公开(公告)号：US20180143204A1

公开(公告)日：2018-05-24

申请号：US15637446

申请日：2017-06-29

Applicant: Biogen MA Inc.

Inventor： Tatiana Plavina ,  Paula S. Hochman ,  Michaela Lerner

IPC: G01N33/68 ,  G01N33/566 ,  G01N33/94

CPC classification number: G01N33/6854 ,  G01N33/558 ,  G01N33/566 ,  G01N33/94 ,  G01N2333/70546 ,  G01N2333/7055 ,  G01N2800/26 ,  G01N2800/52

Abstract: Methods and apparatus for assaying the level of analytes in a sample, related to VLA-4, are disclosed. A method of decreasing the level of an anti-integrin antibody in a subject is described including a) contacting a biological sample from a subject with a detectable capture agent associated with a substrate, wherein the capture agent can bind an anti-integrin antibody in the sample; b) detecting binding of the capture agent with the level of the anti-integrin antibody; and c) treating the subject with plasma exchange until the level of the anti-integrin antibody in the sample reaches a predetermined level.

公开(公告)号：US20180093973A1

公开(公告)日：2018-04-05

申请号：US15699857

申请日：2017-12-20

Applicant: BIOGEN MA INC.

Inventor： Brian T. Hopkins ,  Bin Ma ,  Timothy Raymond Chan ,  Lihong Sun ,  Lei Zhang ,  Gnanasambandam Kumaravel ,  Joseph P. Lyssikatos ,  Kevin Koch ,  Hua Miao

IPC: C07D403/12 ,  C07D487/04 ,  C07D401/14 ,  C07D413/14 ,  C07D409/14 ,  C07D417/14 ,  C07D495/04 ,  C07D513/04 ,  C07D417/12

CPC classification number: C07D403/12 ,  A61K31/506 ,  C07D239/30 ,  C07D401/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D487/04 ,  C07D495/04 ,  C07D513/04 ,  C07F5/027

Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.

公开(公告)号：US20180079796A1

公开(公告)日：2018-03-22

申请号：US15557980

申请日：2016-03-11

Applicant: SAMSUNG BIOEPIS CO., LTD. ,  Biogen MA Inc.

Inventor： Jeehoon GHIL ,  Yoonseok LEE ,  Songyoung KIM ,  Orlando A. JAQUEZ ,  Robert S. GRONKE

IPC: C07K14/715 ,  C07K16/24

CPC classification number: C07K14/7151 ,  A61K38/00 ,  A61K38/1793 ,  A61K2039/505 ,  A61K2039/545 ,  C07K14/525 ,  C07K16/241 ,  C07K2317/21 ,  C07K2319/30 ,  C07K2319/70

Abstract: The invention provides a composition comprising an anti-tumor necrosis factor (TNF)-alpha polypeptide, wherein the composition produces a reduced level of immunogenicity when administered to a subject, as well as a treatment method involving the administration of the composition.

公开(公告)号：US20180012354A1

公开(公告)日：2018-01-11

申请号：US15642998

申请日：2017-07-06

Applicant: BIOGEN MA INC.

Inventor： Elizabeth FISHER

IPC: G06T7/00 ,  A61B5/055 ,  A61B5/00

CPC classification number: G06T7/0012 ,  A61B5/0042 ,  A61B5/055 ,  A61B5/4064 ,  G06T7/62 ,  G06T2207/10088 ,  G06T2207/30016 ,  G16H50/50

Abstract: Methods of the disclosure may include obtaining a first set of medical images at a first time point and a second set of medical images at a second time point, each set including at least two medical images. First and second algorithms may be used to calculate, respectively, first and third brain volume (BV) values at the first time point based on two or more images from the first set of medical images and second and fourth BV values at the second time point based on two or more images from the second set of medical images. A mathematical weight may be applied to at least one of the first, second, third, or fourth BV values. The first and third BV values may be averaged, and the second and fourth BV values may be averaged to determine overall BV values at the first and second time points, respectively.

公开(公告)号：US20170368013A1

公开(公告)日：2017-12-28

申请号：US15647016

申请日：2017-07-11

Applicant: Biogen MA Inc.

Inventor： Mark Novas ,  Rui (Ray) Zhang

IPC: A61K31/225 ,  A61K47/54 ,  A61K9/00 ,  A61K9/48

CPC classification number: A61K31/225 ,  A61K9/0053 ,  A61K9/28 ,  A61K9/4808 ,  A61K9/4825 ,  A61K9/485 ,  A61K9/4858 ,  A61K9/4866 ,  A61K47/542 ,  A61K47/545 ,  G01N33/492 ,  G09B19/00 ,  Y02A50/467

Abstract: Provided herein are methods of treating multiple sclerosis with a fumarate, wherein the fumarate is a dialkyl fumarate, a monoalkyl fumarate, a combination of a dialkyl fumarate and a monoalkyl fumarate, a prodrug of monoalkyl fumarate, a deuterated form of any of the foregoing, or a pharmaceutically acceptable salt, clathrate, solvate, tautomer, or stereoisomer of any of the foregoing, or a combination of any of the foregoing. The methods provided herein improve the safety of treatment by informing and monitoring patients undergoing treatment regarding progressive multifocal leukoencephalopathy, and/or by monitoring lymphocyte count.

公开(公告)号：US20170363643A1

公开(公告)日：2017-12-21

申请号：US15509642

申请日：2015-09-11

Applicant: Biogen MA Inc.

Inventor： Frank Rigo ,  Katherine M. Bishop

IPC: G01N33/68 ,  C12N15/113

CPC classification number: G01N33/6896 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/322 ,  C12N2310/3341 ,  C12N2320/32 ,  C12N2320/35 ,  G01N33/566 ,  G01N33/6854 ,  G01N33/6887 ,  G01N2333/47 ,  G01N2800/28 ,  G01N2800/2878 ,  G01N2800/52

Abstract: Disclosed herein are compounds, compositions and methods for modulating splicing of SMN2 mRNA in a subject. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders, including spinal muscular atrophy. Also provided are kits for detecting the amount of SMN protein in a sample of cerebrospinal fluid.

公开(公告)号：US20170355947A9

公开(公告)日：2017-12-14

申请号：US15322560

申请日：2015-07-02

Applicant: Biogen MA Inc.

Inventor： Brandon Berry ,  Justin Moretto

IPC: C12M1/34 ,  G01N21/65 ,  C12M1/36

CPC classification number: C12M41/32 ,  C12M41/48 ,  G01N21/65 ,  G01N2201/12

Abstract: Aspect of the disclosure relate to methods of assessing a bioreactor culture that involve determining a culture parameter of the manufacturing-scale bioreactor culture using a model that relates a Raman spectrum to the culture parameter. Related bioreactor system are also provided.

公开(公告)号：US20170335000A1

公开(公告)日：2017-11-23

申请号：US15470442

申请日：2017-03-27

Applicant: BIOGEN MA INC.

Inventor： Michael Karpusas ,  Paul D. Lyne ,  Ellen A. Garber Stark ,  Jose William Saldanha

IPC: C07K16/28 ,  A61K39/00

CPC classification number: C07K16/2842 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  Y02A90/26

Abstract: Antibodies that specifically bind to VLA-1 integrin and methods of using these antibodies to treat immunological disorders in a subject. Also included are crystal structures of complexes formed by VLA-1 antibodies and their ligands, and VLA-1 antagonists and agonists identified by using the structure coordinates of these structures.

公开(公告)号：USD795890S1

公开(公告)日：2017-08-29

申请号：US29542796

申请日：2015-10-16

Applicant: Biogen MA Inc.

Designer： Ajay Verma ,  John W. Hoppin ,  Karl F. Schmidt

公开(公告)号：US20170233485A1

公开(公告)日：2017-08-17

申请号：US15504444

申请日：2015-08-18

Applicant: Biogen MA Inc.

Inventor： Linda C. Burkly ,  Janine Ferrant-Orgettas

IPC: C07K16/28

CPC classification number: C07K16/2878 ,  A61K2039/505 ,  A61K2039/545 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/41 ,  C07K2317/53 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/71 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

Abstract: Antibodies and antibody fragments that bind to human CD40 and inhibit interaction between CD40 and its ligand, CD40L are disclosed. Also disclosed are methods of using the antibodies and antibody fragments to inhibit hyperactivation of B or T cells and treat or prevent disorders such as autoimmune diseases.