公开(公告)号：US20210371507A1

公开(公告)日：2021-12-02

申请号：US17307968

申请日：2021-05-04

Applicant: PROTHENA BIOSCIENCES LIMITED ,  UNIVERSITY HEALTH NETWORK

Inventor： YUE LIU ,  TARLOCHAN S. NIJJAR ,  AVIJIT CHAKRABARTTY ,  JEFFREY N. HIGAKI

IPC: C07K16/18 ,  A61K51/10

Abstract: The invention provides antibodies that specifically bind transthyretin (TTR). The antibodies can be used for treating or effecting prophylaxis of diseases or disorders associated with TTR accumulation or accumulation of TTR deposits (e.g., TTR amyloidosis). The antibodies can also be used for diagnosing TTR amyloidosis and inhibiting or reducing aggregation of TTR, among other applications.

公开(公告)号：US20210308333A1

公开(公告)日：2021-10-07

申请号：US17251525

申请日：2019-06-17

Applicant: John E. Davies ,  UNIVERSITY HEALTH NETWORK

Inventor： Niloufar Khosravi ,  Azusa Maeda ,  Ralph S. Da Costa ,  John E. Davies

IPC: A61L27/50 ,  A61K49/00

Abstract: Compositions, products and devices are provided for promoting wound healing. The compositions, products and devices have a topographical complex surface.

公开(公告)号：US20210290624A1

公开(公告)日：2021-09-23

申请号：US17056275

申请日：2019-05-22

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Benjamin Haibe-Kains ,  David Cescon

IPC: A61K31/519 ,  A61K31/437 ,  A61K31/44 ,  A61K31/517 ,  C12Q1/6886 ,  A61P35/00

Abstract: Provided herein are methods of treating cancers characterized by a high expression of SKA3 gene, such as: breast cancer, prostate cancer, endometrial cancer, ovarian cancer, brain cancer, skin cancer, thyroid cancer, lung cancer, mesothelioma cancer, bladder cancer, colorectal cancer, liver cancer, melanoma, glioblastoma, leukemia or lymphoma, comprising administering a therapeutically effective amount of a TTK inhibitor, such as: CFI-402257, BAY 1161909, BAY 1217389, AZ-3146, NMS-P715, TC Mps1 12, reversine, Mps1-IN-1, Mps1-IN-2, Mps1-IN-3, MPS BAY1, MPS BAY2a, MPS BAY2b, MPI-0479605, SP600125, S81694/NMS-P153; BOS172722; NTRC 0060-0; NTRC 1501-0; and a pharmaceutically acceptable salt thereof.

公开(公告)号：US20210269428A1

公开(公告)日：2021-09-02

申请号：US17172511

申请日：2021-02-10

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Peter Brent Sampson ,  Miklos Feher ,  Heinz W. Pauls

IPC: C07D413/14

Abstract: A fumarate salt and a maleate salt of compound (I) represented by the following structural formula, as well as their corresponding pharmaceutical compositions, are disclosed. Particular single crystalline forms of 1:1 compound (I) fumarate and 1:1 compound (I) maleate are characterized by a variety of properties and physical measurements. Methods of preparing specific crystalline forms of 1:1 compound (I) fumarate and 1:1 compound (I) maleate are also disclosed. The present invention also provides methods of treating a subject with a cancer.

公开(公告)号：US11090288B2

公开(公告)日：2021-08-17

申请号：US16141092

申请日：2018-09-25

Applicant: Canadian Blood Services ,  University Health Network

Inventor： Donald R. Branch ,  Lakshmi P. Kotra

IPC: A61K31/4155 ,  A61K45/06 ,  C07D231/12 ,  C07D231/20 ,  C07D231/22 ,  C07D231/46 ,  C07D403/06 ,  C07D403/12

Abstract: The present disclosure relates to a compound of formula or a pharmaceutically acceptable salt thereof; wherein U, R1, R2, R3 and Q are as defined herein. The disclosure also provides a method for treating or preventing a method for the prevention, treatment and/or alleviation of one or more autoimmune or alloimmune disease, pharmaceutical compositions and combination comprising a therapeutically effective amount of a compound, as defined herein.

公开(公告)号：US11052173B2

公开(公告)日：2021-07-06

申请号：US16419221

申请日：2019-05-22

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Ren-Ke Li

IPC: A61K9/10 ,  A61L27/18 ,  A61L27/20 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58

Abstract: The present disclosure relates to a biocompatible, electrically conductive polymer capable of carrying the electrical potential of a cardiac impulse. The present disclosure also relates to treatments using the electrically conductive polymer, such as for atrial fibrillation.

公开(公告)号：US20210198633A1

公开(公告)日：2021-07-01

申请号：US17057130

申请日：2019-05-30

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Maria Cristina NOSTRO ,  Farida SARANGI ,  Roman KORYTNIKOV ,  Emily MCGAUGH ,  Frankie Hoi Chun POON

IPC: C12N5/071

Abstract: Methods and compositions are provided for producing PDX1+/NKX6-1+ pancreatic progenitor cells from a PDX1+ endodermal cell population. The method comprises contacting the endodermal cell population with an EGF component and tankyrase inhibitor that binds to an adenosine subsite of a tankyrase enzyme, to induce the differentiation of at least a portion of the PDX1+ endodermal cell population into PDX1+NKX6-1+ pancreatic progenitor cells.

公开(公告)号：US20210188956A1

公开(公告)日：2021-06-24

申请号：US17127719

申请日：2020-12-18

Applicant: PROTHENA BIOSCIENCES LIMITED ,  UNIVERSITY HEALTH NETWORK

Inventor： Tarlochan S. Nijjar ,  Avijit Chakrabartty ,  Jeffrey N. Higaki

IPC: C07K16/18 ,  G01N33/68

Abstract: The invention provides antibodies that specifically bind to transthyretin (TTR). The antibodies can be used for treating or effecting prophylaxis of diseases or disorders associated with TTR accumulation or accumulation of TTR deposits (e.g., TTR amyloidosis). The antibodies can also be used for diagnosing TTR amyloidosis and inhibiting or reducing aggregation of TTR, among other applications.

公开(公告)号：US11028158B2

公开(公告)日：2021-06-08

申请号：US16584634

申请日：2019-09-26

Applicant: PROTHENA BIOSCIENCES LIMITED ,  UNIVERSITY HEALTH NETWORK

Inventor： Yue Liu ,  Tarlochan S. Nijjar ,  Avijit Chakrabartty ,  Jeffrey N. Higaki

IPC: G01N33/38 ,  A61K39/00 ,  C07K16/46 ,  C07K16/18 ,  A61K51/10

Abstract: The invention provides antibodies that specifically bind transthyretin (TTR). The antibodies can be used for treating or effecting prophylaxis of diseases or disorders associated with TTR accumulation or accumulation of TTR deposits (e.g., TTR amyloidosis). The antibodies can also be used for diagnosing TTR amyloidosis and inhibiting or reducing aggregation of TTR, among other applications.

公开(公告)号：US20210087336A1

公开(公告)日：2021-03-25

申请号：US16634026

申请日：2018-07-27

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Ren-Ke Li

IPC: C08G69/48 ,  A61L31/16 ,  A61L31/14 ,  A61L31/04 ,  A61L31/06 ,  C08L89/06 ,  A61N1/375 ,  A61N1/05

Abstract: The present disclosure relates to a biocompatible, electrically conductive biomaterial capable of carrying the electrical potential of a cardiac impulse. The biomaterial comprises a conductive polymer and a biocompatible component. The conductive polymer comprising an aminomethoxybenzoic acid (AMBA) polymer. The present disclosure also relates to treatments, uses and devices using the biocompatible, electrically conductive biomaterial.