公开(公告)号：US11466320B2

公开(公告)日：2022-10-11

申请号：US16413563

申请日：2019-05-15

Applicant: University of Utah Research Foundation

Inventor： John D. Phillips ,  Jennifer M. Heemstra

IPC: C12Q1/6874 ,  C12Q1/6806 ,  C12Q1/6876 ,  C12Q1/6816

Abstract: Branching phosphoramidite monomers and molecules having comb-like structures are disclosed and described. A branching phosphoramidite monomer having the structure is provided wherein R4 and R5 are independently —(O—CH2—CH2—)n where n is 1-5 or —O—(CH2—)n where n is 1-10, and R1, R2, and R3 are each one of dimethoxytrityl (DMT)—O—, levulinyl (Lev)—O—, and a phosphoramidite.

公开(公告)号：US11464397B2

公开(公告)日：2022-10-11

申请号：US16586856

申请日：2019-09-27

Applicant: University of Utah Research Foundation

Inventor： Jacob J Abbott ,  Lan N. Pham

IPC: A61B1/00 ,  B63H21/17 ,  A61B1/005

Abstract: A system for propelling a magnetic robotic device through a human comprises a magnetic actuator device operable to generate a rotating magnetic field, and a magnetic robotic device comprising a compliant body and at least two permanent magnets supported by and spatially separated about the compliant body. A non-magnetic region can also be oriented between the at least two permanent magnets. The at least two permanent magnets can be alternating or non-alternating in polarity with each other. In response to application of the rotating magnetic field generated by the magnetic actuator device and that is situated proximate the magnetic robotic device, the rotating magnetic field effectuates undulatory locomotion of the magnetic robotic device to propel the magnetic robotic device through a human, such as through a natural lumen. Further, the magnetic robotic device can optionally be supported by a catheter or endoscope to assist with propelling a distal end through a human.

公开(公告)号：US11450385B2

公开(公告)日：2022-09-20

申请号：US16577309

申请日：2019-09-20

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： Pierre-Emmanuel Gaillardon ,  Edouard Giacomin ,  Joao Vieira

IPC: G11C13/00 ,  G06N3/063 ,  G06N20/10 ,  G06F7/544 ,  G11C7/08 ,  G06F17/16 ,  G06N3/08

Abstract: One embodiment provides a resistive random-access memory (RRAM) based convolutional block including a complementary pair of RRAMs having a first RRAM and a second RRAM, a programming circuit coupled to the complementary pair of RRAMs, and a XNOR sense amplifier circuit coupled to the complementary pair of RRAMs. The programming circuit is configured to receive a kernel bit from a kernel matrix, program the first RRAM to at least one selected from a group consisting of a low resistive state (LRS) and a high resistive state (HRS) based on the kernel bit, and program the second RRAM to other of the LRS and the HRS. The XNOR sense amplifier circuit is configured to receive an input bit from an input matrix, perform a XNOR operation between the input bit and the kernel bit read from the complementary pair of RRAMs, and output a XNOR output based on the XNOR operation.

公开(公告)号：US20220291211A1

公开(公告)日：2022-09-15

申请号：US17691972

申请日：2022-03-10

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION ,  TEXAS TECH UNIVERSITY SYSTEM

Inventor： Jungkyu KIM ,  Ali Khodayari BAVIL

IPC: G01N33/543 ,  B01L3/00 ,  G01N27/12

Abstract: Described herein are devices and methods for improved detection and quantitation of biomolecules. Devices and methods may include a microfluidic biosensing platform for measuring electrical impedance changes in the presence of target analytes from sinusoidal input voltages to improve the sensitivity of immunoassays. In one embodiment, the described devices and methods may provide a point-of-care immunoassay platform for quantitative diagnostics using signal-enhancing microparticles to improve sensitivity and the limit-of-detection.

公开(公告)号：US11441166B2

公开(公告)日：2022-09-13

申请号：US16405859

申请日：2019-05-07

Applicant: University of Utah Research Foundation

Inventor： David P. Hickey ,  Shelley D. Minteer

IPC: C12Q1/00 ,  C12Q1/26 ,  C08J3/075

Abstract: Devices, systems, and compositions of matter involving enzyme-mediated bioelectrocatalysis are disclosed and described. An enzyme electrode can include an electrode, a bioelectric material coupled to the electrode, the bioelectric material further including a water-permeable polymer matrix, a planar linker covalently coupled to the water-permeable polymer matrix and noncovalently coupled to the electrode, and electrochemically active oxidoreductase enzyme molecules functionally embedded in the water-permeable polymer matrix.

公开(公告)号：US20220280722A1

公开(公告)日：2022-09-08

申请号：US17688699

申请日：2022-03-07

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： Preetham Suresh ,  Jerry Ingrande ,  Joseph Wang ,  Ken B. Johnson ,  Talmage Egan

IPC: A61M5/172 ,  G16H20/17 ,  G16H70/40

Abstract: Systems and methods are provided for combining predictive analytics with a cutting-edge electrochemical sensor having specialized coatings designed to reduce biofouling to (1) monitor drug concentration data of a patient in real-time; and (2) predict future pharmacokinetic parameters for the patient more accurately than existing technologies. Embodiments may construct highly accurate and patient-specific pharmacokinetic models which can dynamically adjust predictions of future pharmacokinetic parameters as they receive real-time drug concentration data from the electrochemical sensor. Certain embodiments may automatically adjust administration of a drug to a patient based on the aforementioned predictions and pharmacokinetic models. Other embodiments may provide a notification to a clinician containing, e.g., a recommended course of drug administration before a patient is woken up.

公开(公告)号：US20220280366A1

公开(公告)日：2022-09-08

申请号：US17680662

申请日：2022-02-25

Applicant: University of Utah Research Foundation

Inventor： Brandon Bruce Johnson

IPC: A61G13/06 ,  A61B5/055 ,  A61B5/00 ,  A61G13/08 ,  A61G13/12

Abstract: A kyphotic lift can comprise a support base, and a body support secured to the support base. The body support can be movable away from the support base and can be operable to support at least an upper body of the patient during use. The kyphotic lift can also comprise a lift mechanism operable to raise and lower the body support away from and back towards the support base to position and align a head of the patient with a magnetic resonance imaging (MRI) head coil.

公开(公告)号：US20220275001A1

公开(公告)日：2022-09-01

申请号：US17732447

申请日：2022-04-28

Applicant: University of Utah Research Foundation

Inventor： Darrell Davis ,  Shuanghu Liu

IPC: C07D491/147 ,  C07D487/04 ,  C07D235/30 ,  C07D491/048 ,  C07D491/052 ,  C07D495/14

Abstract: The present disclosure is concerned with benzimidazole compounds and methods of using these compounds for the treatment of hepatitis (e.g., hepatitis C), RNA virus infections (e.g., Zika virus, dengue virus, Powassan virus, Chikungunya virus, Enterovirus, respiratory syntactical virus (RSV), Rift Valley fever, Influenza virus, Tacaribe virus, Mayaro virus, West Nile virus, yellow fever virus, and coronavirus), and disorders of uncontrolled cellular proliferation (e.g., cancer). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US11426433B2

公开(公告)日：2022-08-30

申请号：US16788288

申请日：2020-02-11

Applicant: University of Utah Research Foundation

Inventor： Jo-Anna Reems ,  Jan Pierce

IPC: A61K9/50 ,  A61K35/50 ,  A61K38/17 ,  A61K31/728 ,  A61K45/06 ,  A61K35/28 ,  A61L27/36 ,  A61L27/26 ,  A61L27/20 ,  A61L27/22 ,  A61L27/54 ,  A61L24/04 ,  A61L24/08 ,  A61L24/10 ,  A61L24/00 ,  A61K38/18 ,  A61K9/00 ,  B01D21/26 ,  A61K9/19

Abstract: A therapeutic composition can include an amount of amniotic fluid having a therapeutically effective amount of at least one protein, hyaluronic acid, or both. The therapeutic composition can be substantially free of lanugo, vernix, and cells harvested with the amniotic fluid.

公开(公告)号：US20220265734A1

公开(公告)日：2022-08-25

申请号：US17625866

申请日：2020-07-17

Applicant: University of Utah Research Foundation

Inventor： June L. Round

IPC: A61K35/742 ,  C12N1/20 ,  A61P3/04 ,  A61P3/10 ,  A61P1/00

Abstract: Disclosed herein, are compositions comprising a consortium of Clostridia, and methods of treating obesity, metabolic syndrome, irritable bowel disease, as well as reducing weight gain and inhibiting lipid absorption in the small intestine by administering the compositions to a subject.