公开(公告)号：US09116124B2

公开(公告)日：2015-08-25

申请号：US14044247

申请日：2013-10-02

Applicant: OPKO Diagnostics, LLC

Inventor： Vincent Linder ,  David Steinmiller

IPC: G01N21/00 ,  G01N21/59 ,  B01L3/00 ,  G01N33/543 ,  G01N33/574 ,  B01L7/00

CPC classification number: B01L3/502746 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L7/52 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/0673 ,  B01L2200/0684 ,  B01L2200/143 ,  B01L2200/146 ,  B01L2200/147 ,  B01L2300/021 ,  B01L2300/023 ,  B01L2300/027 ,  B01L2300/04 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/12 ,  B01L2300/14 ,  B01L2300/16 ,  B01L2300/168 ,  B01L2300/1827 ,  B01L2300/1894 ,  B01L2400/0475 ,  B01L2400/049 ,  B01L2400/0666 ,  B01L2400/082 ,  G01N21/05 ,  G01N21/59 ,  G01N21/64 ,  G01N21/76 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/57434 ,  G01N2201/02 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/0621 ,  G01N2201/0697 ,  G01N2333/96433 ,  Y10T137/0324 ,  Y10T436/12

Abstract: Systems and methods for controlling fluids in microfluidic systems are generally described. In some embodiments, control of fluids involves the use of feedback from one or more processes or events taking place in the microfluidic system. For instance, a detector may detect one or more fluids at a measurement zone of a microfluidic system and one or more signals, or a pattern of signals, may be generated corresponding to the fluid(s). In some cases, the signal or pattern of signals may correspond to an intensity, a duration, a position in time relative to a second position in time or relative to another process, and/or an average time period between events. Using this data, a control system may determine whether to modulate subsequent fluid flow in the microfluidic system. In some embodiments, these and other methods can be used to conduct quality control to determine abnormalities in operation of the microfluidic system.

Abstract translation: 通常描述用于控制微流体系统中的流体的系统和方法。 在一些实施例中，流体的控制涉及使用来自在微流体系统中发生的一个或多个过程或事件的反馈。 例如，检测器可以在微流体系统的测量区域处检测一种或多种流体，并且可以对应于流体产生一个或多个信号或信号模式。 在某些情况下，信号的信号或图案可以对应于强度，持续时间，在时间上或相对于另一进程相对于第二位置的时间位置和/或事件之间的平均时间段。 使用该数据，控制系统可以确定是否调制微流体系统中随后的流体流动。 在一些实施方案中，这些和其它方法可用于进行质量控制以确定微流体系统的操作异常。

公开(公告)号：US20150226719A1

公开(公告)日：2015-08-13

申请号：US14614710

申请日：2015-02-05

Applicant: Dräger Safety AG & Co. KGaA

Inventor： Wilfried DIEKMANN

IPC: G01N33/00 ,  G01N21/55

CPC classification number: G01N33/0073 ,  G01N21/01 ,  G01N21/3504 ,  G01N21/55 ,  G01N33/0027 ,  G01N2021/3513 ,  G01N2201/02 ,  G01N2201/021 ,  G01N2201/061

Abstract: A gas detection device with at least one functional device (1), which is fixed to a platform, is pivotable about at least two pivot axes (2, 3) relative to the platform. The functional device (1) is designed to emit and/or receive or reflect radiation that is analyzably variable due to the presence of a gas to be detected. The gas detection device has an adjusting device (9), which has a fixing device for temporary fixation to the platform and an application device for the defined application on the functional device (1) of forces that lead to a pivoting about the pivot axes (2, 3). The application device acts detachably on the functional device (1).

Abstract translation: 具有固定到平台的至少一个功能装置（1）的气体检测装置可相对于平台围绕至少两个枢转轴线（2,3）枢转。 功能装置（1）被设计为发射和/或接收或反射由于要检测的气体的存在而可分析地变化的辐射。 气体检测装置具有调节装置（9），其具有用于临时固定到平台的固定装置和用于在功能装置（1）上限定应用的施加装置（1），其导致围绕枢转轴线的枢转 2，3）。 所述应用装置可移动地作用于所述功能装置（1）。

公开(公告)号：US20150226672A1

公开(公告)日：2015-08-13

申请号：US14620998

申请日：2015-02-12

Applicant: Adrian Fawcett ,  David Tracy ,  Kevin Daley Simmons

Inventor： Adrian Fawcett ,  David Tracy ,  Kevin Daley Simmons

IPC: G01N21/64 ,  B01L7/00 ,  G01N21/03

CPC classification number: G01N21/6486 ,  B01L7/52 ,  B01L2300/046 ,  B01L2300/0829 ,  B01L2300/1805 ,  G01N21/0332 ,  G01N21/6452 ,  G01N2021/0367 ,  G01N2021/6421 ,  G01N2021/6471 ,  G01N2021/6478 ,  G01N2201/02 ,  G01N2201/062 ,  G01N2201/0626 ,  G01N2201/0627 ,  G01N2201/0636

Abstract: Optical systems, and corresponding methods, for multiple reactions are provided. The optical systems are in a fixed position relative to a thermal assembly and include at least one array of excitation sources (e.g., light emitting diodes (LEDs)) configured to output excitation energy along an excitation optical path. In addition, a detector configured to receive emission energy along a detection optical path in the same plane as the excitation optical path is also provided.

Abstract translation: 提供了多种反应的光学系统和相应的方法。 光学系统相对于热组件处于固定位置，并且包括被配置为沿着激发光路输出激发能量的至少一组激励源（例如，发光二极管（LED））。 此外，还提供了被配置为沿着与激励光路相同的平面中的检测光路接收发射能量的检测器。

公开(公告)号：US20150198536A1

公开(公告)日：2015-07-16

申请号：US14668584

申请日：2015-03-25

Applicant: FUJIFILM Corporation

Inventor： Masayuki NAYA ,  Shogo YAMAZOE

IPC: G01N21/65 ,  G01N21/01 ,  G01N21/64

CPC classification number: G01N21/658 ,  G01N21/01 ,  G01N21/6402 ,  G01N2201/02 ,  G01N2201/06113

Abstract: An optical electric field enhancing device is used with a measuring method which includes two-dimensionally scanning a surface in in-plane direction of the surface to detect, from the rear surface side of the device, signal light emitted from each scanning point when excitation light is applied, and obtaining a two-dimensional signal image on the surface based on the detected signal light. The device includes a transparent substrate, a marker pattern directly formed on the transparent substrate and extending in a direction non-parallel to the main scanning direction of the two-dimensional scanning, and fine uneven structures formed on the marker pattern and the transparent substrate where at least the surface is made of a metal film.

Abstract translation: 使用光电场增强装置，该测量方法包括二维地扫描表面的面内方向的表面，从装置的背面检测从激发光的每个扫描点发出的信号光 并且基于检测到的信号光在表面上获得二维信号图像。 该装置包括透明基板，直接形成在透明基板上并且在与二维扫描的主扫描方向不平行的方向上延伸的标记图案，以及形成在标记图案和透明基板上的微细凹凸结构， 至少表面由金属膜制成。

公开(公告)号：US20150185370A1

公开(公告)日：2015-07-02

申请号：US14657279

申请日：2015-03-13

Applicant: Trustees of Boston University

Inventor： Bjoern Markus Reinhard ,  Luca Dal Negro

IPC: G02B5/00 ,  G01N21/65 ,  G01N21/01

CPC classification number: G02B5/008 ,  B82Y30/00 ,  C03C17/40 ,  C03C2217/255 ,  C03C2217/425 ,  G01N21/01 ,  G01N21/658 ,  G01N2201/02 ,  Y10T428/12104 ,  Y10T428/24909

Abstract: Defined nanoparticle cluster arrays (NCAs) with dimensions up to 25.4 μm square are fabricated on a 10 nm gold film using template guided self-assembly. Structural parameters are precisely controlled, allowing systematic variation of the number of nanoparticles in the clusters (n) and edge to edge separation (Λ) between 1

Abstract translation: 使用模板引导的自组装在10nm金膜上制造尺寸高达25.4μm正方形的定义的纳米颗粒簇阵列（NCAs）。 结构参数被精确控制，允许分别在1

公开(公告)号：US20150185075A1

公开(公告)日：2015-07-02

申请号：US14637425

申请日：2015-03-04

Applicant: Bruker Optik GmbH

Inventor： Sven Krause ,  Yifei Wang ,  Lars Schomann ,  Gerhard Matz ,  Roland Harig ,  Jens Eichmann

IPC: G01J3/02 ,  G01N21/11

CPC classification number: G01J3/0267 ,  G01J3/021 ,  G01N21/031 ,  G01N21/11 ,  G01N2201/02

Abstract: A measuring cell for a gas analysis spectrometer has an inner chamber (23) for a sample gas to be analyzed and an inlet (21) and an outlet (22) which are connected thereto. A traversing optical path for a measuring beam (14) is formed in the inner chamber (23). The measuring cell is tubular, the inlet (21) and the outlet (22) are arranged at opposite ends, and the inner chamber (23) of the measuring cell has a cross-sectional shape that is monotonic over the length of the tube and which has an oval-shape at the start, which disappears toward the end. That special shape results in fast gas exchange and thus high dynamics, even with larger measuring cells, which have high sensitivity due to the long optical paths thereof. Two characteristics which until now appeared to be conflicting are thereby combined.

Abstract translation: 用于气体分析光谱仪的测量池具有用于待分析样品气体的内室（23）和与其连接的入口（21）和出口（22）。 用于测量光束（14）的横穿光路形成在内腔（23）中。 测量单元是管状的，入口（21）和出口（22）布置在相对端，并且测量单元的内室（23）具有在管的长度上单调的横截面形状， 它在开始时具有椭圆形，最终消失。 这种特殊形状导致快速的气体交换，从而导致高动力学，即使是由于其长的光程而具有高灵敏度的更大的测量单元。 因此，到目前为止，两个特征似乎是相互矛盾的。

公开(公告)号：US20150160123A1

公开(公告)日：2015-06-11

申请号：US14412832

申请日：2013-05-15

Applicant: AXALTA COATING SYSTEMS IP CO., LLC

Inventor： Anthony Moy ,  Ayumu Yokoyama ,  Allan Blase Joseph Rodrigues ,  Ken Stephen Schermacher ,  Jeff B. Alspach

IPC: G01N21/25 ,  G01N1/28 ,  G01N33/32

CPC classification number: G01N21/251 ,  G01N1/2813 ,  G01N21/8422 ,  G01N33/32 ,  G01N2201/02

Abstract: A liquid measuring system for producing one or more property values of a liquid. The system can include: a thin film device and one or more measuring devices for measuring said one or more property values. The system includes a thin film device for producing a thin film of the liquid on a spinning disk. The system is particularly useful for measuring color and appearance properties of the liquid. The system can be useful for producing coating compositions.

Abstract translation: 一种液体测量系统，用于产生液体的一个或多个特性值。 该系统可以包括：薄膜装置和用于测量所述一个或多个属性值的一个或多个测量装置。 该系统包括用于在旋转盘上产生液体的薄膜的薄膜装置。 该系统对于测量液体的颜色和外观特性特别有用。 该系统可用于生产涂料组合物。

公开(公告)号：US20150157261A1

公开(公告)日：2015-06-11

申请号：US14411825

申请日：2013-06-03

Applicant: Seiko Epson Corporation

Inventor： Yusuke Sakagami

IPC: A61B5/00 ,  G01N21/65

CPC classification number: A61B5/4866 ,  A61B5/0075 ,  A61B5/0833 ,  A61B5/4872 ,  A61B5/681 ,  A61B5/6831 ,  A61B5/742 ,  A61B5/743 ,  G01N21/65 ,  G01N21/658 ,  G01N2201/02 ,  G01N2201/06113

Abstract: A substance detection device capable of detecting a specific component in a biological gas collected from the skin is realized.A substance detection device includes: a detection sample collection section which collects a biological gas released from the human skin, allows only this biological gas to pass through a permeable membrane, and stores the gas in a sensor chamber; a light source which excites a Raman scattered light from acetone in the collected biological gas; a sensor section which enhances the Raman scattered light by localized surface plasmon resonance; a spectrometer which disperses the enhanced Raman scattered light; a light receiving element; a signal processing and control circuit section which compares the acquired spectrum with the fingerprint spectrum of acetone which has been stored in advance and thereby identifies acetone, which is the collected substance to be detected, and calculates the amount of fat burning having a correlation with the concentration of acetone; and a display section.

Abstract translation: 实现能够检测从皮肤收集的生物气体中的特定成分的物质检测装置。 物质检测装置包括：检测样本收集部，其收集从人体皮肤释放的生物体气体，仅允许该生物气体通过可渗透膜，并将气体存储在传感器室中; 在收集的生物气体中激发来自丙酮的拉曼散射光的光源; 通过局部表面等离子体共振增强拉曼散射光的传感器部分; 分散增强拉曼散射光的光谱仪; 光接收元件; 信号处理和控制电路部分，将获取的光谱与预先存储的丙酮的指纹光谱进行比较，从而识别作为被检测物质的丙酮，并计算与所检测的物质相关的脂肪燃烧量 丙酮浓度; 和显示部。

公开(公告)号：US09007574B2

公开(公告)日：2015-04-14

申请号：US14026358

申请日：2013-09-13

Applicant: Beckman Coulter, Inc.

Inventor： Robert Retter ,  Yagang Liu ,  Patty Pang ,  Brian Peterson

IPC: G01N21/01 ,  G01N35/00 ,  G01N35/04 ,  G01N35/10

CPC classification number: G01N21/03 ,  G01N21/01 ,  G01N21/59 ,  G01N35/0099 ,  G01N35/04 ,  G01N35/10 ,  G01N2021/0346 ,  G01N2035/0465 ,  G01N2035/1039 ,  G01N2035/1062 ,  G01N2201/02 ,  G01N2201/062

Abstract: An analytical system is disclosed. The analytical system includes a storage container configured to store a plurality of capillaries. It also includes a gripper configured to receive at least one of the plurality of capillaries, and move the at least one capillary so that an end of the capillary contacts a sample in a sample container and draws the sample in the capillary. The system also includes a reader configured to detect a signal from the sample in the capillary.

Abstract translation: 公开了一种分析系统。 分析系统包括被配置为存储多个毛细管的存储容器。 它还包括构造成容纳多个毛细管中的至少一个毛细管并且移动至少一个毛细管的夹持器，使得毛细管的一端与样品容器中的样品接触并将样品抽吸在毛细管中。 该系统还包括被配置为检测来自毛细管中的样品的信号的读取器。

公开(公告)号：US20150099321A1

公开(公告)日：2015-04-09

申请号：US14244460

申请日：2014-04-03

Applicant: Cheng-Sheng Tsung

Inventor： Cheng-Sheng Tsung ,  Shih-Hao Chuang

IPC: H01L33/60

CPC classification number: H01L33/44 ,  B81C1/00031 ,  B81C2201/0149 ,  G01N21/01 ,  G01N2201/02 ,  G02B5/008 ,  H01L33/60 ,  H01L2933/0058

Abstract: A method for fabricating a microstructure to generate surface plasmon waves comprises steps of: preparing a substrate, and using a carrier material to carry a plurality of metallic nanoparticles and letting the metallic nanoparticles undertake self-assembly to form a microstructure on the substrate, wherein the metallic nanoparticles are separated from each other or partially agglomerated to allow the microstructure to be formed with a discontinuous surface. The present invention fabricates the microstructure having the discontinuous surface by a self-assembly method to generate the surface plasmon waves, thus exempts from using the expensive chemical vapor deposition (CVD) technology and is able to reduce the time and cost of fabrication. The present invention also breaks the structural limitation on generation of surface plasmon waves to enhance the effect of generating the surface plasmon waves.

Abstract translation: 用于制造微结构以产生表面等离子体激元波的方法包括以下步骤：制备基底，并使用载体材料携带多个金属纳米颗粒并使金属纳米粒子进行自组装以在基底上形成微结构，其中 金属纳米颗粒彼此分离或部分团聚以允许微结构形成不连续表面。 本发明通过自组装方法制造具有不连续表面的微结构以产生表面等离子体波，从而免除使用昂贵的化学气相沉积（CVD）技术，并且能够减少制造的时间和成本。 本发明还破坏了表面等离子体激元波的产生的结构限制，以增强产生表面等离子体波的效果。