公开(公告)号：US09885724B2

公开(公告)日：2018-02-06

申请号：US15457683

申请日：2017-03-13

Applicant: Quest Diagnostics Investments Incorporated

Inventor： Nigel Clarke ,  Zhaohui Chen

IPC: G01N33/68 ,  G01N30/72 ,  H01J49/00 ,  H01J49/16 ,  H01J49/40

CPC classification number: G01N33/6848 ,  G01N30/7266 ,  G01N33/487 ,  G01N33/74 ,  G01N2030/027 ,  G01N2333/62 ,  G01N2560/00 ,  H01J49/005 ,  H01J49/165 ,  H01J49/40

Abstract: Methods are described for measuring the amount of C peptide in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying C peptide in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.

公开(公告)号：US09459267B2

公开(公告)日：2016-10-04

申请号：US14710311

申请日：2015-05-12

Applicant: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED

Inventor： Nigel Clarke

IPC: G01N33/15 ,  G01N33/48 ,  H01J49/00 ,  G01N33/94 ,  G01N30/72

CPC classification number: G01N33/15 ,  G01N30/7233 ,  G01N33/48 ,  G01N33/49 ,  G01N33/94 ,  H01J49/00 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/0045 ,  H01J49/10 ,  Y10T436/17 ,  Y10T436/24 ,  Y10T436/25125 ,  Y10T436/25375

Abstract: Provided are methods for determining the amount of tamoxifen and its metabolites in a sample by mass spectrometry. In some aspects, the methods provided herein determine the amount of norendoxifen. In some aspects, the methods provided herein determine the amount of norendoxifen and tamoxifen. In some aspects, the methods provided herein determine the amount of norendoxifen and other tamoxifen metabolites. In some aspects, the methods provided herein determine the amount of tamoxifen, norendoxifen, and other tamoxifen metabolites.

Abstract translation: 提供了通过质谱法测定样品中他莫昔芬及其代谢物的量的方法。 在一些方面，本文提供的方法确定了内啡肽的量。 在某些方面，本文提供的方法确定了诺替昔芬和他莫昔芬的量。 在一些方面，本文提供的方法确定了奈多芬芬和其他他莫昔芬代谢物的量。 在一些方面，本文提供的方法确定了他莫昔芬，去甲肾上腺素和其他他莫昔芬代谢物的量。

公开(公告)号：US11808773B2

公开(公告)日：2023-11-07

申请号：US17208564

申请日：2021-03-22

Applicant: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED

Inventor： Brett Holmquist ,  Nigel Clarke

IPC: G01N33/82 ,  G01N33/68 ,  H01J49/00

CPC classification number: G01N33/82 ,  G01N33/6848 ,  G01N33/6851 ,  H01J49/0027 ,  G01N2560/00 ,  H01J49/00 ,  Y10T436/212

Abstract: The invention relates to the quantitative measurement of steroidal compounds by mass spectrometry. In a particular aspect, the invention relates to methods for quantitative measurement of steroidal compounds from multiple samples by mass spectrometry.

公开(公告)号：US11099198B2

公开(公告)日：2021-08-24

申请号：US16595035

申请日：2019-10-07

Applicant: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED

Inventor： Zhaohui Chen ,  Nigel Clarke

IPC: G01N33/74 ,  G01N33/66 ,  G01N33/49 ,  G01N33/68 ,  H01J49/00

Abstract: Methods are described for determining the amount of insulin in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying insulin in a biological sample utilizing purification methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.

公开(公告)号：US10955424B2

公开(公告)日：2021-03-23

申请号：US15362210

申请日：2016-11-28

Applicant: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED

Inventor： Brett Holmquist ,  Nigel Clarke

IPC: G01N33/82 ,  G01N33/68 ,  H01J49/00

Abstract: The invention relates to the quantitative measurement of steroidal compounds by mass spectrometry. In a particular aspect, the invention relates to methods for quantitative measurement of steroidal compounds from multiple samples by mass spectrometry.

公开(公告)号：US10782305B2

公开(公告)日：2020-09-22

申请号：US16430030

申请日：2019-06-03

Applicant: Quest Diagnostics Investments Incorporated

Inventor： Nigel Clarke ,  Zhaohui Chen

IPC: G01N33/68 ,  G01N33/487 ,  G01N30/72 ,  G01N33/74 ,  G01N30/02 ,  H01J49/00 ,  H01J49/16 ,  H01J49/40

Abstract: Methods are described for measuring the amount of C peptide in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying C peptide in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.

公开(公告)号：US10753950B2

公开(公告)日：2020-08-25

申请号：US16051849

申请日：2018-08-01

Applicant: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED

Inventor： Brett Holmquist ,  Nigel Clarke

IPC: G01N33/82 ,  G01N30/72 ,  H01J49/00 ,  H01J49/14 ,  G01N30/00 ,  G01N30/88 ,  G01N30/02

Abstract: The invention relates to the detection of non-metabolized vitamin D. In a particular aspect, the invention relates to methods for detecting underivatized non-metabolized vitamin D by mass spectrometry.

公开(公告)号：US09594074B2

公开(公告)日：2017-03-14

申请号：US14654964

申请日：2013-12-23

Applicant: Quest Diagnostics Investments Incorporated

Inventor： Nigel Clarke ,  Zhaohui Chen

IPC: G01N33/487 ,  G01N30/72 ,  G01N33/68 ,  G01N33/74 ,  G01N30/02

CPC classification number: G01N33/6848 ,  G01N30/7266 ,  G01N33/487 ,  G01N33/74 ,  G01N2030/027 ,  G01N2333/62 ,  G01N2560/00 ,  H01J49/005 ,  H01J49/165 ,  H01J49/40

Abstract: Methods are described for measuring the amount of C peptide in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying C peptide in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques. The present invention provides methods for detecting the presence or amount of C peptide in a sample by mass spectrometry.

Abstract translation: 描述了用于测量样品中C肽量的方法。 更具体地，描述了通过使用串联质谱法或高分辨率/高精度质谱技术联用的在线提取方法来检测和定量样品中C肽的质谱方法。 本发明提供了通过质谱法检测样品中C肽的存在或量的方法。