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    DYNAMIC EJECTION DELAY TIME FOR ACOUSTIC EJECTION MASS SPECTROMETRY
    2.
    发明公开
    DYNAMIC EJECTION DELAY TIME FOR ACOUSTIC EJECTION MASS SPECTROMETRY 审中-公开

    公开(公告)号：US20240038518A1

    公开(公告)日：2024-02-01

    申请号：US18258359

    申请日：2021-12-22

    Applicant: DH Technologies Development Pte. Ltd.

    Inventor： Chang LIU ,  Hui ZHANG

    IPC: H01J49/04 ,  H01J49/00

    CPC classification number: H01J49/0454 ,  H01J49/0031

    Abstract: A method of ejecting a plurality of samples from a well plate includes receiving a first sample intensity prediction associated with a first sample in a first well of the well plate. A second sample intensity prediction associated with a second sample in a second well is also received. The second sample intensity prediction is less than the first sample intensity prediction. An ejection time delay value for a subsequent analysis of the first sample and the second sample is determined, based at least in part on the second sample intensity prediction. Thereafter, the first sample is acoustically ejected from the first well, and the second sample is acoustically ejected from the second well.

    Focused acoustic radiation for the ejection of sub wavelength droplets
    3.
    发明授权
    Focused acoustic radiation for the ejection of sub wavelength droplets 有权

    公开(公告)号：US11717818B2

    公开(公告)日：2023-08-08

    申请号：US17321201

    申请日：2021-05-14

    Applicant: Labcyte Inc.

    Inventor： Richard G. Stearns

    IPC: H01J49/04 ,  B01L3/02

    CPC classification number: B01L3/0268 ,  H01J49/0454 ,  B01L2200/0642 ,  B01L2200/141 ,  B01L2400/0436

    Abstract: Focused acoustic radiation, referred to as tonebursts, are applied to a volume of liquid to generate a set of droplets. The droplets generated are substantially smaller in scale than the focal spot size of the acoustic beam (e.g., the frequency at which the acoustic transducer operates). Further, the droplets have trajectories that are substantially in the direction of the acoustic beam propagation direction. In one embodiment, a first toneburst is applied to temporarily raise a protuberance on a free surface of the fluid. After the protuberance has reached a certain state, a second toneburst is applied to the protuberance to break it into very small droplets. In one embodiment, the state of the protuberance at which the second toneburst is supplied is the time period shortly after the protuberance reaches its maximum height but before the protuberance recedes back into the volume of fluid.

    Identification of a First Sample in a Series of Sequential Samples
    4.
    发明公开
    Identification of a First Sample in a Series of Sequential Samples 审中-公开

    公开(公告)号：US20230238232A1

    公开(公告)日：2023-07-27

    申请号：US17999635

    申请日：2021-05-21

    Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

    Inventor： David M. Cox ,  Chang Liu ,  Stephen A. Tate

    IPC: H01J49/04 ,  H01J49/00

    CPC classification number: H01J49/0454 ,  H01J49/0404 ,  H01J49/0009 ,  H01J49/0027

    Abstract: An ADE device identifies an identifiable sequence of one or more ejections from at least one sample using a different value or pattern of values for one or more ADE parameters. The identifiable one or more ejections are performed to produce one or more mass peaks that have a different feature value or pattern of feature values for one or more peak features than other mass peaks produced. Ejection times are stored. One or more detected peaks with the different feature values or pattern of feature values are identified as produced by the identifiable one or more ejections. A delay time is calculated from the time of the identifiable ejections and the time of the identified detected peaks and the peaks are aligned with samples using delay time, stored times, and order of the samples.

    Ionization method, mass spectrometry method, extraction method, and purification method
    6.
    发明授权
    Ionization method, mass spectrometry method, extraction method, and purification method 有权
    电离法，质谱法，提取方法和纯化方法

    公开(公告)号：US09190257B2

    公开(公告)日：2015-11-17

    申请号：US13972063

    申请日：2013-08-21

    Applicant: A SCHOOL CORPORATION KANSAI UNIVERSITY ,  CANON KABUSHIKI KAISHA

    Inventor： Yoichi Otsuka ,  Ryuichi Arakawa

    IPC: H01J49/10 ,  H01J49/16 ,  H01J49/04

    CPC classification number: H01J49/165 ,  H01J49/0454

    Abstract: The present invention has an object to achieve soft ionization more easily when a slight amount of substance is ionized under an atmosphere pressure. The present invention provides an ionization method for a substance contained in a liquid, including: supplying the liquid to a substrate from a probe and forming a liquid bridge made of the liquid containing the substance dissolved therein, between the probe and the substrate; oscillating the substrate; and generating an electric field between an electrically conductive portion of the probe in contact with the liquid and an ion extraction electrode.

    Abstract translation: 本发明的目的是在大气压下将少量物质电离时，更容易实现软电离。 本发明提供一种液体中所含物质的离子化方法，包括：从探针供应液体至基底，并形成由溶解于其中的物质形成的液体桥;探针与基底之间; 振荡基板; 以及在与液体接触的探针的导电部分和离子提取电极之间产生电场。

    Methods and systems for mass spectrometry
    7.
    发明授权
    Methods and systems for mass spectrometry 有权
    质谱方法和系统

    公开(公告)号：US08415619B2

    公开(公告)日：2013-04-09

    申请号：US13296793

    申请日：2011-11-15

    Applicant: David R. Goodlett ,  Scott R. Heron ,  Jonathan Cooper

    Inventor： David R. Goodlett ,  Scott R. Heron ,  Jonathan Cooper

    IPC: H01J49/26 ,  G01N23/00

    CPC classification number: H01J49/0454 ,  H01J49/0031

    Abstract: The present invention relates generally to mass spectrometry. The present invention relates more particularly to methods and systems for use in mass spectrometric identification of a variety of analytes, including high molecular weight species such as proteins. One embodiment of the invention is a method for analyzing an analyte. The method includes nebulizing a suspension of the analyte in a solvent with a surface acoustic wave transducer; and performing mass spectrometry on the nebulized suspension. The surface acoustic wave transducer can be used, for example, to transfer non-volatile peptides and proteins (as well as other analyztes, such as oligonucleotides and polymers) to the gas phase at atmospheric pressure. Nebulization using surface acoustic waves can be conducted in a discontinuous or pulsed mode, similar to that used in MALDI, or in a continuous mode, as in ESI.

    Abstract translation: 本发明一般涉及质谱法。 本发明更具体地涉及用于各种分析物（包括高分子量物质如蛋白质）的质谱鉴定中的方法和系统。 本发明的一个实施方案是分析分析物的方法。 该方法包括将分析物在溶剂中的悬浮液与表面声波换能器雾化; 并对雾化悬浮液进行质谱分析。 例如，表面声波换能器可以用于将大气压下的非挥发性肽和蛋白质（以及其它分析物，例如寡核苷酸和聚合物）转移到气相中。 使用表面声波的雾化可以以不连续或脉冲模式进行，类似于在MALDI中使用的模式，或者以连续模式进行，如在ESI中。

    Methods And Systems For Mass Spectrometry
    8.
    发明申请
    Methods And Systems For Mass Spectrometry 有权
    质谱法和系统

    公开(公告)号：US20120145890A1

    公开(公告)日：2012-06-14

    申请号：US13296793

    申请日：2011-11-15

    Applicant: David R. Goodlett ,  Scott R. Heron ,  Jonathan Cooper

    Inventor： David R. Goodlett ,  Scott R. Heron ,  Jonathan Cooper

    IPC: H01J49/26

    CPC classification number: H01J49/0454 ,  H01J49/0031

    Abstract: The present invention relates generally to mass spectrometry. The present invention relates more particularly to methods and systems for use in mass spectrometric identification of a variety of analytes, including high molecular weight species such as proteins. One embodiment of the invention is a method for analyzing an analyte. The method includes nebulizing a suspension of the analyte in a solvent with a surface acoustic wave transducer; and performing mass spectrometry on the nebulized suspension. The surface acoustic wave transducer can be used, for example, to transfer non-volatile peptides and proteins (as well as other analyztes, such as oligonucleotides and polymers) to the gas phase at atmospheric pressure. Nebulization using surface acoustic waves can be conducted in a discontinuous or pulsed mode, similar to that used in MALDI, or in a continuous mode, as in ESI.

    Abstract translation: 本发明一般涉及质谱法。 本发明更具体地涉及用于各种分析物（包括高分子量物质如蛋白质）的质谱鉴定中的方法和系统。 本发明的一个实施方案是分析分析物的方法。 该方法包括将分析物在溶剂中的悬浮液与表面声波换能器雾化; 并对雾化悬浮液进行质谱分析。 例如，表面声波换能器可以用于将大气压下的非挥发性肽和蛋白质（以及其它分析物，例如寡核苷酸和聚合物）转移到气相中。 使用表面声波的雾化可以以不连续或脉冲模式进行，类似于在MALDI中使用的模式，或者以连续模式进行，如在ESI中。

    Acoustic sample introduction for mass spectrometric analysis
    9.
    发明授权
    Acoustic sample introduction for mass spectrometric analysis 有权

    公开(公告)号：US06603118B2

    公开(公告)日：2003-08-05

    申请号：US09784705

    申请日：2001-02-14

    Applicant: Richard N. Ellson ,  Mitchell W. Mutz

    Inventor： Richard N. Ellson ,  Mitchell W. Mutz

    IPC: H01J4904

    CPC classification number: H01J49/0454 ,  Y10T436/2575

    Abstract: The invention relates to the efficient transport of a small fluid sample such as that may be required by analytical devices such as mass spectrometers configured to analyze small samples of biomolecular fluids. Such transport involves nozzleless acoustic ejection, wherein analyte molecules are introduced from a reservoir holding a fluid into an ionization chamber of an analytical device or a small capillary by directing focused acoustic radiation at a focal point near the surface of the fluid sample. This facilitates the analysis of various types of analytes such as biomolecular analytes having a high molecular weight.

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