公开(公告)号：US20230233635A1

公开(公告)日：2023-07-27

申请号：US17999640

申请日：2021-05-26

Applicant: RHODES TECHNOLOGIES ,  UNIVERSITY OF SOUTH FLORIDA

Inventor： Chuanhai CAO ,  Ping CHANG

IPC: A61K36/185 ,  A61K47/34 ,  A61K9/00 ,  A61K9/48 ,  A61K9/51

CPC classification number: A61K36/185 ,  A61K47/34 ,  A61K9/0043 ,  A61K9/4833 ,  A61K9/5153

Abstract: The present invention provides pharmaceutical compositions and methods for use and manufacture thereof. The pharmaceutical compositions comprise a therapeutically effective amount of a cannabinoid or a pharmaceutically acceptable salt or solvate thereof and an amphiphilic copolymer comprising at least one hydrophilic component and at least one hydrophobic component. The cannabinoid is encapsulated in the amphiphilic copolymer, and the composition is suitable for intranasal or inhalation delivery.

公开(公告)号：US20230220273A1

公开(公告)日：2023-07-13

申请号：US17791362

申请日：2022-02-11

Applicant: University of South Florida

Inventor： Elias K. STEFANAKOS ,  Sesha S. SRINIVASAN

IPC: C09K9/02 ,  B01J13/06 ,  B01J19/12 ,  C04B14/36 ,  C04B16/00 ,  C04B20/10 ,  C04B26/02 ,  C04B28/04

CPC classification number: C09K9/02 ,  B01J13/06 ,  B01J19/122 ,  C04B14/36 ,  C04B16/00 ,  C04B20/1066 ,  C04B26/02 ,  C04B28/04 ,  B01J2219/0879 ,  B01J2219/0892 ,  B01J2219/1203

Abstract: Structures of a particle containing a core and at least one shell, a metal oxide material of which is necessarily doped to ensure protection of a material of the core from photodegradation. The core can include any of a thermochromic material, a phase-change material, and a judiciously defined auxiliary material that in turn contains organic and/or polymeric material. Derivative products utilizing a plurality of such particles. Methodologies for producing such particles and derivative products.

公开(公告)号：US20230217977A1

公开(公告)日：2023-07-13

申请号：US18184618

申请日：2023-03-15

Applicant: UNIVERSITY OF SOUTH FLORIDA

Inventor： Rex M. Philpot ,  Bethany Johns

IPC: A61K31/14 ,  A61K31/704 ,  A61K31/675 ,  A61P35/00 ,  A23L33/00

CPC classification number: A61K31/14 ,  A61K31/704 ,  A61K31/675 ,  A61P35/00 ,  A23L33/30 ,  A23L33/40

Abstract: Described herein is a method for reducing tumor volume in a subject, the method including the steps of administering a cancer treatment (administration of at least one chemotherapeutic agent and/or application of radiation) to the subject in conjunction with the administration of choline, a choline metabolite, a choline precursor molecule, or a combination thereof. In another aspect, the disclosure relates to a method for enhancing cognitive response in a subject during cancer treatment, the method including the steps of administering cancer treatment (administration of at least one chemotherapeutic agent and/or application of radiation) to the subject in conjunction with the administration of choline, a choline metabolite, a choline precursor molecule, or a combination thereof. In still another aspect, choline, a choline metabolite, a choline precursor molecule, or a combination thereof can be administered in the form of a choline-enriched diet, a choline supplement, or a combination thereof. In some aspects, the method also enhances the effectiveness of chemotherapy.

公开(公告)号：US20230201455A1

公开(公告)日：2023-06-29

申请号：US18171643

申请日：2023-02-20

Applicant: UNIVERSITY OF SOUTH FLORIDA

Inventor： Farzad Forouzandeh ,  David Borkholder ,  Robert Frisina ,  Joseph Walton ,  Xiaoxia Zhu

IPC: A61M5/142 ,  A61M5/145 ,  A61M5/20 ,  A61M39/06

CPC classification number: A61M5/14276 ,  A61M5/145 ,  A61M5/204 ,  A61M5/14224 ,  A61M5/14593 ,  A61M39/06 ,  A61M2039/0072

Abstract: In one embodiment, a fluid storage device includes a rigid outer housing that defines a septum cavity, a reservoir cavity, and a channel that extends between the two cavities, the outer housing further defining an outlet in fluid communication with the reservoir cavity, a septum provided within the septum cavity, the septum being made of an elastic polymer and facilitating refilling of the fluid storage device, and a thin, collapsible membrane that does not generate significant restoring forces when it is deformed as fluid is drawn from the reservoir cavity and, therefore, does not completely or partially return to its initial non-deformed shape even if the outlet of the device remains open after doses are administered.

公开(公告)号：US11685885B1

公开(公告)日：2023-06-27

申请号：US16799413

申请日：2020-02-24

Applicant: University of South Florida

Inventor： Subhra Mohapatra ,  Shyam S. Mohapatra ,  Tao Wang

IPC: C12M3/06 ,  C12M1/32 ,  C12M1/34 ,  C12M1/12 ,  C12N5/09 ,  B01L3/00 ,  G01N33/50

CPC classification number: C12M23/16 ,  B01L3/502715 ,  C12M23/12 ,  C12M25/14 ,  C12M41/26 ,  C12M41/36 ,  C12N5/0693 ,  G01N33/5011 ,  B01L2300/0627 ,  B01L2300/0819 ,  B01L2300/0829 ,  C12N2503/02 ,  C12N2513/00

Abstract: A 4D-perfused tumoroid-on-a-chip platform used in personalized cancer treatment. The platform includes a plate with a plurality of bottomless wells that resides atop a microfluidic channel layer, which in turn resides atop a surface acoustic wave (SAW) based sensor layer that is capable of measuring potential pH values of fluids disposed within the platform. The microfluidic channel layer includes a plurality of bioreactors, with each bioreactor including an inlet well, a culture well, and an outlet well. The inlet well, culture well, and outlet well form a closed system via fluid conduits spanning from the inlet well to the culture well, as well as from the culture well to the outlet well. Due to the fluid flow from the plate to the chip, and from the inlet well to the outlet well on the chip through the culture well, target cell (tumoroid) growth is promoted within the culture well.

公开(公告)号：US20230166549A1

公开(公告)日：2023-06-01

申请号：US17922055

申请日：2021-05-03

Applicant: UNIVERSITY OF SOUTH FLORIDA ,  REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Ying Zhong ,  Long Wang ,  Rui Kou

IPC: B41M1/30 ,  G01N27/12

CPC classification number: B41M1/305 ,  G01N27/122

Abstract: The invention relates to a non-contact printing method and system as well as to a printed sensor. The method includes the steps of disposing a substrate (130) between a discharge electrode (110) and a printing material (140) such that the substrate (130) is spaced apart from the printing material (140); and activating the discharge electrode (110) to generate an electric field between the substrate (130) and the printing material (140), wherein the printing material (140) moves onto a surface (132) of the substrate (130) when the electric field attracts the printing material (140) to the surface (132) of the substrate (130). A corresponding printing system and printed sensor are also provided.

公开(公告)号：US20230165830A1

公开(公告)日：2023-06-01

申请号：US18152098

申请日：2023-01-09

Applicant: UNIVERSITY OF SOUTH FLORIDA ,  THE UAB RESEARCH FOUNDATION

Inventor： Bill J. Baker ,  Lindsey N. Shaw ,  Andrew Jason Shilling ,  Alexandre Jean Bory ,  Jessie Allen (Adams) ,  Charles Dunkle Amsler, JR. ,  James Bruce McClintock

IPC: A61K31/343 ,  A61K31/352 ,  A61K31/192

CPC classification number: A61K31/343 ,  A61K31/352 ,  A61K31/192 ,  A61K2236/39

Abstract: Described herein are Dendrilla membranosa compounds and derivatives thereof. Also described herein are formulations that can contain an amount of one or more Dendrilla membranosa compounds or derivatives thereof and a carrier. Also described herein are methods of administering one or more Dendrilla membranosa compound and/or derivative thereof or a formulation thereof to a subject in need thereof.

公开(公告)号：US20230162612A1

公开(公告)日：2023-05-25

申请号：US17919238

申请日：2020-11-23

Applicant: UNIVERSITY OF SOUTH FLORIDA

Inventor： Kyle Brandon REED

IPC: G09B5/06 ,  G09B5/14 ,  H04N7/15

CPC classification number: G09B5/065 ,  G09B5/14 ,  H04N7/152

Abstract: Disclosed are various embodiments of a module publication application, interactive modules, and student user interfaces that make lectures more interactive. An instructor user interface generated by the module publication application captures a video of a lecture. Interactive modules including video segments and segment metadata are generated based on the video. A student user interface can render a presentation of the video segments and an interactive region showing questions that are related to the presentation. The questions shown in the interactive region can be updated based on a current timecode of the presentation.

公开(公告)号：US11643366B2

公开(公告)日：2023-05-09

申请号：US16637448

申请日：2018-07-02

Applicant: UNIVERSITY OF SOUTH FLORIDA

Inventor： Christopher Joseph Gardiner ,  Justin Nussbaum ,  Nathan Crane

IPC: C04B35/64 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y50/00 ,  B29C64/264 ,  B29C64/153 ,  B29C64/295 ,  B29C64/393 ,  B28B1/00 ,  B22F10/28 ,  B22F12/13 ,  B22F12/44 ,  B22F10/368 ,  B22F12/90

CPC classification number: C04B35/64 ,  B22F10/28 ,  B22F10/368 ,  B22F12/13 ,  B22F12/44 ,  B28B1/001 ,  B29C64/153 ,  B29C64/264 ,  B29C64/295 ,  B29C64/393 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y50/00 ,  B22F12/90

Abstract: A large area sintering platform, system, and methodology. The system includes a convection oven with a projection window disposed within a top surface of the oven. A platform is disposed within the oven below the window at a spaced distance away from the window. A powder is positioned on top of the platform, with a thermocouple positioned within the powder on the platform. A high intensity projector moves in sync with the platform, and uses low intensities and long exposure times to project an image through the window onto the powder and sinter the powder to fabricate the desired model layer by layer.

公开(公告)号：US20230129434A1

公开(公告)日：2023-04-27

申请号：US18145732

申请日：2022-12-22

Applicant: UNIVERSITY OF SOUTH FLORIDA

Inventor： Arash Takshi ,  Sabrina Marie Rosa-Ortiz

IPC: C25D5/08 ,  C25D1/00 ,  C25D5/02 ,  C25D7/04 ,  C25D3/38 ,  B29C64/20 ,  H05K3/24 ,  C25D17/12 ,  C25D17/10 ,  C25D5/04 ,  H05K3/32 ,  C25D17/00 ,  C25D21/12 ,  C25D7/00 ,  C25D5/00 ,  C25D5/54 ,  C25D17/06

Abstract: A hydrogen evolution assisted electroplating nozzle includes a nozzle tip configured to interface with a portion of a substructure. The nozzle also includes an inner coaxial tube connected to a reservoir containing an electrolyte and an anode, the inner coaxial tube configured to dispense the electrolyte through the nozzle tip onto the portion of the substructure. The nozzle also includes an outer coaxial tube encompassing the inner coaxial tube, the outer coaxial tube configured to extract the electrolyte from the portion of the substructure. The nozzle also includes at least one contact pin configured to make electrical contact with a conductive track on the substrate.