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1.
公开(公告)号:US20190056420A1
公开(公告)日:2019-02-21
申请号:US15898653
申请日:2018-02-18
Applicant: VANRX PHARMASYSTEMS INC.
Inventor: Christopher PROCYSHYN , Marcin CICHY
IPC: G01N35/10 , B01L1/04 , G01N35/00 , B65B3/04 , A61J1/12 , B65B3/00 , B65B55/12 , B01L3/02 , A61J1/14 , A61J1/20
Abstract: A controlled environment enclosure comprises a robotic arm manipulation system used to protect and unprotect a fluid path and a swab within the controlled environment enclosure. The apparatus allows the fluid path to be protected against dangerous decontamination vapors and chemicals before the controlled environment enclosure is decontaminated. The apparatus allows the fluid path to be unprotected without the use of gloves or other means that degrade the integrity of the controlled environment enclosure when decontamination is completed. The apparatus and method allow for the protecting, unprotecting and decontaminating sequences to be automated. In some embodiments the fluid path comprises a fill needle that can removably and aseptically be sealed with a disposable monolithic injection moulded polymeric fill needle sheath. The apparatus and method further allow for the use of a swab disposed in a swab holder that is aseptically and removably sealable to a swab cap to protect the swab against decontamination vapors.
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公开(公告)号:US20230251995A1
公开(公告)日:2023-08-10
申请号:US18134594
申请日:2023-04-14
Applicant: Vanrx Pharmasystems Inc.
Inventor: Christopher PROCYSHYN , Ross M. GOLD
CPC classification number: G06F16/00 , B25J21/00 , B65B55/027 , B65B3/003 , B65B7/2807 , B65B7/2821 , H04M1/72409 , G06F1/1626 , G06F1/1632 , G06F1/1696 , H04M1/04 , G01N35/0099
Abstract: Systems and methods permit gloveless filling containers with a product. A filling arm is disposed within the chamber. An optical sensor is configured to locate and target openings of the containers within the chamber. Locations of the openings are used to guide the filling arm to fill the containers with a product.
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公开(公告)号:US20190135462A1
公开(公告)日:2019-05-09
申请号:US16238433
申请日:2019-01-02
Applicant: VANRX PHARMASYSTEMS INC.
Inventor: Nick BROADBENT , Jeroen IMMERZEEL , Christopher PROCYSHYN , Ross M. GOLD , Steve Sang Joon PARK
IPC: B65B7/16 , B65B7/28 , B65D51/00 , B65D1/02 , B65B3/00 , B65B55/08 , B65B55/04 , B65B63/08 , B65B55/10 , B65B55/02
Abstract: In one general aspect, a method for filling multiple containers with a pharmaceutical product is disclosed, which comprises decontaminating sealed nested materials in a transfer chamber, removing from the sealed nested materials one or both of a container nest holding the multiple containers and a closure nest holding multiple closures, transferring from the transfer chamber to a controlled environment enclosure the removed nest, aseptically filling the containers with the pharmaceutical product, and closing the containers with the multiple closures. The nests are configured to allow multiple closures and containers to be simultaneously aligned concentrically, and closed simultaneously. Spring-loaded retaining structures on the closure nest allow it to releasably retain multiple closures above the corresponding multiple containers. In some embodiments the spring-loaded features are monolithically integrated with the closure nest. The product may be lyophilized in partially sealed containers while the sealing closures are releasably retained by the closure nest.
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公开(公告)号:US20240150050A1
公开(公告)日:2024-05-09
申请号:US18412182
申请日:2024-01-12
Applicant: VANRX PHARMASYSTEMS INC.
Inventor: Nick BROADBENT , Jeroen IMMERZEEL , Christopher PROCYSHYN , Ross M. GOLD , Steve Sang Joon PARK
CPC classification number: B65B7/161 , B65B3/003 , B65B7/2821 , B65B55/027 , B65D41/28 , B65B55/08
Abstract: In one general aspect, a method for filling multiple containers with a pharmaceutical product is disclosed, which comprises decontaminating sealed nested materials in a transfer chamber, removing from the sealed nested materials one or both of a container nest holding the multiple containers and a closure nest holding multiple closures, transferring from the transfer chamber to a controlled environment enclosure the removed nest, aseptically filling the containers with the pharmaceutical product, and closing the containers with the multiple closures. The nests are configured to allow multiple closures and containers to be simultaneously aligned concentrically, and closed simultaneously. Spring-loaded retaining structures on the closure nest allow it to releasably retain multiple closures above the corresponding multiple containers. In some embodiments the spring-loaded features are monolithically integrated with the closure nest. The product may be lyophilized in partially sealed containers while the sealing closures are releasably retained by the closure nest.
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公开(公告)号:US20210089493A1
公开(公告)日:2021-03-25
申请号:US17005606
申请日:2020-08-28
Applicant: Vanrx Pharmasystems Inc.
Inventor: Christopher PROCYSHYN , Ross M. GOLD
Abstract: Systems and methods are disclosed, which permit filling containers with a product. A filling arm is disposed within a chamber and an optical sensor is configured to sense openings of the containers within the chamber. Locations of the sensed openings are used to guide the filling arm to fill the containers with a product.
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公开(公告)号:US20180370665A1
公开(公告)日:2018-12-27
申请号:US15950480
申请日:2018-04-11
Applicant: VANRX PHARMASYSTEMS INC.
Inventor: Nick BROADBENT , Jeroen IMMERZEEL , Christopher PROCYSHYN , Ross M. GOLD , Steve Sang Joon PARK
IPC: B65B7/16 , B65D51/00 , B65D1/02 , B65B7/28 , B65B3/00 , B65B55/08 , B65B55/04 , B65B63/08 , B65B55/10 , B65B55/02
Abstract: In one general aspect, a method for filling multiple containers with a pharmaceutical product is disclosed, which comprises decontaminating sealed nested materials in a transfer chamber, removing from the sealed nested materials one or both of a container nest holding the multiple containers and a closure nest holding multiple closures, transferring from the transfer chamber to a controlled environment enclosure the removed nest, aseptically filling the containers with the pharmaceutical product, and closing the containers with the multiple closures. The nests are configured to allow multiple closures and containers to be simultaneously aligned concentrically, and closed simultaneously. Spring-loaded retaining structures on the closure nest allow it to releasably retain multiple closures above the corresponding multiple containers. In some embodiments the spring-loaded features are monolithically integrated with the closure nest. The product may be lyophilized in partially sealed containers while the sealing closures are releasably retained by the closure nest.
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公开(公告)号:US20180127120A1
公开(公告)日:2018-05-10
申请号:US15719736
申请日:2017-09-29
Applicant: VANRX PHARMASYSTEMS INC.
Inventor: Nick BROADBENT , Jeroen IMMERZEEL , Christopher PROCYSHYN , Ross M. GOLD , Steve Sang Joon PARK
IPC: B65B7/16 , B65D51/00 , B65D1/02 , B65B7/28 , B65B3/00 , B65B55/04 , B65B63/08 , B65B55/10 , B65B55/08 , B65B55/02
CPC classification number: B65B7/28 , B65B3/003 , B65B7/161 , B65B7/2821 , B65B55/027 , B65B55/04 , B65B55/08 , B65B55/10 , B65B63/08 , B65D1/0246 , B65D51/00 , B65D51/002
Abstract: In one general aspect, a method for filling multiple containers with a pharmaceutical product is disclosed, which comprises decontaminating sealed nested materials in a transfer chamber, removing from the sealed nested materials one or both of a container nest holding the multiple containers and a closure nest holding multiple closures, transferring from the transfer chamber to a controlled environment enclosure the removed nest, aseptically filling the containers with the pharmaceutical product, and closing the containers with the multiple closures. The nests are configured to allow multiple closures and containers to be simultaneously aligned concentrically, and closed simultaneously. Spring-loaded retaining structures on the closure nest allow it to releasably retain multiple closures above the corresponding multiple containers. In some embodiments the spring-loaded features are monolithically integrated with the closure nest. The product may be lyophilized in partially sealed containers while the sealing closures are releasably retained by the closure nest.
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公开(公告)号:US20230018492A1
公开(公告)日:2023-01-19
申请号:US17891347
申请日:2022-08-19
Applicant: VANRX PHARMASYSTEMS INC.
Inventor: Ross M. GOLD , Jeroen IMMERZEEL , Christopher PROCYSHYN , Nick BROADBENT , Steve Sang Joon PARK
IPC: B65B7/16 , B65B55/02 , B65B3/00 , B65D41/28 , B65B7/28 , B65B55/04 , B65B55/10 , B65B55/08 , B65D1/02 , B65D51/00
Abstract: In one general aspect, a method for filling multiple containers with a pharmaceutical product is disclosed, which comprises decontaminating sealed nested materials in a transfer chamber, removing from the sealed nested materials one or both of a container nest holding the multiple containers and a closure nest holding multiple closures, transferring from the transfer chamber to a controlled environment enclosure the removed nest, aseptically filling the containers with the pharmaceutical product, and closing the containers with the multiple closures. The nests are configured to allow multiple closures and containers to be simultaneously aligined concentrically, and closed simultaneously. Spring-loaded retaining structures on the closure nest allow it to releasably retain multiple closures above the corresponding multiple containers. In some embodiments the spring-loaded features are monolithically integrated with the closure nest. The product may be lyophilized in partially sealed containers while the sealing closures are releasably retained by the closure nest.
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9.
公开(公告)号:US20210008540A1
公开(公告)日:2021-01-14
申请号:US16901123
申请日:2020-06-15
Applicant: VANRX PHARMASYSTEMS INC.
Inventor: Christopher PROCYSHYN , Marcin CICHY
IPC: B01L1/02 , A61L2/07 , A61L2/16 , A61L2/24 , B25J21/00 , C12M1/00 , C12M1/12 , A61J1/12 , A61J1/14 , A61J1/20 , B01L1/04 , B01L3/02 , B65B3/00 , B65B3/04 , B65B55/12 , G01N35/00 , G01N35/10
Abstract: A controlled environment enclosure comprises a robotic arm manipulation system used to protect and unprotect a fluid path and a swab within the controlled environment enclosure. The apparatus allows the fluid path to be protected against dangerous decontamination vapors and chemicals before the controlled environment enclosure is decontaminated. The apparatus allows the fluid path to be unprotected without the use of gloves or other means that degrade the integrity of the controlled environment enclosure when decontamination is completed. The apparatus and method allow for the protecting, unprotecting and decontaminating sequences to be automated. In some embodiments the fluid path comprises a fill needle that can removably and aseptically be sealed with a disposable monolithic injection moulded polymeric fill needle sheath. The apparatus and method further allow for the use of a swab disposed in a swab holder that is aseptically and removably sealable to a swab cap to protect the swab against decontamination vapors.
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公开(公告)号:US20190324944A1
公开(公告)日:2019-10-24
申请号:US16356734
申请日:2019-03-18
Applicant: Vanrx Pharmasystems Inc.
Inventor: Christopher PROCYSHYN , Ross M. GOLD
Abstract: Systems and methods are disclosed, which permit filling containers with a product. A filling atm is disposed within a chamber and an optical sensor is configured to sense openings of the containers within the chamber. Locations of the sensed openings are used to guide the filling atm to fill the containers with a product.
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