公开(公告)号：US20170319741A1

公开(公告)日：2017-11-09

申请号：US15657868

申请日：2017-07-24

Applicant: Joelle Amedee ,  Didier Letourneur ,  Catherine Le Visage ,  Sidi Mohammed Derkaoui ,  Jean-Christophe Fricain ,  Sylvain Catros

Inventor： Joelle Amedee ,  Didier Letourneur ,  Catherine Le Visage ,  Sidi Mohammed Derkaoui ,  Jean-Christophe Fricain ,  Sylvain Catros

IPC: A61L27/12 ,  A61L27/46 ,  A61L27/56 ,  C08J9/28 ,  C08B37/02 ,  A61L27/20 ,  C08J9/26 ,  C08J9/00 ,  C08B37/00

CPC classification number: A61L27/12 ,  A61L27/20 ,  A61L27/46 ,  A61L27/56 ,  A61L2300/112 ,  A61L2400/08 ,  A61L2400/12 ,  A61L2430/02 ,  C08B37/0018 ,  C08B37/0021 ,  C08J9/0061 ,  C08J9/26 ,  C08J9/28 ,  C08J2201/026 ,  C08J2201/0444 ,  C08J2201/0484 ,  C08J2205/022 ,  C08J2207/10 ,  C08J2305/00 ,  C08J2405/02

Abstract: The present invention relate to three dimensional porous polysaccharide matrices able to induce mineralisation of a tissue in osseous site, as well as in non-osseous site, in the absence of stem cells or growth factors.

公开(公告)号：US09757494B2

公开(公告)日：2017-09-12

申请号：US14728412

申请日：2015-06-02

Applicant: Joelle Amedee ,  Didier Letourneur ,  Catherine Le Visage ,  Sidi Mohammed Derkaoui ,  Jean-Christophe Fricain ,  Sylvain Catros

Inventor： Joelle Amedee ,  Didier Letourneur ,  Catherine Le Visage ,  Sidi Mohammed Derkaoui ,  Jean-Christophe Fricain ,  Sylvain Catros

IPC: A61L27/20 ,  A61L27/12 ,  A61L27/56 ,  A61L27/46 ,  C08B37/00 ,  C08B37/02 ,  C08J9/00 ,  C08J9/26 ,  C08J9/28

CPC classification number: A61L27/12 ,  A61L27/20 ,  A61L27/46 ,  A61L27/56 ,  A61L2300/112 ,  A61L2400/08 ,  A61L2400/12 ,  A61L2430/02 ,  C08B37/0018 ,  C08B37/0021 ,  C08J9/0061 ,  C08J9/26 ,  C08J9/28 ,  C08J2201/026 ,  C08J2201/0444 ,  C08J2201/0484 ,  C08J2205/022 ,  C08J2207/10 ,  C08J2305/00 ,  C08J2405/02

Abstract: The present invention relate to three dimensional porous polysaccharide matrices able to induce mineralisation of a tissue in osseous site, as well as in non-osseous site, in the absence of stent cells or growth factors.

公开(公告)号：US20170210864A1

公开(公告)日：2017-07-27

申请号：US15415692

申请日：2017-01-25

Applicant: ZHEJIANG UNIVERSITY

Inventor： QIAN ZHAO ,  JINGJUN WU ,  TAO XIE ,  DI CHEN

IPC: C08J3/28 ,  C08F220/18 ,  C08F220/56 ,  C08G65/48 ,  C08J3/075 ,  C08J9/28

CPC classification number: C08F220/18 ,  C08F220/56 ,  C08F2220/1825 ,  C08G65/48 ,  C08J3/075 ,  C08J3/28 ,  C08J9/28 ,  C08J2201/0484 ,  C08J2205/022 ,  C08J2333/10 ,  C08J2333/26 ,  C08J2371/08 ,  C08F2222/408 ,  C08F2220/585 ,  C08F220/58 ,  C08F220/60

Abstract: The present invention discloses a freezing-illumination method for preparing porous gels, comprising the steps of: (a) synthesizing the gels containing dynamic exchangeable bonds; (b) illuminating the gels under frozen state by certain wavelength light source; (c) elevating the temperature and melt the ice crystals within the gels to get the porous structure. The dynamic exchangeable bonds existing in the gels include double/multi-sulfur bond, hydrazine bond, boronic ester bond. Catalyst is also included in the gel composition to activate the bond exchange reactions under illumination. This new method for preparing porous gels is easy to operate and suitable for most kinds of gels. Meanwhile, it can spatially control the pore structure within the gels by local illumination.

公开(公告)号：US09708455B2

公开(公告)日：2017-07-18

申请号：US14418599

申请日：2013-08-02

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Stephen Michael Kennedy ,  Sidi Ahmed Bencherif ,  David J. Mooney

IPC: A61K9/00 ,  C08J9/28 ,  A61K9/06 ,  C08F220/06 ,  C08F220/56 ,  C08F222/10

CPC classification number: C08J9/286 ,  A61K9/0009 ,  A61K9/06 ,  C08F220/06 ,  C08F220/56 ,  C08F2222/1013 ,  C08J9/28 ,  C08J2201/0484 ,  C08J2205/022 ,  C08J2207/10 ,  C08J2333/02 ,  C08J2333/26 ,  C08J2343/00 ,  C08J2347/00

Abstract: The invention provides cryogels whose porosity, pore size, pore connectivity, swelling agent concentration, and/or specific volume undergoes a change from a first value to a second value in response to an electrical stimulus. The cryogels have interconnected macropores which greatly enhance their ability to rapidly undergo volumetric collapse when subjected to moderate electric fields. The cryogels of the invention can be easily integrated into arrays capable of rapid configurational and chromatic optical modulations, and when loaded with drugs, are able to coordinate the delivery profile of multiple drugs. The cryogel can be prepared by polymerizing an aqueous solution of charged monomers and cross-linker monomers at a temperature below the freezing temperature of the solvent.

公开(公告)号：US20170145179A1

公开(公告)日：2017-05-25

申请号：US14953811

申请日：2015-11-30

Applicant: Council of Scientific & Industrial Research

Inventor： Guruswamy KUMARASWAMY ,  Soumyajyoti CHATTERJEE ,  Sayam Sen GUPTA

IPC: C08J9/36 ,  C08J9/26

CPC classification number: C08J9/36 ,  C08J9/26 ,  C08J2201/026 ,  C08J2201/048 ,  C08J2201/0484 ,  C08J2207/00 ,  C08J2305/08 ,  C08J2329/04 ,  C08J2379/02

Abstract: The present invention discloses a versatile, macroporous, omniphilic polymeric sponges for absorption of organic liquids of varying polarity as well as water. Particularly, disclosed herein is an ice-templated macroporous omniphilic polymeric sponge as inexpensive versatile absorbents.

公开(公告)号：US09629939B2

公开(公告)日：2017-04-25

申请号：US14403396

申请日：2013-05-16

Applicant: Queen's University at Kingston

Inventor： Lauren E. Flynn ,  Claire Yu

IPC: A61L27/24 ,  A61L27/26 ,  A61L27/38 ,  A61L27/56 ,  A61L27/54 ,  B32B5/32 ,  C08J9/228 ,  C08L89/06 ,  C08H1/06 ,  A61L27/36 ,  C08J9/28

CPC classification number: A61L27/24 ,  A61L27/26 ,  A61L27/3633 ,  A61L27/38 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/64 ,  A61L2430/34 ,  B32B5/32 ,  C08H1/06 ,  C08J9/228 ,  C08J9/28 ,  C08J2201/0484 ,  C08J2389/06 ,  C08L89/06

Abstract: Provided is a foam material, comprising a plurality of substantially collagenous beads, wherein the foam material is a bead foam, and wherein adjacent collagenous beads are fused together by a network of collagen fibers. Also provided are methods for preparation of foam materials comprising a plurality of substantially collagenous beads. The foam materials may be used in applications such as bioscaffolds for wound healing, soft tissue regeneration and augmentation, for localized cell delivery, or as cell culture substrates for research. The foam materials include natural collagen fibrils that provide a stable scaffold and enhance integration of the implanted scaffold and regeneration of cells and tissue.

公开(公告)号：US20170029764A1

公开(公告)日：2017-02-02

申请号：US15169521

申请日：2016-05-31

Applicant: The Regents of the University of California

Inventor： C. Chang I. Lee

IPC: C12N5/00

CPC classification number: C12N5/0068 ,  C08B37/0087 ,  C08J9/28 ,  C08J9/36 ,  C08J2201/0484 ,  C08J2207/10 ,  C08J2305/00 ,  C08L5/00 ,  C12N5/0607 ,  C12N5/0663 ,  C12N2513/00 ,  C12N2533/70 ,  C08L89/06 ,  C08L89/00 ,  C08L77/04

Abstract: The present invention provides a neutralized glucomannan scaffold capable of promoting cell growth and suitable for three-dimensional tissue culture and engineering. The present invention also provides methods for making and degrading the neutralized glucomannan scaffold. The present invention further provides a method of growing cells on a neutralized glucomannan scaffold.

Abstract translation: 本发明提供能够促进细胞生长并适用于三维组织培养和工程的中和葡萄糖甘露聚糖支架。 本发明还提供了制备和降解中和的葡甘聚糖骨架的方法。 本发明还提供了在中和的葡甘聚糖骨架上培养细胞的方法。

公开(公告)号：US20160096941A1

公开(公告)日：2016-04-07

申请号：US14507523

申请日：2014-10-06

Applicant: The Regents of the University of Michigan

Inventor： Peter X. Ma ,  Zhanpeng Zhang

IPC: C08J9/28

CPC classification number: C08J9/28 ,  C08J9/16 ,  C08J2201/0484 ,  C08J2201/0522 ,  C08J2205/044 ,  C08J2207/10 ,  C08J2300/206 ,  C08J2367/04

Abstract: A nanofibrous spongy microsphere includes porous walls that define an exterior of the microsphere and that extend through an interior of the microsphere. The porous walls consist of interconnected nanofibers and spaces formed between the interconnected nanofibers. A plurality of micro-scale pores are formed throughout the interior of the microsphere. Each of the micro-scale pores i) is partially defined by the porous walls, ii) has an interpore opening that opens to an adjacent micro-scale pores, and iii) has a diameter ranging from about 1 μm to about 100 μm. A total diameter of the microsphere ranges from about 5 μm to about 1000 μm.

Abstract translation: 纳米纤维海绵状微球包括限定微球的外部并延伸穿过微球内部的多孔壁。 多孔壁由互连的纳米纤维和互连的纳米纤维之间形成的空间组成。 在微球的整个内部形成多个微尺度孔。 每个微尺度孔隙i）部分地由多孔壁限定，ii）具有通向相邻的微尺度孔隙的插层孔，以及iii）具有约1μm至约100μm的直径。 微球的总直径为约5μm至约1000μm。

公开(公告)号：US20150328365A1

公开(公告)日：2015-11-19

申请号：US14728412

申请日：2015-06-02

Applicant: Joelle AMEDEE ,  Didier LETOURNEUR ,  Catherine LE VISAGE ,  Sidi Mohammed DERKAOUI ,  Jean-Christophe FRICAIN ,  Sylvain CATROS

Inventor： Joelle AMEDEE ,  Didier LETOURNEUR ,  Catherine LE VISAGE ,  Sidi Mohammed DERKAOUI ,  Jean-Christophe FRICAIN ,  Sylvain CATROS

IPC: A61L27/12 ,  A61L27/56 ,  A61L27/20

CPC classification number: A61L27/12 ,  A61L27/20 ,  A61L27/46 ,  A61L27/56 ,  A61L2300/112 ,  A61L2400/08 ,  A61L2400/12 ,  A61L2430/02 ,  C08B37/0018 ,  C08B37/0021 ,  C08J9/0061 ,  C08J9/26 ,  C08J9/28 ,  C08J2201/026 ,  C08J2201/0444 ,  C08J2201/0484 ,  C08J2205/022 ,  C08J2207/10 ,  C08J2305/00 ,  C08J2405/02

Abstract: The present invention relate to three dimensional porous polysaccharide matrices able to induce mineralisation of a tissue in osseous site, as well as in non-osseous site, in the absence of stent cells or growth factors.

Abstract translation: 本发明涉及在不存在支架细胞或生长因子的情况下，能够在骨骼部位以及非骨骼部位诱导组织的矿化的三维多孔多糖基质。

公开(公告)号：US20150246163A1

公开(公告)日：2015-09-03

申请号：US14708996

申请日：2015-05-11

Applicant: INSERM (Institut National de la Sante et de la Recherche Medicale) ,  Universite Paris 7 - Denis Diderot

Inventor： Catherine Le Visage ,  Didier Letourneur ,  Frederic Chaubet ,  Aude Autissier

IPC: A61L27/56 ,  C08J3/24 ,  A61L27/54 ,  A61L27/20 ,  A61L27/38 ,  A61L27/50 ,  C12N11/10 ,  C08B37/02

CPC classification number: A61L27/56 ,  A61L27/20 ,  A61L27/3804 ,  A61L27/3826 ,  A61L27/3834 ,  A61L27/3847 ,  A61L27/3852 ,  A61L27/507 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/21 ,  A61L2430/02 ,  A61L2430/06 ,  C08B37/0018 ,  C08B37/0021 ,  C08B37/003 ,  C08B37/0039 ,  C08B37/0054 ,  C08B37/0063 ,  C08B37/0072 ,  C08B37/0075 ,  C08B37/0084 ,  C08H1/06 ,  C08J3/24 ,  C08J9/28 ,  C08J2201/026 ,  C08J2201/0484 ,  C08J2205/04 ,  C08J2207/10 ,  C08J2305/00 ,  C08J2305/02 ,  C08J2305/08 ,  C08J2305/12 ,  C12N5/0068 ,  C12N11/10 ,  C12N2533/70 ,  Y10T436/147777

Abstract: The present invention relates to a method for preparing a porous scaffold for tissue engineering. It is another object of the present invention to provide a porous scaffold obtainable by the method as above described, and its use for tissue engineering, cell culture and cell delivery. The method of the invention comprise the steps consisting of a) preparing an alkaline aqueous solution comprising an amount of at least one polysaccharide and one cross-linking agent b) freezing the aqueous solution of step a) c) sublimating the frozen solution of step b) characterized in that step b) is performed before the cross-linking of the polysaccharide occurs in the solution of step a).

Abstract translation: 本发明涉及一种用于组织工程的多孔支架的制备方法。 本发明的另一个目的是提供可通过上述方法获得的多孔支架及其在组织工程，细胞培养和细胞递送中的应用。 本发明的方法包括以下步骤：a）制备含有至少一种多糖和一种交联剂的碱性水溶液b）冷冻步骤a）的水溶液c）升华步骤b的冷冻溶液 ），其特征在于步骤b）在多糖的交联发生在步骤a）的溶液中之前进行。