公开(公告)号：US12111378B2

公开(公告)日：2024-10-08

申请号：US18217976

申请日：2023-07-03

Applicant: Purdue Research Foundation

Inventor： Joseph V. Rispoli ,  Xin Li

IPC: G01R33/565 ,  A61B5/055 ,  G01R33/28 ,  G01R33/3415 ,  G01R33/54

CPC classification number: G01R33/5659 ,  A61B5/055 ,  G01R33/288 ,  G01R33/3415 ,  G01R33/543

Abstract: A method of operating a multi-coil magnetic resonance imaging system is disclosed which includes a controller performing a simulation using a predefined tissue model, determining output values of a variable of interest (VOI) associated with operation of two or more coils of an MRI system based on the simulation, comparing the simulated output values of the VOI to an a priori target values of the VOI, if the simulated output values of the VOI are outside of a predetermined envelope about the a priori target values of the VOI, then performing an optimization, wherein the optimization includes iteratively adjusting the circuit values until the simulated output values of the VOI are within the predetermined envelope about the a priori target values of the VOI thereby establishing VOI optimized values, and loading the established VOI optimized values and operating the magnetic resonance imaging system on the tissue to be imaged.

公开(公告)号：US20240328675A1

公开(公告)日：2024-10-03

申请号：US18743052

申请日：2024-06-13

Applicant: Purdue Research Foundation

Inventor： Tian Li

IPC: F24S50/80 ,  F24S50/40 ,  F24S60/00

CPC classification number: F24S50/80 ,  F24S50/40 ,  F24S60/00

Abstract: A system and methods for heating and cooling are provided. The system may include an energy collector and an adaptive panel connected to the energy collector. The adaptive panel may a radiative cooling layer configured to dissipate heat from the energy collector. The radiative cooling layer may further include a thermo-responsive polymer configured to adjust transparency depending on temperature. The system may include a solar heating layer configured to absorb solar irradiation that passes through the radiative cooling layer and transfer heat to the energy collector.

公开(公告)号：US20240328432A1

公开(公告)日：2024-10-03

申请号：US18612085

申请日：2024-03-21

Applicant: Purdue Research Foundation

Inventor： Nicole Leanne Key ,  William Joseph Brown ,  Andrew Curtis Cusator ,  Yu Ning Dai

IPC: F04D29/42 ,  G06F30/28 ,  G06F119/02

CPC classification number: F04D29/4213 ,  G06F30/28 ,  G06F2119/02

Abstract: The casing treatment system includes a compressor having an injection port, an extraction portion, a recirculation channel. It is also contemplated for the casing treatment system to include a plurality of injection ports, a plurality of extraction ports, and/or a plurality of recirculation channels. The casing treatment system is based on using the differences in the flow field at peak efficiency and near stall to “turn on” the recirculation at near stall operation to extend the stall margin, and to “turn off” the recirculation at peak efficiency operation to minimize impact to efficiency.

公开(公告)号：US20240327313A1

公开(公告)日：2024-10-03

申请号：US18437519

申请日：2024-02-09

Applicant: Purdue Research Foundation

Inventor： Steven F. Son ,  Derek Keith Messer ,  Cohen Thomas Vestal Nunes ,  Thomas Hafner

IPC: C06D5/00 ,  F02K9/10 ,  F03G7/06

CPC classification number: C06D5/00 ,  F03G7/06143 ,  F03G7/0616 ,  F02K9/10

Abstract: The throttleable solid propellant system includes a substantially solid propellant, a shape-altering structure, and an actuation source. The shape-altering structure is at least partially disposed within the substantially solid propellant. The actuation source is to be coupled to the shape-altering structure. The actuation source is to be configured to actuate the shape-altering structure between a first position and a second position. Transitioning the shape-altering structure between the first position and the second position may crack and/or deform the substantially solid propellant. Cracking and/or deforming the substantially solid propellant may increase the burning surface area of the propellant, thereby altering the thrust produced from the throttleable solid propellant system.

公开(公告)号：US20240310323A1

公开(公告)日：2024-09-19

申请号：US18607045

申请日：2024-03-15

Applicant: Purdue Research Foundation

Inventor： Philip James Kauffmann ,  Jeffery Edward Dick

IPC: G01N27/416 ,  G01N27/30

CPC classification number: G01N27/416 ,  G01N27/30

Abstract: The electrochemical sensor system includes a capillary and a conductive wire at least partially disposed within the capillary. The wire is provided as a plurality of wires, such as a pair wires. The plurality of wires is disposed substantially parallel within the capillary. The wire extends from a first terminal end of the capillary to a second terminal end of the capillary. Where the wire is provided as a plurality of wires, the capillary includes a capillary wall separating the plurality of wires. The first terminal end of the capillary includes an electrode surface where the wire is disposed therethrough and is exposed, thus forming an electrode. The exposed wire is configured to form a liquid-air interface where a droplet is disposed on the exposed wire. The wire extending from the second terminal end of the capillary is coupled to a processor configured to perform the electrochemical analysis.

公开(公告)号：US12091693B2

公开(公告)日：2024-09-17

申请号：US17497085

申请日：2021-10-08

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Philip Stewart Low ,  Venkatesh Chelvam ,  Youngsoon Kim ,  Sumith A Kularatne

IPC: C12N9/48 ,  A61K31/454 ,  A61K31/4745 ,  A61K31/475 ,  A61K38/00 ,  A61K47/54 ,  A61K49/00 ,  A61K51/04 ,  C12N9/96

CPC classification number: C12N9/485 ,  A61K31/454 ,  A61K31/4745 ,  A61K31/475 ,  A61K47/542 ,  A61K49/0032 ,  A61K49/0052 ,  A61K51/0402 ,  A61K51/0497 ,  C12N9/96 ,  A61K38/00 ,  C12Y304/17021

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical compositions containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

公开(公告)号：US20240293456A1

公开(公告)日：2024-09-05

申请号：US18255094

申请日：2021-11-29

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Philip S. LOW ,  Weichuan LOU

IPC: A61K35/17 ,  A61K39/00 ,  A61K47/55 ,  C07K16/28

CPC classification number: A61K35/17 ,  A61K39/4611 ,  A61K39/4631 ,  A61K39/464412 ,  A61K47/551 ,  C07K16/2803 ,  A61K2239/13 ,  A61K2239/49

Abstract: A combination cancer therapy comprising a small molecule drug conjugate (SMDC), which targets a cell-surface receptor on an immunosuppressive cell or a cancerous cell, and cytotoxic lymphocytes, which express a chimeric antigen receptor (CAR); and a method of treating a patient for cancer using the same.

公开(公告)号：US12076245B2

公开(公告)日：2024-09-03

申请号：US17480719

申请日：2021-09-21

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Thomas J. Webster ,  Venu Perla

IPC: A61F2/30 ,  A61B17/08 ,  A61K9/00 ,  A61L27/04 ,  A61L27/32 ,  A61L27/34 ,  A61L27/50 ,  A61L27/54 ,  A61L27/56 ,  A61L31/02 ,  A61L31/16 ,  C25D5/34 ,  C25D11/02

CPC classification number: A61F2/30771 ,  A61B17/08 ,  A61F2/30 ,  A61K9/0024 ,  A61K9/0092 ,  A61L27/04 ,  A61L27/32 ,  A61L27/34 ,  A61L27/50 ,  A61L27/54 ,  A61L27/56 ,  A61L31/022 ,  A61L31/16 ,  C25D5/34 ,  C25D11/02 ,  A61F2002/30011 ,  A61F2002/30062 ,  A61F2002/30064 ,  A61F2002/3084 ,  A61F2002/3092 ,  A61F2002/30929 ,  A61F2002/3093 ,  A61F2002/30968 ,  A61F2310/00023 ,  A61F2310/0097 ,  A61F2310/00982 ,  A61L2300/414 ,  A61L2300/604 ,  A61L2300/624 ,  A61L2400/12 ,  A61L2400/18 ,  A61L2430/02 ,  Y10T428/24355

Abstract: One embodiment of the present invention is directed to compositions and methods for enhancing attachment of soft tissues to a metal prosthetic device. In one embodiment a construct is provided comprising a metal implant having a porous metal region, wherein said porous region exhibits a nano-textured surface.

公开(公告)号：US20240285776A1

公开(公告)日：2024-08-29

申请号：US18560670

申请日：2022-05-13

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Philip LOW ,  Imrul SHAHRIAR

IPC: A61K47/55 ,  A61P31/16

CPC classification number: A61K47/55 ,  A61P31/16

Abstract: A conjugate of formula EVTsmL-L-AMRL, wherein EVTsmL is an enveloped virus-targeting, small molecule ligand, AMRL is an activated macrophage-recruiting ligand, and L is a linker that is covalently bound to EVTsmL and AMRL; a composition comprising the same; and a method of using the conjugate or composition to treat (therapeutically or prophylactically) a viral infection.

公开(公告)号：US12075564B2

公开(公告)日：2024-08-27

申请号：US17823021

申请日：2022-08-29

Applicant: Purdue Research Foundation

Inventor： Chi Hwan Lee ,  Laurent Couetil ,  Tae Hoo Chang ,  Semih Akin ,  Martin Byung-Guk Jun

IPC: H05K1/03 ,  A61B5/27 ,  D06B11/00 ,  D06M11/65 ,  D06M11/83 ,  D06M15/693 ,  D06M23/08 ,  H01B3/28 ,  H05K1/09 ,  H05K3/14 ,  D06M101/06 ,  D06M101/32 ,  D06M101/38

CPC classification number: H05K1/038 ,  A61B5/27 ,  D06B11/0059 ,  D06M11/65 ,  D06M11/83 ,  D06M15/693 ,  D06M23/08 ,  H01B3/28 ,  H05K1/092 ,  H05K3/14 ,  A61B2503/40 ,  A61B2562/0215 ,  A61B2562/0285 ,  D06M2101/06 ,  D06M2101/32 ,  D06M2101/38 ,  D10B2201/02 ,  D10B2331/04 ,  D10B2331/10 ,  D10B2401/16 ,  H05K2201/10151

Abstract: Electronic textiles and methods of fabrication electronic textiles. Nanoparticles of a conductive material are sprayed along a conductive path into a fabric material so as to penetrate into the fabric. A layer of a second conductor material is coated over the nanoparticles along the conductive path. A layer of an insulator material is coated over the layer of the second conductor material so as to encapsulate the conductive path and form a trace. An electrode configured to contact a subject wearing the fabric material includes a layer of a third conductor material coated over the layer of the second conductor and electrically coupled with the conductive path. An electrical connector is secured to the fabric material and electrically coupled with the conductive path. The nanoparticles are sprayed onto the fabric material using a dual regime spray process implemented with a dual regime spray system.