公开(公告)号：US20210322388A1

公开(公告)日：2021-10-21

申请号：US17359314

申请日：2021-06-25

Applicant: Purdue Research Foundation

Inventor： Philip Stewart Low ,  Sumith A. Kularatne

IPC: A61K31/426 ,  C07C323/52 ,  C07D207/416 ,  A61K47/54 ,  A61K49/00 ,  A61K51/04 ,  C07K5/08 ,  A61K31/4745 ,  A61K31/475 ,  A61K51/08 ,  A61K47/64

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

公开(公告)号：US20210275694A1

公开(公告)日：2021-09-09

申请号：US17105308

申请日：2020-11-25

Applicant: Purdue Research Foundation

Inventor： Philip Stewart Low ,  Sumith A. Kularatne ,  Mahalingam M. Sakkarapalayam

IPC: A61K49/00 ,  A61B5/00 ,  G01N33/574 ,  G01N33/58

Abstract: The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds. The disclosure also relates to compositions for incorporating the compounds as used for the targeted imaging of tumors. Conjugation of the amino acid linking groups increase specificity and detection of the compound. Methods and compositions for use thereof in diagnostic imaging are contemplated.

公开(公告)号：US20200155696A1

公开(公告)日：2020-05-21

申请号：US16749827

申请日：2020-01-22

Applicant: Purdue Research Foundation

Inventor： Philip S. Low ,  Sumith A. Kularatne

IPC: A61K47/64 ,  A61K47/54 ,  A61K51/08 ,  A61K49/00 ,  A61K31/475 ,  A61K31/4745 ,  A61K31/426 ,  C07K5/08 ,  A61K51/04 ,  C07D207/416 ,  C07C323/52

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

公开(公告)号：US20180303950A1

公开(公告)日：2018-10-25

申请号：US15997451

申请日：2018-06-04

Applicant: Purdue Research Foundation

Inventor： Philip S. Low ,  Sumith A. Kularatne

IPC: A61K47/64 ,  C07C323/52 ,  A61K51/04 ,  A61K47/54 ,  A61K49/00 ,  A61K31/475 ,  A61K51/08 ,  C07K5/08 ,  A61K31/426 ,  A61K31/4745 ,  C07D207/416

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

公开(公告)号：US10046054B2

公开(公告)日：2018-08-14

申请号：US14794482

申请日：2015-11-23

Applicant: Purdue Research Foundation

Inventor： Philip S. Low ,  Sumith A. Kularatne

IPC: A61K47/54 ,  A61K31/426 ,  C07C323/52 ,  A61K47/48 ,  C07D207/416 ,  A61K49/00 ,  A61K51/04 ,  C07K5/08 ,  A61K31/4745 ,  A61K31/475 ,  A61K51/08

CPC classification number: A61K47/64 ,  A61K31/426 ,  A61K31/4745 ,  A61K31/475 ,  A61K47/54 ,  A61K47/542 ,  A61K47/547 ,  A61K47/548 ,  A61K49/0041 ,  A61K49/0043 ,  A61K49/0052 ,  A61K49/0056 ,  A61K51/04 ,  A61K51/0402 ,  A61K51/0489 ,  A61K51/088 ,  C07C323/52 ,  C07D207/416 ,  C07K5/08

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

公开(公告)号：US09789208B2

公开(公告)日：2017-10-17

申请号：US15259719

申请日：2016-09-08

Applicant: Purdue Research Foundation

Inventor： Sumith A. Kularatne

IPC: A61B5/00 ,  A61B8/00 ,  A61B10/00 ,  A61K49/00

CPC classification number: A61K49/0052 ,  A61K49/001 ,  A61K49/0032 ,  A61K49/0034

Abstract: The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyl ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods and compositions for incorporating the compounds as used for the targeted imaging of tumors. Conjugation of the amino acid linking groups increase specificity and detection of the compound. Methods and compositions for use thereof in diagnostic imaging are contemplated.

公开(公告)号：US20170281800A9

公开(公告)日：2017-10-05

申请号：US14953928

申请日：2015-11-30

Applicant: Purdue Research Foundation

Inventor： Sumith A. Kularatne

IPC: A61K49/00 ,  G01N33/574 ,  G01N21/64 ,  G01N33/58

CPC classification number: A61K49/0052 ,  A61K49/001 ,  A61K49/0021 ,  A61K49/0032 ,  A61K49/0034 ,  C07D475/04 ,  G01N21/6428 ,  G01N33/5091 ,  G01N33/566 ,  G01N33/56966 ,  G01N33/57492 ,  G01N33/582 ,  G01N33/6893 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2201/061 ,  G01N2333/705 ,  G01N2800/24

Abstract: The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyl ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.

公开(公告)号：US20160339122A1

公开(公告)日：2016-11-24

申请号：US14953928

申请日：2015-11-30

Applicant: Purdue Research Foundation

Inventor： Sumith A. Kularatne

IPC: A61K49/00 ,  G01N33/574 ,  G01N21/64 ,  G01N33/58

CPC classification number: A61K49/0052 ,  A61K49/001 ,  A61K49/0021 ,  A61K49/0032 ,  A61K49/0034 ,  C07D475/04 ,  G01N21/6428 ,  G01N33/5091 ,  G01N33/566 ,  G01N33/56966 ,  G01N33/57492 ,  G01N33/582 ,  G01N33/6893 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2201/061 ,  G01N2333/705 ,  G01N2800/24

Abstract: The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyl ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.

公开(公告)号：US09279813B2

公开(公告)日：2016-03-08

申请号：US14187844

申请日：2014-02-24

Applicant: Purdue Research Foundation

Inventor： Philip Stewart Low ,  Wei He ,  Sumith A. Kularatne

IPC: G01N33/574 ,  G01N33/58 ,  G01N33/50 ,  G01N15/14 ,  G01N15/10

CPC classification number: G01N33/582 ,  G01N15/1459 ,  G01N15/1463 ,  G01N33/5091 ,  G01N33/574 ,  G01N33/57434 ,  G01N2015/1006 ,  G01N2015/1438 ,  G01N2015/149 ,  G01N2458/00

Abstract: The invention relates to a method for diagnosing a disease state mediated by pathogenic cells. The method comprises the steps of combining with an ex vivo patient sample a composition comprising a conjugate or complex of the general formula Ab-X wherein the group Ab comprises a ligand that binds to the pathogenic cells and the group X comprises an imaging agent, and detecting the pathogenic cells that express a receptor for the ligand using flow cytometry.

Abstract translation: 本发明涉及诊断由致病细胞介导的疾病状态的方法。 该方法包括以下步骤：将离体患者样品与包含通式Ab-X的缀合物或复合物的组合物组合，其中组Ab包含与致病细胞结合的配体，X组包含成像剂，以及 使用流式细胞术检测表达配体受体的致病细胞。

公开(公告)号：US20140271482A1

公开(公告)日：2014-09-18

申请号：US14010098

申请日：2013-08-26

Applicant: Purdue Research Foundation

Inventor： Philip S. Low ,  Sumith A. Kularatne ,  Sakkarapalayam M. Mahalingam

IPC: A61K49/00 ,  G01N33/50

CPC classification number: A61K49/0052 ,  A61K49/001 ,  A61K49/0021 ,  A61K49/0032 ,  A61K49/0034 ,  C07D475/04 ,  G01N21/6428 ,  G01N33/5091 ,  G01N33/566 ,  G01N33/56966 ,  G01N33/57492 ,  G01N33/582 ,  G01N33/6893 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2201/061 ,  G01N2333/705 ,  G01N2800/24

Abstract: The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyl ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.