公开(公告)号：US09224586B2

公开(公告)日：2015-12-29

申请号：US12976543

申请日：2010-12-22

Applicant: Chung-Hsuan Chen ,  Jung-Lee Lin ,  Ming-Lee Chu

Inventor： Chung-Hsuan Chen ,  Jung-Lee Lin ,  Ming-Lee Chu

IPC: H01J49/42 ,  H01J49/00

CPC classification number: H01J49/0022 ,  H01J49/424 ,  H01J49/429

Abstract: Methods and apparatuses for portable mass spectrometry are disclosed. The apparatuses comprise at least one source of ionized analyte, at least one frequency scanning subsystem, at least one detector, and optionally at least one vacuum pump, and are portable. In some embodiments, the apparatuses comprise multiple sources of ionized analyte and/or are configured to obtain mass spectra of a large analyte, such as analyte with an m/z ratio of at least 105, or analyte with a molecular weight of at least 105 Da, as well as mass spectra of small molecule analyte. In some embodiments, the methods comprise obtaining mass spectra with a portable apparatus described above.

Abstract translation: 公开了便携式质谱法的方法和装置。 该装置包括至少一个离子化分析物源，至少一个频率扫描子系统，至少一个检测器和可选的至少一个真空泵，并且是便携式的。 在一些实施方案中，装置包括多个电离分析物源和/或配置成获得大分析物的质谱，例如m / z比至少为105的分析物，或分子量至少为105的分析物 Da，以及小分子分析物的质谱。 在一些实施例中，所述方法包括使用上述便携式装置获得质谱。

公开(公告)号：US09190258B2

公开(公告)日：2015-11-17

申请号：US14445551

申请日：2014-07-29

Applicant: The Charles Stark Draper Laboratory, Inc. ,  Johns Hopkins University School of Medicine ,  Mini-Mass Counseling

Inventor： Theresa Evans-Nguyen ,  Di Wang ,  Friso Van Amerom

IPC: H01J49/26 ,  H01J49/02 ,  H01J49/42 ,  H01J49/00

CPC classification number: H01J49/427 ,  H01J49/0031 ,  H01J49/022 ,  H01J49/424 ,  H01J49/429

Abstract: The present disclosure discusses a system and method for continuous operation of an ion trap mass spectrometer. The described system does not introduce ions into the ion trap in distinct trapping phase, rather the described system continuously injects ions into the ion trap while continuously scanning out the ions. The system and method described herein achieves a much higher duty cycle and cycle rate when compared to standard mass spectrometer devices.

Abstract translation: 本公开内容讨论了用于离子阱质谱仪的连续操作的系统和方法。 所描述的系统不会在不同的俘获阶段将离子引入离子阱，而是所描述的系统在连续扫描离子的同时将离子连续地注入到离子阱中。 与标准质谱仪器件相比，本文所述的系统和方法实现了更高的占空比和循环速率。

公开(公告)号：US20150034820A1

公开(公告)日：2015-02-05

申请号：US14445551

申请日：2014-07-29

Applicant: The Charles Stark Draper Laboratory, Inc. ,  Johns Hopkins University School of Medicine ,  Mini-Mass Counseling

Inventor： Theresa Evans-Nguyen ,  Di Wang ,  Friso Van Amerom

IPC: H01J49/42 ,  H01J49/00 ,  H01J49/02

CPC classification number: H01J49/427 ,  H01J49/0031 ,  H01J49/022 ,  H01J49/424 ,  H01J49/429

Abstract: The present disclosure discusses a system and method for continuous operation of an ion trap mass spectrometer. The described system does not introduce ions into the ion trap in distinct trapping phase, rather the described system continuously injects ions into the ion trap while continuously scanning out the ions. The system and method described herein achieves a much higher duty cycle and cycle rate when compared to standard mass spectrometer devices.

Abstract translation: 本公开内容讨论了用于离子阱质谱仪的连续操作的系统和方法。 所描述的系统不会在不同的俘获阶段将离子引入离子阱，而是所描述的系统在连续扫描离子的同时将离子连续地注入到离子阱中。 与标准质谱仪器件相比，本文所述的系统和方法实现了更高的占空比和循环速率。

公开(公告)号：US08664591B2

公开(公告)日：2014-03-04

申请号：US13833785

申请日：2013-03-15

Applicant: Agilent Technologies, Inc.

Inventor： Kenneth Newton

IPC: H01J49/42 ,  H01J49/26

CPC classification number: H01J49/02 ,  H01J49/004 ,  H01J49/40 ,  H01J49/429

Abstract: An ion trap includes a trap exit at which an ion energy adjusting device is located. The adjusting device may be configured for focusing a beam of ions ejected from the trap, reducing the energy distribution of the ions, and/or reducing the average kinetic energy of the ions. The adjusting device may include lenses to which RF and/or DC voltages are applied.

Abstract translation: 离子阱包括离子能量调节装置所在的捕集器出口。 调节装置可以被配置用于聚焦从陷阱喷出的离子束，减少离子的能量分布和/或降低离子的平均动能。 调整装置可以包括施加RF和/或DC电压的透镜。

公开(公告)号：US20140034825A1

公开(公告)日：2014-02-06

申请号：US13833785

申请日：2013-03-15

Applicant: Agilent Technologies, Inc.

Inventor： Kenneth Newton

IPC: H01J49/02

CPC classification number: H01J49/02 ,  H01J49/004 ,  H01J49/40 ,  H01J49/429

Abstract: An ion trap includes a trap exit at which an ion energy adjusting device is located. The adjusting device may be configured for focusing a beam of ions ejected from the trap, reducing the energy distribution of the ions, and/or reducing the average kinetic energy of the ions. The adjusting device may include lenses to which RF and/or DC voltages are applied.

Abstract translation: 离子阱包括离子能量调节装置所在的捕集器出口。 调节装置可以被配置用于聚焦从陷阱喷出的离子束，减少离子的能量分布和/或降低离子的平均动能。 调整装置可以包括施加RF和/或DC电压的透镜。

公开(公告)号：US08637816B1

公开(公告)日：2014-01-28

申请号：US13827685

申请日：2013-03-14

Applicant: Agilent Technologies, Inc.

Inventor： Alexander Mordehai ,  Kenneth R. Newton

IPC: H01J3/00 ,  H01J49/42 ,  H01J49/26 ,  B01D59/44

CPC classification number: H01J49/02 ,  H01J49/004 ,  H01J49/40 ,  H01J49/429

Abstract: A mass spectrum is acquired by accumulating parent ions in an ion trap, ejecting parent ions of a selected m/z ratio into a collision cell, producing fragment ions from the parent ions, and analyzing the fragment ions in a mass analyzer. The other parent ions remain stored in the ion trap, and thus the process may be repeated by mass-selectively scanning parent ions from the ion trap. In this manner, the full mass range of parent ions or any desired subset of the full mass range may be analyzed without significant ion loss or undue time expenditure. The collision cell may provide a large ion acceptance aperture and relatively smaller ion emission aperture. The collision cell may pulse ions out to the mass analyzer. The mass analyzer may be a time-of-flight analyzer. The timing of pulsing of ions out from the collision cell may be matched with the timing of pulsing of ions into the time-of-flight analyzer.

Abstract translation: 通过在离子阱中积聚母体离子获得质谱，将所选择的m / z比的母体离子喷射到碰撞池中，从母体离子产生碎片离子，并分析质量分析器中的碎片离子。 其他母体离子保留在离子阱中，因此可以通过从离子阱中大量选择性地扫描母体离子来重复该过程。 以这种方式，可以分析母体离子的全质量范围或完全质量范围的任何所需子集，而没有显着的离子损失或不适当的时间支出。 碰撞池可以提供大的离子接受孔和相对较小的离子发射孔。 碰撞单元可以将离子脉冲输出到质量分析器。 质量分析仪可以是飞行时间分析仪。 从碰撞池中脉冲离子的时间可以与离子脉冲到飞行时间分析仪的时间相匹配。

公开(公告)号：US20130284919A1

公开(公告)日：2013-10-31

申请号：US13997550

申请日：2010-12-28

Applicant: Kazuo Mukaibatake

Inventor： Kazuo Mukaibatake

IPC: H01J49/42

CPC classification number: H01J49/4215 ,  G01N30/7233 ,  G01N30/8658 ,  H01J49/0027 ,  H01J49/429

Abstract: When an SIM measurement for ions originating from a target component separated by a chromatograph is performed, the measurement is performed while the mass-resolving power is switched among a plurality of levels of resolving power, with the mass-to-charge ratio fixed at a target value (S2), and an extracted ion chromatogram is created based on each of data obtained corresponding to respective mass-resolving powers (S3). After the extracted ion chromatograms are obtained, an S/N ratio is calculated for a peak of the target component on each of the chromatograms (S4), and a mass-resolving power which yields the highest S/N ratio is selected (S5). The selected mass-resolving power is set as the mass-resolving power in the subsequent measurements of the same target component in the same kind of sample (S6), and the quantitative determination of the target component is performed using the extracted ion chromatogram obtained with the selected mass-resolving power (S7).

Abstract translation: 当进行对由色谱仪分离的目标成分的离子进行SIM测定时，在多个分辨能力等级之间切换质量分辨能力的同时进行测定，将质荷比固定为 目标值（S2），并且基于相应于各个质量分辨能力获得的每个数据创建提取的离子色谱图（S3）。 在得到提取的离子色谱图之后，计算每个色谱图上的目标组分的峰的S / N比（S4），并且选择产生最高S / N比的质量分辨率（S5） 。 将所选择的质量分辨能力设定为同一样品样品中相同目标成分的后续测量中的质量分辨能力（S6），并且使用通过提取的离子色谱图 所选择的质量分辨率（S7）。

公开(公告)号：US20130214146A1

公开(公告)日：2013-08-22

申请号：US13589989

申请日：2012-08-20

Applicant: Daisuke OKUMURA

Inventor： Daisuke OKUMURA

IPC: H01J49/00

CPC classification number: H01J49/0009 ,  H01J49/004 ,  H01J49/4215 ,  H01J49/429

Abstract: A mass analysis of a sample having a known mass-to-charge ratio is carried out by performing a scan at a first-stage quadrupole over a predetermined mass range, under the condition that a collision induced dissociation gas is introduced into a collision cell and a voltage applied to a third-stage quadrupole is set so that no substantial mass separation occurs in this quadrupole. Various product ions originating from a precursor ion selected by the first-stage quadrupole arrive at and are detected by a detector without being mass separated. Accordingly, based on the detection data, a data processor can obtain a relationship between the voltage applied to the first-stage quadrupole and the mass-to-charge ratio of the selected ions, with a time delay in the collision cell reflected in that relationship. This relationship is stored in a calibration data memory, to be utilized in a neutral loss scan measurement or the like.

Abstract translation: 具有已知质荷比的样品的质量分析通过在预定质量范围内的第一级四极杆进行扫描，在碰撞诱导的解离气体被引入到碰撞池中的条件下进行， 设置施加到第三级四极的电压，使得在该四极中不发生实质的质量分离。 源自由第一级四极杆选择的前体离子的各种产物离子到达并被检测器检测而不被质量分离。 因此，基于检测数据，数据处理器可以获得施加到第一级四极杆的电压与所选择的离子的质荷比之间的关系，以该关系反映的碰撞单元中的时间延迟 。 该关系存储在校准数据存储器中，以用于中性损失扫描测量等。

公开(公告)号：US08188426B2

公开(公告)日：2012-05-29

申请号：US12993246

申请日：2008-05-22

Applicant: Kazuo Mukaibatake

Inventor： Kazuo Mukaibatake

IPC: H01J49/42

CPC classification number: H01J49/4215 ,  H01J49/429

Abstract: If a scanning rate of a mass scanning is set to be high, the amount of change in an applied voltage between a time of an incidence of a certain ion into a quadrupole mass filter and a time of an emission of the ion therefrom increases. This leads to a change in the condition of a passage of ions, causing the amount of ions to decrease and thereby deteriorating detection sensitivity. In order to avoid this problem, according to the present invention, the values of direct current voltage U and an amplitude V of radio-frequency voltage, both voltages being applied to rod electrodes during a mass scanning, are respectively determined so that a voltage ratio U/V of the voltage U to the amplitude V becomes smaller as the scanning rate becomes higher. Accordingly, in a stability diagram based on the Mathieu equation, the inclination of line L indicating the change in the applied voltage during the mass scanning becomes gradual and the amount of ions passing through the quadrupole mass filter increases particularly when the mass is high.

Abstract translation: 如果质量扫描的扫描速率设定为高，则将特定离子入射到四极质量过滤器中的时间与离子的发射时间之间的施加电压的变化量增加。 这导致离子通过的条件的变化，导致离子的量减少，从而降低检测灵敏度。 为了避免这个问题，根据本发明，分别确定在质量扫描期间施加到杆电极的两个电压的直流电压U和射频电压的振幅V，使得电压比 随着扫描速率变高，电压U与振幅V的U / V变小。 因此，在基于Mathieu方程式的稳定性图中，指示质量扫描期间施加电压变化的线L的倾斜度逐渐变化，并且通过四极质量过滤器的离子的量特别地在质量高时增加。

公开(公告)号：US08053723B2

公开(公告)日：2011-11-08

申请号：US12433459

申请日：2009-04-30

Applicant: Michael W. Senko

Inventor： Michael W. Senko

IPC: G01N21/31 ,  H01J49/00

CPC classification number: H01J49/0031 ,  H01J49/429

Abstract: A mass spectrometer data dependent method and apparatus is introduced to alter scanning parameters based upon data acquired during that scan. Such a method an apparatus may include the identification of ion species of interest meeting user specified criteria so that a determination can be made as to whether or not the present scan is to be continued, terminated, or alternatively paused while such a decision is being made. Such a method of operation saves overall cycle time and allows examination of, for example, marker ion ratios for additional peptides that might otherwise be missed.

Abstract translation: 引入质谱数据相关方法和装置，以便根据扫描期间获得的数据来改变扫描参数。 这种方法一种装置可以包括识别满足用户指定标准的感兴趣的离子种类，使得可以进行关于当前扫描是否要继续，终止或者在进行这样的决定时候暂停的确定 。 这种操作方法节省了整个循环时间，并且允许检查例如另外可能错过的附加肽的标记离子比例。