公开(公告)号：US20230399744A1

公开(公告)日：2023-12-14

申请号：US18126948

申请日：2023-03-27

Applicant: AGILENT TECHNOLOGIES, INC.

Inventor： Elizabeth CARR ,  Frank STRELLER ,  Li-Chih HU ,  David Michael LYNCH ,  Richard CLOSSER

IPC: C23C16/455 ,  C23C16/40 ,  C23C16/44 ,  C23C16/52

CPC classification number: C23C16/45542 ,  C23C16/402 ,  C23C16/4412 ,  C23C16/45502 ,  C23C16/4404 ,  C23C16/45548 ,  C23C16/45565 ,  C23C16/52

Abstract: A device, including a hydrophilic layer on a portion of an inner surface of a transparent polymer forming a body; wherein the hydrophilic layer includes a sulfonated inner surface of the transparent polymer, a silica, a silicon oxycarbide, an O2 plasma treatment of the transparent polymer, or a combination thereof. The device can be a nebulizer or a spray chamber, for example used in an inductively coupled plasma device. A method of making the device is also disclosed.

公开(公告)号：US11835495B2

公开(公告)日：2023-12-05

申请号：US17566330

申请日：2021-12-30

Applicant: Agilent Technologies, Inc.

Inventor： Daniel Thielsch ,  Thomas Ortmann ,  Sam Wouters

IPC: G01N30/20 ,  G01N30/32 ,  G01N30/02

CPC classification number: G01N30/20 ,  G01N30/32 ,  G01N2030/027 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/328

Abstract: An injector, for injecting a fluidic sample into a flow path between a fluid drive and a sample separation unit, includes a sample accommodation volume, a sample drive, and a fluidic valve switchable to selectively couple the volume with the flow path or decouple the volume from the flow path. In an injection switching state, the fluid drive, the separation unit and the sample drive are coupled by the valve so that fluid driven by the sample drive and flowing from the volume to the separation unit and further fluid driven by the fluid drive and flowing from the fluid drive to the separation unit are combined at a fluidic connection upstream of the separation unit. A control unit controls a pressure of the fluid and/or the further fluid during injecting.

公开(公告)号：US20230368504A1

公开(公告)日：2023-11-16

申请号：US18170878

申请日：2023-02-17

Applicant: Agilent Technologies, Inc.

Inventor： Frederik AIDT

IPC: G06V10/774 ,  G06T7/00 ,  G06T7/33

CPC classification number: G06V10/774 ,  G06T7/0014 ,  G06T7/344 ,  G06T2207/10056 ,  G06T2207/10064 ,  G06T2207/20081 ,  G06T2207/20084 ,  G06T2207/30024

Abstract: There is provided a computer implemented method for training a virtual stainer machine learning model, comprising: creating an imaging multi-record training dataset, wherein a record comprises: a first image of a sample of tissue of a subject stained with a removable stain, and a ground truth indicated by a second image of the sample of tissue of the subject stained with a permanent stain, and training a virtual stainer machine learning model on the imaging multi-record training dataset for generating a virtual image depicting the permanent stain in response to an input image depicting the removable stain.

公开(公告)号：USD1004453S1

公开(公告)日：2023-11-14

申请号：US29840058

申请日：2022-05-25

Applicant: AGILENT TECHNOLOGIES, INC.

Designer： Lucas Serge ,  Wei J. Song ,  Eileen Huang ,  Olga Schikurski ,  Kathleen Noblet

Abstract: FIG. 1 is a perspective view, in an expanded position, of the column depth measuring guide;
FIG. 2 is a second perspective view thereof;
FIG. 3 is a rear plan view thereof;
FIG. 4 is a front plan view thereof;
FIG. 5 is a left side elevation view thereof;
FIG. 6 is a right side elevation view thereof;
FIG. 7 is a top plan view thereof;
FIG. 8 is a bottom plan view thereof;
FIG. 9 is a perspective view of FIG. 1, in a collapsed position;
FIG. 10 is a second perspective view thereof;
FIG. 11 is a rear plan view thereof;
FIG. 12 is a front plan view thereof;
FIG. 13 is a left side elevation view thereof;
FIG. 14 is a right side elevation view thereof;
FIG. 15 is a top plan view thereof; and,
FIG. 16 is a bottom plan view thereof.
The broken lines are included for the purpose of depicting portions of the column depth measuring guide that form no part of the claimed design.

公开(公告)号：US20230356226A1

公开(公告)日：2023-11-09

申请号：US18023961

申请日：2021-07-30

Applicant: AGILENT TECHNOLOGIES, INC.

Inventor： Curt A. FLORY ,  Dustin CHANG ,  Kelly KROEGER

IPC: B01L3/00

CPC classification number: B01L3/502784 ,  B01L2200/0621 ,  B01L2200/0673 ,  B01L2300/087 ,  B01L2400/0415

Abstract: A microfluidic apparatus for forming one or more droplets of an aqueous fluid suspended in a non-aqueous fluid is described. The microfluidic apparatus includes a first microfluidic channel configured for flowing an aqueous fluid through the first microfluidic channel and a second microfluidic channel fluidically connected to the first microfluidic channel and adapted to flow a non-aqueous fluid through the second microfluidic channel into the first microfluidic channel. A microfluidic reservoir fluidically connected to the first microfluidic channel and configured to receive a plurality of droplets of the first aqueous fluid. The microfluidic apparatus further includes a first electrode and a second electrode positioned such that application of voltage to the first electrode moves one or more droplets of the aqueous fluid in a first direction and application of voltage to the second electrode moves one or more droplets of the aqueous fluid in a second direction.

公开(公告)号：US11808742B2

公开(公告)日：2023-11-07

申请号：US17446096

申请日：2021-08-26

Applicant: Agilent Technologies, Inc.

Inventor： Konstantin Shoykhet ,  Stephan Buckenmaier

IPC: G01N30/46 ,  G01N30/14 ,  G01N30/32 ,  G01N30/02

CPC classification number: G01N30/46 ,  G01N30/14 ,  G01N30/32 ,  G01N2030/027 ,  G01N2030/324 ,  G01N2030/326

Abstract: A multi-dimensional liquid chromatography system includes first and second liquid chromatography systems. The first system is configured for providing a first chromatographic separation of a sample fluid comprised in a first mobile phase and to provide a first effluent including at least a portion of the separated sample fluid. The second system is configured for providing a second chromatographic separation of at least a portion of the first effluent comprised in a second mobile phase. A control unit is configured to operate the first liquid chromatography system by maintaining a first flow rate of the first mobile phase substantially constant during the first chromatographic separation, and to operate the second liquid chromatography system during the second chromatographic separation according to a control value different from the second flow rate, so that a variation in the control value can lead to a variation in the second flow rate.

公开(公告)号：US11808370B2

公开(公告)日：2023-11-07

申请号：US16929062

申请日：2020-07-14

Applicant: Agilent Technologies, Inc.

Inventor： Clemens Plachetka ,  Manfred Berndt ,  Konstantin Shoykhet

IPC: F16K29/00 ,  F16K11/00 ,  G01N30/16 ,  G01N30/34 ,  G01N30/80 ,  B01F33/452 ,  G01N30/02 ,  B01F101/23

CPC classification number: F16K19/00 ,  B01F33/452 ,  F16K29/00 ,  G01N30/16 ,  G01N30/34 ,  G01N30/80 ,  B01F2101/23 ,  G01N2030/027 ,  G01N2030/347

Abstract: A mixer for mixing a mobile phase in a sample separation device for separating a fluidic sample, wherein the mixer includes a fluid inlet for supplying the mobile phase to be mixed to a mixing volume, a movable body configured for rotating and axially moving in the mixing volume to thereby mix the mobile phase, and a fluid outlet for supplying the mixed mobile phase to a mobile phase consumer.

公开(公告)号：US20230331865A1

公开(公告)日：2023-10-19

申请号：US18023280

申请日：2021-08-25

Applicant: Agilent Technologies, Inc.

Inventor： Morten Dræby SØRENSEN ,  Lasse RAMSGAARD

IPC: C07K16/30 ,  G01N33/58 ,  G01N33/574

CPC classification number: C07K16/30 ,  G01N33/57423 ,  G01N33/58 ,  C07K2317/20 ,  C07K2317/34 ,  G01N2474/20

Abstract: In alternative embodiments, provided are chimeric or recombinant rabbit antihuman p40 (p63 isoform DeltaNp63, or ΔNp63) antibodies, including products of manufacture and kits comprising them, and methods for making and using them, where the antibodies can be used for in vitro diagnostics by immunohistochemistry (IHC). In alternative embodiments, antibodies as provided herein are used in IHC protocols to diagnose a cancer, for example, a squamous-cell carcinoma (SCC) or a lung cancer such as non-small cell lung carcinoma (NCSLC) or pulmonary SCC.

公开(公告)号：US20230322742A1

公开(公告)日：2023-10-12

申请号：US17971421

申请日：2022-10-21

Applicant: Agilent Technologies, Inc.

Inventor： Douglas J. DELLINGER ,  Joel MYERSON ,  Brian SMART

IPC: C07D405/12 ,  C07D317/34 ,  C07D403/06 ,  C07H21/02

CPC classification number: C07D405/12 ,  C07D317/34 ,  C07D403/06 ,  C07H21/02 ,  C07H1/06

Abstract: Compounds and methods for purifying oligonucleotides such as RNA and DNA. A target oligonucleotide is reacted with an orthoester linker comprising an affinity tag to form an orthoester oligonucleotide-orthoester linker conjugate which is subjected to a purification technique to separate the target oligonucleotide from impurities such as truncated oligonucleotides. The orthoester linker can be then removed under mild conditions to generate the target oligonucleotide in high purity.

公开(公告)号：US20230303398A1

公开(公告)日：2023-09-28

申请号：US18319985

申请日：2023-05-18

Applicant: AGILENT TECHNOLOGIES, INC.

Inventor： Ta-Chen WEI

IPC: C01B33/18 ,  C09C1/30

CPC classification number: C01B33/18 ,  C09C1/3072 ,  C09C1/309 ,  C09C1/3045 ,  C01P2004/62 ,  C01P2006/14 ,  C01P2006/12 ,  C01P2004/61

Abstract: There is disclosed a method of producing etched non-porous particles. The method includes, in some examples, coating a non-porous particle with a hydrophilic polymer and treating the coated particle with acid or base. Also provided is etched non-porous particles capable of separating a variety of analytes, including biomolecules.