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    Plastic microfluidic chip and methods for isolation of nucleic acids from biological samples
    52.
    发明申请
    Plastic microfluidic chip and methods for isolation of nucleic acids from biological samples 审中-公开
    塑料微流体芯片和从生物样品中分离核酸的方法

    公开(公告)号：US20070015179A1

    公开(公告)日：2007-01-18

    申请号：US11411528

    申请日：2006-04-26

    Applicant: Catherine Klapperich ,  Arpita Bhattacharyya

    Inventor： Catherine Klapperich ,  Arpita Bhattacharyya

    IPC: C12Q1/68 ,  C12P19/34 ,  C12M3/00

    CPC classification number: B01J20/28026 ,  B01J20/28042 ,  B01L3/5023 ,  B01L3/502707 ,  B01L2200/0631 ,  B01L2200/10 ,  B01L2200/12 ,  B81B2201/051 ,  B81B2203/0338 ,  B81C1/00206 ,  B81C2201/0197 ,  C12Q1/6813 ,  G01N1/405

    Abstract: The present invention is directed to methods of manufacture of microfluidic chip such as a plastic microfluidic chips, which has channels packed with polymer-embedded particles and uses thereof. The chip of the present invention is designed for application of an untreated biological sample on the chip thus allowing isolation, purification and detection of biomolecules, such as nucleic acids, proteins or peptides in one step. The invention also provides a microfluidic chip for combined isolation, purification and detection of biomolecules thus providing a complete Lab-on-a-Chip analysis system for biomolecules such as nucleic acids and proteins. The chips of the invention can be adapted to perform highly specific immunoassays and diagnostic test, for example, for diagnosis of infectious agents, such as bacteria, viruses or parasites.

    Abstract translation: 本发明涉及微流控芯片的制造方法，例如具有填充有聚合物嵌入颗粒的通道的塑料微流体芯片及其用途。 本发明的芯片设计用于在芯片上施加未处理的生物样品，从而允许在一个步骤中分离，纯化和检测生物分子，例如核酸，蛋白质或肽。 本发明还提供用于组合分离，纯化和检测生物分子的微流体芯片，从而为生物分子例如核酸和蛋白质提供完整的实验室在芯片分析系统。 本发明的芯片可以适用于进行高度特异性的免疫测定和诊断测试，例如用于诊断感染因子如细菌，病毒或寄生虫。

    Self-Limited, Anisotropic Wet Etching of Transverse Vias in Microfluidic Chips
    58.
    发明申请
    Self-Limited, Anisotropic Wet Etching of Transverse Vias in Microfluidic Chips 有权
    微流控芯片中横向气道的自限，各向异性湿蚀刻

    公开(公告)号：US20160133517A1

    公开(公告)日：2016-05-12

    申请号：US14933958

    申请日：2015-11-05

    Applicant: International Business Machines Corporation

    Inventor： Emmanuel Delamarche ,  Bilge Eker ,  Yuksel Temiz

    IPC: H01L21/768 ,  H01L21/56 ,  H01L21/306 ,  H01L29/04 ,  H01L23/31 ,  H01L29/16 ,  H01L21/311 ,  H01L23/538

    CPC classification number: H01L29/045 ,  B01L3/502707 ,  B01L2300/0816 ,  B01L2300/0874 ,  B01L2300/0887 ,  B81B2201/051 ,  B81B2203/0338 ,  B81B2203/0353 ,  B81C1/00087 ,  B81C2201/0133 ,  F16K99/0001 ,  F16K2099/0074 ,  H01L29/04 ,  H01L29/16

    Abstract: The present invention is notably directed to a method of fabrication of a microfluidic chip (1). comprising: providing (S10-S20) a wafer (10, 12) of semiconductor material having a diamond cubic crystal structure, exhibiting two opposite main surfaces (S1, S2), one on each side of the wafer, and having, each, a normal in the or direction; and performing (S30) self-limited, anisotropic wet etching steps on each of the two main surfaces on each side of the wafer, to create a via (20, 20a) extending transversely through the thickness of the wafer, at a location such that the resulting via connects an in-plane microchannel (31) on a first one (51) of the two main surfaces to a second one (S2) of the two main surfaces, the via exhibiting slanted sidewalls (20s) as a result of the self-limited wet etching. The invention further concerns microfluidic chips accordingly obtained.

    Abstract translation: 本发明特别涉及一种微流控芯片（1）的制造方法。 包括：提供（S10-S20）具有菱形立方晶体结构的半导体材料的晶片（10,12），具有两个相对的主表面（S1，S2），每个晶片的每一侧上具有一个 在<100>或<110>方向正常; 并且在晶片的每一侧上的两个主表面中的每一个上执行（S30）自限制的各向异性湿蚀刻步骤，以形成横向延伸穿过晶片的厚度的通路（20,20a），位于使得 所得到的通孔将两个主表面中的第一个（51）上的平面内微通道（31）连接到两个主表面的第二个（S2），由于这些主表面的结果，通孔呈现倾斜的侧壁（20s） 自限湿法蚀刻。 本发明还涉及由此获得的微流控芯片。

    Microfluidic device
    59.
    发明授权
    Microfluidic device 有权
    微流控装置

    公开(公告)号：US09205396B2

    公开(公告)日：2015-12-08

    申请号：US13131356

    申请日：2009-11-26

    Applicant: Susumu Arai

    Inventor： Susumu Arai

    IPC: B01L3/00 ,  B81B1/00 ,  B01F5/06 ,  B01J19/00 ,  B01F13/00 ,  B01F15/02

    CPC classification number: B01J19/0093 ,  B01F5/0646 ,  B01F5/0647 ,  B01F13/0059 ,  B01F15/0203 ,  B01F15/0234 ,  B01J2219/0086 ,  B01J2219/00907 ,  B01J2219/00984 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/502776 ,  B01L2200/0636 ,  B01L2200/10 ,  B01L2300/0867 ,  B01L2300/0874 ,  B01L2300/0883 ,  B01L2300/161 ,  B01L2400/0406 ,  B01L2400/0457 ,  B81B1/00 ,  B81B2201/051 ,  Y10T137/0318

    Abstract: The present invention is to provide a microfluidic device capable of allowing a fluid to stably flow in a microchannel without using an external source such as a pump or a suction device, and the microfluidic device, provided with a microchannel to which a sample liquid is transported, includes: an inlet reservoir which reserves a sample liquid to be introduced into said microchannel; an inlet which is provided on a sample-introduced side of the microchannel, and communicates with the inlet reservoir; an outlet provided on a sample-discharged side of the microchannel; and an open channel which is provided as communicating with the outlet, and part of at least one surface of which is opened to the outside atmosphere, wherein the inlet is provided at a higher position in a gravity direction than the outlet.

    Abstract translation: 本发明提供一种微流体装置，其能够允许流体在微通道内稳定地流动而不使用诸如泵或抽吸装置的外部源，以及微流体装置，其设置有运送样品液体的微通道 包括：入口储存器，其保留待引入所述微通道的样品液体; 入口，设置在所述微通道的样品导入侧，并与所述入口容器连通; 设置在微通道的样品排出侧的出口; 以及开口通道，其设置为与所述出口连通，并且其至少一个表面的一部分向外部大气开放，其中所述入口设置在比所述出口在重力方向更高的位置。

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