公开(公告)号：US20030160167A1

公开(公告)日：2003-08-28

申请号：US10134806

申请日：2002-04-29

Inventor： Jean-Luc Truche ,  Jian Bai

IPC: H01J049/00 ,  B01D059/44

CPC classification number: H01J49/164 ,  H01J49/0418 ,  H01J49/0477

Abstract: The present invention relates to an apparatus and method for use with a mass spectrometer. The ion production and enhancement system of the present invention is used to enhance analyte ions for ease of detection in a mass spectrometer. The method of the invention comprises producing and enhancing analyte ions with an ion production and enhancement system and detecting the enhanced analyte ions with a detector.

Abstract translation: 本发明涉及一种与质谱仪一起使用的装置和方法。 本发明的离子生成和增强系统用于增强分析物离子以便于质谱仪中的检测。 本发明的方法包括用离子产生和增强系统生产和增强分析物离子，并用检测器检测增强的分析物离子。

公开(公告)号：US20030160165A1

公开(公告)日：2003-08-28

申请号：US10080879

申请日：2002-02-22

Inventor： Jean-Luc Truche ,  Jian Bai

IPC: H01J049/00 ,  B01D059/44

CPC classification number: H01J49/164 ,  H01J49/0477

Abstract: The present invention relates to an apparatus and method for use with a mass spectrometer. The ion enhancement system of the present invention is used to direct a heated gas toward ions produced by a matrix based ion source and detected by a detector. The ion enhancement system is interposed between the ion source and the detector. The analyte ions that contact the heated gas are enhanced and an increased number of ions are more easily detected by a detector. The method of the invention comprises producing analyte ions from a matrix based ion source, enhancing the analyte ions with an ion enhancement system and detecting the enhanced analyte ions with a detector.

Abstract translation: 本发明涉及一种与质谱仪一起使用的装置和方法。 本发明的离子增强系统用于将加热气体引导到由基于基质的离子源产生的离子并由检测器检测。 离子增强系统介于离子源和检测器之间。 接触加热气体的分析物离子增强，并且更多的离子更容易被检测器检测。 本发明的方法包括从基于基质的离子源产生分析物离子，用离子增强系统增强分析物离子并用检测器检测增强的分析物离子。

公开(公告)号：US20030155497A1

公开(公告)日：2003-08-21

申请号：US10221844

申请日：2003-02-11

Inventor： Yoshiaki Kato

IPC: H01J049/00 ,  B01D059/44

CPC classification number: H01J49/0031 ,  H01J49/0431 ,  H01J49/165

Abstract: Because of a low flow rate of the micro LC/MS, the dead volume or the diameter of a capillary tube must be minimized, and a sample and salt are likely to deposit in the capillary tube, with the result that clogging of the capillary tube and ESI nozzle often occurs. An electrospray ionization mass analysis apparatus and its system of the present invention predicts clogging, permit earlier cleaning or parts replacement, and detect clogging even if it has occurred, thereby suspending measurement and preventing samples from being introduced into an injector, with the result that waste of samples is avoided and effective data is ensured. The aforementioned electrospray ionization mass analysis apparatus directly coupled to the micro LC prevents a micro LC, piping and ESI capillary tube from being clogged, and records an alarm in the data and stops the system whenever clogging has occurred, whereby highly reliable direct coupling with micro LC is ensured. In the aforementioned electrospray ionization mass analysis apparatus and its system, a sample solution from a chromatograph is introduced into a capillary tube, and an electrospray ion source arranged for generating ions under atmospheric pressure generates ions, which are led into a mass spectrometer disposed in a vacuum chamber where the ion is subjected to mass analysis. The current value or strength of the ion having a specified mass in the sample solution is measured, and, when the current value has reduced below a threshold value, an error state is displayed.

Abstract translation: 由于微LC / MS的流速低，毛细管的死体积或直径必须最小化，并且样品和盐可能沉积在毛细管中，导致毛细管堵塞 和ESI喷嘴经常发生。 本发明的电喷雾离子化质量分析装置及其系统预测堵塞，允许更早的清洁或部件更换，并且即使发生堵塞也可以检测到堵塞，从而悬挂测量并防止样品被引入注射器，结果是浪费 避免了样品，确保了有效的数据。 直接耦合到微LC的上述电喷雾电离质量分析装置防止微LC，管道和ESI毛细管被堵塞，并且在数据中记录报警并且每当发生堵塞时停止系统，由此高度可靠的与微观的直接耦合 LC保证。 在上述电喷雾离子化质量分析装置及其系统中，将来自色谱仪的样品溶液引入毛细管中，并且设置用于在大气压下产生离子的电喷雾离子源产生离子，将其引入设置在 真空室，离子进行质量分析。 测定样品溶液中具有特定质量的离子的当前值或强度，并且当当前值降低到阈值以下时，显示错误状态。

公开(公告)号：US20020172618A1

公开(公告)日：2002-11-21

申请号：US10157957

申请日：2002-05-31

Inventor： James E. Moon ,  Timothy J. Davis ,  Gregory J. Galvin ,  Gary A. Schultz ,  Thomas N. Corso ,  Stephen Lowes

IPC: G01N023/06 ,  H01J049/00

CPC classification number: G01N30/6095 ,  G01N30/7266 ,  G01N2030/6013 ,  H01J49/0018 ,  H01J49/167 ,  Y10T436/24 ,  Y10T436/2575

Abstract: An electrospray device, a liquid chromatography device and an electrospray-liquid chromatography system are disclosed. The electrospray device comprises a substrate defining a channel between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle defined by a portion recessed from the ejection surface surrounding the exit orifice, and an electrode for application of an electric potential to the substrate to optimize and generate an electrospray; and, optionally, additional electrode(s) to further modify the electrospray. The liquid chromatography device comprises a separation substrate defining an introduction channel between an entrance orifice and a reservoir and a separation channel between the reservoir and an exit orifice, the separation channel being populated with separation posts perpendicular to the fluid flow; a cover substrate bonded to the separation substrate to enclose the reservoir and the separation channel adjacent the cover substrate; and, optionally, electrode(s) for application of a electric potential to the fluid. The exit orifice of the liquid chromatography device may be homogeneously interfaced with the entrance orifice of the electrospray device to form an integrated single system. An array of multiple systems may be fabricated in a single monolithic chip for rapid sequential fluid processing and generation of electrospray for subsequent analysis, such as by positioning the exit orifices of the electrospray devices near the sampling orifice of a mass spectrometer.

公开(公告)号：US20020162774A1

公开(公告)日：2002-11-07

申请号：US10052891

申请日：2002-01-18

Applicant: The University of Washington

Inventor： Adi A. Scheidemann ,  Kem Robinson ,  Patrick L. Jones ,  Stephen C. Gottschalk

IPC: B03C001/00 ,  H01J049/00

CPC classification number: H01J49/025 ,  H01J49/30

Abstract: A magnetic sector for charged particle beam transport that includes a magnetic field profile that achieves a linear dispersion from a collimated beam of charged particles proportional to their mass-energy-to-charge ratio. In one embodiment, the field profile necessary for the linear dispersion is obtained by the use of shaped, highly permeable poles powered by permanent magnets or electromagnetic coils.

Abstract translation: 用于带电粒子束传输的磁性部分，其包括实现与其质量 - 能量 - 电荷比成比例的带电粒子的准直束的线性色散的磁场分布。 在一个实施例中，通过使用由永磁体或电磁线圈供电的成形的，高可渗透的极点获得线性色散所需的场分布。

公开(公告)号：US20020125424A1

公开(公告)日：2002-09-12

申请号：US10066546

申请日：2002-01-30

Inventor： Richard N. Ellson ,  Mitchell W. Mutz

IPC: H01J049/00

CPC classification number: H01J49/0454 ,  Y10T436/2575

Abstract: The invention relates to the efficient transport of a small volume of fluid, such as may be required by mass spectrometers and other devices configured to process and/or analyze small samples of biomolecular fluids. Such transport involves nozzleless acoustic ejection. In some instances, sample molecules contained in droplets of fluid are introduced from a reservoir into an ionization chamber of an analytical device. In other instances, sample molecules are introduced into a small capillary by directing focused acoustic radiation at a focal point near the surface of a fluid sample. In still other instances, acoustic ejection is used to form an array on a surface, wherein the features of the array are ionized for analysis. The invention may be used with microfluidic devices. Thus, the invention facilitates the processing and/or analysis of various types of samples, such as biomolecules having high molecular weights.

Abstract translation: 本发明涉及小体积流体的有效输送，例如质谱仪可能需要的，以及被配置为处理和/或分析生物分子流体的小样品的其它装置。 这种运输涉及喷嘴无声弹射。 在一些情况下，包含在流体液滴中的样品分子从储器引入分析装置的电离室。 在其他情况下，通过将聚焦声辐射引导到流体样品表面附近的焦点处，将样品分子引入小毛细管中。 在其他情况下，使用声弹出来在表面上形成阵列，其中阵列的特征被电离以便分析。 本发明可以与微流体装置一起使用。 因此，本发明有助于各种类型的样品（例如具有高分子量的生物分子）的加工和/或分析。

公开(公告)号：US20020125423A1

公开(公告)日：2002-09-12

申请号：US09802322

申请日：2001-03-08

Inventor： Daniel D. Ebeling ,  Michael S. Westphall ,  Mark A. Scalf ,  Lloyd M. Smith

IPC: H01J049/00

CPC classification number: H01J49/165 ,  H01J49/044 ,  Y10S977/786 ,  Y10S977/795

Abstract: Methods and devices for use in mass spectral analysis of samples. In particular, methods and devices for generating ions from liquid samples containing chemical species with high molecular masses. These methods and devices provide a continuous or pulsed stream of gas phase analyte ions of either positive polarity, negative polarity or both possessing either a selected fixed charge-state distribution or one that may be selectively varied with time. More specifically, ion sources with adjustable control of the charge-state distribution of the gas phase analyte ions generated are provided in which charged droplets and/or gas phase analyte ions are exposed to electrons and/or gas phase reagent ions generated by a reagent ion source to provide desired control. A corona discharge exemplifies the reagent ion source employed in charge-state distribution control. In a specific preferred ion source, a corona discharge is provided within a shielded region to minimize the deflection of gas phase analyte ions, charged droplets. The methods and devices provided herein are particularly well-suited to the analysis of polymers and biological species.

Abstract translation: 用于样品质谱分析的方法和装置。 特别地，用于从含有高分子量化学物质的液体样品中产生离子的方法和装置。 这些方法和装置提供具有正极性，负极性或具有选定的固定电荷状态分布或可随时间有选择地变化的气相分析离子的连续或脉冲流。 更具体地，提供了可调节控制所产生的气相分析物离子的电荷状态分布的离子源，其中带电液滴和/或气相分析物离子暴露于由试剂离子产生的电子和/或气相试剂离子 来源提供所需的控制。 电晕放电示出了电荷状态分布控制中使用的试剂离子源。 在特定的优选离子源中，在屏蔽区域内提供电晕放电以最小化气相分析物离子带电液滴的偏转。 本文提供的方法和装置特别适用于聚合物和生物物种的分析。

公开(公告)号：US20020092980A1

公开(公告)日：2002-07-18

申请号：US09765251

申请日：2001-01-18

Inventor： Melvin A. Park

IPC: H01J049/00 ,  B01D059/44

CPC classification number: H01J49/063 ,  H01J49/0054 ,  H01J49/401 ,  H01J49/42

Abstract: The invention relates to means and methods for the orthogonal introduction of ions into a TOF mass spectrometer, whereby ions from an ion source can be efficiently transferred via a multipole ion guide such that they can be readily analyzed in a TOF analyzer. The invention includes first introducing ions into an ion guide, preferably an RF/DC ion guide, which guides the ions into a multipole ion trap. Both the ion guide and ion trap are preferably orthogonal to the flight direction of the TOF mass spectrometer. By changing the potentials on the electrodes of the multipole ion trap, the ions may be extracted from the trap in the direction of the flight region. Also, in accordance with the invention, the entrance region of the ion guide is held at moderate pressure to cool the ions to thermal energies. These ions are cooled due to collisions with neutral background gas molecules, thus lowering the energy spread of the ions. Preferably, the invention uses different DC and RF electrodes to trap and extract ions. By minimizing the energy spread of the ions, the invention results in improved performance of any TOF mass spectrometer.

Abstract translation: 本发明涉及用于将离子正交引入TOF质谱仪的方法和方法，其中来自离子源的离子可以通过多极离子导向器有效地传递，使得它们可以在TOF分析仪中容易地分析。 本发明包括首先将离子引入离子导向器中，优选地将RF / DC离子导向器引导到多极离子阱中。 离子导向器和离子阱优选地与TOF质谱仪的飞行方向正交。 通过改变多极离子阱电极上的电位，离子可以从捕获器沿着飞行区域的方向提取。 此外，根据本发明，离子导向器的入口区域保持在中等压力下以将离子冷却成热能。 这些离子由于与中性背景气体分子的碰撞而被冷却，因此降低了离子的能量扩散。 优选地，本发明使用不同的DC和RF电极来捕获和提取离子。 通过最小化离子的能量扩散，本发明导致任何TOF质谱仪的改进的性能。

公开(公告)号：US20020070339A1

公开(公告)日：2002-06-13

申请号：US10074210

申请日：2002-02-12

Inventor： David E. Clemmer

IPC: H01J049/00 ,  B01D059/44

CPC classification number: G01N27/622 ,  H01J49/004 ,  H01J49/38 ,  H01J49/40

Abstract: An ion separation instrument includes an ion source coupled to at least a first ion mobility spectrometer having an ion outlet coupled to a mass spectrometer. In one embodiment, the ion source includes a molecule separation instrument operable to separate ions in time according to a molecular characteristic such as ion retention time. The resultant instrument is thus operable to provide molecular information separated in time as functions of retention time, ion mobility and ion mass/charge. In another embodiment, the ion separation instrument includes first and second ion mobility instruments disposed in a cascade arrangement between the ion source and mass spectrometer, wherein the two ion mobility instruments are operable to separate ions in time each according to different ion mobility functions. For example, the two ion mobility instruments may have different flight tube lengths, operate at different temperatures, operate in the presence of different electric fields and/or operate in the presence of different gases. The resultant instrument is thus operable to provide molecular information separated in time according to at least two different functions of ion mobility as well as ion mass/charge.

公开(公告)号：US20020066857A1

公开(公告)日：2002-06-06

申请号：US09935909

申请日：2001-08-23

Inventor： Barbara J. Hughey ,  Paul L. Skipper ,  John S. Wishnok ,  Ruth E. Shefer ,  John T. Mehl ,  Steven R. Tannenbaum

IPC: H01J049/00

CPC classification number: H01J49/0463 ,  G01N30/7233 ,  G01N2030/8405 ,  H01J49/0445

Abstract: An interface system for introducing a non-gaseous sample as a predetermined gaseous form into an analytical instrument which comprises a substrate that receives the non-gaseous sample and a directed energy source that heats at least a portion of said substrate containing the non-gaseous sample to convert the sample to the predetermined gaseous form.

Abstract translation: 一种用于将非气态样品作为预定气体形式引入到分析仪器中的界面系统，该分析仪器包括接收非气态样品的基底和加热含有非气态样品的所述基底的至少一部分的定向能量源 以将样品转化为预定的气体形式。