公开(公告)号：US09636020B2

公开(公告)日：2017-05-02

申请号：US14322517

申请日：2014-07-02

Applicant: The Board of Trustees of the Leland Stanford Junior University

Inventor： Benjamin A. Flusberg ,  Eric David Cocker ,  Juergen Claus Jung ,  Mark Jacob Schnitzer

IPC: A61B5/00 ,  G01N21/64 ,  G01J3/44 ,  G01N21/65

CPC classification number: A61B5/0068 ,  A61B5/0013 ,  A61B5/0059 ,  A61B5/0062 ,  A61B5/0064 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0079 ,  A61B5/4064 ,  A61B5/6814 ,  A61B2503/40 ,  A61B2576/026 ,  G01J3/44 ,  G01J3/4406 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/6456 ,  G01N21/6458 ,  G01N21/6486 ,  G01N21/65

Abstract: Analysis of live beings is facilitated. According to an example embodiment of the present invention, a light-directing arrangement such as an endoscope is mounted to a live being. Optics in the light-directing arrangement are implemented to pass source light (e.g., laser excitation light) into the live being, and to pass light from the live being for detection thereof. The light from the live being may include, for example, photons emitted in response to the laser excitation light (i.e., fluoresced). The detected light is then used to detect a characteristic of the live being.

公开(公告)号：US09594023B2

公开(公告)日：2017-03-14

申请号：US14360248

申请日：2012-10-29

Applicant: Sony Corporation

Inventor： Sakuya Tamada

IPC: G01N21/65 ,  G01J3/44 ,  G01J3/12 ,  G01J3/02

CPC classification number: G01N21/65 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/1256 ,  G01J3/44 ,  G01N2021/653 ,  G01N2021/655 ,  G01N2201/067

Abstract: There is provided a measurement apparatus including a light source unit configured to emit pulsed laser light used for pump light and Stokes light that excite predetermined molecular vibration of a measurement sample and for probe light that is intensity-modulated with a predetermined reference frequency and that has a same wavelength as the pump light or the Stokes light, a pulse control unit configured to cause time delay of the probe light generated by the light source unit and then to guide the pump light, the Stokes light, and the time-delayed probe light to the measurement sample, and a detection unit configured to detect transmitted light transmitted through the measurement sample or reflected light from the measurement sample. A relaxation time of the molecular vibration of the measurement sample is measured using time-resolved stimulated Raman gain spectroscopic measurement or time-resolved stimulated Raman loss spectroscopic measurement of the measurement sample.

Abstract translation: 提供了一种测量装置，包括：光源单元，被配置为发射用于泵浦光的脉冲激光;以及斯托克斯光，其激发测量样本的预定分子振动，以及激发预定参考频率强度调制的探测光， 与泵浦光或斯托克斯光相同的波长;脉冲控制单元，被配置为引起由光源单元产生的探测光的时间延迟，然后引导泵浦光，斯托克斯光和时间延迟的探测光 以及检测单元，被配置为检测透射通过测量样本的透射光或来自测量样本的反射光。 使用时间分辨的受激拉曼增益光谱测量或测量样品的时间分辨激发拉曼损耗光谱测量来测量测量样品的分子振动的松弛时间。

公开(公告)号：US09581497B2

公开(公告)日：2017-02-28

申请号：US14435439

申请日：2012-10-19

Applicant: Hitachi, Ltd.

Inventor： Hideharu Mikami

IPC: G01B9/02 ,  G01J3/44 ,  G01N21/65 ,  G02B21/16 ,  G02B21/00 ,  G02B21/06 ,  G01J3/02 ,  G01J3/10

CPC classification number: G01J3/44 ,  G01J3/0205 ,  G01J3/10 ,  G01N21/65 ,  G01N2021/653 ,  G01N2201/06113 ,  G02B21/0004 ,  G02B21/002 ,  G02B21/06 ,  G02B21/16

Abstract: A microscope includes: a first light dividing part that divides a light flux of light from a light source into a first pump light flux and a second pump light flux; a Stokes light source that receives the second pump light flux as an input and outputs a Stokes light flux; a multiplexing part that multiplexes the first pump light flux and the Stokes light flux to generate a multiplexed light flux; a first light-collecting part that collects the multiplexed light flux in a sample; a first detector that detects CARS light generated from the sample, the CARS light having a wavelength different from the multiplexed light flux; a second light dividing part that lets at least one of the second pump light flux and the Stokes light flux branch partially as a reference light flux; a second multiplexing part that multiplexes a light flux from the sample and the reference light flux to generate interfering light; and a second detector that detects the interfering light.

Abstract translation: 显微镜包括：将来自光源的光的光束分成第一泵浦光束的第一分光部和第二泵浦光束; 接收第二泵浦光束作为输入的斯托克斯光源并输出斯托克斯光通量; 多路复用部分，其复用第一泵浦光束和斯托克斯光束，以产生多路复用的光通量; 收集样品中的多路复用光通量的第一聚光部; 检测从样品产生的CARS光的第一检测器，具有与复用光通量不同的波长的CARS光; 第二分光部，其使第二泵浦光束和斯托克斯光束分支中的至少一个部分地作为参考光通量; 第二多路复用部分，其将来自所述样本的光通量和所述参考光束多路复用以产生干涉光; 以及检测干涉光的第二检测器。

公开(公告)号：US09554743B2

公开(公告)日：2017-01-31

申请号：US12650437

申请日：2009-12-30

Applicant: Moshe Sarfaty ,  Amir Lev

Inventor： Moshe Sarfaty ,  Amir Lev

IPC: A61B6/00 ,  A61B5/00 ,  G01N21/65 ,  G01J3/44 ,  G01J3/02

CPC classification number: A61B5/415 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0091 ,  A61B5/418 ,  A61B2562/0233 ,  A61B2562/16 ,  G01J3/0218 ,  G01J3/0291 ,  G01J3/44 ,  G01N21/658

Abstract: An optical system and apparatus for the diagnosis of a biological sample is disclosed. An embodiment of the apparatus includes an optical probe, a probe head distally connectable to the optical probe, the optical probe further comprising at least one optical element for applying an electromagnetic radiation of a first wavelength to the biological sample, and one or more collection elements positioned proximate the at least one optical element; and an analyzer for analyzing a signal received from the biological sample by the one or more collection elements.

Abstract translation: 公开了用于诊断生物样品的光学系统和装置。 所述装置的一个实施例包括光学探针，可远端连接到光学探针的探针头，所述光学探针还包括用于将第一波长的电磁辐射施加到所述生物样品的至少一个光学元件，以及一个或多个收集元件 定位在所述至少一个光学元件附近; 以及用于分析由一个或多个收集元件从生物样品接收的信号的分析器。

公开(公告)号：US09551617B2

公开(公告)日：2017-01-24

申请号：US14903530

申请日：2014-06-17

Applicant: SHIMADZU CORPORATION

Inventor： Takahide Hatahori ,  Naoji Moriya

IPC: G01J3/44 ,  G01N21/05 ,  G01N21/65 ,  G01J3/02

CPC classification number: G01J3/44 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0224 ,  G01J3/0262 ,  G01J3/0291 ,  G01N21/05 ,  G01N21/65

Abstract: Raman spectroscopic analyzer including: a beam-casting unit 3 for receiving a light beam generated by a light source and for converging the light beam on a predetermined position in a perpendicular direction to the longitudinal direction of a measurement chamber through which a liquid sample is passed; and a light-receiving unit placed at a distance in the longitudinal direction from the predetermined position, for receiving scattered light emitted from the fluid sample. Among the scattered light which enters the light-receiving unit, the portion which enters this unit after being reflected by the inner wall surface opposite to this unit is eliminated, so that the amount of noise in the Raman spectroscopic measurement is considerably reduced.

Abstract translation: 拉曼光谱分析仪，包括：光束铸造单元3，用于接收由光源产生的光束，并且用于将光束会聚在与通过液体样品的测量室的纵向方向垂直的预定位置上 ; 以及光接收单元，其从所述预定位置沿所述纵向方向放置，用于接收从所述流体样本发射的散射光。 在进入光接收单元的散射光中，消除了在被与该单元相对的内壁面反射之后进入该单元的部分，使得拉曼光谱测量中的噪声量显着降低。

公开(公告)号：US09546958B2

公开(公告)日：2017-01-17

申请号：US14699025

申请日：2015-04-29

Applicant: UNIVERSITY OF HOUSTON SYSTEM

Inventor： Wei-Chuan Shih

IPC: G01J3/44 ,  G01N21/65 ,  B82Y30/00 ,  G01J3/02

CPC classification number: G01N21/658 ,  B82Y30/00 ,  G01J3/02 ,  G01J3/44

Abstract: The present disclosure relates the use of a stamping surface enhanced Raman scattering (S-SERS) technique with nanoporous gold disk (NPGD) plasmonic substrates to produce a label-free, multiplexed molecular sensing and imaging technique. A NPGD SERS substrate is stamped onto a surface containing one or more target molecules, followed by SERS measurement of the target molecules located between the surface and SERS substrate. The target molecules may be deposited on the surface, which may be a carrier substrate such as polydimethylsiloxane (PDMS).

Abstract translation: 本公开内容涉及冲压表面增强拉曼散射（S-SERS）技术与纳米多孔金盘（NPGD）等离子体激元基板的使用以产生无标记的复合分子感测和成像技术。 将NPGD SERS底物冲压到含有一种或多种靶分子的表面上，随后对位于表面和SERS底物之间的靶分子进行SERS测量。 靶分子可以沉积在表面上，其可以是载体基底如聚二甲基硅氧烷（PDMS）。

公开(公告)号：US09506867B2

公开(公告)日：2016-11-29

申请号：US14103801

申请日：2013-12-11

Applicant: Biogen MA Inc.

Inventor： Justin Moretto ,  Kelly Wiltberger

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01N21/65 ,  G01J3/44

Abstract: In some embodiments, aspects of the disclosure relate to methods of evaluating cell culture materials, for example, nutrient materials, or other materials that can be used in cell culture media.

Abstract translation: 在一些实施方案中，本公开的方面涉及评估细胞培养物质，例如营养物质或可用于细胞培养基的其它材料的方法。

公开(公告)号：US20160341668A1

公开(公告)日：2016-11-24

申请号：US15111894

申请日：2015-01-15

Applicant: Raj Gupta ,  Steven Francis Nagle ,  Gajendra P. Singh ,  Owen R. Falk

Inventor： Raj Gupta ,  Steven Francis Nagle ,  Gajendra P. Singh ,  Owen R. Falk

IPC: G01N21/65 ,  G01J3/02 ,  G01J3/44

CPC classification number: G01N21/65 ,  G01J3/0202 ,  G01J3/0208 ,  G01J3/0237 ,  G01J3/0262 ,  G01J3/44 ,  G01N21/4795 ,  G01N21/6458

Abstract: Disclosed herein are systems and methods for performing angled confocal spectroscopy. Angled confocal spectroscopy permits sensitive, non-invasive investigation of numerous analytes in a wide variety of samples, including tissues and bodily fluids. The methods and systems disclosed herein can be used to measure spectroscopic signatures of analytes within well-defined and very small regions of samples, while at the same time achieving superior rejection of signal contributions from analytes within the sample that do not fall within a volume of interest. Accordingly, measurements can be performed at comparatively high signal-to-noise ratios, and can provide information such as concentrations and distributions of sample analytes at high spatial resolution. By using cylindrically-focused illumination light, samples can be excited by a “sheet” of light, allowing spatial signal averaging and enhancing the stability and reproducibility of the measurements.

Abstract translation: 本文公开了用于进行角度共焦光谱的系统和方法。 角度共焦光谱法允许对各种样品（包括组织和体液）中的许多分析物进行敏感，非侵入性的研究。 本文公开的方法和系统可用于测量在定义良好且非常小的样品区域内的分析物的光谱特征，同时从样品内的分析物的信号贡献优先排除不属于 利益。 因此，可以在相对高的信噪比下进行测量，并且可以以高空间分辨率提供诸如样品分析物的浓度和分布的信息。 通过使用圆柱聚焦的照明光，可以通过“片”光来激发样品，从而允许空间信号平均并增强测量的稳定性和再现性。

公开(公告)号：US09494465B2

公开(公告)日：2016-11-15

申请号：US15058683

申请日：2016-03-02

Applicant: Seiko Epson Corporation

Inventor： Kohei Yamada

IPC: G01J3/44 ,  G01N21/65 ,  G01N33/00 ,  G01J3/10 ,  G01J3/02

CPC classification number: G01J3/44 ,  G01J3/02 ,  G01J3/10 ,  G01N21/658 ,  G01N33/0047

Abstract: A Raman spectroscopic apparatus analyzes a substance under analysis and includes a light source that emits light of a first wavelength, an optical device that adsorbs the substance under analysis and is irradiated with the light of the first wavelength, and an optical detector that receives light radiated from the optical device. The optical device includes a first structural member that generates charge transfer resonance in response to the light of the first wavelength and a second structural member that is less than or equal to 5 nm from the first structural member and generates surface plasmon resonance in response to the light of the first wavelength. The first structural member is made of a metal or a semiconductor, and the second structural member is made of a metal different from the material of the first structural member.

Abstract translation: 拉曼分光装置分析被分析物质，并且包括发射第一波长的光的光源，吸附被分析物质并用第一波长的光照射的光学装置，以及接收光辐射的光检测器 从光学装置。 光学装置包括响应于第一波长的光产生电荷传递共振的第一结构部件和距离第一结构部件小于或等于5nm的第二结构部件，并响应于第一结构部件产生表面等离子体共振 第一波长的光。 第一结构构件由金属或半导体制成，第二结构构件由与第一结构构件的材料不同的金属制成。

公开(公告)号：US09459214B2

公开(公告)日：2016-10-04

申请号：US14603711

申请日：2015-01-23

Applicant: Seiko Epson Corporation

Inventor： Kohei Yamada ,  Akiko Yamada

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01N21/658 ,  G01J3/44

Abstract: A sensor unit array includes a first sensor unit and a second sensor unit. The first sensor unit and the second sensor unit each include a sensor chip and a holding body adapted to hold the sensor chip. A housing chamber is formed by a holding body of the first sensor unit and a holding body of the second sensor unit when the first sensor unit and the second sensor unit are disposed adjacent to each other. The sensor chip of one of the first sensor unit and the second sensor unit is disposed in the housing chamber.

Abstract translation: 传感器单元阵列包括第一传感器单元和第二传感器单元。 第一传感器单元和第二传感器单元各自包括适于保持传感器芯片的传感器芯片和保持体。 当第一传感器单元和第二传感器单元相邻布置时，容纳室由第一传感器单元的保持体和第二传感器单元的保持体形成。 第一传感器单元和第二传感器单元之一的传感器芯片设置在容纳室中。