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    ANTI-VLA-4 RELATED ASSAYS
    4.
    发明申请
    ANTI-VLA-4 RELATED ASSAYS 有权

    公开(公告)号：US20220357338A1

    公开(公告)日：2022-11-10

    申请号：US17700242

    申请日：2022-03-21

    Applicant: Biogen MA Inc.

    Inventor： Tatiana Plavina ,  Paula S. Hochman ,  Michaela Lerner

    IPC: G01N33/68 ,  G01N33/558 ,  G01N33/566 ,  G01N33/94

    Abstract: Methods and apparatus for assaying the level of analytes in a sample, related to VLA-4, are disclosed. A method of decreasing the level of an anti-integrin antibody in a subject is described including a) contacting a biological sample from a subject with a detectable capture agent associated with a substrate, wherein the capture agent can bind an anti-integrin antibody in the sample; b) detecting binding of the capture agent with the level of the anti-integrin antibody; and c) treating the subject with plasma exchange until the level of the anti-integrin antibody in the sample reaches a predetermined level.

    ANTI-VLA-4 RELATED ASSAYS
    6.
    发明申请
    ANTI-VLA-4 RELATED ASSAYS 审中-公开

    公开(公告)号：US20200088738A1

    公开(公告)日：2020-03-19

    申请号：US16422822

    申请日：2019-05-24

    Applicant: Biogen MA Inc.

    Inventor： Tatiana Plavina ,  Paula S. Hochman ,  Michaela Lerner

    IPC: G01N33/68 ,  G01N33/94 ,  G01N33/566 ,  G01N33/558

    Abstract: Methods and apparatus for assaying the level of analytes in a sample, related to VLA-4, are disclosed. A method of decreasing the level of an anti-integrin antibody in a subject is described including a) contacting a biological sample from a subject with a detectable capture agent associated with a substrate, wherein the capture agent can bind an anti-integrin antibody in the sample; b) detecting binding of the capture agent with the level of the anti-integrin antibody; and c) treating the subject with plasma exchange until the level of the anti-integrin antibody in the sample reaches a predetermined level.

    Anti-VLA-4 related assays
    9.
    发明授权
    Anti-VLA-4 related assays 有权

    公开(公告)号：US10302654B2

    公开(公告)日：2019-05-28

    申请号：US15637446

    申请日：2017-06-29

    Applicant: Biogen MA Inc.

    Inventor： Tatiana Plavina ,  Paula S. Hochman ,  Michaela Lerner

    IPC: G01N33/68 ,  G01N33/566 ,  G01N33/94 ,  G01N33/558

    Abstract: Methods and apparatus for assaying the level of analytes in a sample, related to VLA-4, are disclosed. A method of decreasing the level of an anti-integrin antibody in a subject is described including a) contacting a biological sample from a subject with a detectable capture agent associated with a substrate, wherein the capture agent can bind an anti-integrin antibody in the sample; b) detecting binding of the capture agent with the level of the anti-integrin antibody; and c) treating the subject with plasma exchange until the level of the anti-integrin antibody in the sample reaches a predetermined level.

    ANTI-VLA-4 RELATED ASSAYS
    10.
    发明申请
    ANTI-VLA-4 RELATED ASSAYS 有权
    抗VLA-4相关测定

    公开(公告)号：US20160274125A1

    公开(公告)日：2016-09-22

    申请号：US15166514

    申请日：2016-05-27

    Applicant: Biogen MA Inc.

    Inventor： Tatiana Plavina ,  Paula S. Hochman ,  Michaela Lerner

    IPC: G01N33/68 ,  G01N33/94

    CPC classification number: G01N33/6854 ,  G01N33/558 ,  G01N33/566 ,  G01N33/94 ,  G01N2333/70546 ,  G01N2333/7055 ,  G01N2800/26 ,  G01N2800/52

    Abstract: Methods and apparatus for assaying the level of analytes in a sample, related to VLA-4, are disclosed. A method of decreasing the level of an anti-integrin antibody in a subject is described including a) contacting a biological sample from a subject with a detectable capture agent associated with a substrate, wherein the capture agent can bind an anti-integrin antibody in the sample; b) detecting binding of the capture agent with the level of the anti-integrin antibody; and c) treating the subject with plasma exchange until the level of the anti-integrin antibody in the sample reaches a predetermined level.

    Abstract translation: 公开了用于测定与VLA-4相关的样品中分析物水平的方法和装置。 描述了降低受试者中抗整联蛋白抗体水平的方法，其包括：a）将来自受试者的生物样品与与底物相关的可检测的捕获剂接触，其中所述捕获剂可以结合抗 - 整联蛋白抗体 样品; b）检测捕获剂与抗整联蛋白抗体水平的结合; 和c）用血浆置换治疗受试者，直到样品中抗整联蛋白抗体的水平达到预定水平。

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