公开(公告)号：US07504620B2

公开(公告)日：2009-03-17

申请号：US10592299

申请日：2005-05-17

Applicant: Takaya Sato ,  Michisato Toyoda ,  Morio Ishihara

Inventor： Takaya Sato ,  Michisato Toyoda ,  Morio Ishihara

IPC: H01J49/40

CPC classification number: H01J49/164 ,  H01J49/408

Abstract: A method and apparatus for time-of-flight (TOF) mass spectrometry. The apparatus improves the ion focusing properties in an orthogonal direction and permits connection with an orthogonal-acceleration ion source for improvement of sensitivity. The apparatus comprises an ion source for emitting ions in a pulsed manner, an analyzer for realizing a helical trajectory, and a detector for detecting the ions. The analyzer is composed of plural laminated toroidal electric fields to realize the helical trajectory.

Abstract translation: 用于飞行时间（TOF）质谱的方法和装置。 该装置改善了正交方向上的离子聚焦性能，并且允许与正交加速度离子源的连接以提高灵敏度。 该装置包括用于以脉冲方式发射离子的离子源，用于实现螺旋轨迹的分析器和用于检测离子的检测器。 分析仪由多层叠环形电场组成，实现螺旋轨迹。

公开(公告)号：US07482583B2

公开(公告)日：2009-01-27

申请号：US11603159

申请日：2006-11-22

Applicant: Yoshihiro Ueno

Inventor： Yoshihiro Ueno

IPC: B01D59/48

CPC classification number: H01J49/30 ,  H01J49/408

Abstract: In a time of flight mass spectrometer (TOFMS) having a flight space in which ions fly in a loop orbit formed by a plurality of electric sector fields, the present invention provides a simple structure that creates a spiral path by deflecting the ions in the axial direction of the electric fields at every turn of the ions. In a mode of the present invention, the TOFMS has cylindrical electrodes 11 and 12 for creating electric sector fields E1 and E2, between which a parallel pair of planer magnetic poles 15a and 15b are provided. The planer magnetic poles 15a and 15b create a deflecting magnetic field B1 for shifting the ions in the axial direction (Y-direction) of the electric sector fields. The ions experience a Lorenz force once every turn when they pass through the deflecting magnetic field B1. This construction uses only one pair of magnetic poles facing each other across the ion path P to deflect every ion irrespective of its number of turns. There is no need to provide one deflector for each turn of the ions, as in the case of conventional TOFMSs.

Abstract translation: 在具有飞行空间的飞行时间质谱仪（TOFMS）中，离子飞行在由多个电扇区形成的环轨道中，本发明提供了一种简单的结构，其通过在轴向上偏转离子而产生螺旋路径 方向的电场每转一圈的离子。 在本发明的模式中，TOFMS具有用于产生电扇区E1和E2的圆柱形电极11和12，平行的一对平面磁极15a和15b之间形成有电扇区E1和E2。 平面磁极15a和15b产生偏转磁场B1，用于使离子在电扇区的轴向（Y方向）上移位。 当离子经过偏转磁场B1时，离子经历一次洛伦茨力。 这种结构仅使一对磁极彼此跨过离子路径P，以偏转每个离子而不考虑其匝数。 对于常规TOFMS的情况，不需要为每一圈的离子提供一个偏转器。

公开(公告)号：US20080128613A1

公开(公告)日：2008-06-05

申请号：US11818913

申请日：2007-06-15

Applicant: Sidney E. Buttrill

Inventor： Sidney E. Buttrill

IPC: H01J49/40

CPC classification number: H01J49/282 ,  H01J49/408

Abstract: The invention provides apparatus and methods for performing time-of-flight (TOF) mass spectrometry. A TOF mass spectrometer of the present invention comprises one or more ion focusing electric sectors. At least one of the electric sectors is associated with an ion optical element. The ion optical elements comprise at least one adjustable electrode, such that the adjustable electrode is able to modify the potential experienced by an ion entering or exiting the electric sector with which it is associated.

Abstract translation: 本发明提供了用于执行飞行时间（TOF）质谱的装置和方法。 本发明的TOF质谱仪包括一个或多个离子聚焦电扇区。 电扇区中的至少一个与离子光学元件相关联。 离子光学元件包括至少一个可调电极，使得可调节电极能够改变进入或离开与其相关联的电扇区的离子所经历的电位。

公开(公告)号：US07355168B2

公开(公告)日：2008-04-08

申请号：US11353112

申请日：2006-02-14

Applicant: Shinichi Yamaguchi

Inventor： Shinichi Yamaguchi

IPC: H01J49/40

CPC classification number: H01J49/282 ,  H01J49/408

Abstract: The present invention provides a time of flight mass spectrometer having an ion optics forming a multi-turn track, which is capable of time-focusing the ions while allowing the multi-turn track to be configured in an unlimited and highly variable manner. In a specific form of the invention, a reflector 9 is provided on the flight path between the position where the ions leave the loop orbit P and the ion detector 10 located outside the loop orbit P, and the condition of the electric field generated by the reflector 9 is appropriately determined. Thus, even if the ions cannot be well time-focused by the ion optics 2 creating the sector-shaped electric fields 4 and 7, it is possible to compensate the time-focusing performance with the reflector 9 to achieve a good performance of time-focusing of the ion throughout the overall system wherein the ions leave the ion source 1 and finally reach the ion detector 10. Thereby, the ions can reach the ion detector 10 at approximately the same time even if the ions having the same mass number have different levels of energy at the moment they leave the ion source 1.

Abstract translation: 本发明提供了具有形成多匝轨道的离子光学器件的飞行时间质谱仪，其能够对离子进行时间聚焦，同时允许多匝轨道以无限和高度可变的方式配置。 在本发明的具体形式中，在离开离开环路轨道P的位置和位于环路轨道P外部的离子检测器10之间的飞行路径上设置反射器9，以及由 反射器9被适当地确定。 因此，即使由离子光学器件2产生的扇形电场4和7不能很好地对离子进行时间聚焦，也可以利用反射体9补偿时间聚焦性能， 将离子聚焦在整个系统中，其中离子离开离子源1并最终到达离子检测器10。 因此，即使具有相同质量数的离子在离开离子源1的时刻具有不同的能量水平，离子也可以在大约相同的时间到达离子检测器10。

公开(公告)号：US20060214100A1

公开(公告)日：2006-09-28

申请号：US11277181

申请日：2006-03-22

Applicant: Anatoli Verentchikov ,  Mikhail Yavor

Inventor： Anatoli Verentchikov ,  Mikhail Yavor

IPC: H01J49/40

CPC classification number: H01J49/408 ,  H01J49/406 ,  H01J49/48

Abstract: The present invention relates generally to a multi-reflecting time-of-flight mass spectrometer (MR TOF MS). To improve mass resolving power of a planar MR TOF MS, a spatially isochronous and curved interface may be used for ion transfer in and out of the MR TOF analyzer. One embodiment comprises a planar grid-free MR TOF MS with periodic lenses in the field-free space, a linear ion trap for converting ion flow into pulses and a C-shaped isochronous interface made of electrostatic sectors. The interface allows transferring ions around the edges and fringing fields of the ion mirrors without introducing significant time spread. The interface may also provide energy filtering of ion packets. The non-correlated turn-around time of ion trap converter may be reduced by using a delayed ion extraction from the ion trap and excessive ion energy is filtered in the curved interface.

Abstract translation: 本发明一般涉及多反射飞行时间质谱仪（MR TOF MS）。 为了提高平面MR TOF MS的质量分辨能力，可以使用空间等时和弯曲界面来进出MR TOF分析仪的离子传输。 一个实施例包括在无场空间中具有周期性透镜的平面无格MR TOF MS，用于将离子流转换成脉冲的线性离子阱和由静电扇区构成的C形等时接口。 该界面允许在离子镜的边缘和边缘场附近转移离子，而不会引入显着的时间扩散。 界面还可以提供离子包的能量过滤。 离子阱转换器的非相关周转时​​间可以通过使用来自离子阱的延迟离子提取而减少，并且过多的离子能量在弯曲界面中被过滤。

公开(公告)号：US06949736B2

公开(公告)日：2005-09-27

申请号：US10934329

申请日：2004-09-03

Applicant: Morio Ishihara

Inventor： Morio Ishihara

IPC: G01N27/62 ,  B01D59/44 ,  H01J49/00 ,  H01J49/40

CPC classification number: H01J49/408 ,  H01J49/0036

Abstract: A method of mass analysis using a multi-turn time-of-flight mass spectrometer starts with recording plural heterogeneous turn number spectra F1(t), F2(t), . . . , Fq(t) containing plural ion peaks that might be different in number of turns, the spectra being obtained with different ion residence times taken from entry to departure using a multi-correlation function for reconstructing a single turn number spectrum.

Abstract translation: 使用多匝飞行时间质谱仪进行质量分析的方法开始于记录多个异质转数谱F 1（t），F 2（t） ，。 。 。 （t），其包含可能与匝数不同的多个离子峰，使用多相关函数从入口到出发使用不同的离子停留时间获得的光谱，用于重建单个 转数谱。

公开(公告)号：US20050151076A1

公开(公告)日：2005-07-14

申请号：US11032002

申请日：2005-01-11

Applicant: Shinichi Yamaguchi ,  Morio Ishihara ,  Michisato Toyoda ,  Daisuke Okumura

Inventor： Shinichi Yamaguchi ,  Morio Ishihara ,  Michisato Toyoda ,  Daisuke Okumura

IPC: G01N27/62 ,  B01D59/44 ,  H01J49/06 ,  H01J49/16 ,  H01J49/26 ,  H01J49/40

CPC classification number: H01J49/408

Abstract: In the mass spectrometer of the present invention, a flight space is provided before the mass analyzer, and the flight space includes a loop orbit on which ions fly repeatedly. While ions fly on the loop orbit repeatedly, ion selecting electrodes placed on the loop orbit selects object ions having a specific mass to charge ratio in such a manner that, for a limited time period when the object ions are flying through the ion selecting electrodes, an appropriate voltage is applied to the ion selecting electrodes to make them continue to fly on the loop orbit, but otherwise to make or let other ions deflect from the loop orbit. If ions having various mass to charge ratios are introduced in the loop orbit almost at the same time, the object ions having the same mass to charge ratio continue to fly on the loop orbit in a band, but ions having mass to charge ratios different from that are separated from the object ions while flying on the loop orbit repeatedly. Even if the difference in the mass to charge ratio is small, the separation becomes large when the number of turns of the flight becomes large. After such a separation is adequately achieved, the ion selecting electrodes can select the object ions with high selectivity, or at high mass resolution. By adding dissociating means, fragment ions originated only from the selected object ions can be analyzed, which enables the identification and structural analysis of the sample at high accuracy.

Abstract translation: 在本发明的质谱仪中，在质量分析器之前提供飞行空间，并且飞行空间包括离子重复飞行的环轨道。 当离子重复地在环路轨道上飞行时，放置在环路轨道上的离子选择电极以这样的方式选择具有特定质荷比的物体离子，使得在物体离子飞过离子选择电极的有限时间段内， 对离子选择电极施加适当的电压使它们继续在环轨道上飞行，而另外使其它离子从环轨道偏转。 如果几乎同时在环路轨道中引入具有各种质荷比的离子，则具有相同质荷比的物体离子在带内的环路轨道上继续飞行，但质量与电荷比的离子不同于 它们与物体离子分离，同时在环路轨道上重复飞行。 即使质荷比的差小，当飞行匝数变大时，分离也变大。 在这种分离充分实现之后，离子选择电极可以以高选择性或高质量分辨率选择目标离子。 通过添加解离手段，可以分析仅从所选择的对象离子产生的碎片离子，这使得能够高精度地鉴定和结构分析样品。

公开(公告)号：US20050077462A1

公开(公告)日：2005-04-14

申请号：US10959433

申请日：2004-10-07

Applicant: Shinichi Yamaguchi ,  Morio Ishihara ,  Michisato Toyoda

Inventor： Shinichi Yamaguchi ,  Morio Ishihara ,  Michisato Toyoda

IPC: G01N27/62 ,  H01J49/04 ,  H01J49/40

CPC classification number: H01J49/408

Abstract: In an analysis using a mass spectrometer having a loop orbit along which ions are made to fly a plurality of times, the present invention provides a method of determining the mass-to-charge ratio of an ion without limiting the range of the mass-to-charge ratio of the ions to be brought into the loop orbit while allowing the lapping of the orbiting ions. The measurement is carried out two or more times under different conditions (Tg=500[μs], 400[μs]) under which the number of turns of the ion concerned is different. Flight times are determined from the flight time spectrums obtained by at least two measurements. Though the numbers of turns themselves are unknown, it is possible to calculate possible mass-to-charge ratios for each flight time by incrementally setting the number of turns at plural values. The two sets of possible mass-to-charge ratios derived from the two flight time values (525[μs], 441[μs]) determined by the two measurements are compared with each other, and a value that is found in both measurement results is selected as the mass-to-charge ratio of the ion concerned. Thus, it is possible to determine the mass-to-charge ratio without limiting the range of the mass-to-charge ratio before the ions are brought into the loop orbit.

Abstract translation: 在使用具有环形轨道的质谱仪进行分析时，离子通过该轨道多次飞行，本发明提供了一种确定离子的质荷比而不限制质量 - 进入环轨道的离子的充电比例，同时允许研磨轨道离子。 在不同条件下（Tg = 500 [mus]，400 [mus]）进行两次以上的测定，在该条件下，有关离子的匝数不同。 从通过至少两次测量获得的飞行时间谱确定飞行时间。 虽然转弯数量本身是未知的，但是可以通过逐个设定多个值的匝数来计算每个飞行时间的可能的质荷比。 将由两个测量确定的两个飞行时间值（525 [mus]，441 [mus]）得到的两组可能的质荷比相互比较，并在两个测量结果中找到 被选为相关离子的质荷比。 因此，可以在离子进入环轨道之前不限制质荷比的范围来确定质荷比。

公开(公告)号：US20050077461A1

公开(公告)日：2005-04-14

申请号：US10957642

申请日：2004-10-05

Applicant: Shinichi Yamaguchi ,  Morio Ishihara ,  Michisato Toyoda

Inventor： Shinichi Yamaguchi ,  Morio Ishihara ,  Michisato Toyoda

IPC: G01N27/62 ,  H01J49/06 ,  H01J49/10 ,  H01J49/40

CPC classification number: H01J49/0036 ,  H01J49/408

Abstract: A mass spectrometer includes a flight control device for allowing ions from an ion source to repeatedly fly along an orbit in a flight space for predetermined times; a detecting device for detecting the ions after the ions repeatedly fly along the orbit for the predetermined times; and a data processing device for starting collection of ion strength data detected by the detecting device. The ion strength data is obtained during the flight of the ions along the orbit, or when the ions are headed toward the detecting device after departing from the orbit, or when one of the above situations is estimated.

Abstract translation: 质谱仪包括用于允许来自离子源的离子在飞行空间中沿着轨道重复飞行预定次数的飞行控制装置; 检测装置，用于在离子重复沿着轨道飞行预定时间之后检测离子; 以及用于开始由检测装置检测的离子强度数据的收集的数据处理装置。 离子强度数据是在沿着轨道的离子飞行过程中获得的，或者离子离开轨道时离子朝向检测装置，或当估计出上述情况之一时获得。

公开(公告)号：US20040056190A1

公开(公告)日：2004-03-25

申请号：US10424351

申请日：2003-04-24

Applicant: Ciphergen Biosystems, Inc.

Inventor： Sidney E. Buttrill JR.

IPC: H01J049/40

CPC classification number: H01J49/282 ,  H01J49/408

Abstract: The invention provides apparatus and methods for performing time-of-flight (TOF) mass spectrometry. A TOF mass spectrometer of the present invention comprises one or more ion focusing electric sectors. At least one of the electric sectors is associated with an ion optical element. The ion optical elements comprise at least one adjustable electrode, such that the adjustable electrode is able to modify the potential experienced by an ion entering or exiting the electric sector with which it is associated.

Abstract translation: 本发明提供了用于执行飞行时间（TOF）质谱的装置和方法。 本发明的TOF质谱仪包括一个或多个离子聚焦电扇区。 电扇区中的至少一个与离子光学元件相关联。 离子光学元件包括至少一个可调电极，使得可调节电极能够改变进入或离开与其相关联的电扇区的离子所经历的电位。