公开(公告)号：US09691594B2

公开(公告)日：2017-06-27

申请号：US14890512

申请日：2014-06-27

Applicant: RIGAKU CORPORATION

Inventor： Tadashi Arii ,  Koichi Matsushima ,  Satoshi Otake

IPC: H01J49/00 ,  H01J49/04 ,  H01J49/16 ,  G01N5/04 ,  G01N25/20

CPC classification number: H01J49/0081 ,  G01N5/04 ,  G01N25/20 ,  H01J49/004 ,  H01J49/0059 ,  H01J49/049 ,  H01J49/161 ,  H01J49/162

Abstract: A thermal analysis step, a molecule ionization step and a molecular structure analysis step are executed in parallel to a temperature increasing step. In the molecule ionization step, component molecules contained in gas evolved from a sample S due to temperature increase are ionized, and in the molecular structure analysis step, any selected ion out of molecular ions obtained in the molecule ionization step is dissociated to generate fragment ions corresponding to the structural factors of the molecule, and the structure of the molecule is analyzed on the basis of the fragment ions.

公开(公告)号：US09123523B2

公开(公告)日：2015-09-01

申请号：US14401300

申请日：2013-05-16

Applicant: Micromass UK Limited

Inventor： Martin Raymond Green ,  Jeffery Mark Brown

IPC: H01J49/10 ,  H01J27/24 ,  G01N27/64 ,  H01J49/42 ,  H01J49/00 ,  H01J49/16 ,  H01J49/14 ,  H01J49/24

CPC classification number: H01J49/422 ,  H01J49/0059 ,  H01J49/062 ,  H01J49/10 ,  H01J49/145 ,  H01J49/162 ,  H01J49/24

Abstract: A mass spectrometer is disclosed comprising an RF ion guide or ion trap and a device arranged and adapted to supply a reagent gas within the RF ion guide or ion trap. The mass spectrometer further comprises a photo-ionization device and a control system arranged and adapted: (i) to cause first ions to fragment or dissociate within the RF ion guide or ion trap to form second ions and neutral molecules; and (ii) to cause the photo-ionization device to photo-ionize and/or photo-excite the reagent gas to form reagent ions, excited species or radical species. The reagent ions, excited species or radical species interact with at least some of the neutral molecules located within the RF ion guide or ion trap to form analyte ions.

Abstract translation: 公开了一种质谱仪，其包括RF离子导向器或离子阱，以及布置并适于在RF离子导向器或离子阱内提供反应气体的装置。 质谱仪还包括光电离装置和控制系统，其布置和适应：（i）使第一离子在RF离子导向器或离子阱内分裂或解离以形成第二离子和中性分子; 和（ii）使光电离装置光电离和/或光激发反应气体以形成试剂离子，激发物质或自由基物质。 试剂离子，激发的物质或自由基物质与位于RF离子导向器或离子阱内的至少一些中性分子相互作用以形成分析物离子。

公开(公告)号：US08563924B2

公开(公告)日：2013-10-22

申请号：US13170282

申请日：2011-06-28

Applicant: James Edward Cooley ,  Sameer Kothari

Inventor： James Edward Cooley ,  Sameer Kothari

IPC: H01J49/00

CPC classification number: H01J27/24 ,  H01J49/162

Abstract: An ionization device comprises: a plasma source configured to generate a plasma. The plasma comprises light, plasma ions and plasma electrons. The plasma source comprises an aperture disposed such that at least part of the light passes through the aperture and is incident on a gas sample. The ionization device further comprises an ionization region; and a plasma deflection device comprising a plurality of electrodes configured to establish an electric field, wherein the electric field substantially prevents the plasma ions from entering the ionization region.

Abstract translation: 电离装置包括：构造成产生等离子体的等离子体源。 等离子体包括光，等离子体离子和等离子体电子。 等离子体源包括孔，其设置成使得至少一部分光通过孔并入射在气体样品上。 电离装置还包括电离区域; 以及等离子体偏转装置，其包括被配置为建立电场的多个电极，其中所述电场基本上防止所述等离子体离子进入所述电离区域。

公开(公告)号：US20130082172A1

公开(公告)日：2013-04-04

申请号：US13248501

申请日：2011-09-29

Applicant: Jack A. Syage ,  Kaveh Jorabchi

Inventor： Jack A. Syage ,  Kaveh Jorabchi

IPC: H01J49/26 ,  B23P11/00 ,  G01N1/20 ,  G01N1/00 ,  G01N1/22

CPC classification number: H01J49/049 ,  G01N2001/028 ,  H01J49/14 ,  H01J49/162

Abstract: A chemical sampling system includes a direct analysis in real time (DART) device and an atmospheric pressure photoionization (APPI) device positioned proximate the DART device. Another chemical sampling system includes the APPI device positioned proximate to a thermal desorption device.

Abstract translation: 化学取样系统包括实时直接分析（DART）设备和位于DART设备附近的大气压光电离（APPI）设备。 另一种化学取样系统包括靠近热解吸装置定位的APPI装置。

公开(公告)号：US08265110B2

公开(公告)日：2012-09-11

申请号：US12489195

申请日：2009-06-22

Applicant: Marcos Dantus ,  Vadim V. Lozovoy ,  Matthew Comstock

Inventor： Marcos Dantus ,  Vadim V. Lozovoy ,  Matthew Comstock

IPC: H01S3/13

CPC classification number: H01J49/162 ,  G01B9/02014 ,  G01B9/02091 ,  H01J49/164 ,  H01S3/0057

Abstract: A laser and monitoring system is provided. In another aspect of the present invention, the system includes a laser, pulse shaper and detection device. A further aspect of the present invention employs a femtosecond laser and binary pulse shaping (BPS). Still another aspect of the present invention uses a laser beam pulse, a pulse shaper and a SHG crystal. In yet another aspect of the present invention, a multiphoton intrapulse interference phase scan (hereinafter “MIIPS”) method is used to characterize the spectral phase of femtosecond laser pulses and to correct them. A further aspect of the system of the present invention is employed to monitor environmental chemicals and biological agents, including toxins, explosives, and diseases.

Abstract translation: 提供激光和监控系统。 在本发明的另一方面，该系统包括激光器，脉冲整形器和检测装置。 本发明的另一方面采用飞秒激光和二进制脉冲整形（BPS）。 本发明的另一方面是使用激光束脉冲，脉冲整形器和SHG晶体。 在本发明的另一方面，使用多光子脉冲间干涉相位扫描（以下称为“MIIPS”）方法表征飞秒激光脉冲的光谱相位并对其进行校正。 本发明的系统的另一方面用于监测环境化学物质和生物制剂，包括毒素，爆炸物和疾病。

公开(公告)号：US08101923B2

公开(公告)日：2012-01-24

申请号：US12269825

申请日：2008-11-12

Applicant: Thomas Michael Orlando ,  Joshua Milbourne Symonds

Inventor： Thomas Michael Orlando ,  Joshua Milbourne Symonds

IPC: H01J17/00 ,  H01J17/49

CPC classification number: H01J49/142 ,  H01J49/162

Abstract: A method and system for desorbing and ionizing molecules from a sample for mass spectrometry using a microplasma device is disclosed. The system and method relies upon a microplasma device, or array of such devices, to partially ionize a gas to form a microplasma. The ionized gas can be a mixture of a noble gas, such as neon or argon, and hydrogen (H2). The ionized gas can form a effluent stream directed onto the surface of a sample to desorb molecules from the remainder of the sample. The desorbed molecules can be ionized by the effluent stream as they leave the surface of the sample. The ionization process can include: photoionization, penning ionization, chemical ionization (proton transfer), and electron impact ionization. The ionized particles from the sample can be directed to a mass spectrometer for analysis. This can produce spatially-resolved mass spectral data, and can be conducted concurrently with another imaging system, such as a microscope.

Abstract translation: 公开了一种用于使用微质体装置从用于质谱的样品中分离和离子化分子的方法和系统。 该系统和方法依赖于微等离子体装置或这种装置的阵列，以部分地电离气体以形成微血浆。 电离气体可以是诸如氖或氩的惰性气体和氢气（H 2）的混合物。 电离气体可以形成指向样品表面的流出物流，以从样品的其余部分解吸分子。 解吸的分子在离开样品表面时可以通过流出物流离子化。 电离过程可以包括：光离子化，电离离子化，化学电离（质子转移）和电子碰撞电离。 来自样品的离子化颗粒可以被引导到质谱仪进行分析。 这可以产生空间分辨的质谱数据，并且可以与诸如显微镜的另一成像系统同时进行。

公开(公告)号：US08044346B2

公开(公告)日：2011-10-25

申请号：US11962578

申请日：2007-12-21

Applicant: Risto Kostiainen ,  Tiina Kauppila ,  Markus Haapala ,  Jaroslav Pol ,  Tapio Kotiaho

Inventor： Risto Kostiainen ,  Tiina Kauppila ,  Markus Haapala ,  Jaroslav Pol ,  Tapio Kotiaho

IPC: H01J49/00 ,  B01D59/44

CPC classification number: H01J49/162 ,  H01J49/142

Abstract: The invention relates to a method and system for ionizing analyte-containing sample lying on a surface of a substrate. The method comprises directing to the sample a heated flow of desorption gas in order to desorb analyte from the surface, and simultaneously directing to the sample light capable of ionizing the desorbed analyte in the presence of the desorption gas. The invention provides a method and system suitable for efficiently producing ions of neutral and nonpolar molecules on surfaces, for example for mass spectrometric purposes.

Abstract translation: 本发明涉及用于电离位于基底表面上的含分析物的样品的方法和系统。 该方法包括向样品引导加热的解吸气流，以便从表面解吸分析物，并且同时引导能够在解吸气体存在下将解吸的分析物电离的样品光。 本发明提供了一种适于在表面上有效地产生中性和非极性分子的离子的方法和系统，例如用于质谱目的。

公开(公告)号：US20110180699A1

公开(公告)日：2011-07-28

申请号：US12693857

申请日：2010-01-26

Applicant: James Edward COOLEY ,  Viorica LOPEZ-AVILA ,  Randall URDAHL

Inventor： James Edward COOLEY ,  Viorica LOPEZ-AVILA ,  Randall URDAHL

IPC: H01J49/26 ,  H01J27/02 ,  H01J27/24

CPC classification number: H01J49/107 ,  H01J49/162

Abstract: A device includes a first substrate having a principal surface having a plurality of sample sites having a corresponding sample; a second substrate having a principal surface facing and spaced apart from the principal surface of the first substrate, the second substrate having a plurality of ultraviolet emission sites corresponding to the sample sites of the first substrate, each of the ultraviolet emission sites being spaced apart from and facing a corresponding one of the sample sites of the first substrate, each of the ultraviolet emission sites being configured to emit ultraviolet light to a corresponding one of the sample sites on the first substrate, and to ionize at least a portion of a sample provided at each sample site; and an ion extraction device configured to extract ions from a gap between the first substrate and the structure.

Abstract translation: 一种器件包括具有主表面的第一衬底，所述主表面具有多个具有相应样品的样品位点; 第二基板，其主表面面对并与第一基板的主表面间隔开，第二基板具有对应于第一基板的样品位置的多个紫外发射部位，每个紫外发射部位与第一基板间隔开 并且面对第一衬底的相应的一个样品位置，每个紫外发射部位被配置为向第一衬底上的对应的一个样品位点发射紫外光，并离子化所提供的样品的至少一部分 在每个样品处; 以及离子提取装置，被配置为从第一基板和结构之间的间隙提取离子。

公开(公告)号：US07910883B2

公开(公告)日：2011-03-22

申请号：US12064124

申请日：2006-08-05

Applicant: Fabian Muehlberger ,  Ralf Zimmermann

Inventor： Fabian Muehlberger ,  Ralf Zimmermann

IPC: H01J49/10 ,  H01J49/16

CPC classification number: H01J49/107 ,  H01J49/162

Abstract: A method for mass-spectrometric detection of compounds in a gas flow includes: alternatingly forming first and a second beams by switching between electron pulses/pulse trains and photon pulses/pulse trains, the photon pulses/pulse trains being generated by an excimer lamp, and the switching between the electron pulses/pulse trains and the photon pulses/pulse trains occurring at a switching frequency above 50 Hz; disposing the gas flow in an ionization region crossed by the first and second beams so as to ionize volume units in the gas flow so as to form ions of the compounds; deflecting the ions in an effective region of an electric field to a mass-spectrometric device; and sensing the ions with a mass-spectrometric process of the mass-spectrometric device.

Abstract translation: 用于气流中化合物的质谱检测方法包括：通过在电子脉冲/脉冲列和光子脉冲/脉冲串之间切换来交替地形成第一和第二束，由准分子灯产生的光子脉冲/脉冲串， 电子脉冲/脉冲串之间的切换以及在50Hz以上的开关频率下发生的光子脉冲/脉冲串; 将气流设置在由第一和第二光束穿过的电离区域中，以便离子化气流中的体积单位，以形成化合物的离子; 将电场的有效区域中的离子偏转到质谱仪; 并通过质谱仪的质谱过程感测离子。

公开(公告)号：US20110049354A1

公开(公告)日：2011-03-03

申请号：US12768023

申请日：2010-04-27

Applicant: Matthias Englmann ,  Phillippe Schmitt-Kopplin ,  Istvan Gebefuegi ,  Heinz Frisch ,  Wolfgang Dietz

Inventor： Matthias Englmann ,  Phillippe Schmitt-Kopplin ,  Istvan Gebefuegi ,  Heinz Frisch ,  Wolfgang Dietz

IPC: B01D59/44

CPC classification number: H01J49/162 ,  H01J49/164

Abstract: Method for detecting at least one target substance, including converting molecules of at least one of the target substances to a gaseous state and a spectrometric detection of the molecules. The object is to significantly increase the resolving capacity of the method in its detection limit and in its selectivity. This is achieved in that the conversion includes soluble mixing, formation of aerosol and evaporation of at least one of the target substances with a solvent, the molecules being integrated into a gas phase, and the spectrometric detection includes an ionisation of the molecules in the gas phase to form ions.

Abstract translation: 用于检测至少一种目标物质的方法，包括将目标物质中的至少一种的分子转化为气态和分子的光谱检测。 目的是显着提高该方法在其检测限和其选择性中的分辨能力。 这是因为转化包括可溶性混合，气溶胶形成和至少一种目标物质与溶剂的蒸发，该分子被整合到气相中，而光谱检测包括气体中的分子的离子化 相形成离子。