collection procedure 有权

    公开(公告)号：US11517919B2

    公开(公告)日：2022-12-06

    申请号：US16880022

    申请日：2020-05-21

    Applicant: Fenwal, Inc.

    Inventor： Benjamin E. Kusters ,  Kyungyoon Min

    IPC: B04B5/04 ,  B01D63/16 ,  B04B13/00

    Abstract: A blood separation system is provided that includes a blood separation device that includes a centrifugal separator and a spinning membrane separator drive unit incorporated into a common case and a fluid flow circuit having both a separation chamber configured to be mounted in the centrifugal separator of the blood separation device and a spinning membrane separator configured to be received in the spinning membrane separator drive unit. In an exemplary procedure, the system is used to collect concentrated platelets and/or concentrated platelets and plasma, and to further permit harvesting of the mononuclear cells from the centrifugal separator at the conclusion of platelet collection, and transfer of the mononuclear cells to the spinning membrane separator.

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