公开(公告)号：US07091477B2

公开(公告)日：2006-08-15

申请号：US10864106

申请日：2004-06-09

Applicant: Charles Jolliffe ,  Gholamreza Javahery ,  Lisa Cousins

Inventor： Charles Jolliffe ,  Gholamreza Javahery ,  Lisa Cousins

IPC: B01D59/44 ,  H01J49/00

CPC classification number: H01J49/0422 ,  H01J49/04 ,  H01J49/044 ,  H01J49/0468 ,  H01J49/06 ,  H01J49/26 ,  Y10T436/24

Abstract: A mass spectrometer interface, having improved sensitivity and reduced chemical background, is disclosed. The mass spectrometer interface provides improved desolvation, chemical selectivity and ion transport. A flow of partially solvated ions is transported along a tortuous path into a region of disturbance of flow, where ions and neutral molecules collide and mix. Thermal energy is applied to the region of disturbance to promote liberation of at least some of the ionized particles from any attached impurities, thereby increasing the concentration of the ionized particles having the characteristic m/z ratios in the flow. Molecular reactions and low pressure ionization methods can also be performed for selective removal or enhancement of particular ions.

公开(公告)号：US20060131497A1

公开(公告)日：2006-06-22

申请号：US11015235

申请日：2004-12-17

Applicant: Zicheng Yang ,  Roger Tong

Inventor： Zicheng Yang ,  Roger Tong

IPC: H01J49/04

CPC classification number: H01J49/0477 ,  H01J49/044

Abstract: An apparatus for use in atmospheric pressure ionization includes a sample receiving chamber, a sample droplet source communicating with the sample receiving chamber, an outlet conduit, and a boundary. The outlet conduit defines a sampling orifice that communicates with the sample receiving chamber. The boundary is interposed between the sample receiving chamber and the sampling orifice and comprises an opening. The opening defines a first passage through which a drying gas is flowable into the sample receiving chamber in an elongated flow profile, and a second passage through which sample material is flowable from the sample receiving chamber toward the sampling orifice. The first passage is positioned in non-coaxial relation to the second passage. The first passage is configured to introduce the elongated flow profile of the drying gas into a pathway of droplets of the sample material flowing toward the second passage.

Abstract translation: 用于大气压离子化的装置包括样品接收室，与样品接收室连通的样品液滴源，出口导管和边界。 出口导管限定了与样品接收室连通的采样孔。 边界置于样品接收室和采样孔之间，并包括一个开口。 开口限定第一通道，干燥气体可以通过该第一通道以细长的流动分布流入样品接收室，以及第二通道，样品材料可以通过该第二通道从样品接收室朝向采样孔流动。 第一通道定位成与第二通道非同轴的关系。 第一通道构造成将干燥气体的细长流动剖面引入流向第二通道的样品材料液滴的通路。

公开(公告)号：US20050035287A1

公开(公告)日：2005-02-17

申请号：US10864106

申请日：2004-06-09

Applicant: Charles Jolliffe ,  Gholamreza Javahery ,  Lisa Cousins

Inventor： Charles Jolliffe ,  Gholamreza Javahery ,  Lisa Cousins

IPC: H01J49/04 ,  H01J49/26 ,  H01J49/42

CPC classification number: H01J49/0422 ,  H01J49/04 ,  H01J49/044 ,  H01J49/0468 ,  H01J49/06 ,  H01J49/26 ,  Y10T436/24

Abstract: A mass spectrometer interface, having improved sensitivity and reduced chemical background, is disclosed. The mass spectrometer interface provides improved desolvation, chemical selectivity and ion transport. A flow of partially solvated ions is transported along a tortuous path into a region of disturbance of flow, where ions and neutral molecules collide and mix. Thermal energy is applied to the region of disturbance to promote liberation of at least some of the ionized particles from any attached impurities, thereby increasing the concentration of the ionized particles having the characteristic m/z ratios in the flow. Molecular reactions and low pressure ionization methods can also be performed for selective removal or enhancement of particular ions.

Abstract translation: 公开了具有改进的灵敏度和降低的化学背景的质谱仪界面。 质谱仪界面提供改进的去溶剂化学选择性和离子迁移。 部分溶剂化离子的流动沿曲折路径输送到流动扰动区域，其中离子和中性分子碰撞和混合。 热能被施加到扰动区域以促进至少一些离子化颗粒从任何附着的杂质的释放，从而增加流动中具有特征m / z比的离子化颗粒的浓度。 还可以进行分子反应和低压离子化方法以选择性去除或增强特定的离子。

公开(公告)号：US06815667B2

公开(公告)日：2004-11-09

申请号：US10362510

申请日：2003-02-25

Applicant: Scott D. Tanner ,  Dmitry R. Bandura ,  Vladimir I. Baranov

Inventor： Scott D. Tanner ,  Dmitry R. Bandura ,  Vladimir I. Baranov

IPC: H01J4900

CPC classification number: H01J49/061 ,  H01J49/044

Abstract: A mass spectrometer has an ion source for producing sample ions. The ions pass through an ion interface, to a reaction/collision cell section. An inn-neutral decoupling device is provided between the ion interface and the reaction/collision cell section, to provide substantial separation between ions and neutral particles, whereby only ions pass on to the reaction/collision cell section. The supersonic jet entering the spectrometer can have sufficient energy to cause the plasma gases, such as argon, to overcome the pressure differential between the reaction/collision cell and an upstream section of the spectrometer so as to penetrate into the reaction/collision cell; the decoupling device prevents this. The decoupling device can have offset apertures provided by plates or rods or other comparable arrangements, or can comprise a quadrupolar electrostatic deflector, an electrostatic sector deflector or a magnetic sector deflector.

Abstract translation: 质谱仪具有用于产生样品离子的离子源。 离子通过离子界面到反应/碰撞电池部分。 在离子界面和反应/碰撞电池部分之间提供了一个inn-neutral去耦装置，以提供离子和中性粒子之间的实质性分离，从而只有离子传递到反应/碰撞电池部分。 进入光谱仪的超音速喷射器可以具有足够的能量来引起诸如氩气的等离子体气体克服反应/碰撞池与光谱仪的上游部分之间的压力差，从而渗入反应/碰撞池中; 去耦设备防止这种情况。 去耦装置可以具有由板或杆或其他可比较的布置提供的偏移孔，或者可以包括四极静电偏转器，静电扇形偏转器或磁性扇形偏转器。

公开(公告)号：US06770875B1

公开(公告)日：2004-08-03

申请号：US09762239

申请日：2001-06-28

Applicant: Roger Guevremont ,  Randy Purves

Inventor： Roger Guevremont ,  Randy Purves

IPC: H01J4904

CPC classification number: G01N27/624 ,  B01D59/46 ,  B01D59/48 ,  H01J49/004 ,  H01J49/044

Abstract: This invention provides an apparatus and method for desolvating and selectively transmitting and focussing ions, including ions produced by electrospray ionization (ESI), based on the ion focussing principles of high field asymmetric waveform ion mobility spectrometry (FAIMS), for introduction into a mass spectrometer. The ion focussing, trapping and desolvating effects of FAIMS, as identified by the inventors, provides high ion transmission efficiency and high sensitivity for the detection of ions. An apparatus comprising an ESI source, a FAIMS device and a mass spectrometer provides a way of desolvating and selectively transmitting highly solvated ions for introduction into a mass spectrometer for analysis.

Abstract translation: 本发明提供了一种基于高场非对称波形离子淌度光谱法（FAIMS）的离子聚焦原理，通过电喷雾离子化（ESI）产生的离子来去离子并选择性地透射和聚焦离子的设备和方法，用于引入质谱仪 。 如本发明人所确定的，FAIMS的离子聚焦，捕获和脱溶剂效应为离子的检测提供了高离子传输效率和高灵敏度。 包括ESI源，FAIMS装置和质谱仪的装置提供了一种解吸和选择性地透射高度溶剂化的离子以引入质谱仪进行分析的方法。

公开(公告)号：US20040056189A1

公开(公告)日：2004-03-25

申请号：US10362510

申请日：2003-02-25

Inventor： Scott D Tanner ,  Dmitry R. Bandura ,  Vladimir I. Baranov

IPC: G02F001/15

CPC classification number: H01J49/061 ,  H01J49/044

Abstract: A mass spectrometer has an ion source for producing sample ions. The ions pass through an ion interface, to a reaction/collision cell section. An ion-neutral decoupling device is provided between the ion interface and the reaction/collision cell section, to provide substantial separation between ions and neutral particles, whereby only ions pass on to the reaction/collision cell section. The supersonic jet entering the spectrometer can have sufficient energy to cause the plasma gases, such as argon, to overcome the pressure differential between the reaction/collision cell and an upstream section of the spectrometer so as to penetrate into the reaction/collision cell; the decoupling device prevents this. The decoupling device can have offset apertures provided by plates or rods or other comparable arrangements, or can comprise a quadrupolar electrostatic deflector, an electrostatic sector deflector or a magnetic sector deflector.

Abstract translation: 质谱仪具有用于产生样品离子的离子源。 离子通过离子界面到反应/碰撞电池部分。 在离子界面和反应/碰撞电池部分之间提供离子中性去耦装置，以提供离子和中性粒子之间的实质性分离，从而只有离子传递到反应/碰撞电池部分。 进入光谱仪的超音速喷射器可以具有足够的能量来引起诸如氩气的等离子体气体克服反应/碰撞池与光谱仪的上游部分之间的压力差，从而渗入反应/碰撞池中; 去耦设备防止这种情况。 去耦装置可以具有由板或杆或其他可比较的布置提供的偏移孔，或者可以包括四极静电偏转器，静电扇形偏转器或磁性扇形偏转器。

公开(公告)号：US06649907B2

公开(公告)日：2003-11-18

申请号：US09802322

申请日：2001-03-08

Applicant: Daniel D. Ebeling ,  Michael S. Westphall ,  Mark A. Scalf ,  Lloyd M. Smith

Inventor： Daniel D. Ebeling ,  Michael S. Westphall ,  Mark A. Scalf ,  Lloyd M. Smith

IPC: B01D5944

CPC classification number: H01J49/165 ,  H01J49/044 ,  Y10S977/786 ,  Y10S977/795

Abstract: Methods and devices for use in mass spectral analysis of samples. In particular, methods and devices for generating ions from liquid samples containing chemical species with high molecular masses. These methods and devices provide a continuous or pulsed stream of gas phase analyte ions of either positive polarity, negative polarity or both possessing either a selected fixed charge-state distribution or one that may be selectively varied with time. More specifically, ion sources with adjustable control of the charge-state distribution of the gas phase analyte ions generated are provided in which charged droplets and/or gas phase analyte ions are exposed to electrons and/or gas phase reagent ions generated by a reagent ion source to provide desired control. A corona discharge exemplifies the reagent ion source employed in charge-state distribution control. In a specific preferred ion source, a corona discharge is provided within a shielded region to minimize the deflection of gas phase analyte ions, charged droplets. The methods and devices provided herein are particularly well-suited to the analysis of polymers and biological species.

公开(公告)号：US20010054687A1

公开(公告)日：2001-12-27

申请号：US09931910

申请日：2001-08-20

Applicant: Hitachi, Ltd.,

Inventor： Yoshiaki Kato

IPC: H01J049/00 ,  B01D059/44

CPC classification number: H01J49/044 ,  Y10T436/24 ,  Y10T436/25

Abstract: A solution containing nonvolatile salts is pumped from a pump to an electrospray nebulization probe in the LC/MS interface, and spouted out from a tip of the probe into an atmospheric pressure environment in a form of fine liquid droplets having charges. The sample ions contained in the droplets are deflected by a deflector and enter into a mass analysis portion through an ion sampling aperture to be mass analyzed. On the other hand, the nonvolatile salts travel straight without being affected by the deflector, and collide against and are collected on a wall of a particle collector. The collected salts are precipitated in a form of crystals. The collected salts are washed away by spraying a particle washing solution from the washing nozzle. The above-described structure can provide an atmospheric pressure ionization mass spectrometer which can prevent effects of nonvolatile salts on the mass analysis without deteriorating the vacuum condition of the mass analysis portion by the preventing action.

Abstract translation: 将包含非挥发性盐的溶液从泵泵送到LC / MS界面中的电喷雾雾化探针，并从具有电荷的细液滴的形式从探针的尖端喷出到大气压环境中。 包含在液滴中的样品离子被偏转器偏转并通过离子采样孔进入质量分析部分进行质量分析。 另一方面，非挥发性盐直接行进而不受偏转器的影响，并且碰撞并收集在颗粒收集器的壁上。 收集的盐以晶体的形式沉淀。 通过从洗涤喷嘴喷射颗粒洗涤溶液来洗涤收集的盐。 上述结构可以提供大气压离子化质谱仪，其能够防止非挥发性盐对质量分析的影响，而不会由于防止作用而使质量分析部的真空状态恶化。

公开(公告)号：US20010050337A1

公开(公告)日：2001-12-13

申请号：US09845287

申请日：2001-05-01

Applicant: SHIMADZU CORPORATION

Inventor： Yasufumi Tanaka

IPC: H01J049/00 ,  B01D059/44

CPC classification number: H01J49/067 ,  G01N30/724 ,  H01J49/044 ,  H01J49/063

Abstract: A liquid chromatograph mass spectrometer includes a solvent removing tube, a first ion lens and a second ion lens. Voltages applied to the solvent removing tube, and the first and second ion lenses corresponding to each mass number of a standard sample are studied in advance so that efficiencies of passing ions become best. A voltage scanning pattern is made based on the impressed voltages, and stored in a memory portion. When a scanning measurement is carried out, a control portion controls a current voltage source and a high frequency voltage source according to the voltage scanning pattern, synchronizing with the scanning of the impressed voltage to the quadrupole filter. As a result of the control, an objective ion which is generated by being atomized from a nozzle may effectively pass through the entrance of a quadrupole filter.

Abstract translation: 液相色谱质谱仪包括溶剂去除管，第一离子透镜和第二离子透镜。 预先施加到溶剂去除管的电压以及与标准样品的每个质量数对应的第一和第二离子透镜，使得通过离子的效率变得最佳。 基于外加电压进行电压扫描图案，并存储在存储器部分中。 当执行扫描测量时，控制部分根据电压扫描图案控制电流电压源和高频电压源，与向四极滤波器的外加电压的扫描同步。 作为控制的结果，通过从喷嘴雾化产生的客观离子可以有效地通过四极过滤器的入口。

公开(公告)号：US4977320A

公开(公告)日：1990-12-11

申请号：US467978

申请日：1990-01-22

Applicant: Swapan K. Chowdhury ,  Viswanatham Katta ,  Brian T. Chait

Inventor： Swapan K. Chowdhury ,  Viswanatham Katta ,  Brian T. Chait

IPC: H01J49/04 ,  H01J49/10

CPC classification number: H01J49/0404 ,  H01J49/044 ,  H01J49/0468 ,  H01J49/165

Abstract: An electrospray ion source is designed for ready and simple plugging into commercial mass analyzers for mass spectrometric analysis of organic molecules. The electrospray is carried out is the ambient air and the ions and other charged species enter the mass analyuzer through a long metal capillary tube and three stages of differential pumping. The use of the long tube allows (a) convenient injection of the ions into the mass analyzer (b) optimization of the spray by direct visualization in the air (c) efficient and controlled heat transfer to the droplets and (d) efficient pumping of the region between the capillary exit and the skinner. Desolvation of the solvated ions is carried out using a combination of controlled heat transfer to the charged droplets during the transit through the tube and collisional activation in a region of reduced pressure. Desolvation with this system does not involve use of a strong countercurrent flow of heated gas. The system also may be used to obtain the collisional activated fragmentation spectra of molecule ions. The use of a metal capillary tube avoids complications from charging that arise from the use of dielectric capilliary tubes.

Abstract translation: 电喷雾离子源设计用于准备和简单的插入商业质量分析仪，用于有机分子的质谱分析。 进行电喷雾是环境空气，离子和其他带电物质通过长金属毛细管进入质量分析仪和三级差动泵送。 使用长管允许（a）方便地将离子注入质量分析器中（b）通过在空气中直接可视化来优化喷雾（c）有效和可控制的热传递到液滴，以及（d）有效泵送 毛细管出口与皮肤之间的区域。 溶剂化离子的去溶剂使用在通过管的运输过程中受控的热传递到带电液滴和在减压区域中的碰撞活化的组合来进行。 该系统的去溶剂不涉及使用强逆流的加热气体。 该系统也可用于获得分子离子的碰撞激活的碎裂光谱。 使用金属毛细管避免了使用电介质毛细管引起的充电并发症。