公开(公告)号：US20240148027A1

公开(公告)日：2024-05-09

申请号：US18411486

申请日：2024-01-12

Applicant: Duke University

Inventor： Warren M. Grill ,  James A. Hokanson ,  Christopher L. Langdale

IPC: A23L2/54 ,  A23L2/40 ,  B01F23/2361 ,  B65B3/04

CPC classification number: A23L2/54 ,  A23L2/40 ,  B01F23/23611 ,  B65B3/04

Abstract: The present disclosure provides a device for state-dependent pudendal nerve stimulation for bladder control in a subject and methods of making and using the same.

公开(公告)号：US20240141341A1

公开(公告)日：2024-05-02

申请号：US18279996

申请日：2022-03-01

Applicant: Duke University

Inventor： Charles A. Gersbach ,  Alejandro Barrera ,  Tyler S. Klann ,  Maria ter Weele ,  Gregory E. Crawford ,  Timothy E. Reddy

IPC: C12N15/113 ,  A61K38/00 ,  C12N9/22

CPC classification number: C12N15/113 ,  C12N9/22 ,  A61K38/00 ,  C12N2310/20 ,  C12N2320/12

Abstract: Disclosed herein am compositions and methods for targeting a novel regulatory element of agene. The compositions may be used in methods of modifying growth of a cell, decreasing cell fitness, increasing cell fitness, and/or treating cancer such as leukemia.

公开(公告)号：US20240132833A1

公开(公告)日：2024-04-25

申请号：US18187102

申请日：2023-03-20

Applicant: Duke University

Inventor： Michael Lynch ,  Jeovanna Rios

IPC: C12N1/20 ,  C12N9/88 ,  C12N15/113 ,  C12N15/52

CPC classification number: C12N1/205 ,  C12N9/88 ,  C12N15/113 ,  C12N15/52 ,  C12R2001/19

Abstract: Methods and microorganisms for improved malonyl-CoA flux and production of products having malonyl-CoA as a precursor. The methods comprise dynamically regulating, in a stationary phase of a method, a nitrogen regulatory protein. The methods may dynamically regulate more than one gene.

公开(公告)号：US20240131197A1

公开(公告)日：2024-04-25

申请号：US18547332

申请日：2022-02-24

Applicant: Duke University

Inventor： Aravind Asokan ,  Rita Meganck

IPC: A61K48/00 ,  C12N15/86

CPC classification number: A61K48/0066 ,  C12N15/86 ,  C12N2750/14143 ,  C12N2770/24122 ,  C12N2770/24143

Abstract: Disclosed herein are compositions comprising one or more subgenomic Flavivirus RNA (sfRNA) elements and using those compositions in methods of improving mRNA transcript stability, improving mRNA transcript translation efficiency, enhancing gene therapy, and treating and/or preventing a disease or disorder.

公开(公告)号：US20240124878A1

公开(公告)日：2024-04-18

申请号：US18547688

申请日：2022-02-25

Applicant: DUKE UNIVERSITY

Inventor： Aravind Asokan ,  David Fiflis

IPC: C12N15/113 ,  C12N9/22

CPC classification number: C12N15/113 ,  C12N9/22 ,  C12N2310/20 ,  C12N2320/33

Abstract: Disclosed herein are compositions for and methods of generating chimeric RNA molecules and methods of treating and/or preventing a genetic disease or disorder using chimeric RNA molecules.

公开(公告)号：US20240120125A1

公开(公告)日：2024-04-11

申请号：US18107942

申请日：2023-02-09

Applicant: DUKE UNIVERSITY

Inventor： Shilin HUANG ,  Ye WANG ,  Kenneth BROWN

IPC: G21K1/00 ,  G06N10/20

CPC classification number: G21K1/003 ,  G06N10/20

Abstract: Technologies for suppressing effects of crosstalk in a quantum circuit of a quantum computing system are disclosed. A pair of target qubits on which to perform a quantum gate operation is selected. The quantum gate operation is performed. A rotation is induced on the target qubits such that crosstalk between any of the target qubits and any of the neighboring qubits in the quantum circuit is canceled out.

公开(公告)号：US20240115185A1

公开(公告)日：2024-04-11

申请号：US18376919

申请日：2023-10-05

Applicant: Duke University

Inventor： Olaf T. Von Ramm ,  John C. Moore

IPC: A61B5/346 ,  G06T5/50 ,  G06T7/00 ,  G06V10/25 ,  G06V10/60 ,  G06V10/75

CPC classification number: A61B5/346 ,  G06T5/50 ,  G06T7/0012 ,  G06V10/25 ,  G06V10/60 ,  G06V10/751 ,  G06T2207/20224 ,  G06T2207/30048

Abstract: A method of providing a regional motion display includes receiving a set of temporal images of a target area, generating a set of temporal difference images from the set of temporal images and generating a regional motion display from the set of temporal difference images. The regional motion display includes a representative line through the target area along a y-axis and an x-axis representing time. The method further includes displaying the regional motion display. In some cases, generating the regional motion display includes calculating, for each y-axis pixel, an integral of all pixels along a perpendicular or non-perpendicular line to the target area, a contour along the target area, or a surface of the target area in a temporally corresponding difference image of the set of temporal difference images in a difference image and assigning, for each y-axis pixel, the integral of all pixels as a pixel value.

公开(公告)号：US20240108852A1

公开(公告)日：2024-04-04

申请号：US17768454

申请日：2020-10-14

Applicant: Duke University

Inventor： Carmelo A. Milano

IPC: A61M25/00 ,  A61M1/16 ,  A61M1/36

CPC classification number: A61M25/0026 ,  A61M1/1698 ,  A61M1/3659 ,  A61M25/0045

Abstract: A catheter system with two lumens (e.g., a major lumen and a minor lumen) that can be inserted peripherally into the left heart. The major lumen is used for venting, or blood volume removal, and the minor lumen is used to deliver a treatment substance directly to the left heart. In particular, the minor lumen can be used to deliver an anticoagulation medication directly to the left ventricle. The major lumen can be incorporated into an ECMO system.

公开(公告)号：US20240101642A1

公开(公告)日：2024-03-28

申请号：US18522688

申请日：2023-11-29

Applicant: Duke University

Inventor： Robert J. Lefkowitz ,  Seungkirl Ahn ,  Biswaranjan Pani ,  Alem W. Kahsai ,  Laura Wingler ,  Dean Staus

IPC: C07K14/72 ,  C07K14/47 ,  C07K14/705 ,  C07K19/00 ,  G01N33/68

CPC classification number: C07K14/723 ,  C07K14/4703 ,  C07K14/70567 ,  C07K14/70571 ,  C07K19/00 ,  G01N33/6872 ,  C07K2319/00 ,  C07K2319/70 ,  G01N2333/726 ,  G01N2500/02 ,  G01N2500/04 ,  G01N2500/10

Abstract: The disclosure is directed to a G-protein coupled receptor complex. The complex includes (i) a chimeric G protein-coupled receptor (GPCR) comprising a non-native amino acid sequence located within the C-terminus of the GPCR and a synthetic phosphopeptide ligated to the non-native amino acid sequence; and (ii) a β-arrestin (βarr) protein bound to the C-terminus of the GPCR. The disclosure also provides an in vitro method for producing the aforementioned complex, as well as methods for identifying compounds or ligands which bind to and modulate the activity of the complex. Positive allosteric modulators of the β2 adrenergic receptor identified by screening a DNA-encoded library potentiate the activity of β2 agonists and have application in the treatment of obstructive airway disease, bronchospasm, or pre-term labor.

公开(公告)号：US11931562B2

公开(公告)日：2024-03-19

申请号：US17336017

申请日：2021-06-01

Applicant: Duke University

Inventor： Boyla Mainsah ,  Priyesh Patel ,  Leslie M. Collins ,  Ravi Karra ,  Emma LaPorte ,  Xinlin Chen

IPC: A61M60/00 ,  A61M60/178 ,  A61M60/216 ,  A61M60/515 ,  A61M60/538 ,  G10L21/0232 ,  G10L25/18 ,  G10L25/21 ,  G10L25/66 ,  G16H40/67

CPC classification number: A61M60/515 ,  A61M60/178 ,  A61M60/216 ,  A61M60/538 ,  G10L21/0232 ,  G10L25/18 ,  G10L25/21 ,  G10L25/66 ,  G16H40/67 ,  A61M2205/3365 ,  A61M2205/3375 ,  A61M2205/50 ,  A61M2230/04

Abstract: Disclosed are systems and techniques for determining an acoustic biomarker. For example, a precordial sound recording that includes at least a first sound component corresponding to a heart and a second sound component corresponding to a left ventricular assist device (LVAD) can be obtained. At least a portion of the second sound component corresponding to the LVAD can be filtered from the precordial sound recording to yield a filtered precordial sound recording. Based on the filtered precordial sound recording, at least one acoustic biomarker can be determined.