公开(公告)号：US20160189944A1

公开(公告)日：2016-06-30

申请号：US14890512

申请日：2014-06-27

Applicant: RIGAKU CORPORATION

Inventor： Tadashi Arii ,  Koichi Matsushima ,  Satoshi Otake

IPC: H01J49/00 ,  H01J49/16 ,  G01N25/20

CPC classification number: H01J49/0081 ,  G01N5/04 ,  G01N25/20 ,  H01J49/004 ,  H01J49/0059 ,  H01J49/049 ,  H01J49/161 ,  H01J49/162

Abstract: A thermal analysis step, a molecule ionization step and a molecular structure analysis step are executed in parallel to a temperature increasing step. In the molecule ionization step, component molecules contained in gas evolved from a sample S due to temperature increase are ionized, and in the molecular structure analysis step, any selected ion out of molecular ions obtained in the molecule ionization step is dissociated to generate fragment ions corresponding to the structural factors of the molecule, and the structure of the molecule is analyzed on the basis of the fragment ions.

Abstract translation: 与升温步骤并行地执行热分析步骤，分子离子化步骤和分子结构分析步骤。 在分子离子化步骤中，由于温度升高而从样品S放出的气体中所含的成分分子被离子化，在分子结构分析步骤中，分子离子化步骤中得到的分子离子中任意选出的离子离解，生成碎片离子 对应于分子的结构因子，并且基于片段离子分析分子的结构。

公开(公告)号：US09251991B2

公开(公告)日：2016-02-02

申请号：US13777237

申请日：2013-02-26

Applicant: KABUSHIKI KAISHA TOSHIBA

Inventor： Akiko Kakutani ,  Kazuo Hayashi ,  Akihiro Osanai ,  Kiyokazu Sato ,  Takeshi Yoshiyuki ,  Tsutomu Kurusu

IPC: H01J27/24 ,  H01J49/16

CPC classification number: H01J27/24 ,  H01J49/161 ,  H01J49/162 ,  H01J49/164

Abstract: According to one embodiment, there is provided a laser ion source. The laser ion source includes a vacuum chamber which is vacuum-exhausted and in which a target is transported and set, a valve which is opened when the target is transported into the vacuum chamber and is closed except for the transportation, a target supply chamber which holds the target to be movable, and a transportation unit which transports to the vacuum chamber the target held on the target supply chamber while opening the valve after the target supply chamber is vacuum-exhausted while closing the valve.

Abstract translation: 根据一个实施例，提供了一种激光离子源。 激光离子源包括真空室，真空排出，目标物被输送和固定，当靶被输送到真空室中时被打开并且除运输之外是关闭的阀;目标供给室， 保持能够移动的目标;以及运送单元，其在关闭所述阀的同时在所述目标供给室被真空排气之后，在打开所述阀的同时将保持在所述目标供给室上的所述目标物输送到所述真空室。

公开(公告)号：US20140284204A1

公开(公告)日：2014-09-25

申请号：US13849171

申请日：2013-03-22

Applicant: AIRMODUS OY ,  UNIVERSITY OF HELSINKI

Inventor： Mikko SIPILÄ ,  Joonas VANHANEN

IPC: G01N27/64

CPC classification number: B01J19/125 ,  H01J49/145 ,  H01J49/162

Abstract: A device for ionizing particles (molecules or clusters) of a sample gas flow comprises a first flow tube for providing the sample gas flow, and a generator for producing reagent primary ions from particles of candidate reagent gas flow at a primary ion production region. The device also has an interaction region for introducing the reagent ions into the sample gas flow in order to arrange interaction between the reagent primary ions and the particles of the sample gas flow, thereby producing sample gas ions to be delivered to a detector. The generator for producing reagent primary ions is a non-radioactive soft X-ray radiation source.

Abstract translation: 用于离子化样品气体流的颗粒（分子或团簇）的装置包括用于提供样品气体流的第一流动管和用于在初级离子产生区域从候选反应物气体流的颗粒产生试剂初级离子的发生器。 该装置还具有用于将试剂离子引入到样品气体流中的相互作用区域，以便布置试剂初级离子与样品气体流的颗粒之间的相互作用，由此产生待传送到检测器的样品气体离子。 用于生产试剂初级离子的发生器是非放射性的软X射线辐射源。

公开(公告)号：US08431889B2

公开(公告)日：2013-04-30

申请号：US13423738

申请日：2012-03-19

Applicant: Ralf Zimmermann ,  Mohammad Reza Saraji-Bozorgzad ,  Markus Simon Eschner ,  Thomas Maximilian Groeger

Inventor： Ralf Zimmermann ,  Mohammad Reza Saraji-Bozorgzad ,  Markus Simon Eschner ,  Thomas Maximilian Groeger

IPC: H01J49/04 ,  H01J47/02

CPC classification number: G01N30/12 ,  G01N30/462 ,  G01N30/463 ,  G01N30/7206 ,  G01N2030/122 ,  G01N2030/3046 ,  G01N2030/3076 ,  H01J27/24 ,  H01J49/162

Abstract: The present invention relates to a method for repetitive chemical analysis of a gas flow, wherein said gas flow consists of a carrier gas and gaseous chemical compounds, comprising the following method steps: feeding said gas flow to a gas chromatographic separation column by means of a feeding device; collecting at least a part of said gaseous chemical compounds for a defined time period by means of a thermally based collecting device which is coupled to said gas chromatographic separation column and/or said feeding device; releasing said collected gaseous chemical compounds in a temporally focused manner by means of said thermally based collecting device; separating said released gaseous chemical compounds by means of said gas chromatographic separation column; and analyzing said separated gaseous chemical compounds by means of an analyzer. The present invention further relates to a device for performing such a method.

Abstract translation: 本发明涉及一种用于气流的重复化学分析的方法，其中所述气流由载气和气态化合物组成，包括以下方法步骤：将所述气流通过气相色谱分离柱 喂食装置; 通过耦合到所述气相色谱分离柱和/或所述进料装置的热基收集装置收集至少一部分所述气态化合物一段规定的时间段; 通过所述热基收集装置以时间聚焦的方式释放所述收集的气态化合物; 通过所述气相色谱分离柱分离所述释放的气态化合物; 并通过分析仪分析所述分离的气态化合物。 本发明还涉及一种用于执行这种方法的装置。

公开(公告)号：US20120286154A1

公开(公告)日：2012-11-15

申请号：US13423738

申请日：2012-03-19

Applicant: Ralf Zimmermann ,  Mohammad Reza Saraji-Bozorgzad ,  Markus Simon Eschner ,  Thomas Maximilian Groeger

Inventor： Ralf Zimmermann ,  Mohammad Reza Saraji-Bozorgzad ,  Markus Simon Eschner ,  Thomas Maximilian Groeger

IPC: H01J49/04

CPC classification number: G01N30/12 ,  G01N30/462 ,  G01N30/463 ,  G01N30/7206 ,  G01N2030/122 ,  G01N2030/3046 ,  G01N2030/3076 ,  H01J27/24 ,  H01J49/162

Abstract: The present invention relates to a method for repetitive chemical analysis of a gas flow, wherein said gas flow consists of a carrier gas and gaseous chemical compounds, comprising the following method steps: feeding said gas flow to a gas chromatographic separation column by means of a feeding device; collecting at least a part of said gaseous chemical compounds for a defined time period by means of a thermally based collecting device which is coupled to said gas chromatographic separation column and/or said feeding device; releasing said collected gaseous chemical compounds in a temporally focused manner by means of said thermally based collecting device; separating said released gaseous chemical compounds by means of said gas chromatographic separation column; and analyzing said separated gaseous chemical compounds by means of an analyzer. The present invention further relates to a device for performing such a method.

Abstract translation: 本发明涉及一种用于气流的重复化学分析的方法，其中所述气流由载气和气态化合物组成，包括以下方法步骤：通过以下步骤将所述气流进料到气相色谱分离塔 喂食装置; 通过耦合到所述气相色谱分离柱和/或所述进料装置的热基收集装置收集至少一部分所述气态化合物一段规定的时间; 通过所述热基收集装置以时间聚焦的方式释放所述收集的气态化合物; 通过所述气相色谱分离柱分离所述释放的气态化合物; 并通过分析仪分析所述分离的气态化合物。 本发明还涉及一种用于执行这种方法的装置。

公开(公告)号：US20090256071A1

公开(公告)日：2009-10-15

申请号：US12489195

申请日：2009-06-22

Applicant: Marcos Dantus ,  Vadim V. Lozovoy ,  Matthew Comstock

Inventor： Marcos Dantus ,  Vadim V. Lozovoy ,  Matthew Comstock

IPC: B01D59/44

CPC classification number: H01J49/162 ,  G01B9/02014 ,  G01B9/02091 ,  H01J49/164 ,  H01S3/0057

Abstract: A laser and monitoring system is provided. In another aspect of the present invention, the system includes a laser, pulse shaper and detection device. A further aspect of the present invention employs a femtosecond laser and binary pulse shaping (BPS). Still another aspect of the present invention uses a laser beam pulse, a pulse shaper and a SHG crystal. In yet another aspect of the present invention, a multiphoton intrapulse interference phase scan (hereinafter “MIIPS”) method is used to characterize the spectral phase of femtosecond laser pulses and to correct them. A further aspect of the system of the present invention is employed to monitor environmental chemicals and biological agents, including toxins, explosives, and diseases.

Abstract translation: 提供激光和监控系统。 在本发明的另一方面，该系统包括激光器，脉冲整形器和检测装置。 本发明的另一方面采用飞秒激光和二进制脉冲整形（BPS）。 本发明的另一方面是使用激光束脉冲，脉冲整形器和SHG晶体。 在本发明的另一方面，使用多光子脉冲间干涉相位扫描（以下称为“MIIPS”）方法表征飞秒激光脉冲的光谱相位并对其进行校正。 本发明的系统的另一方面用于监测环境化学物质和生物制剂，包括毒素，爆炸物和疾病。

公开(公告)号：US07521671B2

公开(公告)日：2009-04-21

申请号：US10593091

申请日：2005-03-15

Applicant: Naotoshi Kirihara ,  Norifumi Kitada ,  Kenji Takahashi ,  Haruaki Yoshida ,  Mizuho Tanaka ,  Yasuo Suzuki

Inventor： Naotoshi Kirihara ,  Norifumi Kitada ,  Kenji Takahashi ,  Haruaki Yoshida ,  Mizuho Tanaka ,  Yasuo Suzuki

IPC: H01J49/00 ,  B01D59/44 ,  G01N1/00

CPC classification number: H01J49/162 ,  H01J49/0422 ,  H01J49/40

Abstract: The invention provides an ultra-sonic jet multi-photon resonance ionization type mass analyzing device.The laser beam ionization mass analyzing device includes a pulsed gas ejecting device 12 for ejecting in pulse mode carrier gas containing sample molecules into a vacuum vessel 17, a laser beam irradiation system for irradiating laser beam for selective photo-reaction of sample molecules in said pulsed gas, repeller and extraction electrodes 18 and 19 generating an electric field for extraction of sample molecular ions generated by the photo reaction and a mass analyzing device 26 for mass analysis of extracted sample molecular ions. The laser beam irradiation system is set to irradiate laser beam to sample molecules near a position whereat a pressure time distribution of pulsed gas translating in the vacuum vessel 17 transitions from a flat-top pressure distribution to a triangular pressure distribution.

Abstract translation: 本发明提供超声波喷射多光子共振电离型质量分析装置。 激光束离子化质量分析装置包括：脉冲气体喷射装置12，用于以脉冲模式将含有样品分子的载气喷射到真空容器17中;激光束照射系统，用于照射激光束用于所述脉冲的样品分子的选择性光反应 产生用于提取由光反应产生的样品分子离子的电场的气体，推斥器和引出电极18和19，以及用于质量分析提取的样品分子离子的质量分析装置26。 设置激光束照射系统以将激光束照射到在真空容器17中平移的脉冲气体的压力时间分布从平顶压力分布转换到三角形压力分布的位置附近的样品分子。

公开(公告)号：US20090026362A1

公开(公告)日：2009-01-29

申请号：US12281908

申请日：2007-03-16

Applicant: Tadashi Arii ,  Yoshihiro Takata ,  Satoshi Otake ,  Shigeki Matsuura

Inventor： Tadashi Arii ,  Yoshihiro Takata ,  Satoshi Otake ,  Shigeki Matsuura

IPC: B01D59/44

CPC classification number: G01N27/64 ,  H01J49/08 ,  H01J49/147 ,  H01J49/162

Abstract: A plurality of molecule components included in a gas are to be ionized at the same time by PI method. For instance, a plurality of molecule components included in a gas generated at a certain instance are accurately analyzed in real time based on PI method. A gas analyzer is provided with a gas transfer apparatus for transferring a gas generated from a sample in a sample chamber to an analyzing chamber; an ionizer for ionizing the gas; a quadruple filter for separating ions by mass/charge ratio; and an ion detector for detecting the separated ions. The ionizer is provided with an ionizing region arranged in the vicinity of a gas exhaust of the gas transfer apparatus, and a lamp for applying light on the ionizing region. Since the lamp outputs light which has light directivity lower than that of a laser beam and travels by spreading, the gas entered the ionizing region in the ionizer receives light in a wide range, and the gas components inside are ionized at the same time.

Abstract translation: 包含在气体中的多个分子成分将通过PI法同时离子化。 例如，在某种情况下产生的气体中包含的多个分子成分可以基于PI法实时准确分析。 气体分析装置具备：气体传送装置，用于将样本室中的样品产生的气体转移到分析室; 用于离子化气体的离子发生器; 用于通过质量/电荷比分离离子的四重滤波器; 以及用于检测分离的离子的离子检测器。 电离器设置有布置在气体传送装置的排气附近的电离区域和用于在电离区域上施加光的灯。 由于灯输出光指向性低于激光束的光并通过扩展而行进，所以进入离子发生器中的电离区域的气体接收到宽范围的光，同时内部的气体成分被离子化。

公开(公告)号：US20080296485A1

公开(公告)日：2008-12-04

申请号：US11569145

申请日：2005-05-24

Applicant: Thorsten Benter ,  Klaus-Josef Brockman ,  Marc Constapel ,  Siegmar Gab ,  Ronald Giese ,  Oliver J. Schmitz

Inventor： Thorsten Benter ,  Klaus-Josef Brockman ,  Marc Constapel ,  Siegmar Gab ,  Ronald Giese ,  Oliver J. Schmitz

IPC: H01J49/26

CPC classification number: H01J49/162

Abstract: The invention relates to a method for the mass spectrometry examination of at least one analyte, wherein an analyte to be examined is photoionized and the mass of the ions produced is determined in a mass spectrometer. The analyte to be examined is ionized at normal atmospheric ambient pressure by means of laser light using multiphoton ionization, especially resonant multiphoton ionization. The invention also relates to a device which comprises an ionization chamber in which an analyte to be examined is ionized at normal atmospheric ambient pressure using resonant multiphoton ionization and is transferred into a mass spectrometer. Said device can be used as an interface between a device for the chromatographic or electrophoretic separation of analytes and a mass spectrometer.

Abstract translation: 本发明涉及一种用于对至少一种分析物进行质谱检测的方法，其中待测试的分析物被光电离并且在质谱仪中测定产生的离子的质量。 待测分析物通过使用多光子电离，特别是共振多光子电离的激光在正常大气环境压力下离子化。 本发明还涉及一种装置，其包括电离室，其中使用共振多光子电离在正常大气环境压力下将待检测的被分析物离子化并转移到质谱仪中。 所述装置可用作分析物的色谱或电泳分离装置与质谱仪之间的界面。

公开(公告)号：US07309859B2

公开(公告)日：2007-12-18

申请号：US11290187

申请日：2005-11-30

Applicant: Steven M. Fischer ,  Darrell L. Gourley ,  Patricia H. Cormia ,  James L. Bertsch ,  Karl Hanold

Inventor： Steven M. Fischer ,  Darrell L. Gourley ,  Patricia H. Cormia ,  James L. Bertsch ,  Karl Hanold

IPC: H01J49/26

CPC classification number: G01N30/7253 ,  H01J27/24 ,  H01J49/0431 ,  H01J49/145 ,  H01J49/162

Abstract: An atmospheric pressure ion source, e.g. for a mass spectrometer, that produces ions by atmospheric pressure photoionization (APPI). It includes a vaporizer, a photon source for photoionizing vapor molecules upon exit from the vaporizer, a passageway for transporting ions to, for example, a mass spectrometer system, and a means for directing the ions into the passageway. The center axis of the vaporizer and the center axis of the passageway form an angle that may be about 90 degrees. Included in the invention is a method for creating ions by atmospheric pressure photoionization along an axis and directing them into a passageway oriented at an angle to that axis.

Abstract translation: 大气压离子源，例如 用于通过大气压光电离（APPI）产生离子的质谱仪。 它包括蒸发器，用于在蒸发器出口时使蒸汽分子光离子化的光子源，用于将离子输送到例如质谱仪系统的通道和用于将离子引导到通道中的装置。 蒸发器的中心轴线和通道的中心轴线形成大约90度的角度。 本发明中包括一种通过沿着轴的大气压力光离子化产生离子的方法，并将它们引导到与该轴成一定角度的通道中。