公开(公告)号：US11717514B2

公开(公告)日：2023-08-08

申请号：US17086063

申请日：2020-10-30

Applicant: Purdue Research Foundation

Inventor： Philip Stewart Low ,  Sumith A. Kularatne

IPC: A61K31/426 ,  A61K47/54 ,  A61K49/00 ,  C07K5/08 ,  A61K31/4745 ,  A61K31/475 ,  A61K47/64 ,  C07C323/52 ,  C07D207/416 ,  A61K51/04 ,  A61K51/08

CPC classification number: A61K31/426 ,  A61K31/475 ,  A61K31/4745 ,  A61K47/54 ,  A61K47/542 ,  A61K47/547 ,  A61K47/548 ,  A61K47/64 ,  A61K49/0041 ,  A61K49/0043 ,  A61K49/0052 ,  A61K49/0056 ,  A61K51/04 ,  A61K51/0402 ,  A61K51/0489 ,  A61K51/088 ,  C07C323/52 ,  C07D207/416 ,  C07K5/08

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

公开(公告)号：US20230000836A1

公开(公告)日：2023-01-05

申请号：US17573304

申请日：2022-01-11

Applicant: Purdue Research Foundation

Inventor： Philip Steward Low ,  Sumith A. Kularatne

IPC: A61K31/426 ,  C07C323/52 ,  C07D207/416 ,  A61K47/54 ,  A61K49/00 ,  A61K51/04 ,  C07K5/08 ,  A61K31/4745 ,  A61K31/475 ,  A61K51/08 ,  A61K47/64

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

公开(公告)号：US11524082B2

公开(公告)日：2022-12-13

申请号：US16640539

申请日：2018-08-21

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Philip S. Low ,  Isaac J. Marks ,  Spencer Gardeen ,  Sumith A. Kularatne

IPC: A61K51/04 ,  A61B90/00 ,  A61K47/54 ,  A61P35/00 ,  A61B5/00 ,  A61K31/395 ,  A61K31/454 ,  A61K31/537 ,  A61K49/00

Abstract: The present disclosure relates to compositions and methods of carbonic anhydrase IX inhibitors. The present disclosure also relates to targeting conjugates of carbonic anhydrase IX inhibitors. The present disclosure also relates to the use of targeting conjugates of carbonic anhydrase IX inhibitors in methods of treating disease and for imaging of disease.

公开(公告)号：US20200283748A1

公开(公告)日：2020-09-10

申请号：US16724729

申请日：2019-12-23

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Philip Stewart Low ,  Venkatesh Chelvam ,  Youngsoon Kim ,  Sumith A. Kularatne

IPC: C12N9/48 ,  A61K31/454 ,  A61K31/4745 ,  A61K31/475 ,  C12N9/96 ,  A61K49/00 ,  A61K51/04 ,  A61K47/54

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical compositions containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

公开(公告)号：US10557128B2

公开(公告)日：2020-02-11

申请号：US15934974

申请日：2018-03-24

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Philip Stewart Low ,  Venkatesh Chelvam ,  Youngsoon Kim ,  Sumith A. Kularatne

IPC: C12N9/48 ,  A61K31/454 ,  A61K31/4745 ,  A61K31/475 ,  C12N9/96 ,  A61K49/00 ,  A61K51/04 ,  A61K47/54 ,  A61K38/00

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical compositions containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

公开(公告)号：US10517957B2

公开(公告)日：2019-12-31

申请号：US15997451

申请日：2018-06-04

Applicant: Purdue Research Foundation

Inventor： Philip S. Low ,  Sumith A. Kularatne

IPC: A61K47/64 ,  A61K47/54 ,  A61K51/04 ,  C07K5/08 ,  C07C323/52 ,  C07D207/416 ,  A61K49/00 ,  A61K31/426 ,  A61K31/4745 ,  A61K31/475 ,  A61K51/08

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

公开(公告)号：US10517956B2

公开(公告)日：2019-12-31

申请号：US15990083

申请日：2018-05-25

Applicant: Purdue Research Foundation

Inventor： Philip S. Low ,  Sumith A. Kularatne

IPC: A61K47/64 ,  A61K47/54 ,  A61K31/4745 ,  A61K31/475 ,  A61K51/04 ,  A61K51/08 ,  C07K5/08 ,  C07C323/52 ,  C07D207/416 ,  A61K49/00 ,  A61K31/426

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

公开(公告)号：US10406240B2

公开(公告)日：2019-09-10

申请号：US15606913

申请日：2017-05-26

Applicant: Purdue Research Foundation

Inventor： Philip S. Low ,  Sumith A. Kularatne

IPC: A61K47/64 ,  A61K47/54 ,  A61K51/04 ,  C07C323/52 ,  C07K5/08 ,  C07D207/416 ,  A61K49/00 ,  A61K31/426 ,  A61K31/4745 ,  A61K31/475 ,  A61K51/08

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

公开(公告)号：US09951324B2

公开(公告)日：2018-04-24

申请号：US15018068

申请日：2016-02-08

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Philip Stewart Low ,  Venkatesh Chelvam ,  Youngsoon Kim ,  Sumith A. Kularatne

IPC: A61K38/00 ,  C07K2/00 ,  C07K4/00 ,  C07K5/00 ,  C07K7/00 ,  C07K14/00 ,  C07K16/00 ,  C07K17/00 ,  C12N9/48 ,  A61K31/454 ,  A61K31/4745 ,  A61K31/475 ,  C12N9/96 ,  A61K49/00 ,  A61K51/04 ,  A61K47/54

CPC classification number: C12N9/485 ,  A61K31/454 ,  A61K31/4745 ,  A61K31/475 ,  A61K38/00 ,  A61K47/542 ,  A61K49/0032 ,  A61K49/0052 ,  A61K51/0402 ,  C12N9/96 ,  C12Y304/17021

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical compositions containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

公开(公告)号：US20170232119A1

公开(公告)日：2017-08-17

申请号：US15584752

申请日：2017-05-02

Applicant: Purdue Research Foundation

Inventor： Sumith A. Kularatne ,  Sunil Singhal

IPC: A61K49/00 ,  A61B5/00

CPC classification number: A61K49/0052 ,  A61B5/0071 ,  A61K49/0032 ,  G01N33/57411 ,  G01N33/57415 ,  G01N33/57423 ,  G01N33/57426 ,  G01N33/57449 ,  G01N33/582

Abstract: The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyl ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods and compositions for incorporating the compounds as used for the targeted imaging of non-small cell lung cancer (NSCLC) in human subjects. Conjugation of the amino acid linking groups increase specificity and detection of the compound. Methods and compositions for use thereof in diagnostic imaging are contemplated.