Abstract:
The present invention provides methods of synthesizing libraries of molecules comprising a functional moiety which is operatively linked to an encoding oligonucleotide, wherein the encoding oligonucleotide comprises a capping sequence containing degenerate nucleotides. The methods generally include providing a solution comprising initiator compounds comprising an initial functional moiety comprising n building blocks which is operatively linked to an initial oligonucleotide; dividing the solution into reaction vessels; reacting the initiator compounds in each reaction vessel with a building block comprising a complementary reactive group to form a covalent bond; and reacting the initial oligonucleotide in each aliquot with a distinct incoming oligonucleotide in the presence of an enzyme which catalyzes the ligation of the incoming oligonucleotide and the initial oligonucleotide, under conditions suitable for enzymatic ligation of the incoming oligonucleotide and the initial oligonucleotide to form an encoding oligonucleotide.
Abstract:
Methods and systems for analyzing a macromolecule for potential binding sites are disclosed. Multiple molecular species and a free energy value may be selected. An operation for a molecular fragment of one of the molecular species may be selected from insertion, deletion and movement operations. The selected operation may be performed on a computer representation of an instance of a molecular fragment at one of a plurality of binding sites based on a grand canonical ensemble probability density function associated with the selected operation. Information may be stored pertaining to the plurality of binding sites. The operation selecting, performing and information storing operations may be performed multiple times. Multiple occupation probabilities may be provided based on the stored information. The occupation probabilities may include, for each molecular species, a probability that an instance of a molecular fragment of the molecular species resides at a binding site.
Abstract:
An apparatus, system and method for providing electronic dispersion compensation. In one embodiment an apparatus may include an analog-to-digital converter and a plurality of adaptive filters arranged in parallel. The analog-to-digital converter may output blocks of samples, associated portions of which may be provided as inputs to the filters. Data combining circuitry may receive each of the associated outputs and provide a digital signal output. Of course, many alternatives, variations, and modifications are possible without departing from this embodiment.
Abstract:
A computer readable storage medium includes executable instructions to store load data in new rows of an append only table within a data warehouse, without updating or deleting existing rows in the append only table. The new rows are added in a database transaction that guarantees that the distributed reads and writes of all transactions are processed reliably and that the transactions obey snapshot isolation rules. Data changes associated with the load data are maintained in a separate update table. Data from the append only table is merged with data changes from the update table to supply read data.
Abstract:
A system for heating a stator segment includes a first frame member, a plurality of arms extending radially from the first frame member, and a heater releasably connected to each arm. The system further includes a biasing element for biasing each heater away from the first frame member.
Abstract:
An apparatus for cleaning an inner surface of a slot includes a first block segment that has an outer perimeter that conforms to and fits inside the inner surface of the slot. A first cleaning pad is connected to the first block segment and extends beyond at least a portion of the outer perimeter of the first block segment.
Abstract:
An apparatus includes a sheet of circuit board material, at least one electrically conductive trace positioned on the sheet of circuit board material, and at least one electrically conductive contact pad positioned on the sheet of circuit board material and coupled to the at least one electrically conductive trace. The apparatus further includes at least one deformation point configured to absorb stresses developed in the sheet of circuit board material when the sheet of circuit board material experiences resistance to expansion or compression caused by connection to an object resisting expansion or compression.