公开(公告)号：US08987685B2

公开(公告)日：2015-03-24

申请号：US12841725

申请日：2010-07-22

Applicant: Adrian Fawcett ,  David Tracy ,  Kevin Daley Simmons

Inventor： Adrian Fawcett ,  David Tracy ,  Kevin Daley Simmons

IPC: G01J1/58 ,  G01N21/64 ,  B01L7/00

CPC classification number: G01N21/6486 ,  B01L7/52 ,  B01L2300/046 ,  B01L2300/0829 ,  B01L2300/1805 ,  G01N21/0332 ,  G01N21/6452 ,  G01N2021/0367 ,  G01N2021/6421 ,  G01N2021/6471 ,  G01N2021/6478 ,  G01N2201/02 ,  G01N2201/062 ,  G01N2201/0626 ,  G01N2201/0627 ,  G01N2201/0636

Abstract: Optical systems, and corresponding methods, for multiple reactions are provided. The optical systems are in a fixed position relative to a thermal assembly and include at least one array of excitation sources (e.g., light emitting diodes (LEDs)) configured to output excitation energy along an excitation optical path. In addition, a detector configured to receive emission energy along a detection optical path in the same plane as the excitation optical path is also provided.

Abstract translation: 提供了多种反应的光学系统和相应的方法。 光学系统相对于热组件处于固定位置，并且包括被配置为沿着激发光路输出激发能量的至少一组激励源（例如，发光二极管（LED））。 此外，还提供了被配置为沿着与激励光路相同的平面中的检测光路接收发射能量的检测器。

公开(公告)号：US08922094B2

公开(公告)日：2014-12-30

申请号：US13022353

申请日：2011-02-07

Applicant: Omar Daniel Lopez ,  Gary Wiederrecht ,  David J. Gosztola ,  Derrick C. Mancini

Inventor： Omar Daniel Lopez ,  Gary Wiederrecht ,  David J. Gosztola ,  Derrick C. Mancini

IPC: H02N1/00

CPC classification number: H02N1/008 ,  B25J7/00 ,  G01N21/658 ,  G01N2201/02 ,  G02B5/008 ,  G02F1/17 ,  Y10T74/20354 ,  Y10T74/2036

Abstract: A nanopositioning system for producing a coupling interaction between a first nanoparticle and a second nanoparticle. A first MEMS positioning assembly includes an electro-static comb drive actuator configured to selectively displace a first nanoparticle in a first dimension and an electrode configured to selectively displace the first nanoparticle in a second dimensions. Accordingly, the first nanoparticle may be selectively positioned in two dimensions to modulate the distance between the first nanoparticle and a second nanoparticle that may be coupled to a second MEMS positioning assembly. Modulating the distance between the first and second nanoparticles obtains a coupling interaction between the nanoparticles that alters at least one material property of the nanoparticles applicable to a variety of sensing and control applications.

Abstract translation: 一种用于产生第一纳米颗粒和第二纳米颗粒之间的偶联相互作用的纳米定位系统。 第一MEMS定位组件包括静电梳状驱动致动器，其被配置为选择性地置换第一尺寸中的第一纳米颗粒和被配置成在第二维度中选择性地置换第一纳米颗粒的电极。 因此，第一纳米颗粒可以被选择性地定位在二维上以调节第一纳米颗粒和第二纳米颗粒之间的距离，第二纳米颗粒可以耦合到第二MEMS定位组件。 调节第一和第二纳米颗粒之间的距离获得纳米颗粒之间的耦合相互作用，其改变适用于各种感测和控制应用的纳米颗粒的至少一种材料性质。

公开(公告)号：US08853650B2

公开(公告)日：2014-10-07

申请号：US13871622

申请日：2013-04-26

Applicant: Ludwig Maximilians Universität München

Inventor： Stefan Duhr ,  Phillip Baaske

IPC: G01N21/64 ,  G01N21/63 ,  G01N21/62 ,  G01N21/17 ,  G01N15/14 ,  B01L3/00 ,  G01N15/00 ,  G01N15/02 ,  B01F13/00

CPC classification number: G01N33/6803 ,  B01F13/0079 ,  B01L3/502715 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2400/0442 ,  B01L2400/0451 ,  B01L2400/0454 ,  C12Q1/68 ,  G01K11/12 ,  G01N15/0205 ,  G01N15/1434 ,  G01N15/1475 ,  G01N21/171 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/6458 ,  G01N21/6486 ,  G01N33/6845 ,  G01N2015/0065 ,  G01N2015/0092 ,  G01N2015/025 ,  G01N2021/6439 ,  G01N2201/02 ,  G01N2201/06113 ,  G01N2201/0638 ,  Y10T436/143333

Abstract: The present invention relates to a method and an apparatus for a fast thermo-optical characterization of particles. In particular, the present invention relates to a method and a device to measure the stability of (bio)molecules, the interaction of molecules, in particular biomolecules, with, e.g. further (bio)molecules, particularly modified (bio)molecules, particles, beads, and/or the determination of the length/size (e.g. hydrodynamic radius) of individual (bio)molecules, particles, beads and/or the determination of length/size (e.g. hydrodynamic radius).

Abstract translation: 本发明涉及用于快速热光学表征颗粒的方法和装置。 特别地，本发明涉及测量（生物）分子的稳定性，特别是生物分子与分子的相互作用的方法和装置。 进一步（生物）分子，特别是改性（生物）分子，颗粒，珠粒和/或单个（生物）分子，颗粒，珠子的长度/尺寸（例如流体动力学半径）的确定和/或长度/ 尺寸（例如流体动力学半径）。

公开(公告)号：US20140260104A1

公开(公告)日：2014-09-18

申请号：US14293307

申请日：2014-06-02

Applicant: Ackley Machine Corporation

Inventor： E. Michael ACKLEY ,  Mark FORD

IPC: B07C5/342 ,  B07C5/34

CPC classification number: B07C5/3422 ,  B07C5/34 ,  B07C5/3412 ,  B07C5/362 ,  B07C5/363 ,  G01N21/85 ,  G01N21/8806 ,  G01N21/8851 ,  G01N2021/845 ,  G01N2021/8592 ,  G01N2201/02 ,  G01N2201/062 ,  G01N2201/0621 ,  Y10T29/49826

Abstract: An inspection system is configured for use with a conveyer apparatus including carrier bars. Each carrier bar conveys pellet-shaped articles along a predetermined path. The inspection system includes at least one camera unit for sensing a predetermined characteristic of the pellet-shaped articles, a removal unit, and a controller. The removal unit, downstream from the at least one camera unit, removes selected pellet-shaped article(s) from the carrier bar(s) depending on whether the characteristic is sensed by the at least one camera unit. The controller is in communication with the at least one camera unit and the removal unit. The controller provides a signal to the removal unit in accordance with the sensed characteristic. The removal unit includes a rotatable ejection drum having extended vacuum nozzles along its length, equal to the number of articles conveyed in each carrier bar. Each vacuum nozzle selectively removes article(s) from the carrier bar(s) by suction.

Abstract translation: 检查系统构造成与包括承载杆的输送装置一起使用。 每个承载杆沿预定路径传送颗粒状物品。 检查系统包括用于感测颗粒状物品的预定特征的至少一个照相机单元，去除单元和控制器。 去除单元，从至少一个照相机单元的下游，取决于该特性是否被至少一个照相机单元感测到，从载体棒移除所选的颗粒状物品。 控制器与至少一个相机单元和拆卸单元通信。 控制器根据感测到的特性向去除单元提供信号。 移除单元包括可旋转的排出滚筒，其具有沿其长度延伸的真空喷嘴，其等于在每个承载杆中输送的物品的数量。 每个真空喷嘴通过抽吸选择性地从承载杆去除物品。

公开(公告)号：US20140234180A1

公开(公告)日：2014-08-21

申请号：US14266894

申请日：2014-05-01

Applicant: OPKO Diagnostics, LLC

Inventor： Vincent Linder ,  David Steinmiller ,  Jason Taylor

IPC: B01L3/00

CPC classification number: B01L3/502746 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L7/52 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/0673 ,  B01L2200/0684 ,  B01L2200/143 ,  B01L2200/146 ,  B01L2200/147 ,  B01L2300/021 ,  B01L2300/023 ,  B01L2300/027 ,  B01L2300/04 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/12 ,  B01L2300/14 ,  B01L2300/16 ,  B01L2300/168 ,  B01L2300/1827 ,  B01L2300/1894 ,  B01L2400/0475 ,  B01L2400/049 ,  B01L2400/0666 ,  B01L2400/082 ,  G01N21/05 ,  G01N21/59 ,  G01N21/64 ,  G01N21/76 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/57434 ,  G01N2201/02 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/0621 ,  G01N2201/0697 ,  G01N2333/96433 ,  Y10T137/0324 ,  Y10T436/12

Abstract: Systems and methods for analysis of samples, and in certain embodiments, microfluidic sample analyzers configured to receive a cassette containing a sample therein to perform an analysis of the sample are described. The microfluidic sample analyzers may be used to control fluid flow, mixing, and sample analysis in a variety of microfluidic systems such as microfluidic point-of-care diagnostic platforms. Advantageously, the microfluidic sample analyzers may be, in some embodiments, inexpensive, reduced in size compared to conventional bench top systems, and simple to use. Cassettes that can operate with the sample analyzers are also described.

Abstract translation: 描述了用于分析样品的系统和方法，并且在某些实施方案中，被配置为接收包含样品的盒以执行样品分析的微流体样品分析器。 微流体样品分析仪可用于控制各种微流体系统（如微流体点护理诊断平台）中的流体流动，混合和样品分析。 有利地，在一些实施例中，与常规台式系统相比，微流体样品分析仪可能是便宜的，尺寸减小并且使用简单。 还描述了可以与样品分析仪一起操作的盒。

公开(公告)号：US08786838B2

公开(公告)日：2014-07-22

申请号：US13423029

申请日：2012-03-16

Applicant: James R. Braig ,  Peter Rule ,  Philip C. Hartstein ,  Bernhard B. Sterling ,  Jennifer H. Gable ,  Kenneth I. Li

Inventor： James R. Braig ,  Peter Rule ,  Philip C. Hartstein ,  Bernhard B. Sterling ,  Jennifer H. Gable ,  Kenneth I. Li

IPC: G01N33/48

CPC classification number: A61B5/157 ,  A61B5/01 ,  A61B5/1411 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/150022 ,  A61B5/150083 ,  A61B5/150213 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150458 ,  A61B5/150503 ,  A61B5/150618 ,  A61B5/150717 ,  A61B5/15087 ,  A61B5/151 ,  A61B5/15107 ,  A61B5/15136 ,  A61B5/1514 ,  A61B5/15194 ,  A61B5/6826 ,  A61B5/6838 ,  A61B10/0045 ,  A61B2562/0295 ,  A61B2562/12 ,  G01N21/03 ,  G01N21/0332 ,  G01N21/35 ,  G01N21/3577 ,  G01N21/3581 ,  G01N33/49 ,  G01N33/66 ,  G01N2021/0389 ,  G01N2201/02 ,  G01N2201/068

Abstract: A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.

Abstract translation: 能够在患者附近部署的无试剂全血分析物检测系统具有能够发射包括光谱带的辐射束的源。 全血系统还具有光束的光路中的检测器。 全血系统还具有容纳源和检测器的壳体。 全血系统还具有位于束的光路中的样品元件。 样品元件具有不消除光谱带中的辐射束的透射率的样品池和样品池壁。

公开(公告)号：US08770413B2

公开(公告)日：2014-07-08

申请号：US13740684

申请日：2013-01-14

Applicant: Ackley Machine Corporation

Inventor： E. Michael Ackley ,  Mark Ford

IPC: G01N33/34

CPC classification number: B07C5/3422 ,  B07C5/34 ,  B07C5/3412 ,  B07C5/362 ,  B07C5/363 ,  G01N21/85 ,  G01N21/8806 ,  G01N21/8851 ,  G01N2021/845 ,  G01N2021/8592 ,  G01N2201/02 ,  G01N2201/062 ,  G01N2201/0621 ,  Y10T29/49826

Abstract: An inspection system is configured for use with a conveyer apparatus including carrier bars. Each carrier bar conveys pellet-shaped articles along a predetermined path. The inspection system includes at least one camera unit for sensing a predetermined characteristic of the pellet-shaped articles, a removal unit, and a controller. The removal unit, downstream from the at least one camera unit, removes selected pellet-shaped article(s) from the carrier bar(s) depending on whether the characteristic is sensed by the at least one camera unit. The controller is in communication with the at least one camera unit and the removal unit. The controller provides a signal to the removal unit in accordance with the sensed characteristic. The removal unit includes a rotatable ejection drum having extended vacuum nozzles along its length, equal to the number of articles conveyed in each carrier bar. Each vacuum nozzle selectively removes article(s) from the carrier bar(s) by suction.

Abstract translation: 检查系统构造成与包括承载杆的输送装置一起使用。 每个承载杆沿预定路径传送颗粒状物品。 检查系统包括用于感测颗粒状物品的预定特征的至少一个照相机单元，去除单元和控制器。 去除单元，从至少一个照相机单元的下游，取决于该特性是否被至少一个照相机单元感测到，从载体棒移除所选的颗粒状物品。 控制器与至少一个相机单元和拆卸单元通信。 控制器根据感测到的特性向去除单元提供信号。 移除单元包括可旋转的排出滚筒，其具有沿其长度延伸的真空喷嘴，其等于在每个承载杆中输送的物品的数量。 每个真空喷嘴通过抽吸选择性地从承载杆去除物品。

公开(公告)号：US20130335734A1

公开(公告)日：2013-12-19

申请号：US13885178

申请日：2011-11-18

Applicant: Sven Krause ,  Yifei Wang ,  Lars Schomann ,  Gerhard Matz ,  Roland Harig ,  Jens Eichmann

Inventor： Sven Krause ,  Yifei Wang ,  Lars Schomann ,  Gerhard Matz ,  Roland Harig ,  Jens Eichmann

IPC: G01J3/02

CPC classification number: G01J3/0267 ,  G01J3/021 ,  G01N21/031 ,  G01N21/11 ,  G01N2201/02

Abstract: A measuring cell for a gas analysis spectrometer has an inner chamber (23) for a sample gas to be analyzed and an inlet (21) and an outlet (22) which are connected thereto. A traversing optical path for a measuring beam (14) is formed in the inner chamber (23). The measuring cell is tubular, the inlet (21) and the outlet (22) are arranged at opposite ends, and the inner chamber (23) of the measuring cell has a cross-sectional shape that is monotonic over the length of the tube and which has an oval-shape at the start, which disappears toward the end. That special shape results in fast gas exchange and thus high dynamics, even with larger measuring cells, which have high sensitivity due to the long optical paths thereof. Two characteristics which until now appeared to be conflicting are thereby combined.

公开(公告)号：US20130224075A1

公开(公告)日：2013-08-29

申请号：US13849084

申请日：2013-03-22

Applicant: OPKO Diagnostics, LLC

Inventor： Vincent Linder ,  David Steinmiller ,  Jason Taylor

IPC: G01N21/59

CPC classification number: B01L3/502746 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L7/52 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/0673 ,  B01L2200/0684 ,  B01L2200/143 ,  B01L2200/146 ,  B01L2200/147 ,  B01L2300/021 ,  B01L2300/023 ,  B01L2300/027 ,  B01L2300/04 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/12 ,  B01L2300/14 ,  B01L2300/16 ,  B01L2300/168 ,  B01L2300/1827 ,  B01L2300/1894 ,  B01L2400/0475 ,  B01L2400/049 ,  B01L2400/0666 ,  B01L2400/082 ,  G01N21/05 ,  G01N21/59 ,  G01N21/64 ,  G01N21/76 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/57434 ,  G01N2201/02 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/0621 ,  G01N2201/0697 ,  G01N2333/96433 ,  Y10T137/0324 ,  Y10T436/12

Abstract: Systems and methods for analysis of samples, and in certain embodiments, microfluidic sample analyzers configured to receive a cassette containing a sample therein to perform an analysis of the sample are described. The microfluidic sample analyzers may be used to control fluid flow, mixing, and sample analysis in a variety of microfluidic systems such as microfluidic point-of-care diagnostic platforms. Advantageously, the microfluidic sample analyzers may be, in some embodiments, inexpensive, reduced in size compared to conventional bench top systems, and simple to use. Cassettes that can operate with the sample analyzers are also described.

公开(公告)号：US20120301907A1

公开(公告)日：2012-11-29

申请号：US13537267

申请日：2012-06-29

Applicant: SUBRAMANI SELLAPPAN ,  ANDREW HEARN ,  SALVATORE SEMINARA

Inventor： SUBRAMANI SELLAPPAN ,  ANDREW HEARN ,  SALVATORE SEMINARA

IPC: G01N21/76 ,  C12M1/34 ,  G01N1/34

CPC classification number: C12Q1/04 ,  G01N1/38 ,  G01N21/76 ,  G01N21/77 ,  G01N33/56911 ,  G01N2001/028 ,  G01N2001/4061 ,  G01N2001/4088 ,  G01N2201/02

Abstract: A rapid, sensitive method of separating and detecting microorganisms from a sample potentially containing microorganisms, such as but not limited to bacteria, fungi, yeast, viruses, and the like. The method relies on separation techniques to separate and concentrate the cells from the sample, together with chemical techniques to amplify the amount of detectable signal from low numbers of cells to provide a rapid and sensitive method of detecting microorganisms. This detection method may utilize: a filtration device; a centrifugation device; a system; a swab device; and kit comprising one or more of the devices and components to perform the present method of separating and detecting microorganisms in a sample potentially containing microorganisms. The sample may be a chemical, cosmetic, personal care, pharmaceutical, or consumable good in its raw material, in-process, and/or finished product states that needs to be tested for any contaminating microorganisms prior to shipment to the consumer.

Abstract translation: 从可能含有微生物（例如但不限于细菌，真菌，酵母，病毒等）的样品中分离和检测微生物的快速，灵敏的方法。 该方法依赖于分离技术以将样品中的细胞与化学技术一起分离和浓缩，从而扩增来自低细胞数量的可检测信号的量，以提供检测微生物的快速和灵敏的方法。 该检测方法可以利用：过滤装置; 离心装置; 一个系统; 拭子装置 以及包含一个或多个装置和组件的试剂盒，以执行分离和检测可能含有微生物的样品中的微生物的本方法。 样品可能是化学，化妆品，个人护理，药物或消耗品的原材料，在制品和/或成品状态，需要在装运到消费者之前对任何污染的微生物进行测试。