公开(公告)号：US20240154626A1

公开(公告)日：2024-05-09

申请号：US18240162

申请日：2023-08-30

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Richard D. Wesel ,  Linfang Wang ,  Sean Chen ,  Dariush Divsalar ,  Jonathan Nguyen

IPC: H03M13/11

CPC classification number: H03M13/1111

Abstract: Neural Normalized MinSum (N-NMS) decoding for improving frame error rate (FER) performance on linear block codes over conventional normalized MinSum (NMS). Dynamic multiplicative weights are assigned to each check-to-variable message in each iteration to efficiently provide training parameters of N-NMS that support N-NMS for longer block lengths. Embodiment are described for neural two-dimensional normalized MinSum (N-2D-NMS) decoders requiring fewer training parameters. The N-2D-NMS approaches for example use the same weight for edges with the same check and/or variable node degree. Simulation results indicate that that this LDPC decoding performs similarly to previous techniques while substantially reducing the amount of training necessary.

公开(公告)号：US20240139329A1

公开(公告)日：2024-05-02

申请号：US18495508

申请日：2023-10-26

Applicant: California Institute of Technology

Inventor： Viviana Gradinaru ,  Timothy F. Shay ,  Xinhong Chen ,  Seongmin Jang

IPC: A61K47/64 ,  A61K48/00 ,  C07K14/00

CPC classification number: A61K47/64 ,  A61K48/0041 ,  C07K14/001

Abstract: Disclosed herein include novel blood-brain barrier (BBB)-crossing receptors on the BBB interface, targeting peptides and derivatives thereof capable of binding to the novel receptors, and related methods of using the receptors to increase the permeability of the BBB and to deliver an agent to a nervous system (e.g., CNS). In some embodiments, the BBB-crossing receptor is LRP6. Disclosed herein also include recombinant adeno-associated viruses (rAAVs) with increased specificity and transduction efficiency across the BBB and related compositions and methods of treating various diseases and conditions.

公开(公告)号：US11968848B2

公开(公告)日：2024-04-23

申请号：US17071364

申请日：2020-10-15

Applicant: SAMSUNG ELECTRONICS CO., LTD. ,  CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Seunghoon Han ,  Kwanghee Lee ,  Yongwan Jin ,  Yongsung Kim ,  Changgyun Shin ,  Jeongyub Lee ,  Amir Arbabi ,  Andrei Faraon ,  Yu Horie

IPC: H10K39/32 ,  H01L27/146

CPC classification number: H10K39/32 ,  H01L27/14621 ,  H01L27/14636 ,  H01L27/14645

Abstract: An image sensor includes a first light sensor layer including light sensing cells configured to sense first light of an incident light and generate electrical signals based on the sensed first light, and a color filter array layer disposed on the first light sensor layer, and including color filters respectively facing the light sensing cells. The image sensor further includes a second light sensor layer disposed on the color filter array layer, and configured to sense second light of the incident light and generate an electrical signal based on the sensed second light. Each of the color filters includes a nanostructure including a first material having a first refractive index, and a second material having a second refractive index greater than the first refractive index, the first material and the second material being alternately disposed with a period.

公开(公告)号：US20240125189A1

公开(公告)日：2024-04-18

申请号：US18277351

申请日：2022-03-31

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Kristopher V. SHERRILL ,  Jacob F. TIMS ,  Scott J. MORELAND

IPC: E21B23/00

CPC classification number: E21B23/001

Abstract: Systems and methods for driving and steering of a robot, or mobile vessel, for operation in a downhole pipe of an oil/gas/water well are presented. According to one aspect, the mobile vessel includes a plurality of wheels arranged outwardly from the mobile vessel so that each wheel may contact the inner wall of the casing. According to another aspect, the plurality of wheels may include respective wheel-centerlines that intersect the centerline of the casing that is at an offset from a centerline of the mobile vessel. The plurality of wheels includes at least two drive wheels and at least one passive wheel. According to a further aspect, the drive wheels are configured to rotate about their respective wheel-centerlines to steer the mobile vessel during traversal of the casing. In one case, the mobile vessel includes two drive and steering wheels and one passive wheel.

公开(公告)号：US20240124913A1

公开(公告)日：2024-04-18

申请号：US18486875

申请日：2023-10-13

Applicant: California Institute of Technology

Inventor： Andrew C. Lu ,  Michael J. Flynn ,  Lucy S. Chong ,  Ronghui Zhu ,  Michael B. Elowitz

IPC: C12Q1/37 ,  A61K38/48 ,  A61P35/00 ,  C12N9/22

CPC classification number: C12Q1/37 ,  A61K38/4873 ,  A61P35/00 ,  C12N9/22 ,  C12N2310/20

Abstract: Disclosed herein include methods, compositions, and kits suitable for use in signal amplification. There are provided, in some embodiments, protease-based signal amplification modules. Disclosed herein include amplifier proteins comprising a first part of a first protease domain, a first dimerization domain, a first cut site a protease in a protease active state is capable of cutting, a second dimerization domain, a second cut site a protease in a protease active state is capable of cutting, and a first caging domain. Disclosed herein include companion amplifier proteins comprising a second part of a first protease domain, a third dimerization domain, a third cut site a protease in a protease active state is capable of cutting, a fourth dimerization domain, a fourth cut site a protease in a protease active state is capable of cutting, and a second caging domain.

公开(公告)号：US11959856B2

公开(公告)日：2024-04-16

申请号：US15701014

申请日：2017-09-11

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Imran R. Malik ,  Xiomara Linnette Madero ,  Erika F. Garcia ,  Sheel Mukesh Shah ,  Axel Scherer

IPC: G01N21/64 ,  C12Q1/6851

CPC classification number: G01N21/6486 ,  C12Q1/6851 ,  C12Q1/6851 ,  C12Q2537/143 ,  C12Q2537/165 ,  C12Q2565/629

Abstract: Methods and algorithms for a multiplexed single detection channel amplification process and quantification of generated amplicons is presented. Various mathematical approaches for quantifying and verifying the amplicons in a reaction are presented. Usage of such methods and approaches allow upgrading of existing single and multiple channel instruments for further multiplexing capabilities.

公开(公告)号：US11959127B2

公开(公告)日：2024-04-16

申请号：US17204782

申请日：2021-03-17

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Mikhail G. Shapiro ,  Dan Piraner ,  Mohamad H. Abedi ,  Brittany Moser ,  Audrey Lee-Gosselin

IPC: C12Q1/68 ,  B01L7/00 ,  C12N15/10 ,  C12N15/63 ,  C12N15/82 ,  C12Q1/6825 ,  G01N33/53 ,  C12N15/00

CPC classification number: C12Q1/6825 ,  B01L7/52 ,  C12N15/1055 ,  C12N15/63 ,  C12N15/8217 ,  G01N33/53 ,  C12N15/00 ,  C12Q2525/30

Abstract: Temperature sensitive transcriptional bioswitches and related genetic circuits and in particular bandpass and/or multiplex genetic circuits, vectors, cells, compositions methods and systems are described.

公开(公告)号：US11958741B2

公开(公告)日：2024-04-16

申请号：US17397826

申请日：2021-08-09

Applicant: California Institute of Technology

Inventor： Yunxi Yao ,  Konstantinos P. Giapis

IPC: C01B13/02 ,  B01J19/12 ,  C01B32/05 ,  C01B32/19 ,  H05H1/46 ,  H05H5/00

CPC classification number: C01B13/0203 ,  B01J19/123 ,  C01B32/05 ,  C01B32/19 ,  H05H1/46 ,  H05H5/00 ,  H05H2245/10

Abstract: Apparatus and methods for facilitating an intramolecular reaction that occurs in single collisions of CO2 molecules (or their derivatives amenable to controllable acceleration, such as CO2+ ions) with a solid surface, such that molecular oxygen (or its relevant analogs, e.g., O2+ and O2− ions) is directly produced are provided. The reaction is driven by kinetic energy and is independent of surface composition and temperature. The methods and apparatus may be used to remove CO2 from Earth's atmosphere, while, in other embodiments, the methods and apparatus may be used to prevent the atmosphere's contamination with CO2 emissions. In yet other embodiments, the methods and apparatus may be used to obtain molecular oxygen in CO2-rich environments, such as to facilitate exploration of extraterrestrial bodies with CO2-rich atmospheres (e.g. Mars).

公开(公告)号：US11950887B2

公开(公告)日：2024-04-09

申请号：US17020740

申请日：2020-09-14

Applicant: California Institute of Technology

Inventor： Aditya Rajagopal ,  Dominic Yurk ,  Yaser Abu-Mostafa ,  Alaina Ann Brinley Rajagopal

IPC: A61B5/021 ,  A61B5/00

CPC classification number: A61B5/02133 ,  A61B5/6832 ,  A61B5/7405 ,  A61B5/02141

Abstract: Some implementations of the disclosure describe a blood pressure measurement apparatus and method that enable continuous, non-invasive blood pressure measurement using sound and ultrasound transducers. In one implementation, a blood pressure measurement device includes: a first transducer configured to emit multiple soundwaves having multiple frequencies, the soundwaves configured to cause a blood vessel of a subject to vibrate; a second transducer configured to capture one or more ultrasound images of the blood vessel; and a processing device configured to: determine, based on the one or more ultrasound images, a wall thickness, a radius, and a resonant frequency of the blood vessel; and calculate, based on the wall thickness, the radius, and the resonant frequency, a blood pressure of the subject.

公开(公告)号：US20240108303A1

公开(公告)日：2024-04-04

申请号：US18372626

申请日：2023-09-25

Applicant: California Institute of Technology

Inventor： Alessio TAMBORINI ,  Morteza GHARIB

IPC: A61B7/00 ,  A61B5/00 ,  A61B5/021 ,  A61B5/022

CPC classification number: A61B7/00 ,  A61B5/02116 ,  A61B5/022 ,  A61B5/7264 ,  A61B5/7282 ,  A61B5/025

Abstract: The disclosure relates to systems and methods for noninvasively performing cardiac auscultation. In some implementations, a method includes: performing, using a BP cuff of a BP cuff system, a blood pressure measurement of a subject to obtain one or more blood pressure values corresponding to the subject; inflating, based on the one or more blood pressure values corresponding to the subject, the BP cuff to a subject specific pressure value; capturing, using the BP cuff system, while the BP cuff is inflated to the subject specific pressure value, a pulse pressure waveform signal associated with an artery of the subject; obtaining a sound waveform signal associated with a heart valve of the subject by filtering the pulse pressure waveform signal to extract sound components associated with the opening or closing of the heart valve; and analyzing the sound waveform signal to identify characteristics of the heart of the subject.