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    TRI-BLOCK COPOLYMERS AND NANO-FIBROUS GELLING MICROSPHERES INCLUDING THE SAME
    1.
    发明申请
    TRI-BLOCK COPOLYMERS AND NANO-FIBROUS GELLING MICROSPHERES INCLUDING THE SAME 有权

    公开(公告)号：US20220162398A1

    公开(公告)日：2022-05-26

    申请号：US17602678

    申请日：2020-04-09

    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

    Inventor： Peter X. Ma ,  Chao Zhao ,  Zhong Wang

    IPC: C08G81/02 ,  B01J13/16

    Abstract: A tri-block copolymer includes a first end block consisting of a hydrophobic, nano-fiber forming polymer, wherein the first end block is present in the tri-block copolymer at a weight percentage ranging from about 10% to about 89%; a middle block attached to the first end block, the middle block consisting of a hydrophilic polymer, wherein the middle block is present in the tri-block copolymer at a weight percentage ranging from about 1% to about 89%; and a second end block attached to the middle block, the second end block consisting of a temperature-responsive polymer, wherein the second end block is present in the tri-block copolymer at a weight percentage ranging from about 1% to about 89%.

    NANOFIBROUS SPONGY MICROSPHERES
    5.
    发明申请
    NANOFIBROUS SPONGY MICROSPHERES 有权

    公开(公告)号：US20160096941A1

    公开(公告)日：2016-04-07

    申请号：US14507523

    申请日：2014-10-06

    Applicant: The Regents of the University of Michigan

    Inventor： Peter X. Ma ,  Zhanpeng Zhang

    IPC: C08J9/28

    CPC classification number: C08J9/28 ,  C08J9/16 ,  C08J2201/0484 ,  C08J2201/0522 ,  C08J2205/044 ,  C08J2207/10 ,  C08J2300/206 ,  C08J2367/04

    Abstract: A nanofibrous spongy microsphere includes porous walls that define an exterior of the microsphere and that extend through an interior of the microsphere. The porous walls consist of interconnected nanofibers and spaces formed between the interconnected nanofibers. A plurality of micro-scale pores are formed throughout the interior of the microsphere. Each of the micro-scale pores i) is partially defined by the porous walls, ii) has an interpore opening that opens to an adjacent micro-scale pores, and iii) has a diameter ranging from about 1 μm to about 100 μm. A total diameter of the microsphere ranges from about 5 μm to about 1000 μm.

    Abstract translation: 纳米纤维海绵状微球包括限定微球的外部并延伸穿过微球内部的多孔壁。 多孔壁由互连的纳米纤维和互连的纳米纤维之间形成的空间组成。 在微球的整个内部形成多个微尺度孔。 每个微尺度孔隙i）部分地由多孔壁限定，ii）具有通向相邻的微尺度孔隙的插层孔，以及iii）具有约1μm至约100μm的直径。 微球的总直径为约5μm至约1000μm。

    DELIVERY DEVICES AND METHODS FOR MAKING THE SAME
    6.
    发明申请
    DELIVERY DEVICES AND METHODS FOR MAKING THE SAME 审中-公开

    公开(公告)号：US20190307697A1

    公开(公告)日：2019-10-10

    申请号：US16335947

    申请日：2017-09-21

    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

    Inventor： Peter X. Ma ,  Ming Dang ,  Laurie K. McCauley

    IPC: A61K9/20 ,  A61K38/29 ,  A61K9/70 ,  A61K47/34

    Abstract: In an example of a method for making a pulsatile delivery device, one type of charges are generated on a polymeric layer, and charges opposite the one type of charges are generated on a delivery layer including a film forming material and a predetermined substance dispersed throughout the film forming material. The charged polymeric and delivery layers are placed into contact to form a bi-layer structure. A stack with at least two bi-layer structures is formed so that the polymeric layers and the delivery layers are alternating throughout the stack. The stack is sealed so that one of the polymeric layers remains exposed.

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