公开(公告)号：US20210206521A1

公开(公告)日：2021-07-08

申请号：US17100686

申请日：2020-11-20

Applicant: VANRX PHARMASYSTEMS INC.

Inventor： Marcin Czeslaw CICHY ,  Carlos Alberto DIAZ GUERRERO

IPC: B65B3/12 ,  F04B43/12 ,  B65B3/00 ,  F04B49/06 ,  F04B13/00

Abstract: The present invention involves a rotary peristaltic pump and associated method employing the relaxation of pressure on flexible tubing between the rotor and stator of the pump to restore the rotor to a start angle while a valve on the output of the pump is closed to avoid progress of fluid through the system. Three different implementations of the pump and method are presented including reciprocating the stator, reciprocating the rotor, and retracting the idler rollers of the rotor into the rotor to relieve the pressure on the flexible tubing. A controller ensures the appropriate switching and timing of the valve and rotor of the pump. The pump and associated method are directed to the precision dispensing of pharmaceutical fluids into containers, including containers held in container nests.

公开(公告)号：US11014697B2

公开(公告)日：2021-05-25

申请号：US16430383

申请日：2019-06-03

Applicant: VANRX PHARMASYSTEMS INC.

Inventor： Marcin Czeslaw Cichy ,  Carlos Alberto Diaz Guerrero

IPC: B65B3/12 ,  F04B43/12 ,  F04B13/00 ,  F04B49/06 ,  B65B3/00

Abstract: The present invention involves a rotary peristaltic pump and associated method employing the relaxation of pressure on flexible tubing between the rotor and stator of the pump to restore the rotor to a start angle while a valve on the output of the pump is closed to avoid progress of fluid through the system. Three different implementations of the pump and method are presented including reciprocating the stator, reciprocating the rotor, and retracting the idler rollers of the rotor into the rotor to relieve the pressure on the flexible tubing. A controller ensures the appropriate switching and timing of the valve and rotor of the pump. The pump and associated method are directed to the precision dispensing of pharmaceutical fluids into containers, including containers held in container nests.

公开(公告)号：US20210078846A1

公开(公告)日：2021-03-18

申请号：US17033865

申请日：2020-09-27

Applicant: VANRX PHARMASYSTEMS INC.

Inventor： Christopher A. PROCYSHYN ,  Ross M GOLD ,  Steve Sang Joon PARK ,  Jeroen IMMERZEEL

IPC: B67B7/14 ,  B25J21/00 ,  B65B55/02

Abstract: An apparatus and method are presented for removing container covers within a controlled environment enclosure without using gloves. The apparatus comprises an articulated arm apparatus and a gripping apparatus and can further comprise a controller. The articulated arm apparatus can be configurable for holding and moving a container in three dimensions; and the gripping apparatus can be configured for gripping a container cover sealing the container. The method comprises moving the container using the articulated arm apparatus while holding a gripping area of the container cover substantially stationary using the gripping apparatus. The apparatus can further comprise a sensor configured for supplying information to the controller for determining the location of the container cover gripping area and an orientation of the container cover. The method can further comprise inspecting the container cover using the sensor. The container can be moved along a path and within a space determined by the controller.

公开(公告)号：US20210008540A1

公开(公告)日：2021-01-14

申请号：US16901123

申请日：2020-06-15

Applicant: VANRX PHARMASYSTEMS INC.

Inventor： Christopher PROCYSHYN ,  Marcin CICHY

IPC: B01L1/02 ,  A61L2/07 ,  A61L2/16 ,  A61L2/24 ,  B25J21/00 ,  C12M1/00 ,  C12M1/12 ,  A61J1/12 ,  A61J1/14 ,  A61J1/20 ,  B01L1/04 ,  B01L3/02 ,  B65B3/00 ,  B65B3/04 ,  B65B55/12 ,  G01N35/00 ,  G01N35/10

Abstract: A controlled environment enclosure comprises a robotic arm manipulation system used to protect and unprotect a fluid path and a swab within the controlled environment enclosure. The apparatus allows the fluid path to be protected against dangerous decontamination vapors and chemicals before the controlled environment enclosure is decontaminated. The apparatus allows the fluid path to be unprotected without the use of gloves or other means that degrade the integrity of the controlled environment enclosure when decontamination is completed. The apparatus and method allow for the protecting, unprotecting and decontaminating sequences to be automated. In some embodiments the fluid path comprises a fill needle that can removably and aseptically be sealed with a disposable monolithic injection moulded polymeric fill needle sheath. The apparatus and method further allow for the use of a swab disposed in a swab holder that is aseptically and removably sealable to a swab cap to protect the swab against decontamination vapors.

公开(公告)号：US10850873B2

公开(公告)日：2020-12-01

申请号：US15453615

申请日：2017-03-08

Applicant: Vanrx Pharmasystems Inc.

Inventor： Christopher Procyshyn ,  Juvenal Naing ,  John Senger ,  Marcin Cichy

IPC: B65B3/00 ,  B65B55/02 ,  A61M5/178 ,  B67C3/00 ,  B65D41/20

Abstract: Systems and methods for aseptically filling pharmaceutical containers with pharmaceutical fluid are disclosed. In one general aspect, these are based on an aseptically sealable chamber that includes a transfer wall to which pre-sealed pharmaceutical source and receiving containers are mounted aseptically. A robotic arm and a syringe store are disposed within the chamber along with a sterilizing facility for establishing in the chamber an aseptic condition. The robotic arm can grip and operate syringes to inject and/or extract pharmaceutical products from the containers by piercing their closures with the needles of the syringes.

公开(公告)号：US20200223573A1

公开(公告)日：2020-07-16

申请号：US16370526

申请日：2019-03-29

Applicant: VANRX PHARMASYSTEMS INC.

Inventor： Juvenal NAING ,  Yacov GOFMAN ,  Marcin CICHY

IPC: B65B55/02 ,  B65B3/00 ,  B65B43/50

Abstract: A system for filling nested pharmaceutical containers with a pharmaceutical fluid is disclosed. In one general aspect, it comprises a sterilizable chamber containing a planar rotary stage with a fiducial locating structure for holding a pharmaceutical container nest. The chamber has a rotatable cover removal station, a rotatable filling station with a dispenser head, and camera guided vacuum pickup facilities for handling container and closure nests. An associated method for filling the containers comprises establishing an aseptic condition within the chamber; removing covers from a container tub and a container closure tub by operating both the rotary stage and the cover removal station. The vacuum pickup facility transfers into the fiducial locating structure a container nest bearing pharmaceutical containers. The fluid is dispensed into the containers by operating both the rotary stage and the filling station. A container closure nest is placed on the container nest in the fiducial locating structure with closures in correspondence with containers. A ram in the chamber forces the closures into the containers.

公开(公告)号：US10710758B2

公开(公告)日：2020-07-14

申请号：US15647633

申请日：2017-07-12

Applicant: VANRX PHARMASYSTEMS INC.

Inventor： Carlos Alberto Diaz-Geurrero

IPC: B65B55/02 ,  B65B3/00 ,  A61J1/16 ,  B65B57/00 ,  B65B43/50 ,  B65B7/28 ,  B65B57/02 ,  B65B57/14 ,  B65B7/16 ,  B65B43/60

Abstract: A system is presented for monitoring and controlling in a sterilizable environment the peeling of a cover from a tub sealed by the cover. The system employs a platform having a fiducial source locating structure for holding the tub, a cover removal station disposed to engage with the cover and to peel the cover from the tub, a light source disposed to illuminate a portion of the platform proximate the cover removal station, a light sensor sensitive to light from the light source and disposed to preferentially collect and measure light diffusely reflected from the illuminated portion of the platform, and a controller with software to operate the system. An associated method for monitoring and controlling the peeling of the cover involves moving a peeled portion of the cover into a predetermined peeling monitor zone within the illuminated portion of the platform, and measuring an intensity of light from the light source diffusely reflected specifically from the peeling monitor zone. The positioning of the elements of the system and the peeling monitor zone allow measured light intensity to be employed as a control measure for the peeling process.

公开(公告)号：US20190324944A1

公开(公告)日：2019-10-24

申请号：US16356734

申请日：2019-03-18

Applicant: Vanrx Pharmasystems Inc.

Inventor： Christopher PROCYSHYN ,  Ross M. GOLD

IPC: G06F16/00 ,  G06F1/16 ,  B65B7/28 ,  B65B55/02 ,  B65B3/00 ,  B25J21/00 ,  H04M1/725 ,  H04M1/04

Abstract: Systems and methods are disclosed, which permit filling containers with a product. A filling atm is disposed within a chamber and an optical sensor is configured to sense openings of the containers within the chamber. Locations of the sensed openings are used to guide the filling atm to fill the containers with a product.

公开(公告)号：US20190193262A1

公开(公告)日：2019-06-27

申请号：US16222985

申请日：2018-12-17

Applicant: VANRX PHARMASYSTEMS INC.

Inventor： Christopher A. PROCYSHYN ,  Jeroen IMMERZEEL ,  Steve Sang Joon PARK ,  Ross M. GOLD

IPC: B25J9/00 ,  B25J18/04 ,  B25J19/00 ,  B25J21/00

CPC classification number: B25J9/0009 ,  B25J9/0075 ,  B25J18/04 ,  B25J19/0075 ,  B25J21/00

Abstract: A hermetically sealed multi-axis articulated arm apparatus for use within a sealable isolator chamber comprises a rotational shaft that passes through an opening in the chamber, a sealing member disposed within the chamber for sealing the shaft to an inner surface of the chamber, a plurality of interconnected hermetically sealed arm segments, operably attached to the linear motion shaft; an end effector operably attached to a terminal arm segment among the plurality of arm segments, and at least one fully enclosed drive system for driving and controlling the shaft and the plurality of arm segments. The linear motion shaft may have a sealing member in the form of a bellows. The materials for the parts of the apparatus exposed to the atmosphere of the chamber are compatible with an aseptic and cleanable environment and the surfaces of the arm segments are shaped to avoid pooling of contaminants.

公开(公告)号：US20190056419A1

公开(公告)日：2019-02-21

申请号：US15898650

申请日：2018-02-18

Applicant: VANRX PHARMASYSTEMS INC.

Inventor： Christopher PROCYSHYN ,  Marcin CICHY

IPC: G01N35/10 ,  B01L1/04 ,  G01N35/00 ,  B65B3/04 ,  A61J1/12 ,  B65B3/00 ,  B65B55/12 ,  B01L3/02 ,  A61J1/14 ,  A61J1/20

CPC classification number: G01N35/10 ,  A61J1/12 ,  A61J1/14 ,  A61J1/20 ,  B01L1/04 ,  B01L3/02 ,  B01L2200/026 ,  B01L2200/0689 ,  B01L2200/141 ,  B01L2300/0609 ,  B01L2400/0487 ,  B65B3/003 ,  B65B3/04 ,  B65B55/12 ,  G01N35/00029 ,  G01N35/0099 ,  G01N2035/00148 ,  G01N2035/00277

Abstract: A controlled environment enclosure comprises a robotic arm manipulation system used to protect and unprotect a fluid path and a swab within the controlled environment enclosure. The apparatus allows the fluid path to be protected against dangerous decontamination vapors and chemicals before the controlled environment enclosure is decontaminated. The apparatus allows the fluid path to be unprotected without the use of gloves or other means that degrade the integrity of the controlled environment enclosure when decontamination is completed. The apparatus and method allow for the protecting, unprotecting and decontaminating sequences to be automated. In some embodiments the fluid path comprises a fill needle that can removably and aseptically be sealed with a disposable monolithic injection moulded polymeric fill needle sheath. The apparatus and method further allow for the use of a swab disposed in a swab holder that is aseptically and removably sealable to a swab cap to protect the swab against decontamination vapors.