公开(公告)号：US11006090B2

公开(公告)日：2021-05-11

申请号：US16318680

申请日：2017-08-04

Applicant: University of Rochester

Inventor： John C. Howell ,  Joseph Spencer Howell

IPC: H04N13/117 ,  G06F3/03 ,  G06F3/01 ,  H04N7/18 ,  H04N13/376 ,  H04N13/204 ,  H04N13/305 ,  H04N13/366

Abstract: The present disclosure is generally related to capturing a scene and projecting a virtual window to one or more observers. A virtual window may mimic the experience a viewer has when looking through a real window. In some embodiments, for a single observer looking at a digital display or digital screen, a head-tracking camera on the same side of the screen as the observer can determine the position of the observer relative to the screen. The camera may be a 3D camera, stereoscopic camera, a wide angle lens camera, or an array of cameras (e.g., two or more). A camera on the other side of the screen can then image the view on the other side of the screen and software can determine the correct portion of the view that should be displayed on the screen to the observer.

公开(公告)号：US20210121604A1

公开(公告)日：2021-04-29

申请号：US17043927

申请日：2019-03-29

Applicant: University of Rochester

Inventor： Omar ALJITAWI ,  Hani AWAD ,  Michael BECKER

IPC: A61L27/36 ,  A61L27/38 ,  A61L27/54 ,  A61L27/56 ,  C12N5/0789 ,  G01N33/50 ,  B33Y80/00 ,  B33Y70/00

Abstract: The present invention provides bioengineered extracellular matrix model derived from decellularized Wharton's jelly matrix (DWJM) and methods for making and using the same. After decellularization, the DWJM is homogenized, frozen, and lyophilized in a mold to form a molded scaffold having a substantially uniform pore size, pore distribution, and matrix component distribution, and can be trimmed and shaped to any desired size. The bioengineered DWJM is able to maintain the stem cell qualities of cultured cells, which is useful in screening chemotherapy drugs that target cancers, especially cancer stem cell populations. The bioengineered DWJM possesses matrix components similar to the bone hematopoietic niche and is useful in expanding and maintaining hematopoietic stem cells as well as promoting bone regeneration and repair.

公开(公告)号：US10966042B2

公开(公告)日：2021-03-30

申请号：US16799286

申请日：2020-02-24

Applicant: The University of Rochester

Inventor： Michael C. Heilemann ,  Mark F. Bocko

IPC: H04S7/00 ,  H04R5/04 ,  H04R3/00 ,  H04R1/28 ,  H04R7/04

Abstract: A loudspeaker system composed of a flexible panel with an affixed array of force actuators, a signal processing system, and interface electronic circuits is described. The system described is capable of creating a pattern of standing bending waves at any location on the panel and the instantaneous amplitude, velocity, or acceleration of the standing waves can be controlled by an audio signal to create localized acoustic sources at the selected locations in the plane of the panel.

公开(公告)号：US20210063769A1

公开(公告)日：2021-03-04

申请号：US17097591

申请日：2020-11-13

Applicant: University of Rochester

Inventor： Wayne H. Knox ,  Gustavo A. Gandara-Montano ,  Leonard Zheleznyak

IPC: G02C7/04 ,  A61F2/16 ,  A61F9/008 ,  A61F2/14

Abstract: Described refractive correctors, include, but are not limited to, intraocular lenses (IOLs), contact lenses, corneal inlays, and other optical components or devices, incorporating a continuous central phase zone and peripheral phase discontinuities. Further embodiments are directed to a method for using a laser to modify the refractive properties of refractive correctors to form such continuous central phase zone and peripheral phase discontinuities, and other applications. The refractive corrector and methods adapt a Fresnel lens structure to include continuous phase retarding regions having a wavefront height of greater than one design wavelength in a central zone of a refractive corrector to improve human vision applications, while maintaining benefits of phase wrapping in the peripheral region.

公开(公告)号：US20210063312A1

公开(公告)日：2021-03-04

申请号：US16964831

申请日：2019-01-25

Applicant: UNIVERSITY OF ROCHESTER

Inventor： Stavros G. Demos ,  Chi Huang

IPC: G01N21/64 ,  G01N1/30

Abstract: Microscopy with Ultraviolet Surface Excitation (MUSE) for use in the classroom to enhance life sciences education and curricula, or for other applications, including without limtiation the operating room, other medical environments, research environments, and low resource environments. MUSE's suitability is based on multiple key factors including its simplicity of use, the incorporation of inexpensive hardware including LED illumination, and very basic tissue preparation. The ultraviolet excitation acts as passive optical sectioning confining the generated fluorescence signal to only a few micrometers below the tissue surface thus eliminating the out of focus signals. This facilitates image capture of tissue microstructure and organization from specimens at the intact or sliced surface arising from varying fluorophore concentration within the different cellular compartments. Although just the tissue auto fluorescence maybe used, image quality is enhanced with brief application of nontoxic fluorescent dyes to selectively highlight cellular compartments. Sample preparation is safe, efficient and familiar to students with basic chemistry or biology lab experience. Mixed-dye powders may be used to simplify translation of this method for educational, medical, research, low resource, and other settings.

公开(公告)号：US20210045920A1

公开(公告)日：2021-02-18

申请号：US17072286

申请日：2020-10-16

Applicant: University of Rochester

Inventor： Wayne H. Knox ,  Krystel R. Huxlin

IPC: A61F9/008

Abstract: A method for modifying a refractive property of ocular tissue in an eye by creating at least one optically-modified gradient index (GRIN) layer in the corneal stroma and/or the crystalline by continuously scanning a continuous stream of laser pulses having a focal volume from a laser having a known average power along a continuous line having a smoothly changing refractive index within the tissue, and varying either or both of the scan speed and the laser average power during the scan. The method may further involve determining a desired vision correction adjustment, and determining a position, number, and design parameters of gradient index (GRIN) layers to be created within the ocular tissue to provide the desired vision correction.

公开(公告)号：US10893936B2

公开(公告)日：2021-01-19

申请号：US16388992

申请日：2019-04-19

Applicant: University of Rochester

Inventor： Wayne H. Knox ,  Li Ding ,  Jay F. Kunzler ,  Dharmendra Jani

IPC: A61F2/16 ,  A61F2/14 ,  G02C7/02 ,  B29D11/00 ,  B29D11/02 ,  C08J7/12 ,  A61B18/20 ,  A61F9/008 ,  A61L27/16 ,  A61L27/52 ,  A61L27/18 ,  G02B1/04 ,  B29K83/00 ,  B29K105/00

Abstract: An optical device comprising an optical hydrogel with select regions that have been irradiated with laser light having a pulse energy from 0.01 nJ to 50 nJ and a wavelength from 600 nm to 900 nm. The irradiated regions are characterized by a positive change in refractive index of from 0.01 to 0.06, and exhibit little or no scattering loss. The optical hydrogel is prepared with a hydrophilic monomer.

公开(公告)号：US10806567B2

公开(公告)日：2020-10-20

申请号：US15923443

申请日：2018-03-16

Applicant: University of Rochester

Inventor： Wayne H. Knox ,  Li Ding ,  Jay Friedrich Kunzler ,  Dharmendra M. Jani

IPC: A61F2/16 ,  A61F9/008 ,  G02C7/04

Abstract: A method for modifying the refractive index of an optical, polymeric material. The method comprises irradiating select regions of the optical, polymeric material with a focused, visible or near-IR laser having a pulse energy from 0.05 nJ to 1000 nJ. The irradiation results in the formation of refractive optical structures, which exhibit little or no scattering loss. The method can he used to modify the refractive index of an intraocular lens following the surgical implantation of the intraocular lens in a human eye. The invention is also directed to an optical device comprising refractive optical structures, which exhibit little or no scattering loss and are characterized by a positive change in refractive index.

公开(公告)号：US20200225347A1

公开(公告)日：2020-07-16

申请号：US16742084

申请日：2020-01-14

Applicant: University of Rochester

Inventor： Kevin J. Parker

IPC: G01S15/89 ,  G01S7/52 ,  G06T11/00

Abstract: A method of forming an image of a region of interest using a pulse-echo imaging device is described. The method includes the steps of generating a pulse using the pulse-echo imaging device, causing the pulse to be incident on the region of interest to generate a reflected echo, receiving the reflected echo in the pulse-echo imaging device, comparing a measure of frequency content of the reflected echo to the transmitted pulse, and frequency shifted replicas of the transmitted pulse, wherein each is associated with a unique label, selecting a label based on the comparison, and generating an image incorporating the selected label.

公开(公告)号：US10649115B2

公开(公告)日：2020-05-12

申请号：US15946287

申请日：2018-04-05

Applicant: University of Rochester

Inventor： Wayne H. Knox ,  Dharmendra Jani ,  Li Ding

IPC: B29D11/00 ,  G02B3/00 ,  A61F9/008 ,  A61L27/16 ,  A61L27/50 ,  A61L27/52 ,  A61F2/16

Abstract: A method for modifying the refractive index of an optical polymeric material. The method comprises continuously irradiating predetermined regions of an optical, polymeric material with femtosecond laser pulses to form a gradient index refractive structure within the material. The optical polymeric material can include a photosensitizer to increase the photoefficiency of the two-photo process resulting in the formation of the observed refractive structures. An optical device includes an optical, polymeric lens material having an anterior surface and posterior surface and an optical axis intersecting the surfaces and at least one laser-modified, GRIN layer disposed between the anterior surface and the posterior surface and arranged along a first axis 45° to 90° to the optical axis. The at least one laser-modified GRIN layer comprises a plurality of adjacent refractive segments characterized by a variation in index of refraction across at least one of at least a portion of the adjacent segments and along each segment.