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公开(公告)号：US5750651A
公开(公告)日：1998-05-12
申请号：US145812
申请日：1993-11-01
Applicant: Hermann Oppermann , Thangavel Kuberasampath , David C. Rueger , Engin Ozkaynak
Inventor： Hermann Oppermann , Thangavel Kuberasampath , David C. Rueger , Engin Ozkaynak
IPC: A61C8/00 , A61F2/00 , A61K9/00 , A61K38/00 , A61L27/22 , A61L27/24 , A61L27/34 , A61L27/36 , A61L27/56 , C07K14/51 , C12N15/18 , C07K14/435 , C12N15/12
CPC classification number: A61K9/0024 , A61L27/227 , A61L27/24 , A61L27/34 , A61L27/3608 , A61L27/365 , A61L27/3654 , A61L27/56 , C07K14/51 , A61C8/0006 , A61F2310/00365 , A61K38/00 , A61L2430/02 , Y10S530/84
Abstract: Disclosed are 1) osteogenic devices comprising a matrix containing osteogenic protein and methods of inducing endochondral bone growth in mammals using the devices; 2) amino acid sequence data, amino acid composition, solubility properties, structural features, homologies and various other data characterizing osteogenic proteins, 3) methods of producing osteogenic proteins using recombinant DNA technology, and 4) osteogenically and chondrogenically active synthetic protein constructs.
Abstract translation: 公开的是1）包含含有成骨蛋白的基质的成骨装置和使用该装置在哺乳动物中诱导软骨内骨生长的方法; 2）氨基酸序列数据，氨基酸组成，溶解性，结构特征，同源性和各种其他数据表征成骨蛋白，3）使用重组DNA技术生产成骨蛋白的方法，以及4）成骨和软骨形成活性合成蛋白质构建体。
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公开(公告)号：US5525491A
公开(公告)日：1996-06-11
申请号：US257341
申请日：1994-06-09
Applicant: James S. Huston , Hermann Oppermann , Serge N. Timasheff
Inventor： James S. Huston , Hermann Oppermann , Serge N. Timasheff
CPC classification number: C07K16/00 , C12N15/62 , C07K2319/00 , C07K2319/35 , C07K2319/705
Abstract: Disclosed are serine-rich peptide linkers for linking two or more protein domains to form a fused protein. The peptide linkers contains at least 40% serine residues and preferably have the formula (Ser, Ser,Ser,Ser,Gly).sub.y where y is .gtoreq.1. The resulting fused domains are biologically active together or individually, have improved solubility in physiological media, and improved resistance to proteolysis.
Abstract translation: 公开了用于连接两个或多个蛋白质结构域以形成融合蛋白的丝氨酸丰富的肽接头。 肽接头含有至少40％的丝氨酸残基，并且优选具有式（Ser，Ser，Ser，Ser，Gly）y，其中y为≥1。 所得的融合结构域在一起或单独地具有生物活性，在生理介质中具有改善的溶解性，并且改善了对蛋白水解的抵抗力。
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公开(公告)号：US5324819A
公开(公告)日：1994-06-28
申请号：US950229
申请日：1992-09-24
Applicant: Hermann Oppermann , Thangavel Kuberasampath , David C. Rueger , Engin Ozkaynak
Inventor： Hermann Oppermann , Thangavel Kuberasampath , David C. Rueger , Engin Ozkaynak
IPC: A61C8/00 , A61F2/00 , A61K9/00 , A61K38/00 , A61L27/22 , A61L27/36 , A61L27/56 , C07K14/51 , C12P21/02 , C12N7/00 , C12N15/00 , C12P19/34
CPC classification number: A61L27/227 , A61K9/0024 , A61L27/56 , C07K14/51 , A61C8/0006 , A61F2310/00365 , A61K38/00 , A61L2430/02 , Y10S530/84
Abstract: Disclosed are 1) osteogenic devices comprising a matrix containing osteogenic protein and methods of inducing endochondral bone growth in mammals using the devices; 2) amino acid sequence data, amino acid compositions, solubility properties, structural features, homologies and various other data characterizing osteogenic proteins, 3) methods of producing osteogenic proteins using recombinant DNA technology, and 4) osteogenically and chondrogenically active synthetic protein constructs.
Abstract translation: 公开的是1）包含含有成骨蛋白的基质的成骨装置和使用该装置在哺乳动物中诱导软骨内骨生长的方法; 2）氨基酸序列数据，氨基酸组成，溶解度性质，结构特征，同源性和各种其他数据表征成骨蛋白，3）使用重组DNA技术生产成骨蛋白的方法，以及4）成骨和软骨形成活性合成蛋白质构建体。
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公开(公告)号：US5266683A
公开(公告)日：1993-11-30
申请号：US841646
申请日：1992-02-21
Applicant: Hermann Oppermann , Engin Ozkaynak , Thangavel Kuberasampath , David C. Rueger , Roy H. L. Pang
Inventor： Hermann Oppermann , Engin Ozkaynak , Thangavel Kuberasampath , David C. Rueger , Roy H. L. Pang
IPC: A61C8/00 , A61F2/00 , A61K6/00 , A61K9/00 , A61K38/00 , A61K38/18 , A61L27/22 , A61L27/24 , A61L27/34 , A61L27/36 , A61L27/56 , C04B14/12 , C04B20/06 , C07K14/51 , A61K37/02 , C07K5/00 , C07K7/00 , C07K15/00
CPC classification number: A61K9/0024 , A61K38/1875 , A61L27/227 , A61L27/24 , A61L27/34 , A61L27/3604 , A61L27/3608 , A61L27/365 , A61L27/3654 , A61L27/3683 , A61L27/54 , A61L27/56 , C04B14/12 , C04B20/068 , C07K14/51 , A61C8/0006 , A61F2310/00365 , A61L2300/412 , A61L2430/02 , Y10S530/84
Abstract: Disclosed are (1) osteogenic devices comprising a matrix containing substantially pure natural-sourced mammalian osteogenic protein; (2) DNA and amino acid sequences for novel polypeptide chains useful as subunits of dimeric osteogenic proteins; (3) vectors carrying sequences encoding these novel polypeptide chains and host cells transfected with these vectors; (4) methods of producing these polypeptide chains using recombinant DNA technology; (5) antibodies specific for these novel polypeptide chains; (6) osteogenic devices comprising these recombinantly produced proteins in association with an appropriate carrier matrix; and (7) methods of using the osteogenic devices to mimic the natural course of endochondral bone formation in mammals.
Abstract translation: 公开的是（1）包含含有基本上纯天然来源的哺乳动物成骨蛋白质的基质的成骨装置; （2）可用作二聚成骨蛋白亚基的新型多肽链的DNA和氨基酸序列; （3）携带编码这些新型多肽链的序列的载体和用这些载体转染的宿主细胞; （4）使用重组DNA技术生产这些多肽链的方法; （5）对这些新型多肽链具有特异性的抗体; （6）包含这些重组产生的蛋白质与合适的载体基质相结合的成骨装置; 和（7）使用成骨装置来模拟哺乳动物软骨内骨形成的自然过程的方法。
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公开(公告)号：US5258498A
公开(公告)日：1993-11-02
申请号：US955399
申请日：1992-10-01
Applicant: James S. Huston , Hermann Oppermann
Inventor： James S. Huston , Hermann Oppermann
CPC classification number: C07K16/464 , C07K16/00 , C12N15/62 , C07K2317/24 , C07K2317/622 , C07K2317/624 , C07K2319/00 , C07K2319/02 , C07K2319/705 , Y10S424/80
Abstract: Disclosed are a family of synthetic proteins having binding affinity for a preselected antigen, and multifunctional proteins having such affinity. The proteins are characterized by one or more sequences of amino acids constituting a region which behaves as a biosynthetic antibody binding site (BABS) The sites comprise V.sub.H -V.sub.L or V.sub.L -V.sub.H -like single chains wherein the V.sub.H and V.sub.L -like sequences are attached by a polypeptide linker, or individual V.sub.H or V.sub.L -like domains. The binding domains comprise linked CDR and FR regions, which may be derived from separate immunoglobulins. The proteins may also include other polypeptide sequences which function, e.g., as an enzyme, toxin, binding site, or site for attachment to an immobilization media or radioactive atom. Methods are disclosed for producing the proteins, for designing BABS having any specificity that can be elicited by in vivo generation of antibody for producing analogs thereof, and for producing multifunctional synthetic proteins which are self-targeted by virtue of their binding site region.
Abstract translation: PCT No.PCT / US88 / 01737 Sec。 371日期1989年1月23日 102（e）日期1989年1月23日PCT提交1988年5月19日PCT公布。 出版物WO88 / 09344 日期为1988年12月1日。公开是对预选抗原具有结合亲和力的合成蛋白家族，以及具有这种亲和力的多功能蛋白质。 蛋白质的特征在于构成表现为生物合成抗体结合位点（BABS）的区域的一个或多个氨基酸序列。位点包含VH和VL-样的单链，其中VH和VL样序列被连接 通过多肽接头，或单独的VH或VL样结构域。 结合域包含连接的CDR和FR区，其可以衍生自单独的免疫球蛋白。 蛋白质还可以包括其它多肽序列，其功能例如作为酶，毒素，结合位点或用于附着到固定化介质或放射性原子的位点。 公开了用于制备蛋白质的方法，用于设计具有可通过体内产生抗体产生其类似物的任何特异性的BABS，以及用于生产通过其结合位点区域自身靶向的多功能合成蛋白质。
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Patent Agency Ranking
公开(公告)号：US20100307804A1
公开(公告)日：2010-12-09
申请号：US12742179
申请日：2008-11-14
Applicant: Hermann Oppermann
Inventor： Hermann Oppermann
IPC: H05K1/00 , B05D3/00 , B05D5/12 , B05D5/00 , B05D1/32 , B05D3/02 , B05D3/10 , H01L21/441 , C23C14/34 , C25D5/48 , C25D5/54
CPC classification number: B81B7/0006 , C22C1/02 , C22C1/08 , H01L24/28 , H01L2924/01004 , H01L2924/01005 , H01L2924/01015 , H01L2924/01024 , H01L2924/01029 , H01L2924/01032 , H01L2924/01033 , H01L2924/01047 , H01L2924/01074 , H01L2924/01078 , H01L2924/01079 , H01L2924/01082 , H01L2924/0132 , H01L2924/09701 , H05K3/24 , H05K3/28 , H05K3/383 , H05K2201/0116 , H05K2203/0361
Abstract: The invention relates to a method for connecting a precious metal surface to a polymer, wherein a layer made of 20% to 40% gold and 80% to 60% silver is deposited on a substrate and the silver is subsequently selectively removed in order to produce a nanoporous gold layer. A fluid polymer is applied to the gold layer and cured.
Abstract translation: 本发明涉及一种将贵金属表面连接到聚合物上的方法，其中将由20％至40％的金和80％至60％的银制成的层沉积在基底上，随后选择性地除去银，以便产生 纳米多孔金层。 将流体聚合物施加到金层并固化。
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公开(公告)号：US20100270673A1
公开(公告)日：2010-10-28
申请号：US12742176
申请日：2008-11-14
Applicant: Hermann Oppermann
Inventor： Hermann Oppermann
IPC: H01L23/538 , H01L21/60 , H01L21/70
CPC classification number: H05K3/24 , B22F2003/244 , B81C3/001 , B81C2203/032 , C22C1/08 , H01L24/10 , H01L24/28 , H01L24/81 , H01L24/83 , H01L2224/81203 , H01L2224/81205 , H01L2224/81801 , H01L2224/83205 , H01L2224/83801 , H01L2924/01004 , H01L2924/01005 , H01L2924/01006 , H01L2924/01013 , H01L2924/01024 , H01L2924/01029 , H01L2924/01033 , H01L2924/01047 , H01L2924/01074 , H01L2924/01078 , H01L2924/01079 , H01L2924/01084 , H01L2924/0132 , H01L2924/0781 , H01L2924/19043 , H05K3/321 , H05K3/325 , H05K3/383 , H05K2201/0116 , H05K2201/209 , H05K2203/0307 , H05K2203/0361
Abstract: The invention relates to a method for connecting two joining surfaces, particularly in the field of semiconductors, wherein at least one joining surface is produced by depositing a layer comprising 20 to 40% gold and 80 to 60% silver onto a substrate and selectively removing the silver from the deposited layer in order to produce a nanoporous gold layer as a joining surface. The joining surface with the nanoporous gold layer and an additional joining surface are disposed one above the other and pressed together.
Abstract translation: 本发明涉及一种用于连接两个接合表面的方法，特别是在半导体领域中，其中至少一个接合表面通过将包含20至40％的金和80至60％的银的层沉积到衬底上而产生，并选择性地除去 银，以便产生作为接合表面的纳米多孔金层。 具有纳米多孔金层的接合表面和另外的接合表面一个放置在另一个上并压在一起。
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公开(公告)号：US20060198835A1
公开(公告)日：2006-09-07
申请号：US11331855
申请日：2006-01-13
Applicant: Hermann Oppermann , Thangavel Kuberasampath , David Rueger , Engin Ozkaynak
Inventor： Hermann Oppermann , Thangavel Kuberasampath , David Rueger , Engin Ozkaynak
Abstract: Disclosed are 1) osteogenic devices comprising a matrix containing osteogenic protein and methods of inducing endochondral bone growth in mammals using the devices; 2) amino acid sequence data, amino acid composition, solubility properties, structural features, homologies and various other data characterizing osteogenic proteins, 3) methods of producing osteogenic proteins using recombinant DNA technology, and 4) osteogenically and chondrogenically active synthetic protein constructs.
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公开(公告)号：US07078221B2
公开(公告)日：2006-07-18
申请号：US09754831
申请日：2001-01-03
Applicant: Hermann Oppermann , Thangavel Kuberasampath , David C. Rueger , Engin Ozkaynak
Inventor： Hermann Oppermann , Thangavel Kuberasampath , David C. Rueger , Engin Ozkaynak
CPC classification number: A61K9/0024 , A61C8/0006 , A61F2310/00365 , A61K38/00 , A61L27/227 , A61L27/24 , A61L27/34 , A61L27/3608 , A61L27/365 , A61L27/3654 , A61L27/56 , A61L2430/02 , C07K14/51 , Y10S530/84 , C08L89/06
Abstract: Disclosed are 1) osteogenic devices comprising a matrix containing osteogenic protein and methods of inducing endochondral bone growth in mammals using the devices; 2) amino acid sequence data, amino acid composition, solubility properties, structural features, homologies and various other data characterizing osteogenic proteins, 3) methods of producing osteogenic proteins using recombinant DNA technology, and 4) osteogenically and chondrogenically active synthetic protein constructs.
Abstract translation: 公开的是1）包含含有成骨蛋白的基质的成骨装置和使用该装置在哺乳动物中诱导软骨内骨生长的方法; 2）氨基酸序列数据，氨基酸组成，溶解性，结构特征，同源性和各种其他数据表征成骨蛋白，3）使用重组DNA技术生产成骨蛋白的方法，以及4）成骨和软骨形成活性合成蛋白质构建体。
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公开(公告)号：US07060680B2
公开(公告)日：2006-06-13
申请号：US10050050
申请日：2002-01-15
Applicant: Charles M. Cohen , Marc F. Charette , Thangavel Kuberasampath , David C. Rueger , Hermann Oppermann , Roy H. L. Pang , Engin Ozkaynak , John E. Smart
Inventor： Charles M. Cohen , Marc F. Charette , Thangavel Kuberasampath , David C. Rueger , Hermann Oppermann , Roy H. L. Pang , Engin Ozkaynak , John E. Smart
CPC classification number: G01N33/6872 , A61F2310/00365 , A61K38/17 , A61K38/1703 , A61K38/1875 , A61L27/227 , A61L27/24 , C07K14/495 , C07K14/51 , C07K16/22 , G01N2500/10 , G01N2800/06 , A61K2300/00
Abstract: Disclosed are methods and compositions for maintaining the integrity of the gastrointestinal tract luminal lining in a mammal, including (1) limiting epithelial cell proliferation, (2) inhibiting ulcerative lesion formation, (3) inhibiting inflammation normally associated with ulcerative diseases, and (4) stimulating the repair of ulcerative lesions and the regeneration of the luminal tissue. The methods and compositions include a therapeutically effective amount of a morphogen as defined herein.
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