公开(公告)号：US11906431B2

公开(公告)日：2024-02-20

申请号：US17178957

申请日：2021-02-18

Applicant: NIKON CORPORATION

Inventor： Ichiro Sase ,  Yasutoshi Kaneko ,  Tatsuo Fukui

IPC: G02B21/36 ,  G02B21/16 ,  G01N21/64 ,  H04N23/00 ,  G02B21/00

CPC classification number: G01N21/6458 ,  G01N21/64 ,  G02B21/0076 ,  G02B21/16 ,  G02B21/365 ,  G02B21/367 ,  H04N23/00 ,  G01N2201/06113

Abstract: A microscope apparatus including: an illumination optical system that radiates activation light to activate some of fluorescent materials included in a sample and excitation light to excite at least some of the activated fluorescent materials; an image forming optical system that: has an objective lens and an astigmatic optical system that generates astigmatism to at least part of fluorescence from the fluorescent materials; and forms an image of the fluorescence; an image-capturing unit that captures an image formed by the image forming optical system; a drive unit that moves an image-capturing position in the sample along an optical axis-direction of the objective lens; and a control unit, wherein the control unit causes the image-capturing unit to capture images in a plurality of numbers of frames respectively at a first image-capturing position and at a second image-capturing position different from the first image-capturing position.

公开(公告)号：US20240053260A1

公开(公告)日：2024-02-15

申请号：US18231809

申请日：2023-08-09

Applicant: Tsinghua University ,  HON HAI PRECISION INDUSTRY CO., LTD.

Inventor： LI-WEN LAI ,  PENG LIU ,  DUAN-LIANG ZHOU ,  QUN-QING LI ,  SHOU-SHAN FAN

IPC: G01N21/35

CPC classification number: G01N21/35 ,  G01N2201/06113 ,  G01N2021/3595

Abstract: The present invention relates to a Fourier transform spectrometer applicable in an array of coherent light sources, comprising: a light source, a light transmission device, a control circuit, a detector, an amplifying circuit, and a computer. The control circuit is electrically connected to the light transmission device for control the on-off of light in the light transmission device. The amplifying circuit is connected with the detector for recording and amplifying the photoelectric signal obtained by the detector. The computer is connected with the amplifying circuit. The computer is equipped with a spectral analysis software is used to perform Fourier transform. The Fourier transform spectrometer based on the coherent light source array further includes a coherent light source array. The light transmission device is used to transmit the light emitted by the light source to the coherent light source array.

公开(公告)号：US20240044800A1

公开(公告)日：2024-02-08

申请号：US18227296

申请日：2023-07-27

Applicant: SHIMADZU CORPORATION

Inventor： Tomoyo TAO

IPC: G01N21/65

CPC classification number: G01N21/65 ,  G01N2021/653 ,  G01N2201/06113 ,  G01N2201/0648 ,  G01N2201/0636

Abstract: Provided is a microscopic Raman device including: a first laser light source that generates a first laser light; a second laser light source that generates a second laser light having a wavelength different from a wavelength of the first laser light; a first optical element; a second optical element; a third optical element; a fourth optical element; and a spectrometer. When the first laser light is reflected by the first optical element and passes through the third optical element to irradiate a sample, a first Raman scattered light is generated from the sample. When the second laser light is sequentially reflected by the second optical element, the fourth optical element, and the third optical element to irradiate the sample, a second Raman scattered light is generated from the sample. The first Raman scattered light passes through the third optical element and the first optical element to enter the spectrometer.

公开(公告)号：US11885809B2

公开(公告)日：2024-01-30

申请号：US17517381

申请日：2021-11-02

Applicant: LUMICKS DSM HOLDING B.V.

Inventor： Iddo Heller ,  Anna Elisabeth Christina Meijering ,  Gijs Jan Lodewijk Wuite ,  Erwin Johannes Gerard Peterman ,  Andreas Sebastian Biebricher

IPC: G01N33/58 ,  G16B15/00 ,  G01N21/64 ,  G06V20/69

CPC classification number: G01N33/58 ,  G01N21/6402 ,  G01N21/6428 ,  G01N21/6458 ,  G06V20/693 ,  G16B15/00 ,  G01N2201/0633 ,  G01N2201/06113

Abstract: A method for determining a presence of at least one guest structure at a host structure. The method comprises a light-sensitive system receiving light from the host structure. The host structure hosts one or more optically active entities at at least one part of the host structure. The at least one part does not host the at least one guest structure. Furthermore, the optically active entities cause light emission from the at least one part. The method also comprises the light-sensitive system outputting a signal based on the received light a step of determining a light value based on the output signal. The light value indicates an amount of light from the host structure incident on the light-sensitive system. The method also comprises determining on the basis of the light value at least one of a quantity and a position of the at least one guest structure.

公开(公告)号：US20240019363A1

公开(公告)日：2024-01-18

申请号：US18221138

申请日：2023-07-12

Applicant: KineoLabs

Inventor： Walid A. Atia ,  Dale C. Flanders

IPC: G01N21/39

CPC classification number: G01N21/39 ,  G01N2201/06113 ,  G01N2201/0633 ,  G01N2201/0636

Abstract: A spectroscopy system comprises a tunable laser including a gain chip, a collimating lens for collimating light from the gain chip, an end reflector, a focusing lens for focusing the collimated light on the end reflector, a thin film bandpass filter between the collimating lens and the focusing lens, and an angle control actuator for changing the angle of the thin film filter to the collimated light. The light from the laser is coupled into a sample cell providing a sample. An amplitude detector detects light from the tunable laser prior to passing into the sample cell and a sample detector detecting light from the tunable laser after passing through the sample cell. A processor controls the angle control actuator and monitors a time response of the sample detector and the amplitude detector to resolve an absorption spectra of the sample.

公开(公告)号：US11867620B2

公开(公告)日：2024-01-09

申请号：US17600438

申请日：2019-12-10

Applicant: Purdue Research Foundation

Inventor： Ji-Xin Cheng ,  Yeran Bai ,  Delong Zhang ,  Ali Shakouri ,  D. Kerry Maize

IPC: G01N21/3577

CPC classification number: G01N21/3577 ,  G01N2201/06113

Abstract: Systems and methods for detecting photothermal effect in a sample are described herein. In these systems and methods, a pump source is configured to generate a pump pulse train, a probe source is configured to generate a probe pulse train and is synchronized with the pump pulse train, and a camera collects the resulting data. The camera is configured to collect a first signal corresponding to a hot frame, wherein the hot frame includes visible probe beam as modified by a pump beam and a second signal corresponding to a cold frame, wherein the cold frame includes visible probe beam that has not been modified by a pump beam. A processor can subtract the second signal from the first signal to detect the photothermal effect.

公开(公告)号：US11860087B2

公开(公告)日：2024-01-02

申请号：US17712128

申请日：2022-04-02

Applicant: The Board of Trustees of the University of Illinois

Inventor： Rohit Bhargava ,  Seth M Kenkel

IPC: G01N21/3563 ,  G01Q60/24 ,  G01N21/39

CPC classification number: G01N21/3563 ,  G01Q60/24 ,  G01N21/39 ,  G01N2201/06113

Abstract: A method for nanoscale tomographic infrared absorption imaging is provided, the method including: generating a first plurality of sets of probe measurements for a plurality of sample locations located across a surface of a sample, and measuring a magnitude and phase of a variation in displacement of the surface of the sample at the particular sample location at the second frequency, wherein the first frequency and the second frequency differ; and generating, based on the first plurality of sets of probe measurements, a three-dimensional tomographic map of absorption of infrared light at the first wavelength by the sample. Generating measurements for a particular location includes generating a first probe measurement by illuminating the sample with infrared light that varies at a first frequency and measuring a variation in displacement of the surface of the sample at the particular sample location at the first frequency.

公开(公告)号：US20230408415A1

公开(公告)日：2023-12-21

申请号：US18455983

申请日：2023-08-25

Applicant: Foss Analytical A/S

Inventor： Daniel ADEN ,  Ahmed FADIL

IPC: G01N21/71

CPC classification number: G01N21/718 ,  G01N2201/06113 ,  G01N2201/068 ,  G01N2201/126

Abstract: A LIBS analysis system comprises a focusing lens arrangement having a focal plane; a laser for propagating a laser beam through the focusing lens arrangement to be focused at the focal plane; a detector for generating an output that is proportional to an intensity of incident electromagnetic radiation that is incident on the detector; a translation mechanism configured to cause a relative movement of the sample holder and the focusing lens arrangement to vary a position of the focal plane along the optical path with respect to the sample holder; and a controller configured to automatically control the translation mechanism to cause the relative movement of the sample holder and the focusing lens arrangement to achieve an optimum position at which the focal plane and an analysis region of the upper surface intersecting the optical path are at or are close to coincidence.

公开(公告)号：US20230375481A1

公开(公告)日：2023-11-23

申请号：US18030570

申请日：2021-09-02

Applicant: SENS-TECH LTD.

Inventor： Stephen JAYE

IPC: G01N21/88

CPC classification number: G01N21/88 ,  G01N2201/06113

Abstract: Sensing apparatus comprising a plurality of sensing units comprising an energy source for transmitting a beam of electromagnetic radiation through a subject article and a detector for receiving said beam emerging from said subject article, and a controller, in which said detectors are arranged in a dispersed configuration, in which said sensing units comprise multiple groups, in which said controller sends a first activation signal to an individual group and a second activation signal to said next group at separate times and subsequent signals to further groups and in which in said dispersed configuration each detector of each group is spaced from each other detector of each other group a greater distance than it is spaced from the nearest detector of the next sequential group.

公开(公告)号：US11821838B1

公开(公告)日：2023-11-21

申请号：US17335867

申请日：2021-06-01

Applicant: Jean-Claude Diels ,  Ladan Arissian

Inventor： Jean-Claude Diels ,  Ladan Arissian

IPC: G01N21/39 ,  G01N21/41 ,  G01N21/49 ,  G01N21/55 ,  G01N22/00

CPC classification number: G01N21/39 ,  G01N21/41 ,  G01N21/49 ,  G01N21/55 ,  G01N22/00 ,  G01N2021/4106 ,  G01N2201/06113

Abstract: Apparatus, systems, and methods associated with remote phase and amplitude spectroscopy in frequency, time, and position with correlated frequency combs are applicable in a variety of applications. Multiple beams can be generated from a single laser source, where, in the frequency domain, the multiple beams are frequency combs with equal repetition rates and shifted in frequency from each other. One or more of the multiple beams can be directed to interact with a sample with another one of the multiple beams used as a reference beam. The interaction can include transmission of one of the multiple beams as a signal beam through the sample, reflection of one of the multiple beams as a signal beam from the sample, or backscattering from the sample. Results from the interaction can be analyzed.