公开(公告)号：US07838300B2

公开(公告)日：2010-11-23

申请号：US11689640

申请日：2007-03-22

Applicant: Kak Namkoong ,  Su-hyeon Kim ,  Jin-tae Kim ,  Chin-sung Park ,  Young-sun Lee

Inventor： Kak Namkoong ,  Su-hyeon Kim ,  Jin-tae Kim ,  Chin-sung Park ,  Young-sun Lee

IPC: G01N25/20 ,  B01L3/02

CPC classification number: B81B3/0081 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00822 ,  B01J2219/00873 ,  B01L3/5027 ,  B01L7/5255 ,  B01L2200/14 ,  B01L2200/147 ,  B01L2300/1805 ,  B01L2300/1827 ,  B81B2201/051 ,  F28F21/02 ,  F28F2013/006

Abstract: A method of reducing a temperature difference between a high-temperature and a low-temperature substrate includes interposing a heat transfer facilitating layer which has a higher thermal conductivity than air and can hold particles between the substrates, and maintaining close contact between the high-temperature substrate, the heat transfer facilitating layer, and the low-temperature substrate, wherein formation of an air layer can be at least substantially prevented between the high-temperature substrate and the heat transfer facilitating layer, and between the low-temperature substrate and the heat transfer facilitating layer.

Abstract translation: 降低高温和低温基板之间的温度差的方法包括：介于热传导率高于空气的传热促进层，并且可以在基板之间保持颗粒，并且保持高温 基板，传热促进层和低温基板，其中至少可以在高温基板和传热促进层之间以及在低温基板和热量之间基本上防止空气层的形成 转移促进层。

公开(公告)号：US07784911B2

公开(公告)日：2010-08-31

申请号：US11747043

申请日：2007-05-10

Applicant: Kui-hyun Kim ,  Byung-chul Kim ,  Kwang-ho Cheong ,  Su-hyeon Kim

Inventor： Kui-hyun Kim ,  Byung-chul Kim ,  Kwang-ho Cheong ,  Su-hyeon Kim

IPC: B41J2/06

CPC classification number: B01J19/0046 ,  B01J2219/00371 ,  B01J2219/00378 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00641 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00743 ,  B01L3/0262 ,  B01L2300/0819 ,  B01L2400/027 ,  C40B60/14

Abstract: An apparatus and method which print a biomolecular droplet onto a solid substrate using an electric charge concentration effect comprises: a needle shaped electric field forming electrode which is made of a conductive material, is disposed vertically, and comprises an accommodating area and a nozzle formed on a bottom end of the accommodating area; a solid substrate which is electrically grounded, is disposed below the electric field forming electrode, and comprises a moisture thin film and a target surface onto which the biomolecular droplet is discharged from the nozzle of the electric field forming electrode; and an open circuit type voltage applying unit which is electrically connected to the electric field forming electrode, applies a charge to the electric field forming electrode, and causes the biomolecular droplet to be ejected onto the target surface.

Abstract translation: 使用电荷浓度效应将生物分子液滴印刷到固体基质上的装置和方法包括：由导电材料制成的针形电场形成电极垂直设置，并且包括容纳区域和形成在 容纳区域的底端; 电气接地的固体基板设置在电场形成电极的下方，并且包括湿气薄膜和生物分子液滴从电场形成电极的喷嘴排出的目标表面; 以及与电场形成电极电连接的开路型电压施加单元，向电场形成电极施加电荷，并使生物分子液滴喷射到目标表面上。

公开(公告)号：US07692794B2

公开(公告)日：2010-04-06

申请号：US11972266

申请日：2008-01-10

Applicant: Su-hyeon Kim ,  Jeong-gun Lee

Inventor： Su-hyeon Kim ,  Jeong-gun Lee

IPC: G01N21/25

CPC classification number: G01N21/07 ,  G01N21/253 ,  G01N21/276 ,  G01N21/314

Abstract: Provided are an optical detection apparatus, a microfluidic system including the same, and an optical detection method. The optical detection apparatus including: at least one light emission unit which emits light of a predetermined wavelength band; at least one light receiving unit which is disposed such that the light receiving unit receives the light emitted from the light emission unit and generates an electrical signal according to the intensity of the light received, wherein the number of light receiving units is the same as the number of light emission units; a rotation operating unit which rotates a disk-type microfluidic apparatus comprising at least one detection chamber in which a sample is to be loaded such that the detection chamber is disposed in a light pathway between the light emission unit and the light receiving unit; and a processor which measures a property of the sample contained in the detection chamber using the electrical signal generated by the light receiving unit.

Abstract translation: 提供了一种光学检测装置，包括该光学检测装置的微流体系统和光学检测方法。 所述光学检测装置包括：发射预定波长带的光的至少一个发光单元; 至少一个光接收单元，其设置成使得所述光接收单元接收从所述发光单元发射的光并根据所接收的光的强度产生电信号，其中所述光接收单元的数量与 发光单位数量; 旋转操作单元，其旋转盘式微流体装置，其包括至少一个检测室，其中样品将被装载，使得所述检测室设置在所述发光单元和所述光接收单元之间的光路径中; 以及处理器，其使用由光接收单元生成的电信号来测量包含在检测室中的样品的性质。

公开(公告)号：US07572644B2

公开(公告)日：2009-08-11

申请号：US11334145

申请日：2006-01-17

Applicant: In-ho Lee ,  Jun-hong Min ,  Su-hyeon Kim

Inventor： In-ho Lee ,  Jun-hong Min ,  Su-hyeon Kim

IPC: G01N33/547 ,  G01N33/544 ,  G01N33/53 ,  C12M1/34 ,  C07K1/14 ,  C07D207/00

CPC classification number: C12N11/06 ,  B82Y30/00 ,  B82Y40/00 ,  C08F220/28 ,  C08F220/56 ,  C08F220/60 ,  C08F230/08 ,  C12Q1/6837 ,  G01N2035/00158 ,  Y10S524/916

Abstract: A novel hydrogel copolymer, a substrate coated with the copolymer, a method of producing a microarray using the copolymer, and a microarray produced by the method are provided. The use of the hydrogel copolymer makes efficient removal of protein and high integration of nucleic acid and protein on a substrate for a microarray possible.

Abstract translation: 提供一种新型水凝胶共聚物，用共聚物涂布的基材，使用该共聚物制备微阵列的方法，以及通过该方法制备的微阵列。 使用水凝胶共聚物可有效去除蛋白质，核基酸和蛋白质在基质上的高度整合可用于微阵列。

公开(公告)号：US20090021741A1

公开(公告)日：2009-01-22

申请号：US11972266

申请日：2008-01-10

Applicant: Su-hyeon KIM ,  Jeong-gun LEE

Inventor： Su-hyeon KIM ,  Jeong-gun LEE

IPC: G01N21/00

CPC classification number: G01N21/07 ,  G01N21/253 ,  G01N21/276 ,  G01N21/314

Abstract: Provided are an optical detection apparatus, a microfluidic system including the same, and an optical detection method. The optical detection apparatus including: at least one light emission unit which emits light of a predetermined wavelength band; at least one light receiving unit which is disposed such that the light receiving unit receives the light emitted from the light emission unit and generates an electrical signal according to the intensity of the light received, wherein the number of light receiving units is the same as the number of light emission units; a rotation operating unit which rotates a disk-type microfluidic apparatus comprising at least one detection chamber in which a sample is to be loaded such that the detection chamber is disposed in a light pathway between the light emission unit and the light receiving unit; and a processor which measures a property of the sample contained in the detection chamber using the electrical signal generated by the light receiving unit.

Abstract translation: 提供了一种光学检测装置，包括该光学检测装置的微流体系统和光学检测方法。 所述光学检测装置包括：发射预定波长带的光的至少一个发光单元; 至少一个光接收单元，其设置成使得所述光接收单元接收从所述发光单元发射的光并根据所接收的光的强度产生电信号，其中所述光接收单元的数量与 发光单位数量; 旋转操作单元，其使包括至少一个检测室的盘式微流体装置旋转，其中样品将被装载，使得检测室设置在发光单元和光接收单元之间的光通路中; 以及处理器，其使用由光接收单元生成的电信号来测量包含在检测室中的样品的性质。

公开(公告)号：US07465545B2

公开(公告)日：2008-12-16

申请号：US11341033

申请日：2006-01-27

Applicant: Su-hyeon Kim ,  Jun-hong Min ,  Kak Namkoong

Inventor： Su-hyeon Kim ,  Jun-hong Min ,  Kak Namkoong

IPC: C12Q1/68 ,  C12P19/34

CPC classification number: B01L3/50273 ,  B01L3/502746 ,  B01L2200/0621 ,  B01L2300/0816 ,  B01L2400/0409 ,  Y10T117/10

Abstract: Provided are a microfluidic chip and a microfluidic manipulating apparatus including the same. The microfluidic chip includes at least one microfluidic manipulating unit formed in a substrate. The microfluidic manipulating unit includes: a plurality of microchannels formed in the substrate; an inlet formed at a first end of the microchannel and exposed through the substrate; a trap formed at the microchannel; a chamber connected to a second end of the microchannel; and an outlet connected to the chamber and exposed through the substrate.

Abstract translation: 提供了一种微流控芯片和包括该微流控芯片的微流控操纵装置。 微流体芯片包括形成在基板中的至少一个微流体操纵单元。 微流体操纵单元包括：形成在基板中的多个微通道; 入口，其形成在所述微通道的第一端处并暴露于所述基底; 在微通道处形成的陷阱; 连接到所述微通道的第二端的室; 以及连接到室并通过基板暴露的出口。

公开(公告)号：US20080008628A1

公开(公告)日：2008-01-10

申请号：US11673291

申请日：2007-02-09

Applicant: Chin-sung PARK ,  Jin-tae KIM ,  Kak NAMGOONG ,  Su-hyeon KIM ,  Young-sun LEE

Inventor： Chin-sung PARK ,  Jin-tae KIM ,  Kak NAMGOONG ,  Su-hyeon KIM ,  Young-sun LEE

IPC: B01J19/00

CPC classification number: B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00822 ,  B01J2219/00828 ,  B01J2219/00833 ,  B01J2219/00837 ,  B01J2219/00873 ,  B01J2219/0097 ,  B01L3/5025 ,  B01L3/502707 ,  B01L3/502746 ,  B01L7/52 ,  B01L2200/12 ,  B01L2300/0887 ,  B01L2300/12 ,  B01L2300/1805 ,  B81C1/00119

Abstract: A microfluidic reaction chip and a method of manufacturing the same include a lower substrate, an upper substrate disposed on the lower substrate, wherein a lower surface of the upper substrate and an upper surface of the lower substrate face each other and are bonded to each other, at least one chamber formed in the upper surface of the lower substrate is configured to contain a fluid and at least one channel formed in the lower surface of the upper substrate, the at least one channel is in fluid communication with the at least one chamber.

Abstract translation: 微流体反应芯片及其制造方法包括下基板，设置在下基板上的上基板，其中上基板的下表面和下基板的上表面彼此接合并彼此结合 形成在下基板的上表面中的至少一个室构造成容纳流体和形成在上基板的下表面中的至少一个通道，所述至少一个通道与至少一个室流体连通 。

公开(公告)号：US20070284254A1

公开(公告)日：2007-12-13

申请号：US11754523

申请日：2007-05-29

Applicant: Young-kyoung Cho ,  Su-hyeon Kim ,  Chin-sung Park ,  Kyu-sang Lee ,  Jeong-gun Lee

Inventor： Young-kyoung Cho ,  Su-hyeon Kim ,  Chin-sung Park ,  Kyu-sang Lee ,  Jeong-gun Lee

IPC: B03C5/02

CPC classification number: B03C5/005 ,  B03C5/026 ,  B03C2201/26

Abstract: An apparatus separating a polarizable analyte using dielectrophoresis includes a vessel including a membrane having a plurality of nano- to micro-sized pores, the membrane disposed inside the vessel, electrodes generating spatially non-uniform electric fields in the nano- to micro-sized pores of the membrane when an AC voltage is applied to the electrodes, and a power source applying the AC voltage to the electrodes, wherein a sectional area of the pores varies along a depth of the pores. A method of separating a polarizable material uses the apparatus.

Abstract translation: 使用介电电泳分离可极化分析物的装置包括容器，其包括具有多个纳米至微米尺寸孔的膜，所述膜设置在容器内部，电极在纳米至微孔中产生空间上不均匀的电场 当向电极施加AC电压时，将膜施加到膜上，并且向电极施加AC电压的电源，其中孔的截面积沿着孔的深度而变化。 分离可极化材料的方法使用该装置。

公开(公告)号：US20070264723A1

公开(公告)日：2007-11-15

申请号：US11684393

申请日：2007-03-09

Applicant: Kui-hyun KIM ,  Byung-chul KIM ,  Su-hyeon KIM

Inventor： Kui-hyun KIM ,  Byung-chul KIM ,  Su-hyeon KIM

IPC: G01N1/00

CPC classification number: C40B60/14 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00369 ,  B01J2219/00371 ,  B01J2219/00385 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00574 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00655 ,  B01J2219/00657 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00729 ,  B01J2219/00731 ,  B01J2219/00743 ,  B01L3/0268 ,  B01L2400/027 ,  B01L2400/043 ,  G01N2035/1034 ,  Y10T436/25

Abstract: An apparatus for printing a biomolecular droplet onto a substrate using an electric charge concentration effect includes; an electric field forming electrode including an accommodating area in which the biomolecular droplet including micro magnetic beads is accommodated and a nozzle formed on an end of the accommodating area through which the biomolecular droplet is discharged, a substrate disposed below the electric field forming electrode, including a grounded target surface onto which the biomolecular droplet discharged from the nozzle of the electric field forming electrode is deposited, a magnet disposed below the substrate which applies a magnetic force on the micro magnetic beads, and an open circuit type voltage applying unit electrically connected to the electric field forming electrode which applies a charge to the electric field forming electrode which generates an electrical force which causes the biomolecular droplet to be ejected onto the target surface of the substrate.

Abstract translation: 使用电荷浓度效应将生物分子液滴印刷到基板上的装置包括： 包括容纳区域的电场形成电极，其中容纳包括微磁珠的生物分子液滴和形成在所述容纳区域的生物分子液滴被排出的端部的喷嘴，设置在所述电场形成电极下方的衬底，包括 沉积从电场形成电极的喷嘴排出的生物分子滴的接地目标表面，设置在基板上的对微小磁珠施加磁力的磁体，以及开路型电压施加单元，电连接到 该电场形成电极向电场形成电极施加电荷，该电场产生使生物分子液滴喷射到基板的目标表面上的电力。

公开(公告)号：US20070254379A1

公开(公告)日：2007-11-01

申请号：US11625877

申请日：2007-01-23

Applicant: Su-hyeon KIM ,  Jin-tae KIM ,  Kak Namkoong ,  In-ho LEE ,  Chin-sung PARK ,  Young-sun LEE

Inventor： Su-hyeon KIM ,  Jin-tae KIM ,  Kak Namkoong ,  In-ho LEE ,  Chin-sung PARK ,  Young-sun LEE

IPC: G01N33/00 ,  B01J19/00 ,  H05H1/00 ,  B29C45/00

CPC classification number: B01L3/502738 ,  B01L7/52 ,  B01L2200/0689 ,  B01L2300/0816 ,  B01L2300/0825 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/0655 ,  B29C33/3857 ,  B29C33/60 ,  Y10T137/218 ,  Y10T137/2202 ,  Y10T137/2224

Abstract: A micro-fluid reaction vessel includes an upper plate formed of an elastomer, a lower plate adhered to the upper plate, a micro-chamber and a micro-channel formed on an inner surface of the upper plate facing the lower plate and an inlet hole and an outlet hole formed in the upper plate and through which a fluid flows into or out of, respectively. The micro-channel is constructed to be closed by pressure applied to the upper plate and elastically restored when the pressure is not applied. A micro fluid reaction method uses the micro fluid reaction vessel and a method of manufacturing forms the microfluid reaction vessel.

Abstract translation: 微流体反应容器包括由弹性体形成的上板，粘附到上板的下板，形成在面向下板的上板的内表面上的微室和微通道，以及入口孔 以及形成在上板中并且流体分别流入或流出的出口孔。 微通道被构造为通过施加到上板的压力而关闭，并且当不施加压力时弹性恢复。 微流体反应方法使用微流体反应容器和制造方法形成微流体反应容器。