公开(公告)号：US20150089694A1

公开(公告)日：2015-03-26

申请号：US14349801

申请日：2012-12-19

Applicant: Neaspec GmbH

Inventor： Nenad Ocelic

IPC: G01Q60/18 ,  G01N21/47 ,  H04B5/00

CPC classification number: G01Q60/18 ,  G01N21/47 ,  G01N2201/101 ,  G01Q30/06 ,  G01Q40/00 ,  H04B5/0031 ,  H04B5/0043

Abstract: The present invention relates to a method for measuring the near-field signal of a sample in a scattering type near-field microscope and to a device for conducting said method.

Abstract translation: 本发明涉及一种用于测量散射型近场显微镜中的样品的近场信号的方法以及用于进行所述方法的装置。

公开(公告)号：US20150008338A1

公开(公告)日：2015-01-08

申请号：US14373646

申请日：2012-11-29

Applicant: Sharp Kabushiki Kaisha

Inventor： Yukio Watanabe

IPC: G02B3/00 ,  G02B19/00 ,  G01N21/64

CPC classification number: G02B3/00 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/6486 ,  G01N2021/6439 ,  G01N2021/6478 ,  G01N2201/06113 ,  G01N2201/101 ,  G02B6/0035 ,  G02B19/0028 ,  G02B19/0047

Abstract: Sensitivity is increased by enhancing the fluorescence collection efficiency while suppressing the increase in size of an objective lens. An objective lens 17 is structured to have a convex lens part 26 in a center portion and to have a truncated conical cylindrical body 27 around the convex lens part 26. Therefore, a fluorescence component b having too wide an emission angle to fit in the convex lens part 26, of fluorescence emitted from a sample 16, can be collected by total reflection on an outer peripheral surface 27b of the cylindrical body 27. Thus, even light having too wide an emission angle to be collected by a normal convex lens can be collected. As a result, it is possible to suppress the increase in size of the objective lens, to enhance the fluorescence collection efficiency, and to prevent the S/N ratio from being decreased by the existence of undetected fluorescence that is blocked by a prism 20. This can realize a fluorescence information reading device having high sensitivity.

Abstract translation: 通过提高荧光收集效率同时抑制物镜尺寸的增加来增加灵敏度。 物镜17被构造为在中心部分具有凸透镜部分26，并且在凸透镜部分26周围具有截头锥形圆柱体27.因此，具有太宽的发射角度的荧光分量b以适合凸起 可以通过在圆筒体27的外周面27b上的全反射来收集从样品16发出的荧光的透镜部分26.因此，即使由普通凸透镜收集的具有太大的发射角的光也可以是 集。 结果，可以抑制物镜的尺寸增加，提高荧光收集效率，并且通过由棱镜20阻挡的未被检测到的荧光的存在来防止S / N比降低。 这可以实现具有高灵敏度的荧光信息读取装置。

公开(公告)号：US07819034B2

公开(公告)日：2010-10-26

申请号：US11973942

申请日：2007-10-10

Applicant: Wojtek T. Jasinski

Inventor： Wojtek T. Jasinski

IPC: G01N33/24 ,  G01D11/00

CPC classification number: G01N33/346 ,  G01N21/86 ,  G01N2021/8663 ,  G01N2201/101

Abstract: The performance of scanning systems can be significantly enhanced by replacing the traditional power track with preferably just two wires or transmission channels for effecting communication between (i) the sensors on the mobile carriage of the scanning system and (ii) the controls, power sources, and related devices that are typically located in a compartment or module which is a significant distance away. This can be implemented by employing selected multiplexer and complementary de-multiplexer combinations in the scanner head and in the module. This technique reduces EMI noise, power loss, drag on the moving scanner heads carrying the sensors, and cost of construction.

Abstract translation: 通过用优选仅两条电线或传输通道代替传统电力轨道来实现扫描系统的性能可以显着提高，以实现（i）扫描系统的移动支架上的传感器与（ii）控制电源， 以及通常位于距离很远的隔间或模块中的相关设备。 这可以通过在扫描仪头部和模块中采用选定的多路复用器和互补解复用器组合来实现。 这种技术降低了EMI噪声，功率损耗，拖动运动的扫描仪头上传感器，以及施工成本。

公开(公告)号：US07443508B1

公开(公告)日：2008-10-28

申请号：US11435505

申请日：2006-05-17

Applicant: Michael J Vrhel ,  Victor L Iseli

Inventor： Michael J Vrhel ,  Victor L Iseli

IPC: G01N21/27 ,  G01N21/47 ,  G02B26/10 ,  G01J3/50

CPC classification number: G01J3/10 ,  G01J3/0262 ,  G01J3/027 ,  G01J3/2823 ,  G01J3/32 ,  G01J3/50 ,  G01J3/501 ,  G01J3/52 ,  G01J3/524 ,  G01N21/25 ,  G01N21/274 ,  G01N21/55 ,  G01N21/8983 ,  G01N2201/0627 ,  G01N2201/101

Abstract: A spectrophotometric scanner suitable for producing spectral reflectance images of surfaces of samples for a plurality of wavelength bands is disclosed. The spectrophotometric scanner comprises a scanner head for collecting spectral reflectance data, a positioning mechanism for positioning the scanner head in relation to a surface, and a computing device for controlling the mechanism and recording and analyzing the spectral reflectance data. The computing device directs the positioning mechanism to position the scanner head on a row of locations in a grid of locations of the surface; directs the scanner head to measure spectral reflectance data for each location in the row of locations; records and analyzes the spectral reflectance data; and produces spectral reflectance images from the spectral reflectance data. A light source in the scanner head comprises a plurality of sequentially controllable LEDs, each producing light in a different wavelength band.

Abstract translation: 公开了一种适于产生多个波段的样品表面的光谱反射率图像的分光光度计扫描仪。 分光光度计扫描仪包括用于收集光谱反射率数据的扫描头，用于相对于表面定位扫描头的定位机构，以及用于控制机构并记录和分析光谱反射率数据的计算装置。 计算装置引导定位机构将扫描仪头部定位在表面位置的网格中的一排位置上; 引导扫描仪头测量位置行中每个位置的光谱反射率数据; 记录和分析光谱反射率数据; 并从光谱反射率数据产生光谱反射率图像。 扫描头中的光源包括多个可顺序控制的LED，每个LED产生不同波长带的光。

公开(公告)号：US07423758B1

公开(公告)日：2008-09-09

申请号：US11829431

申请日：2007-07-27

Applicant: Pekka Typpo

Inventor： Pekka Typpo

IPC: G01N21/55

CPC classification number: G01N21/57 ,  D21G9/0009 ,  G01N21/15 ,  G01N21/278 ,  G01N21/86 ,  G01N21/8901 ,  G01N33/346 ,  G01N2021/8609 ,  G01N2021/8663 ,  G01N2021/8917 ,  G01N2201/101

Abstract: A gloss sensor for optically measuring the gloss of a moving surface includes a housing having an exterior surface which is generally parallel with the moving surface. A light source is carried by the housing and configured for emitting a source beam of light. At least one light detector is carried by the housing. An optical prism is mounted to the housing at the exterior surface. The prism is configured to split the source beam into a reference beam which is reflected by the prism internally within the housing to the one or more light detectors, and a measurement beam which passes through the prism and is reflected by the moving surface to the one or more light detectors.

Abstract translation: 用于光学测量移动表面的光泽度的光泽传感器包括具有大致平行于移动表面的外表面的壳体。 光源由壳体承载并被配置为发射源光束。 至少一个光检测器由壳体承载。 光学棱镜在外表面安装到壳体。 棱镜被配置成将源光束分裂成参考光束，该参考光束由壳体内部的棱镜反射到一个或多个光检测器，以及测量光束，其通过棱镜并被移动表面反射到一个 或更多的光检测器。

公开(公告)号：US20070272878A1

公开(公告)日：2007-11-29

申请号：US11694105

申请日：2007-03-30

Applicant: Daniel Chu ,  Paul Patt

Inventor： Daniel Chu ,  Paul Patt

IPC: A61N5/00

CPC classification number: G01N21/253 ,  B01L7/52 ,  G01N2201/101

Abstract: Translational motion of a scanning head relative to a planar target, or vice versa, is achieved by a belt and pulley system with a counterweight that is also driven by a belt and pulley system at the same speed but in the opposite direction as the scanning head. The components and belt and pulley system are oriented such that all moving components remain on one side of the target and remain so during their entire range of movement.

Abstract translation: 扫描头相对于平面目标的平移运动，反之亦然，通过皮带和皮带轮系统来实现，该带和滑轮系统具有配重，该配重也由皮带和滑轮系统以与扫描头相同的速度但与之相反的方向驱动 。 部件和皮带轮系统被定向成使得所有移动部件保持在目标的一侧并且在其整个移动范围内保持。

公开(公告)号：US20070194247A1

公开(公告)日：2007-08-23

申请号：US11510520

申请日：2006-08-25

Applicant: Taylor Reid ,  Roger Taylor

Inventor： Taylor Reid ,  Roger Taylor

IPC: G01J1/58 ,  G01T1/10 ,  H01L31/14 ,  H01J40/14 ,  F21V9/16

CPC classification number: G01N21/6452 ,  G01N21/6428 ,  G01N2201/062 ,  G01N2201/0642 ,  G01N2201/101 ,  H01L31/167 ,  H01L2224/48472 ,  H01L2924/10253 ,  H01L2924/3025 ,  H01L2224/48091 ,  H01L2924/00014 ,  H01L2924/00

Abstract: A compact optical module for fluorescence excitation and detection and methods for using same are disclosed. An apparatus for detecting fluorescence includes a substrate base, a detector adjacent to the substrate base for determining the amount of fluorescence, an emission filter adjacent to the detector, a light source for emitting an excitation light, the light source engaging the emission filter, and a cover formed over the detector, the emission filter, and the light source.

Abstract translation: 公开了用于荧光激发和检测的紧凑型光学模块及其使用方法。 用于检测荧光的装置包括：基板，与基板基板相邻的用于确定荧光量的检测器，与检测器相邻的发射滤光器，用于发射激发光的光源，与发射滤光器接合的光源;以及 形成在检测器，发射滤光器和光源上的盖。

公开(公告)号：US20070009382A1

公开(公告)日：2007-01-11

申请号：US11174691

申请日：2005-07-05

Applicant: William Bedingham ,  Peter Ludowise ,  Barry Robole

Inventor： William Bedingham ,  Peter Ludowise ,  Barry Robole

IPC: G01N35/00

CPC classification number: G01N21/645 ,  B01L3/5027 ,  B01L7/52 ,  B01L7/54 ,  B01L2200/147 ,  B01L2300/0806 ,  B01L2300/1805 ,  B01L2300/1844 ,  B01L2300/1872 ,  G01N21/07 ,  G01N21/6428 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2201/04 ,  G01N2201/0407 ,  G01N2201/08 ,  G01N2201/10 ,  G01N2201/101

Abstract: Techniques are described for the detection of multiple target species in real-time PCR (polymerase chain reaction). For example, a system comprises a data acquisition device and a detection device coupled to the data acquisition device. The detection device includes a rotating disk having a plurality of process chambers having a plurality of species that emit fluorescent light at different wavelengths. The device further includes a plurality of removable optical modules that are optically configured to excite the species and capture fluorescent light emitted by the species at different wavelengths. A fiber optic bundle coupled to the plurality of removable optical modules conveys the fluorescent light from the optical modules to a single detector. The device further includes a heating element for heating one or more process chambers on the disk. In addition, the device may control the flow of fluid in the disk by locating and selectively opening valves separating chambers by heating the valves with a laser.

Abstract translation: 描述了用于在实时PCR（聚合酶链式反应）中检测多种靶物种的技术。 例如，系统包括数据采集装置和耦合到数据采集装置的检测装置。 检测装置包括具有多个处理室的旋转盘，该多个处理室具有发射不同波长的荧光的多种物质。 该装置还包括多个可移除的光学模块，其被光学配置为激发物种并捕获由不同波长的物质发射的荧光。 耦合到多个可移除光学模块的光纤束将来自光学模块的荧光传送到单个检测器。 该装置还包括用于加热盘上的一个或多个处理室的加热元件。 此外，该装置可以通过利用激光加热阀来定位和选择性地打开阀分离腔来控制盘中的流体流动。

公开(公告)号：US20020179849A1

公开(公告)日：2002-12-05

申请号：US10147940

申请日：2002-05-15

Inventor： Kevin Maher ,  Timothy F. Smith ,  Torleif Ove Bjornson

IPC: G01T001/10 ,  G01J001/58 ,  G21H003/02

CPC classification number: G01N21/6452 ,  B01L3/5027 ,  B01L2200/14 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6439 ,  G01N2021/6478 ,  G01N2201/101

Abstract: An optical detection and orientation device is provided comprising housing having an excitation light source. an optical element for reflecting the excitation light to an aspherical lens and transmitting light emitted by a fluorophore excited by said excitation light, a focussing lens for focusing the emitted light onto the entry of an optical fiber, which serves as a confocal aperture, and means for accurately moving said housing over a small area in relation to a channel in a microfluidic device. The optical detection and orientation device finds use in identifying the center of the channel and detecting fluorophores in the channel during operations involving fluorescent signals.

Abstract translation: 提供了一种光学检测和定向装置，其包括具有激发光源的壳体。 用于将激发光反射到非球面透镜并透射由所述激发光激发的荧光团发射的光的光学元件，用于将发射的光聚焦到用作共焦孔的光纤入口的聚焦透镜，以及装置 用于相对于微流体装置中的通道在小的区域上精确地移动所述壳体。 光学检测和取向装置用于识别通道的中心并且在涉及荧光信号的操作期间检测通道中的荧光团。

公开(公告)号：US5587796A

公开(公告)日：1996-12-24

申请号：US361597

申请日：1994-12-22

Applicant: Peter Rakitsch ,  Hans Zehentbauer

Inventor： Peter Rakitsch ,  Hans Zehentbauer

IPC: G01B11/06 ,  B41F33/00 ,  G01B11/30 ,  G01J3/46 ,  G01N21/15 ,  G01N21/89 ,  G01N21/892 ,  G01N21/55

CPC classification number: B41F33/0036 ,  G01N21/15 ,  G01N2201/101

Abstract: A photoelectric measuring head for the contactless scanning of measurement regions, particularly of measurement fields on a printing sheet resting flat. The measuring head having outlet orifices for compressed air on its underside to generated an air cushion between the measuring head and the printing sheet. A measuring head of this kind, suspended on an air cushion provides for high stability, and the least possible distance from the base. This is achieved in that the outlet orifice for the compressed air are formed from a plate which, by virtue of a microporous structure, is air-permeable.

Abstract translation: 用于测量区域的非接触式扫描的光电测量头，特别是在静止平板印刷纸上的测量场。 测量头在其下侧具有用于压缩空气的出口孔，以在测量头和打印片之间产生气垫。 悬挂在气垫上的这种测量头具有高度的稳定性和与基座的距离最小的距离。 这是因为用于压缩空气的出口孔由一个由微孔结构构成的透气性的板形成。