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公开(公告)号：US20240242950A1
公开(公告)日：2024-07-18
申请号：US18285988
申请日：2022-04-06
Applicant: VANDERBILT UNIVERSITY , THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY, WASHINGTON, DC , TRIAD NATIONAL SECURITY, LLC
Inventor： Trevor C. Glaros , Phillip Mach , Richard Caprioli , Jeremy Norris
CPC classification number: H01J49/005 , G01N30/72 , G01N30/86 , G01N30/88 , G01N33/6851 , G01N2030/8813
Abstract: Systems and devices are disclosed to generate a multidimensional mass fingerprint that allows for identification on a low-resolution mass spectrometer equipped with post-ionization fragmentation. For this approach, rather than interrogating a sample that is processed into peptides using a single high resolution MS scan as in traditional fingerprinting, a raw unprocessed sample (containing all biochemical species: lipids, proteins, peptides, and metabolites) is analyzed by combining Matrix-Assisted Laser Dissociation/Ionization (MALDI) ionization with low resolution tandem mass spectrometry. The proposed system combines improvements in MS hardware and software with state-of-the-art machine learning (ML) approaches to usher in rapid biological detection. This technique does not require any prior separation (liquid or gas chromatography) and is therefore rapid (e.g. less than 5 sec) and amenable to high throughput (e.g. greater than 384 samples/hr).
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公开(公告)号：US20240128069A1
公开(公告)日：2024-04-18
申请号：US18276609
申请日：2022-02-08
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Mircea GUNA , Andrei SONOC
CPC classification number: H01J49/005 , H01J49/0031 , H01J49/062
Abstract: In one aspect, a method of performing mass spectrometry is disclosed, which comprises introducing a plurality of ions into a mass spectrometer, selecting a portion of the precursor ions having m/z ratios within a first desired range to provide a plurality of precursor ions, causing fragmentation of at least a portion of the precursor ions to generate a plurality of product ions, selecting a portion of the product ions having m/z ratios within a second desired range, and performing mass analysis of the selected productions.
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公开(公告)号：US20240038516A1
公开(公告)日：2024-02-01
申请号：US18275557
申请日：2021-12-08
Applicant: NANJING QLIFE MEDICAL TECHNOLOGY CO., LTD.
Inventor： Xiaoliang CHENG , Kejia ZHENG
CPC classification number: H01J49/005 , H01J49/4225 , H05H15/00
Abstract: A collision reaction pool ion acceleration apparatus which has extremely low crosstalk. The apparatus comprises an apparatus body, a vacuum chamber, a first tube bundle channel and a second tube bundle channel. The vacuum chamber is fixedly connected to the interior of the apparatus body; the other end of the interior of the apparatus body is fixedly connected to a first insulation seat. A collision chamber is embeddedly connected to the inside the first insulation seat, and a high-frequency electrode quadrupole lens is fixedly connected to two sides of the collision chamber. When charged ions enter the collision chamber, the high-frequency electrode quadrupole lens focuses on the charged ions, so that the incoming charged ions form a new motion trajectory in the collision chamber, and the charged ions are easily separated from the collision chamber, thereby increasing the working efficiency.
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公开(公告)号：US11881387B2
公开(公告)日：2024-01-23
申请号：US17056965
申请日：2019-05-23
Applicant: Micromass UK Limited
Inventor： Anatoly Verenchikov
CPC classification number: H01J49/406 , H01J49/005 , H01J49/0036 , H01J49/025 , H01J49/061 , H01J49/401
Abstract: Apparatus and method are proposed for the strong improvement of dynamic range (DR) of detectors and of data systems for time-of-flight mass spectrometers (TOF MS) with periodically repetitive signals. TOF separated ions are converted into secondary particles, primarily electrons, and the flow of secondary particles is controllably attenuated to sustain the data acquisition system in a counting mode above the electronic noise threshold. The acquisition time is split between at least two time segments, characterized by alternated transmission efficiency SE of secondary particles. Using strong electron suppression (SE«1) is employed for recording intense ion peak, while counting ions with either ADC, or TDC, or ADC with extracting peak centroids. A longer time segment employs an efficient electron transfer (SE=1) for detecting weak ion species. In another independent aspect, an ion-optical element is provided upstream of the ion detector and is configured to deflect, reflect or retard ions such that ions that have been scattered or fragmented in the time of flight region do not impact on the ion detector.
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公开(公告)号：US11769654B2
公开(公告)日：2023-09-26
申请号：US17356793
申请日：2021-06-24
Applicant: Micromass UK Limited
Inventor： Keith Richardson , Jason Lee Wildgoose
CPC classification number: H01J49/0031 , H01J49/004 , H01J49/005 , H01J49/0009 , H01J49/0072 , H01J49/025
Abstract: A method of mass spectrometry is disclosed comprising: performing a plurality of cycles of operation during a single experimental run, wherein each cycle comprises: mass selectively transmitting precursor ions of a single mass, or range of masses, through or out of a mass separator or mass filter at any given time, wherein the mass separator or mass filter is operated such that the single mass or range of masses transmitted therefrom is varied with time; and mass analysing ions.
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Patent Agency Ranking
公开(公告)号：US11756775B2
公开(公告)日：2023-09-12
申请号：US17298159
申请日：2019-11-29
Applicant: Micromass UK Limited
Inventor： Jakub Ujma , Kevin Giles , Nick Tomczyk
IPC: H01J49/00 , G01N27/624 , H01J49/40 , H01J49/42
CPC classification number: H01J49/0045 , G01N27/624 , H01J49/005 , H01J49/0036 , H01J49/40 , H01J49/4225
Abstract: A method of identifying and/or characterising ions comprises separating analyte ions according to a first physico-chemical property (ion-mobility), selecting first ions of the analyte ions, and activating, fragmenting or reacting the first ions to produce first product ions, separating the first product ions according to the first physico-chemical property, and determining a pattern of the first product ions. The first ions are identified and/or characterised using the pattern of the first product ions.
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公开(公告)号：US11728155B2
公开(公告)日：2023-08-15
申请号：US17612502
申请日：2020-05-19
Applicant: Thermo Fisher Scientific (Bremen) GmbH
Inventor： Henning Wehrs , Johannes Schwieters , Gerhard Jung
CPC classification number: H01J49/063 , F16K1/2007 , H01J49/005 , H01J49/0077 , H01J49/022 , H01J49/065 , H01J49/067 , H01J49/068 , H01J49/105 , H01J49/421 , H01J49/4215
Abstract: An ion optical arrangement (1) for use in a mass spectrometer comprises electrodes (11, 12, 14) comprising a multipole arrangement defining an ion optical axis, and a voltage source for providing voltages to the electrodes to produce electric fields. The ion optical arrangement is configured for producing a radio frequency electric focusing field for focusing ions on the ion optical axis. The radio frequency electric focusing field has a varying frequency so as to reduce any mass dependence of ion trajectories through the ion optical arrangement. The ion optical arrangement may further be configured for producing a static electric field in response to a DC bias voltage applied to the multipole arrangement. A superimposed varying electric field may be produced by superimposing an AC voltage upon the DC bias voltage.
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公开(公告)号：US20190189411A1
公开(公告)日：2019-06-20
申请号：US16146737
申请日：2018-09-28
Applicant: PERKINELMER HEALTH SCIENCES, INC.
Inventor： Urs Steiner
CPC classification number: H01J49/005 , H01J49/063 , H01J49/067 , H01J49/068
Abstract: Certain embodiments described herein are directed to collision cells that comprise one or more integrated lenses. In some examples, a lens is coupled to two sections of a sectioned quadrature rod assembly, the lens comprising an aperture and a plurality of separate conductive elements disposed each one side of the lens, in which a respective disposed conductive element on one side of the lens is configured to electrically couple to a first, second, third, and fourth pole segments of the sectioned quadrature rod assembly.
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公开(公告)号：US20180218893A1
公开(公告)日：2018-08-02
申请号：US15747465
申请日：2015-07-28
Applicant: SHIMADZU CORPORATION
Inventor： Tohru SHIOHAMA
CPC classification number: H01J49/0072 , G01N27/62 , H01J49/0027 , H01J49/005 , H01J49/063 , H01J49/4215 , H01J49/4225
Abstract: A precursor ion selected by a quadrupole mass filter is fragmented by imparting a predetermined amount of collision energy (CE) to the ion. Among the thereby generated product ions, only the ions included within a predetermined m/z range are stored in an ion trap. The ions are subsequently separated and detected by a TOF. For one precursor ion originating from a target compound, a mass spectrometric analysis is performed for each combination of a plurality of the set CE values and subdivided m/z ranges to obtain spectrum data. A spectrum data accumulator accumulates the spectrum data obtained by the mass spectrometric analysis under different combinations of (CE value, m/z range). Based on the accumulated spectrum data, a mass spectrum creator creates a single product-ion spectrum corresponding to the target compound.
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公开(公告)号：US09978578B2
公开(公告)日：2018-05-22
申请号：US15015101
申请日：2016-02-03
Applicant: FASMATECH SCIENCE & TECHNOLOGY LTD.
Inventor： Dimitris Papanastasiou , Emmanuel Raptakis
CPC classification number: H01J49/4225 , H01J49/005 , H01J49/0054 , H01J49/062 , H01J49/426 , H01J49/4265
Abstract: A linear ion trap includes at least two discrete trapping regions for processing ions, a RF electrical potential generator, a multi-output DC electrical potential generator, and a control unit. The RF electrical potential generator produces two RF waveforms each applied to a pair of pole electrodes of the linear ion trap forming a RF trapping field component to trap ions radially. The multi-output DC electrical potential generator produces multiple DC field components superimposed to the RF field component and distributed across the length of the linear ion trap to control ions axially. The control unit switches the DC electrical potentials and corresponding DC field components collectively forming a first trapping region populated with ions to alter ion potential energy from a first level to a second level, and enables a first ion processing step in at least one of the first and second levels.
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