公开(公告)号：US09738813B2

公开(公告)日：2017-08-22

申请号：US15298298

申请日：2016-10-20

Applicant: Novartis AG

Inventor： Yongxing Qiu ,  Newton T. Samuel ,  John Dallas Pruitt ,  Chandana Kolluru ,  Arturo Norberto Medina ,  Lynn Cook Winterton ,  Daqing Wu ,  Xinming Qian ,  Jared Nelson

IPC: G02C7/02 ,  G02C7/04 ,  G02C7/00 ,  C09D177/06 ,  G02B1/04 ,  G02B1/10 ,  G02B1/18 ,  C08J7/04 ,  B29D11/00 ,  C08L83/04 ,  C08G77/388 ,  C08J5/00 ,  C09D5/16 ,  C09D133/02 ,  C09D133/14 ,  C09D133/26 ,  C09D171/02

CPC classification number: C09D177/06 ,  B29D11/00067 ,  C08G77/388 ,  C08J5/00 ,  C08J7/042 ,  C08J2383/04 ,  C08J2383/08 ,  C08J2433/02 ,  C08J2433/26 ,  C08J2487/00 ,  C08L83/04 ,  C09D5/1637 ,  C09D5/1681 ,  C09D133/02 ,  C09D133/14 ,  C09D133/26 ,  C09D171/02 ,  G02B1/043 ,  G02B1/10 ,  G02B1/18 ,  G02C7/049 ,  G02C2202/06 ,  G02C2202/16 ,  C08L101/14

Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.

公开(公告)号：US09239409B2

公开(公告)日：2016-01-19

申请号：US14571350

申请日：2014-12-16

Applicant: Novartis AG

Inventor： Yongxing Qiu ,  Newton T. Samuel ,  John Dallas Pruitt ,  Chandana Kolluru ,  Arturo Norberto Medina ,  Lynn Cook Winterton ,  Daqing Wu ,  Xinming Qian ,  Jared Nelson

IPC: G02C7/00 ,  G02C7/02 ,  G02C7/04 ,  G02B1/10 ,  G02B1/04

CPC classification number: C09D177/06 ,  B29D11/00067 ,  C08G77/388 ,  C08J5/00 ,  C08J7/042 ,  C08J2383/04 ,  C08J2383/08 ,  C08J2433/02 ,  C08J2433/26 ,  C08J2487/00 ,  C08L83/04 ,  C09D5/1637 ,  C09D5/1681 ,  C09D133/02 ,  C09D133/14 ,  C09D133/26 ,  C09D171/02 ,  G02B1/043 ,  G02B1/10 ,  G02B1/18 ,  G02C7/049 ,  G02C2202/06 ,  G02C2202/16 ,  C08L101/14

Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.

公开(公告)号：US20130308093A1

公开(公告)日：2013-11-21

申请号：US13948206

申请日：2013-07-23

Applicant: Novartis AG

Inventor： Yongxing Qiu ,  Newton T. Samuel ,  John Dallas Pruitt ,  Chandana Kolluru ,  Arturo Norberto Medina ,  Lynn Cook Winterton ,  Daqing Wu ,  Xinming Qian ,  Jared Nelson

IPC: G02B1/04

CPC classification number: C09D177/06 ,  B29D11/00067 ,  C08G77/388 ,  C08J5/00 ,  C08J7/042 ,  C08J2383/04 ,  C08J2383/08 ,  C08J2433/02 ,  C08J2433/26 ,  C08J2487/00 ,  C08L83/04 ,  C09D5/1637 ,  C09D5/1681 ,  C09D133/02 ,  C09D133/14 ,  C09D133/26 ,  C09D171/02 ,  G02B1/043 ,  G02B1/10 ,  G02B1/18 ,  G02C7/049 ,  G02C2202/06 ,  G02C2202/16 ,  C08L101/14

Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.