公开(公告)号：US20110269131A1

公开(公告)日：2011-11-03

申请号：US13127207

申请日：2009-10-28

Applicant: Daniel T. Chiu ,  Jason S. Kuo

Inventor： Daniel T. Chiu ,  Jason S. Kuo

IPC: C12M1/00 ,  B01D15/08 ,  C12Q1/02 ,  G01N33/559 ,  B01L3/00 ,  C12Q1/68

CPC classification number: C12M1/00 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/502753 ,  B01L2200/027 ,  B01L2200/0689 ,  B01L2300/0681 ,  B01L2300/12 ,  B01L2400/0418 ,  B01L2400/0421 ,  B01L2400/0487 ,  B01L2400/086 ,  B29C33/44 ,  B29C65/08 ,  B29C65/14 ,  B29C65/1403 ,  B29C65/1406 ,  B29C65/1409 ,  B29C65/1412 ,  B29C66/028 ,  B29C66/1122 ,  B29C66/5346 ,  B29C66/71 ,  B29C66/73151 ,  B29C66/73365 ,  B29C66/73751 ,  B29C66/7392 ,  B29C66/73921 ,  B29C66/7394 ,  B29C66/81267 ,  B29C66/82661 ,  B29C2791/006 ,  B29K2075/00 ,  B29K2995/0025 ,  B29K2995/0027 ,  B29K2995/007 ,  B29L2031/756 ,  B81B2201/051 ,  B81C1/00119 ,  B81C2201/019 ,  B81C2201/034 ,  B29K2033/12

Abstract: Embodiments of the present invention relate to a UV-curable polyurethane-methacrylate (PUMA) substrate for manufacturing microfluidic devices. PUMA is optically transparent, biocompatible, and has stable surface properties. Embodiments include two production processes that are compatible with the existing methods of rapid prototyping, and characterizations of the resultant PUMA microfluidic devices are presented. Embodiments of the present invention also relate to strategies to improve the production yield of chips manufactured from PUMA resin, especially for microfluidic systems that contain dense and high-aspect-ratio features. Described is a mold-releasing procedure that minimizes motion in the shear plane of the microstructures. Also presented are simple yet scalable able methods for forming seals between PUMA substrates, which avoids excessive compressive force that may crush delicate structures. Two methods for forming interconnects with PUMA microfluidic devices are detailed. These improvements produce a microfiltration device containing closely spaced and high-aspect-ratio fins, suitable for retaining and concentrating cells or beads from a highly diluted suspension.

Abstract translation: 本发明的实施方案涉及用于制造微流体装置的可UV固化的聚氨酯 - 甲基丙烯酸酯（PUMA）基材。 PUMA是光学透明的，生物相容的，并且具有稳定的表面性质。 实施例包括与现有快速成型方法兼容的两个生产方法，并且显示所得PUMA微流体装置的特性。 本发明的实施方案还涉及提高由PUMA树脂制造的芯片的生产成本的策略，特别是对于含有密集和高纵横比特征的微流体系统。 描述了使微结构的剪切平面中的运动最小化的脱模程序。 还提出了用于在PUMA基材之间形成密封的简单且可扩展的方法，其避免了可能破坏微细结构的过大的压缩力。 详细说明了与PUMA微流体装置形成互连的两种方法。 这些改进产生了包含紧密间隔和高纵横比的翅片的微滤装置，适用于从高度稀释的悬浮液中保留和浓缩细胞或珠粒。

公开(公告)号：US20110170241A1

公开(公告)日：2011-07-14

申请号：US12686978

申请日：2010-01-13

Applicant: Henry Helvajian ,  William W. Hansen ,  Lee F. Steffeney

Inventor： Henry Helvajian ,  William W. Hansen ,  Lee F. Steffeney

IPC: H05K5/00 ,  H01R43/00

CPC classification number: H05K3/101 ,  B01J19/0093 ,  B01J2219/00824 ,  B01J2219/00835 ,  B01J2219/00853 ,  B01J2219/00941 ,  B01J2219/00948 ,  B01L3/502707 ,  B01L2300/12 ,  B81B2201/051 ,  B81B2203/0338 ,  B81C1/00634 ,  G02B2006/12035 ,  G02B2006/12171 ,  H01P3/121 ,  H05K1/0306 ,  H05K1/16 ,  H05K1/162 ,  H05K1/165 ,  H05K3/0023 ,  Y10T29/49117

Abstract: A photostructurable ceramic is processed using photostructuring process steps for embedding devices within a photostructurable ceramic volume, the devices may include one or more of chemical, mechanical, electrical, electromagnetic, optical, and acoustic devices, all made in part by creating device material within the ceramic or by disposing a device material through surface ports of the ceramic volume, with the devices being interconnected using internal connections and surface interfaces.

Abstract translation: 使用用于将装置嵌入可光可陶瓷陶瓷体积内的光学结构化工艺步骤来处理可光刻陶瓷，所述装置可以包括化学，机械，电气，电磁，光学和声学装置中的一种或多种，​​所有这些都部分地通过在 陶瓷或通过陶瓷体的表面端口设置器件材料，使用内部连接和表面接口互连这些器件。

公开(公告)号：US20110135817A1

公开(公告)日：2011-06-09

申请号：US13026811

申请日：2011-02-14

Applicant: Kunihiko AKAI ,  Hiroshi KAWAZOE

Inventor： Kunihiko AKAI ,  Hiroshi KAWAZOE

IPC: B05D1/38

CPC classification number: B81B3/0067 ,  B01L3/502707 ,  B01L2200/025 ,  B01L2200/12 ,  B01L2300/0838 ,  B01L2300/0874 ,  B81B2201/051 ,  B81B2203/0338 ,  Y10T428/24612 ,  Y10T428/24752 ,  Y10T428/249921

Abstract: The present invention relates to a microfluid-system-supporting unit, comprising a fixing layer formed on a substrate, a protective layer or a fixing layer, wherein part of at least one hollow filament in any shape is placed and fixed in the fixing layer. Thus, it provides a microfluid-system-supporting unit lower in surface irregularity even when there are multiple hollow filaments different in external diameter or the hollow filaments crosses each other and resistant to positional deviation of the hollow filament in the crossing regions, and a production method thereof.

公开(公告)号：US07901527B2

公开(公告)日：2011-03-08

申请号：US12528989

申请日：2008-02-21

Applicant: Kanji Sekihara ,  Masayoshi Uehira

Inventor： Kanji Sekihara ,  Masayoshi Uehira

IPC: B32B38/10 ,  B29C65/08

CPC classification number: B01L3/502707 ,  B01J2219/00511 ,  B01J2219/00527 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00621 ,  B01J2219/00637 ,  B01L2200/0689 ,  B01L2300/0816 ,  B01L2300/0887 ,  B29C65/08 ,  B29C65/16 ,  B29C65/1654 ,  B29C65/48 ,  B29C66/0224 ,  B29C66/345 ,  B29C66/54 ,  B29C66/71 ,  B29C66/72324 ,  B29C66/81267 ,  B29C66/8322 ,  B29C66/91411 ,  B29C66/919 ,  B29C2793/00 ,  B29L2031/756 ,  B81B2201/051 ,  B81C1/00071 ,  B81C2203/032 ,  Y10S156/93 ,  Y10T156/1168 ,  B29K2083/00 ,  B29K2077/00 ,  B29K2069/00 ,  B29K2067/003 ,  B29K2033/20 ,  B29K2033/12 ,  B29K2031/04 ,  B29K2027/08 ,  B29K2027/06 ,  B29K2025/06 ,  B29K2023/12 ,  B29K2023/083 ,  B29K2023/06 ,  B29K2009/00

Abstract: Provided is a microchip manufacturing method by which a functional film is formed in a flow path channel and resin microchip substrates are bonded. The manufacturing method has a first step of forming SiO2 films (12, 22) representing the functional films on a surface having a flow path channel (11) of a microchip substrate (10) and on a surface having a flow path channel (21) of a microchip substrate (20) respectively; a second step of exfoliating the SiO2 films formed on the microchip substrates (10, 20) except the SiO2 films formed on the flow path channels (11, 21) by a cohesive member; and a third step of placing the microchip substrates (10, 20) one over another in such a way that the surfaces on which the flow path channels (11, 21) are formed face inside, and bonding the substrates by laser welding, ultrasonic wave welding or thermocompression bonding.

Abstract translation: 提供了一种在流路通道中形成功能膜并结合树脂微芯片基板的微芯片制造方法。 该制造方法具有在具有微芯片基板（10）的流路通道（11）的表面上和具有流路通道（21）的表面上形成表示功能膜的SiO 2膜（12,22）的第一工序， 的微芯片基板（20）; 第二步骤，除了通过粘合构件在形成在流路通道（11,21）上的SiO 2膜之外，在微芯片基板（10,20）上形成的SiO 2膜剥离; 以及第三步骤，将微芯片基板（10,20）一个一个地放置成使得其上形成有流路通道（11,21）的表面朝向内部，并通过激光焊接，超声波 焊接或热压接合。

公开(公告)号：US20110033338A1

公开(公告)日：2011-02-10

申请号：US12936839

申请日：2009-04-10

Applicant: Sin Kil Cho ,  Seok Chung

Inventor： Sin Kil Cho ,  Seok Chung

IPC: G01N33/48 ,  B29C65/08 ,  B29C65/14

CPC classification number: B29C66/3022 ,  B01L3/502707 ,  B01L3/502746 ,  B01L2200/0689 ,  B01L2300/0825 ,  B01L2300/0887 ,  B01L2400/0406 ,  B29C65/02 ,  B29C65/08 ,  B29C65/1635 ,  B29C65/168 ,  B29C65/48 ,  B29C65/4895 ,  B29C65/8253 ,  B29C66/1122 ,  B29C66/30223 ,  B29C66/53461 ,  B29C66/71 ,  B29C66/8322 ,  B29K2033/08 ,  B29K2033/12 ,  B29K2069/00 ,  B29L2031/756 ,  B81B3/0094 ,  B81B2201/0214 ,  B81B2201/051 ,  B81B2201/058 ,  B81B2203/0338 ,  B81B2203/0392 ,  B81C1/00103 ,  B81C2201/019 ,  B29K2083/00

Abstract: A microfluidic circuit element comprising a microfluidic channel, in which the microfluidic channel has nano interstices formed at both sides thereof and having a height less than that of the center of the channel, gives more driving force of the microfluidic channel and provides stable flow of a fluid.

Abstract translation: 一种微流体电路元件，包括微流体通道，其中微流体通道在其两侧形成有具有低于通道中心的高度的纳米空隙，给予更多的微流体通道的驱动力并提供稳定的流动 流体。

公开(公告)号：US20100326844A1

公开(公告)日：2010-12-30

申请号：US12636344

申请日：2009-12-11

Applicant: Mark Hyland ,  Sylvain Hallynck ,  Christian Schoen ,  Michael Wagener

Inventor： Mark Hyland ,  Sylvain Hallynck ,  Christian Schoen ,  Michael Wagener

IPC: G01N27/26

CPC classification number: B81C1/00119 ,  B01L3/50273 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/0825 ,  B01L2300/0887 ,  B01L2300/161 ,  B01L2400/0406 ,  B01L2400/084 ,  B81B2201/0214 ,  B81B2201/051 ,  B81B2203/0338 ,  B81B2203/0392

Abstract: A channel is provided for conveying fluid by capillary action between a first end of the channel and a second end of the channel, in which the channel is fully enclosed within an object and the cross-section of the channel has a concave shape, encouraging capillary flow.

Abstract translation: 提供通道，用于在通道的第一端和通道的第二端之间通过毛细管作用输送流体，其中通道被完全封闭在物体内，并且通道的横截面具有凹形，鼓励毛细管 流。

公开(公告)号：US20090291264A1

公开(公告)日：2009-11-26

申请号：US11721361

申请日：2005-12-09

Applicant: Kunihiko Akai ,  Hiroshi Kawazoe

Inventor： Kunihiko Akai ,  Hiroshi Kawazoe

IPC: B81B1/00 ,  B01J19/00 ,  B32B3/00 ,  B05D1/36 ,  B05D1/00 ,  B81C3/00 ,  G01N37/00

CPC classification number: B81B3/0067 ,  B01L3/502707 ,  B01L2200/025 ,  B01L2200/12 ,  B01L2300/0838 ,  B01L2300/0874 ,  B81B2201/051 ,  B81B2203/0338 ,  Y10T428/24612 ,  Y10T428/24752 ,  Y10T428/249921

Abstract: The present invention relates to a microfluid-system-supporting unit, comprising a fixing layer formed on a substrate, a protective layer or a fixing layer, wherein part of at least one hollow filament in any shape is placed and fixed in the fixing layer. Thus, it provides a microfluid-system-supporting unit lower in surface irregularity even when there are multiple hollow filaments different in external diameter or the hollow filaments crosses each other and resistant to positional deviation of the hollow filament in the crossing regions, and a production method thereof.

Abstract translation: 本发明涉及一种微流体系统支撑单元，其包括形成在基板上的固定层，保护层或固定层，其中至少一个任何形状的中空丝的一部分被放置并固定在固定层中。 因此，即使存在外径不同的多根中空丝或中空丝彼此交叉并且能够抵抗交叉区域中的中空丝的位置偏离，也提供了表面不规则性较低的微流体系支撑单元， 方法。

公开(公告)号：US20090274585A1

公开(公告)日：2009-11-05

申请号：US12501120

申请日：2009-07-10

Applicant: Hiroshi Kawazoe ,  Akishi Nakaso ,  Shigeharu Arike

Inventor： Hiroshi Kawazoe ,  Akishi Nakaso ,  Shigeharu Arike

IPC: B01L3/00

CPC classification number: B01L3/502707 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00788 ,  B01J2219/00822 ,  B01J2219/00833 ,  B01J2219/0086 ,  B01J2219/00869 ,  B01L2200/12 ,  B01L2300/0816 ,  B01L2300/0838 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2400/0481 ,  B01L2400/0655 ,  B81B2201/051 ,  B81C1/00119 ,  B81C2201/019 ,  B81C2203/032 ,  Y10T156/10

Abstract: A support unit for a microfluidic system includes a first support; a first adhesive layer provided on a surface of the first support; and a hollow filament laid on a surface of the first adhesive layer to have an arbitrary shape and functioning as a flow channel layer of the microfluidic system.

公开(公告)号：US20090274584A1

公开(公告)日：2009-11-05

申请号：US12501108

申请日：2009-07-10

Applicant: Hiroshi KAWAZOE ,  Akishi NAKASO ,  Shigeharu ARIKE

Inventor： Hiroshi KAWAZOE ,  Akishi NAKASO ,  Shigeharu ARIKE

IPC: B01L3/00

CPC classification number: B01L3/502707 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00788 ,  B01J2219/00822 ,  B01J2219/00833 ,  B01J2219/0086 ,  B01J2219/00869 ,  B01L2200/12 ,  B01L2300/0816 ,  B01L2300/0838 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2400/0481 ,  B01L2400/0655 ,  B81B2201/051 ,  B81C1/00119 ,  B81C2201/019 ,  B81C2203/032 ,  Y10T156/10

Abstract: A support unit for a microfluidic system includes a first support; a first adhesive layer provided on a surface of the first support; and a hollow filament laid on a surface of the first adhesive layer to have an arbitrary shape and functioning as a flow channel layer of the microfluidic system.

Abstract translation: 用于微流体系统的支撑单元包括第一支撑件; 设置在所述第一支撑体的表面上的第一粘合剂层; 以及放置在第一粘合剂层的表面上以具有任意形状并用作微流体系统的流路层的中空丝。

公开(公告)号：US20080087478A1

公开(公告)日：2008-04-17

申请号：US11757341

申请日：2007-06-01

Applicant: Harold Stalford

Inventor： Harold Stalford

IPC: B60K1/00

CPC classification number: B81B3/0024 ,  B81B2201/032 ,  B81B2201/034 ,  B81B2201/037 ,  B81B2201/051 ,  H02N1/008

Abstract: A micro transport machine may include a substrate and a movable device comprising a drive component responsive to a wireless power source. The movable device is operable to move between a plurality of disparate areas on the substrate.

Abstract translation: 微型运输机器可以包括基板和可移动装置，其包括响应于无线电源的驱动部件。 可移动装置可操作以在基板上的多个不同区域之间移动。