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    Dual fiber optic spectrophotometer
    31.
    发明授权
    Dual fiber optic spectrophotometer 失效
    双光纤光谱仪

    公开(公告)号：US5184193A

    公开(公告)日：1993-02-02

    申请号：US293218

    申请日：1989-01-04

    Applicant: David A. LeFebre

    Inventor： David A. LeFebre

    IPC: G01J1/18 ,  G01J3/06 ,  G01J3/08 ,  G01J3/42

    CPC classification number: G01J3/08 ,  G01J2001/182 ,  G01J2003/068 ,  G01J3/42 ,  G01N2201/04 ,  G01N2201/0833

    Abstract: Spectrophotometric apparatus and methodology suitable for continuous and long-term use. The apparatus includes a monochromator providing pre-dispersed monochromatic light to the optical inputs of a pair of fiber optic cables and a translator for alternatively positioning the fiber optic cables at the same location with respect to the monochromator output. One of the cables conducts light to a sample under study while the other cable provides a reference for light intensity measurements. The methodology includes the steps of performing two scans through the monochromator output for each measurement on the sample. The fiber optic cables are moved between scans so that the cable employed in the latter scan occupies the former position of the cable employed in prior scan.

    Abstract translation: 分光光度仪和方法适用于连续和长期使用。 该装置包括单色仪，其将预分散的单色光提供给一对光纤电缆的光输入端，以及用于相对于单色仪输出将光纤缆线替代地定位在相同位置处的转换器。 其中一根电缆对正在研究的样品进行光照，而另一根电缆为光强测量提供参考。 该方法包括通过单色仪输出进行两次扫描以对样本进行每次测量的步骤。 光纤电缆在扫描之间移动，使得在后一扫描中使用的电缆占据先前扫描中使用的电缆的前一位置。

    Detector assembly for analyzer instrument
    32.
    发明授权
    Detector assembly for analyzer instrument 失效
    用于分析仪器的检测器组件

    公开(公告)号：US4826660A

    公开(公告)日：1989-05-02

    申请号：US046953

    申请日：1987-05-07

    Applicant: Roger E. Smith ,  Randall W. Smith

    Inventor： Roger E. Smith ,  Randall W. Smith

    IPC: G01N21/64 ,  G01N21/25 ,  G01N21/27 ,  G01N35/02

    CPC classification number: G01N21/255 ,  G01N2201/04

    Abstract: A detector assembly for use with an analyzer instrument comprises a light source for providing a light beam for analyzing one or more substances in a sample. A detector is included for detecting light associated with the sample under analysis. An analysis station permits the light beam to enter the sample and shields the sample from extraneous light. The analysis station further permits light to pass from the sample to the light detector. A plurality of filters is selectively positionable in the light beam between the light source and the sample. These filters permit different wavelengths of light to pass therethrough so that selective light analysis of the sample may be performed.

    Process and device for the detection and quantification of agglutinates
    34.
    发明授权
    Process and device for the detection and quantification of agglutinates 失效
    用于检测和定量凝集物的方法和装置

    公开(公告)号：US4575492A

    公开(公告)日：1986-03-11

    申请号：US602509

    申请日：1984-04-20

    Applicant: Pierre David ,  Jean A. Jarricot

    Inventor： Pierre David ,  Jean A. Jarricot

    IPC: G01N21/17 ,  G01N21/59 ,  G01N21/82 ,  G01N33/49 ,  G01N33/80 ,  G01N33/86 ,  G01N33/53

    CPC classification number: G01N21/82 ,  G01N2021/5934 ,  G01N2201/04 ,  Y10S436/805

    Abstract: The present invention relates to a process and device for the detection and quantification of agglutinates, in recipients of which at least the bottom are transparent. According to the invention, it is decided that there is agglutination when, at the same time, the calculated mean value of the bottom of the reaction studied is higher than that of a reference sample and when there exist points of measurement whose transmission is less than said threshold, and, on the other hand, that there is no agglutination when, at the same time, this calculated mean value is not greater than that of said reference sample and when there exist no points of measurement whose transmission is less than said threshold. The invention is more particularly applicable to immunohaematology.

    Abstract translation: 本发明涉及用于检测和定量凝集物的方法和装置，其中至少底部是透明的受体。 根据本发明，当所研究的反应的底部的计算平均值高于参考样品的平均值时，当存在透射小于测量点的测量点时，确定存在凝集 所述阈值，另一方面，当同时计算的平均值不大于所述参考样本的平均值时，不存在凝集，并且当不存在透射小于所述阈值的测量点时 。 本发明更特别适用于免疫血液学。

    Fluorometer having an improved optical system
    35.
    发明授权
    Fluorometer having an improved optical system 失效
    荧光计具有改进的光学系统

    公开(公告)号：US4536655A

    公开(公告)日：1985-08-20

    申请号：US527366

    申请日：1983-08-29

    Applicant: Clarence W. Barnes

    Inventor： Clarence W. Barnes

    IPC: G01N21/64 ,  G01L1/20

    CPC classification number: G01N21/6452 ,  G01N2201/04

    Abstract: A fluorometer system is disclosed in which a carousel-like system is rotated by a stepper motor to provide a sequence of sample wells to a single optical exciting path. An ultraviolet tube positioned adjacent that path provides an excitation beam which is reflected into common optical path which coincides with the position of the well along the common path is deflected by a beam splitter or the like through an appropriate filtering device to a photomultiplier tube which is located adjacent the common light path on the same side of the path as the ultraviolet tube. The photomultiplier tube is located below the ultraviolet tube to provide a proper direction of convection current.Further, a solid state photosensor sensitive in red spectrum such as a phototransistor or photodiode is provided adjacent the ultraviolet tube, with a ruby positioned between the ultraviolet tube and the photosensor the take advantage of the fact that solid-state photosensors are especially responsive to light in the red range. The output of the photosensor is fed back to the A to D converter and microprocessor software to take account for the fact that with tube aging or fluctuation in the line current, the output of the ultraviolet tube may vary.

    Abstract translation: 公开了一种荧光计系统，其中转盘式系统由步进电机旋转以向单个光学激发路径提供一系列样品阱。 位于该路径附近的紫外线管提供激发光束，其被反射到共同的光路中，这与沿着公共路径的井的位置重合，由分束器等通过适当的过滤装置偏转到光电倍增管，光电倍增管是 位于与紫外线管相同的一侧的公共光路附近。 光电倍增管位于紫外线管下方，以提供适当的对流方向。 此外，在红外光谱下敏感的固体光敏传感器如光电晶体管或光电二极管被设置在紫外线管附近，红宝石位于紫外线管和光电传感器之间，利用固态光电传感器特别适用于光 在红色范围内。 将光电传感器的输出反馈到A到D转换器和微处理器软件，以考虑到管线老化或线路电流波动的事实，紫外线管的输出可能变化。

    Methods and systems for pure dye instrument normalization
    37.
    发明授权
    Methods and systems for pure dye instrument normalization 有权

    公开(公告)号：US09809849B2

    公开(公告)日：2017-11-07

    申请号：US15016713

    申请日：2016-02-05

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Jeffrey Marks

    IPC: G01N21/64 ,  C12Q1/68 ,  G01N21/27

    CPC classification number: C12Q1/686 ,  G01N21/274 ,  G01N21/6428 ,  G01N21/6452 ,  G01N2021/6421 ,  G01N2201/04 ,  G01N2201/068 ,  G01N2201/12746

    Abstract: The present teachings relate to a method and system for normalizing spectra across multiple instruments. In an embodiment of the present invention, the method comprises at least one reference instrument and a test instrument. Each instrument comprises at least one excitation filter and at least one emission filter arranged in pairs. Each instrument further comprises a pure dye plate comprising a plurality of wells. Each well contains a plurality of dyes where each dye comprises a fluorescent component. Fluorescent spectra are obtained from each instrument for each dye across multiple filter combinations to contribute to a pure dye matrix Mref for the reference instrument and pure dye matrix M for the test instrument. The pure dye spectra can then be multiplied by correction factors for each filter pair to result in corrected pure dye spectra, then normalized and the multicomponenting data can be extracted.

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