公开(公告)号：US11061022B2

公开(公告)日：2021-07-13

申请号：US15160578

申请日：2016-05-20

Applicant: Labrador Diagnostics LLC

Inventor： Tammy Burd ,  Ian Gibbons ,  Elizabeth A. Holmes ,  Gary Frenzel ,  Anthony Joseph Nugent

IPC: G01N33/53 ,  G01N33/543 ,  B01J19/00 ,  B01L3/02 ,  B01L3/00 ,  G01N35/02 ,  B01L9/00 ,  G16H10/40 ,  G01N1/38 ,  G01N33/569 ,  A61B5/15 ,  A61B5/151 ,  G01N35/10 ,  B01L7/00 ,  G01N33/68 ,  G01N33/94 ,  G01N35/00 ,  G01N33/574 ,  A61B10/00 ,  A61B10/02

Abstract: The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.

公开(公告)号：US11054432B2

公开(公告)日：2021-07-06

申请号：US15461081

申请日：2017-03-16

Applicant: Labrador Diagnostics LLC

Inventor： Elizabeth A. Holmes ,  Joy Roy ,  Peter Kardassakis

IPC: C12Q1/00 ,  C12Q1/68 ,  C12Q1/02 ,  C12Q1/28 ,  G01N33/48 ,  G01N30/02 ,  G01N35/02 ,  G01N35/00 ,  G01N33/559 ,  G01N33/566 ,  G01N33/86

Abstract: Systems and methods are provided for sample processing. The system, in one configuration, includes a sample processing apparatus for use with a biological sample and/or a reagent, a housing and a touchscreen display mounted to the housing. The system, in one configuration, contains a cartridge insertion location; at least one optical detector; a control unit having a processor that is programmed to execute computer-readable commands; and a sample handling system.

公开(公告)号：US20210029007A1

公开(公告)日：2021-01-28

申请号：US16989011

申请日：2020-08-10

Applicant: Labrador Diagnostics LLC

Inventor： Elizabeth A. Holmes

IPC: H04L12/26 ,  G16H10/20 ,  H04W76/18 ,  H04L12/24 ,  H04L12/707 ,  H04L12/703 ,  H04L12/911 ,  G06F13/00 ,  H04L29/08

Abstract: The disclosure provides methods, systems, and computer readable media for calibrating user responses to questions. The method may comprise presenting, with the aid of a computer system and an interactive display operatively coupled to the computer system, a query to a user. The query may relate to the user's dietary consumption, exercise, health condition or mental condition. The system may receive from the user a response to the query. The system may interpret a user's response to a query based on a set of reference information. The set of reference information may comprise a pictorial depiction of portion size of the dietary consumption, exertion level of the exercise, existing state of the health condition or existing state of the mental condition.

公开(公告)号：US20210025866A1

公开(公告)日：2021-01-28

申请号：US16990232

申请日：2020-08-11

Applicant: Labrador Diagnostics LLC

Inventor： Chinmay Pangarkar ,  Elizabeth A. Holmes

IPC: G01N33/483

Abstract: Devices, systems and methods for optical analysis of cells in microgravity are disclosed.
Effective cellular microscopic and image analysis requires placement of cells into a proper focal plane, region, or volume. Such placement often requires immobilization of the cells. Cell settling onto a substrate is often sufficient for cell immobilization; however, no significant settling occurs in microgravity. Cell immobilization in microgravity may be accomplished by treatment of a substrate, the cells, or both effective that the substrate captures and immobilizes the cells for inspection. Cells may be immobilized in microgravity by adhering magnetic particles to the cells and applying a magnetic field. Cells may be placed in a proper location for viewing in microgravity by placing the cells into a small chamber or narrow channel. Centrifugal force may effect cell settling and aid cell immobilization. Proper placement or immobilization of cells aids cellular microscopic and image analysis in microgravity.

公开(公告)号：US10856791B2

公开(公告)日：2020-12-08

申请号：US15244990

申请日：2016-08-23

Applicant: Labrador Diagnostics LLC

Inventor： Patricia McHale ,  Michael Chen ,  Pey-Jiun Ko ,  Tammy Burd ,  Adrit Lath ,  Elizabeth A. Holmes ,  Joy Roy

IPC: A61B5/15 ,  G01N1/10 ,  A61B10/00 ,  A61B5/154 ,  A61B5/151 ,  A61B5/155 ,  B01L3/00 ,  G01N1/14

Abstract: Bodily fluid sample collection systems, devices, and method are provided. The device may comprise a first portion comprising at least a sample collection channel configured to draw the fluid sample into the sample collection channel via a first type of motive force. The sample collection device may include a second portion comprising a sample container for receiving the bodily fluid sample collected in the sample collection channel, the sample container operably engagable to be in fluid communication with the collection channel, whereupon when fluid communication is established, the container provides a second motive force different from the first motive force to move a majority of the bodily fluid sample from the channel into the container.

公开(公告)号：US10712282B2

公开(公告)日：2020-07-14

申请号：US14481264

申请日：2014-09-09

Applicant: Labrador Diagnostics LLC

Inventor： Elizabeth A. Holmes ,  Ian Gibbons ,  Timothy M. Kemp ,  John Howard ,  Shaunak Roy

IPC: G01N21/76 ,  B01L3/00 ,  G01N33/53 ,  A61B5/151 ,  A61B5/157 ,  A61B5/145 ,  A61B5/00 ,  G16H40/63 ,  A61B5/15 ,  G01N33/50 ,  A61B5/155 ,  G01N33/543 ,  A61B5/1495

Abstract: This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow real-time detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.

公开(公告)号：US11899010B2

公开(公告)日：2024-02-13

申请号：US17664790

申请日：2022-05-24

Applicant: Labrador Diagnostics LLC

Inventor： Tammy Burd ,  Ian Gibbons ,  Elizabeth A. Holmes ,  Gary Frenzel ,  Anthony Joseph Nugent

IPC: G01N33/53 ,  G01N33/543 ,  B01J19/00 ,  B01L3/02 ,  B01L3/00 ,  G01N35/02 ,  B01L9/00 ,  G16H10/40 ,  G01N1/38 ,  G01N33/569 ,  A61B5/15 ,  A61B5/151 ,  G01N35/10 ,  B01L7/00 ,  G01N33/68 ,  G01N33/94 ,  G01N35/00 ,  G01N33/574 ,  A61B10/00 ,  A61B10/02

CPC classification number: G01N33/5304 ,  A61B5/15 ,  A61B5/151 ,  A61B5/150755 ,  B01J19/0046 ,  B01L3/0262 ,  B01L3/5025 ,  B01L3/527 ,  B01L7/52 ,  B01L9/543 ,  G01N1/38 ,  G01N33/5302 ,  G01N33/54326 ,  G01N33/54366 ,  G01N33/54386 ,  G01N33/56966 ,  G01N33/57484 ,  G01N33/6803 ,  G01N33/94 ,  G01N35/00732 ,  G01N35/00871 ,  G01N35/028 ,  G01N35/10 ,  G01N35/1065 ,  G01N35/1074 ,  G16H10/40 ,  A61B10/007 ,  A61B10/0038 ,  A61B10/0045 ,  A61B10/0051 ,  A61B10/0058 ,  A61B10/02 ,  A61B2010/0074 ,  A61B2010/0077 ,  B01J2219/005 ,  B01J2219/00283 ,  B01J2219/00292 ,  B01J2219/00315 ,  B01J2219/00369 ,  B01J2219/00371 ,  B01J2219/00385 ,  B01J2219/00466 ,  B01J2219/00495 ,  B01J2219/00693 ,  B01J2219/00702 ,  B01L3/021 ,  B01L7/5255 ,  B01L2200/04 ,  B01L2200/0689 ,  B01L2200/141 ,  B01L2200/148 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/1805 ,  B01L2400/043 ,  G01N2035/0097 ,  G01N2035/00237 ,  G01N2035/00851 ,  G01N2035/00881 ,  G01N2035/1032 ,  G01N2035/1034 ,  G01N2035/1048 ,  G01N2333/475 ,  G01N2333/4737 ,  G01N2333/71 ,  G01N2333/912 ,  G01N2333/9129 ,  G01N2333/91205 ,  G01N2800/26 ,  G01N2800/60 ,  Y10T29/49826 ,  Y10T436/25375

Abstract: The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.

公开(公告)号：US11754554B2

公开(公告)日：2023-09-12

申请号：US15403553

申请日：2017-01-11

Applicant: Labrador Diagnostics LLC

Inventor： Shaunak Roy ,  Melissa Takahashi ,  Ian Gibbons ,  Edmond Ku ,  Thanh Dang ,  Tammy Burd ,  Adam Vollmer ,  Elizabeth A. Holmes

IPC: G01N33/53 ,  G01N35/10 ,  G01N33/49 ,  G01N27/07 ,  G01N33/86 ,  G01N27/06

CPC classification number: G01N33/5304 ,  G01N27/07 ,  G01N33/49 ,  G01N33/5302 ,  G01N33/86 ,  G01N35/1002 ,  G01N27/06 ,  G01N2201/12746 ,  G01N2800/52 ,  Y10S435/973 ,  Y10S436/809 ,  Y10T436/106664

Abstract: The present invention provides fluidic devices and systems that allow detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.

公开(公告)号：US11630069B2

公开(公告)日：2023-04-18

申请号：US15689905

申请日：2017-08-29

Applicant: Labrador Diagnostics LLC

Inventor： Timothy Michael Kemp ,  Chris Todd ,  Ron Oral ,  Shulin Zeng ,  John Howard ,  Jeff Fenton ,  Elizabeth A. Holmes ,  Ian Gibbons ,  Shaunak Roy

IPC: G01N33/543 ,  G01N21/76 ,  A61B5/155 ,  A61B5/145 ,  A61B5/157 ,  A61B5/151 ,  A61B5/00 ,  B01L3/00 ,  G01N33/50 ,  G01N33/53 ,  G16H40/63 ,  A61B5/15 ,  A61B5/1495

Abstract: This invention is in the field of medical devices. Specifically, the present invention provides fluidic systems having a plurality of reaction sites surrounded by optical barriers to reduce the amount of optical cross-talk between signals detected from various reaction sites. The invention also provides a method of manufacturing fluidic systems and methods of using the systems.

公开(公告)号：US20220374264A1

公开(公告)日：2022-11-24

申请号：US17667510

申请日：2022-02-08

Applicant: Labrador Diagnostics LLC

Inventor： Elizabeth A. Holmes ,  Daniel Young

IPC: G06F9/48 ,  G06F15/16 ,  G01N35/00 ,  H04L67/10 ,  H04L67/12

Abstract: Provided herein are medical testing devices, systems, and methods that integrate multiplex, multi-technology, multi-configuration, multisample, or multi-threading capabilities. These capabilities are achieved using one or more of a level operations and communications architecture, a protocol exection engine, and a machine vision and processing system, method, or device in order to make testing of biologic or other samples more efficient in terms of cost, time, energy, or by prioritizing at least one other objective.